CY1118111T1 - Υποκατεστημενα αλειφανια, κυκλοφανια, ετεραφανια, ετεροφανια, ετερο-ετεραφανια και μεταλλοκενια που ειναι χρησιμα για τη θεραπευτικη αντιμετωπιση hcv λοιμωξεων - Google Patents

Υποκατεστημενα αλειφανια, κυκλοφανια, ετεραφανια, ετεροφανια, ετερο-ετεραφανια και μεταλλοκενια που ειναι χρησιμα για τη θεραπευτικη αντιμετωπιση hcv λοιμωξεων

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Publication number
CY1118111T1
CY1118111T1 CY20161100824T CY161100824T CY1118111T1 CY 1118111 T1 CY1118111 T1 CY 1118111T1 CY 20161100824 T CY20161100824 T CY 20161100824T CY 161100824 T CY161100824 T CY 161100824T CY 1118111 T1 CY1118111 T1 CY 1118111T1
Authority
CY
Cyprus
Prior art keywords
transfer
heterophane
treatment
hetero
substituted aliphatic
Prior art date
Application number
CY20161100824T
Other languages
English (en)
Inventor
Jason Allan Wiles
Qiuping Wang
Akihiro Hashimoto
Godwin Pais
Dawei Chen
Xiangzhu Wang
Venkat Gadhachanda
Avinash Phadke
Milind Deshpande
Original Assignee
Achillion Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achillion Pharmaceuticals, Inc. filed Critical Achillion Pharmaceuticals, Inc.
Publication of CY1118111T1 publication Critical patent/CY1118111T1/el

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
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Abstract

Η παρούσα αποκάλυψη παρέχει υποκατεστημένα αλειφάνια, κυκλοφάνια, ετεραφάνια, ετεροφάνια, ετερο-ετεραφάνια και μεταλλοκένια, του Χημικού Τύπου (I) D-M-D (Χημικός Τύπος I) που είναι χρήσιμα ως αντιιικοί παράγοντες. Σε ορισμένες ενσωματώσεις που αποκαλύπτονται στο παρόν το Μ είναι μια ομάδα -Ρ-Α-Ρ- όπου το Α είναι ορισμένα υποκατεστημένα αλειφάνια, κυκλοφάνια, ετεραφάνια, ετεροφάνια, ετερο-ετεραφάνια και μεταλλοκένια που αποκαλύπτονται στο παρόν είναι ισχυροί και/ή επιλεκτικοί αναστολείς της ιικής αντιγραφής, συγκεκριμένα της αντιγραφής του ιού της Ηπατίτιδας C. Φαρμακευτικές συνθέσεις και συνδυασμοί που περιέχουν ένα ή περισσότερα υποκατεστημένα αλειφάνια, κυκλοφάνια, ετεραφάνια, ετεροφάνια, ετερο-ετεραφάνια και μεταλλοκένια και ένα φαρμακευτικά αποδεκτό φορέα παρέχονται επίσης σε αυτή την αποκάλυψη. Μέθοδοι για τη θεραπευτική αντιμετώπιση ιογενών λοιμώξεων, που περιλαμβάνουν ιογενείς λοιμώξεις Ηπατίτιδας C παρέχονται στην αποκάλυψη.
CY20161100824T 2011-05-27 2016-08-22 Υποκατεστημενα αλειφανια, κυκλοφανια, ετεραφανια, ετεροφανια, ετερο-ετεραφανια και μεταλλοκενια που ειναι χρησιμα για τη θεραπευτικη αντιμετωπιση hcv λοιμωξεων CY1118111T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161490881P 2011-05-27 2011-05-27
US201161504905P 2011-07-06 2011-07-06
US201161567216P 2011-12-06 2011-12-06
PCT/US2012/039835 WO2012166716A2 (en) 2011-05-27 2012-05-29 Subsituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating hcv infections

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CY1118111T1 true CY1118111T1 (el) 2017-06-28

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JP (2) JP6198721B2 (el)
KR (1) KR101931311B1 (el)
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AP (1) AP2013007263A0 (el)
AU (2) AU2012262338B2 (el)
BR (1) BR112013030045A2 (el)
CA (1) CA2837481A1 (el)
CY (1) CY1118111T1 (el)
EA (2) EA029099B1 (el)
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HK (1) HK1196559A1 (el)
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SI (1) SI2714036T1 (el)
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WO (1) WO2012166716A2 (el)

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