HRP20220479T1 - Spojevi - Google Patents
Spojevi Download PDFInfo
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- HRP20220479T1 HRP20220479T1 HRP20220479TT HRP20220479T HRP20220479T1 HR P20220479 T1 HRP20220479 T1 HR P20220479T1 HR P20220479T T HRP20220479T T HR P20220479TT HR P20220479 T HRP20220479 T HR P20220479T HR P20220479 T1 HRP20220479 T1 HR P20220479T1
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- 150000001875 compounds Chemical class 0.000 title claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 229910052805 deuterium Inorganic materials 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 201000004569 Blindness Diseases 0.000 claims 1
- 206010011891 Deafness neurosensory Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 108010077895 Sarcosine Proteins 0.000 claims 1
- 208000009966 Sensorineural Hearing Loss Diseases 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 229960003767 alanine Drugs 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 229960003121 arginine Drugs 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 108700003601 dimethylglycine Proteins 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960002449 glycine Drugs 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229960003136 leucine Drugs 0.000 claims 1
- 229960003646 lysine Drugs 0.000 claims 1
- 229940078490 n,n-dimethylglycine Drugs 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 229940043230 sarcosine Drugs 0.000 claims 1
- 208000023573 sensorineural hearing loss disease Diseases 0.000 claims 1
- 229960001153 serine Drugs 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 229960002898 threonine Drugs 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 229960004295 valine Drugs 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 230000004393 visual impairment Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0217—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -C(=O)-C-N-C(=O)-N-C-C(=O)-
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (9)
1. Spoj formule II:
[image]
gdje:
n je 1, 2, 3, 4, 5, 6, 7, 8 ili 9;
m je 0, 1, 2, 3 ili 4;
R1 je odabran iz skupine koju čine: C1-C12 alkil, C1-C12 supstituirani alkil, C1-C12 alkenil, C1-C12 supstituirani alkenil, C1-C12 alkinil i C1-C12 supstituirani alkinil;
R2 je odabran iz skupine koju čine: vodik,
[image]
PO(OY)2,
[image]
PO(OH)2, -C(=O)-Y i -CO-U;
Y je -Z-(CH2)q-W-Rb, ili -C(=O)-Y alternativno obrazuje amidnu vezu preko atoma azota na Y, u kom slučaju je Y odabran iz skupine koja se sastoji od: glicina, sarkozina, N,N-dimetil glicina, alanina, valina, leucina, izoleucina, lizina, ornitina, arginina, serina i treonina;
q je 0-4;
Z i W su neovisno odabrani iz skupine sastavljene od: CH2, O, S, NRc i Rb, pri čemu su Z i W po izboru zajedno uzeti, da bi oblikovali C3-C8 heterocikloalkilni ili C4-C10 heteroarilni ili biciklički sustav prstenova u kojem je jedan od prstenova C4-C10 heteroaril;
Rc je odabran iz skupine koju čine: vodik, C1-C4 alkil i C3-C6 cikloalkil;
Rb je odabran iz skupine koju čine: vodik, C1-C12 alkil, C1-C12 supstituirani alkil, C3-C8 cikloalkil, C3-C8 supstituirani cikloalkil, C3-C8 heterocikloalkil i C3-C8 supstituirani heterocikloalkil;
U je odabran iz skupine koju čine: piridin, 1,4-dihidropiridin, N-alkil-1,4-dihidropiridin i C-imidazol, ili je U odabran od arila, heteroarila ili heterocikloalkila;
R3 i R4 su zajedno vezani tako da oblikuju spirociklički sustav prstenova;
svaki R6 je neovisno odabran iz skupine sastavljene od: vodika, deuterijuma, CH3, F, 19F i 18F;
a pri čemu svaki heterociklički i heteroarilni prsten sadrži do četiri heteroatoma odabrana iz skupine sastavljene od: O, N i S;
pod uvjetom da kada su i Z i W heteroatomi, vrijednost q ne može biti 1;
ili njegov tautomer i/ili farmaceutski prihvatljiva sol.
2. Spoj sukladno patentnom zahtjevu 1, gdje je m 0, R1 je C1-C12 alkil i R3 i R4 zajedno oblikuju spirociklički sustav prstenova.
3. Spoj sukladno patentnom zahtjevu 1, gdje je m 1 ili 2, R1 je C1-C12 alkil, R3 i R4 zajedno oblikuju spirociklički sustav prstenova, a R6 je odabran iz skupine sastavljene od: vodika, deuterija, F, 19F i 18F.
4. Spoj odabran od slijedećih struktura:
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
[image]
i
[image]
ili njegov tautomer i/ili farmaceutski prihvatljiva sol.
5. Pripavak koji sadrži najmanje jedan spoj od navedenih u bilo kojem od patentnih zahtjeva 1-4, ili njihove tautomere, stereoizomere, soli, solvate ili hidrate.
6. Farmaceutski pripravak koja sadrži najmanje jedan spoj od navedenih sukladna bilo kojem od patentnih zahtjeva 1-4, ili njihove tautomere, stereoizomere, soli, solvate ili hidrate, i farmaceutski prihvatljiv nosač ili ekscipijens.
7. Farmaceutski pripravak sukladno patentnom zahtjevu 6, koji nadalje sadrži N-heksanoički-L-tirozin-L-izoleucin-(6)-aminoheksanoički amid.
8. Spoj sukladno bilo kojem od patentnih zahtjeva 1-4, ili farmaceutski pripravak sukladno patentnom zahtjevu 6 ili 7, za uporebu u postupku liječenja neurodegenerativne bolesti.
9. Spoj sukladno bilo kojem od patentnih zahtjeva 1-4, ili farmaceutski pripravak sukladno patentnom zahtjevu 6 ili 7, za uporabu sukladno patentnom zahtjevu 8, pri čemu je neurodegenerativna bolest odabrana iz skupine koju čine: Alzheimerova bolest, Parkinsonova bolest, amiotrofična lateralna skleroza, druge demencije i neurodegenerativne bolesti, povreda leđne moždine, traumatska povreda mozga, senzorneuralni gubitak sluha i vida, a poželjno je Alzheimerova bolest ili Parkinsonova bolest.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662344305P | 2016-06-01 | 2016-06-01 | |
| PCT/US2017/035547 WO2017210489A1 (en) | 2016-06-01 | 2017-06-01 | Compounds |
| EP17807519.8A EP3464336B1 (en) | 2016-06-01 | 2017-06-01 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220479T1 true HRP20220479T1 (hr) | 2022-05-27 |
Family
ID=60478958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220479TT HRP20220479T1 (hr) | 2016-06-01 | 2017-06-01 | Spojevi |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11021514B2 (hr) |
| EP (2) | EP3464336B1 (hr) |
| JP (3) | JP2019525947A (hr) |
| CN (3) | CN116655730A (hr) |
| AU (3) | AU2017273857B2 (hr) |
| CA (1) | CA3026074A1 (hr) |
| DK (1) | DK3464336T3 (hr) |
| ES (1) | ES2912035T3 (hr) |
| HR (1) | HRP20220479T1 (hr) |
| LT (1) | LT3464336T (hr) |
| PL (1) | PL3464336T3 (hr) |
| RS (1) | RS63143B1 (hr) |
| SI (1) | SI3464336T1 (hr) |
| WO (1) | WO2017210489A1 (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017273857B2 (en) | 2016-06-01 | 2021-08-19 | Athira Pharma, Inc. | Compounds |
| CA3223668A1 (en) * | 2021-07-23 | 2023-01-26 | Athira Pharma, Inc. | Methods of treating parkinson's disease and/or lewy body disease or disorder(s) |
| TW202406554A (zh) | 2022-05-04 | 2024-02-16 | 美商雅斯娜製藥公司 | 治療神經發炎性病況之方法 |
| WO2023215376A1 (en) | 2022-05-04 | 2023-11-09 | Athira Pharma, Inc. | Methods of treating neuropathies |
| WO2023215378A1 (en) | 2022-05-04 | 2023-11-09 | Athira Pharma, Inc. | Methods of treating fibrosis |
| CN114907288B (zh) * | 2022-05-13 | 2023-12-08 | 中国医学科学院医药生物技术研究所 | 硝基苯类化合物在制备铜绿假单胞菌群体感应抑制剂中的应用 |
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| GB8311286D0 (en) | 1983-04-26 | 1983-06-02 | Searle & Co | Carboxyalkyl peptide derivatives |
| DE3320175A1 (de) | 1983-06-03 | 1984-12-06 | Boehringer Mannheim Gmbh, 6800 Mannheim | Aminosaeure- bzw. peptidderivate, verfahren zu deren herstellung und verwendung als arzneimittel |
| US4477440A (en) | 1983-09-14 | 1984-10-16 | Merck & Co., Inc. | Renin inhibitors containing an n-terminal disulfide cycle |
| EP0163237A3 (en) | 1984-05-29 | 1988-04-27 | Merck & Co. Inc. | Di- and tri-peptidal renin inhibitors |
| JPS63503380A (ja) | 1986-01-16 | 1988-12-08 | アボット・ラボラトリーズ | ペプチド類似体 |
| US5378691A (en) | 1988-04-14 | 1995-01-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Amino acid derivatives |
| AU4035189A (en) | 1988-08-19 | 1990-03-23 | Upjohn Company, The | Renin inhibitory peptides containing suleptanic acid or derivatives thereof |
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| CN116731101A (zh) | 2023-09-12 |
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