EA201301335A1 - Замещенные алифаны, циклофаны, гетерафаны, гетерофаны, гетеро-гетерафаны и металлоцены, пригодные для использования при лечении инфекции вгс - Google Patents

Замещенные алифаны, циклофаны, гетерафаны, гетерофаны, гетеро-гетерафаны и металлоцены, пригодные для использования при лечении инфекции вгс

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EA201301335A1
EA201301335A1 EA201301335A EA201301335A EA201301335A1 EA 201301335 A1 EA201301335 A1 EA 201301335A1 EA 201301335 A EA201301335 A EA 201301335A EA 201301335 A EA201301335 A EA 201301335A EA 201301335 A1 EA201301335 A1 EA 201301335A1
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Eurasian Patent Office
Prior art keywords
heteraphanes
hetero
cyclophans
substituted
aliphans
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EA201301335A
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EA029099B1 (ru
Inventor
Джейсон Аллан Уайлс
Цюпин Ван
Акихиро Хасимото
Годвин Пейс
Давэй Чэнь
Сянцзу Ван
Венкат Гадхачанда
Авинаш Фадке
Милинд Дешпанде
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Ачиллион Фармасьютикалз, Инк.
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Application filed by Ачиллион Фармасьютикалз, Инк. filed Critical Ачиллион Фармасьютикалз, Инк.
Publication of EA201301335A1 publication Critical patent/EA201301335A1/ru
Publication of EA029099B1 publication Critical patent/EA029099B1/ru

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Abstract

Настоящее изобретение предлагает замещенные алифаны, циклофаны, гетерафаны, гетерофаны, гетеро-гетерафаны и металлоцены формулы (I) D-M-D (формула I), пригодные для использования в качестве противовирусных агентов. В определенных вариантах осуществления, описанных в настоящем документе, М представляет собой группу -Р-А-Р-, где А представляет собой (формулу I). Определенные замещенные алифаны, циклофаны, гетерафаны, гетерофаны, гетеро-гетерафаны и металлоцены, описанные в настоящем документе, представляют собой сильнодействующие и/или селективные ингибиторы репликации вирусов, в частности репликации вируса гепатита С. Фармацевтические композиции и комбинации, содержащие один или несколько замещенных алифанов, циклофанов, гетерафанов, гетерофанов, гетеро-гетерафанов и металлоценов и фармацевтически приемлемый носитель, также предлагаются настоящим изобретением. Изобретением предлагаются способы лечения вирусной инфекции, включая вирусную инфекцию гепатита С.
EA201301335A 2011-05-27 2012-05-29 Замещенные циклофаны для использования при лечении инфекции вгс EA029099B1 (ru)

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US201161490881P 2011-05-27 2011-05-27
US201161504905P 2011-07-06 2011-07-06
US201161567216P 2011-12-06 2011-12-06
PCT/US2012/039835 WO2012166716A2 (en) 2011-05-27 2012-05-29 Subsituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating hcv infections

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EA201301335A1 true EA201301335A1 (ru) 2014-04-30
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