JP2016501223A5 - - Google Patents
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- Publication number
- JP2016501223A5 JP2016501223A5 JP2015545193A JP2015545193A JP2016501223A5 JP 2016501223 A5 JP2016501223 A5 JP 2016501223A5 JP 2015545193 A JP2015545193 A JP 2015545193A JP 2015545193 A JP2015545193 A JP 2015545193A JP 2016501223 A5 JP2016501223 A5 JP 2016501223A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 61
- 125000003118 aryl group Chemical group 0.000 claims 35
- 125000001072 heteroaryl group Chemical group 0.000 claims 31
- 229910052799 carbon Inorganic materials 0.000 claims 20
- 150000001204 N-oxides Chemical class 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 229920006395 saturated elastomer Polymers 0.000 claims 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 14
- 229910052717 sulfur Inorganic materials 0.000 claims 14
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000004429 atom Chemical group 0.000 claims 6
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 6
- 125000006747 (C2-C10) heterocycloalkyl group Chemical group 0.000 claims 5
- -1 fused ring Chemical group 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 3
- 125000003003 spiro group Chemical group 0.000 claims 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 claims 2
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 1
- 229940088872 Apoptosis inhibitor Drugs 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000000158 apoptosis inhibitor Substances 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001721 carbon Chemical class 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 108091006086 inhibitor proteins Proteins 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261731794P | 2012-11-30 | 2012-11-30 | |
| US61/731,794 | 2012-11-30 | ||
| PCT/US2013/072064 WO2014085489A1 (en) | 2012-11-30 | 2013-11-26 | Inhibitor of apoptosis protein (iap) antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018101004A Division JP2018162256A (ja) | 2012-11-30 | 2018-05-25 | アポトーシス阻害タンパク質（ｉａｐ）のアンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016501223A JP2016501223A (ja) | 2016-01-18 |
| JP2016501223A5 true JP2016501223A5 (enExample) | 2016-12-15 |
| JP6382831B2 JP6382831B2 (ja) | 2018-08-29 |
Family
ID=50828427
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545193A Active JP6382831B2 (ja) | 2012-11-30 | 2013-11-26 | アポトーシス阻害タンパク質（ｉａｐ）のアンタゴニスト |
| JP2018101004A Pending JP2018162256A (ja) | 2012-11-30 | 2018-05-25 | アポトーシス阻害タンパク質（ｉａｐ）のアンタゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018101004A Pending JP2018162256A (ja) | 2012-11-30 | 2018-05-25 | アポトーシス阻害タンパク質（ｉａｐ）のアンタゴニスト |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US9546174B2 (enExample) |
| EP (1) | EP2925764B1 (enExample) |
| JP (2) | JP6382831B2 (enExample) |
| CA (1) | CA2896577C (enExample) |
| WO (1) | WO2014085489A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2896577C (en) | 2012-11-30 | 2024-01-23 | Sanford-Burnham Medical Research Institute | Inhibitor of apoptosis protein (iap) antagonists |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| JP6768522B2 (ja) | 2014-06-04 | 2020-10-14 | サンフォード−バーンハム メディカル リサーチ インスティテュート | Ｈｉｖ治療におけるアポトーシスタンパク質阻害剤（ｉａｐ）のアンタゴニストの使用 |
| WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
| WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| US10870663B2 (en) | 2018-11-30 | 2020-12-22 | Glaxosmithkline Intellectual Property Development Limited | Compounds useful in HIV therapy |
| CN113613724B (zh) * | 2018-11-30 | 2024-11-08 | 葛兰素史克知识产权开发有限公司 | 可用于hiv疗法的化合物 |
| EP3911316A1 (en) | 2019-01-17 | 2021-11-24 | Debiopharm International SA | Combination product for the treatment of cancer |
| CN110028508B (zh) * | 2019-05-16 | 2021-05-28 | 南京华威医药科技集团有限公司 | 一种抗肿瘤的重氮双环类细胞凋亡蛋白抑制剂 |
| US12636370B2 (en) | 2019-08-08 | 2026-05-26 | Institute For Cancer Research | Combination therapy for treatment of cancer |
| AU2020356356A1 (en) | 2019-09-25 | 2022-05-12 | Debiopharm International S.A. | Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma |
| US12678509B2 (en) | 2019-11-08 | 2026-07-14 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitor of apoptosis (IAP) protein antagonists |
| EP4143198A4 (en) * | 2020-04-30 | 2024-05-01 | Sanford Burnham Prebys Medical Discovery Institute | INHIBITOR OF APOPTOSIS PROTEIN ANTAGONISTS (API) |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| US20250129099A1 (en) * | 2021-11-04 | 2025-04-24 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitor of apoptosis (iap) protein antagonists |
| AR131299A1 (es) * | 2022-12-09 | 2025-03-05 | Debiopharm Int Sa | Nuevos inhibidores de iap, métodos para fabricarlos y usos de los mismos |
| AU2024367811A1 (en) * | 2023-10-24 | 2026-05-07 | Tract Pharmaceuticals, Inc. | Combination of iap inhibitors and cellular kinase inhibitors, such as ponatinib, for use in the treatment of cancer or pulmonary diseases, such as copd, cystic fibrosis, pulmonary fibrosis and covid-19 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5455242A (en) | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| US5457196A (en) | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| PT669936E (pt) | 1992-10-30 | 2001-04-30 | Merrell Pharma Inc | Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| FR2803594B1 (fr) * | 2000-01-11 | 2002-07-19 | Centre Nat Rech Scient | Oligomeres de mimes contraints non peptidiques de dipeptides ou de tripeptides, et leurs utilisations |
| BRPI0506883A (pt) * | 2004-01-16 | 2007-05-29 | Univ Michigan | miméticos de smac conformacionalmente comprimidos e seus usos |
| KR100926203B1 (ko) | 2004-07-02 | 2009-11-09 | 제넨테크, 인크. | Ｉａｐ의 억제제 |
| WO2006010118A2 (en) | 2004-07-09 | 2006-01-26 | The Regents Of The University Of Michigan | Conformationally constrained smac mimetics and the uses thereof |
| BRPI0513310A (pt) * | 2004-07-12 | 2008-05-06 | Idun Pharmaceuticals Inc | análogos de tetrapeptìdeo |
| AU2006255084A1 (en) * | 2005-06-08 | 2006-12-14 | Novartis Ag | Organic compounds |
| WO2007101347A1 (en) | 2006-03-07 | 2007-09-13 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| US20090010941A1 (en) | 2007-04-09 | 2009-01-08 | University Of Massachusetts | Methods for treating HIV |
| WO2008128171A2 (en) | 2007-04-13 | 2008-10-23 | The Regents Of The University Of Michigan | Diazo bicyclic smac mimetics and the uses thereof |
| US8445473B2 (en) | 2008-04-11 | 2013-05-21 | The Regents Of The University Of Michigan | Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof |
| JP2010174138A (ja) | 2009-01-29 | 2010-08-12 | Nok Kluber Kk | グリース組成物の製造方法及び該方法により製造されるグリース組成物 |
| US8642544B2 (en) * | 2009-04-01 | 2014-02-04 | Amylin Pharmaceuticals, Llc | N-terminus conformationally constrained GLP-1 receptor agonist compounds |
| US9346852B2 (en) | 2011-03-14 | 2016-05-24 | Bristol-Myers Scuibb Company | Substituted adipic acid amides and uses thereof |
| US20150174235A1 (en) | 2012-06-06 | 2015-06-25 | Bionor Immuno As | Vaccine |
| CA2896577C (en) | 2012-11-30 | 2024-01-23 | Sanford-Burnham Medical Research Institute | Inhibitor of apoptosis protein (iap) antagonists |
| JP6768522B2 (ja) | 2014-06-04 | 2020-10-14 | サンフォード−バーンハム メディカル リサーチ インスティテュート | Ｈｉｖ治療におけるアポトーシスタンパク質阻害剤（ｉａｐ）のアンタゴニストの使用 |
-
2013
- 2013-11-26 CA CA2896577A patent/CA2896577C/en active Active
- 2013-11-26 JP JP2015545193A patent/JP6382831B2/ja active Active
- 2013-11-26 US US14/648,435 patent/US9546174B2/en active Active
- 2013-11-26 WO PCT/US2013/072064 patent/WO2014085489A1/en not_active Ceased
- 2013-11-26 EP EP13859485.8A patent/EP2925764B1/en active Active
-
2016
- 2016-11-29 US US15/363,935 patent/US10047119B2/en active Active
-
2018
- 2018-05-25 JP JP2018101004A patent/JP2018162256A/ja active Pending
- 2018-07-10 US US16/031,837 patent/US10544188B2/en active Active
-
2020
- 2020-01-10 US US16/740,240 patent/US11111270B2/en active Active
-
2021
- 2021-07-29 US US17/389,171 patent/US11912786B2/en active Active
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