HRP20180447T1 - Derivati kinazolina za liječenje virusnih infekcija i drugih bolesti - Google Patents
Derivati kinazolina za liječenje virusnih infekcija i drugih bolesti Download PDFInfo
- Publication number
- HRP20180447T1 HRP20180447T1 HRP20180447TT HRP20180447T HRP20180447T1 HR P20180447 T1 HRP20180447 T1 HR P20180447T1 HR P20180447T T HRP20180447T T HR P20180447TT HR P20180447 T HRP20180447 T HR P20180447T HR P20180447 T1 HRP20180447 T1 HR P20180447T1
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- Croatia
- Prior art keywords
- alkyl
- alkylamino
- alkoxy
- hydroxyl
- compound
- Prior art date
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- 208000036142 Viral infection Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 150000001408 amides Chemical class 0.000 claims 4
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 4
- 150000002825 nitriles Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 3
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 3
- -1 di-(C1-6)alkylamino Chemical group 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 2
- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- 102100033110 Toll-like receptor 8 Human genes 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (7)
1. Spoj s formulom (I)
[image]
ili njegova farmaceutski prihvatljiva sol, solvat ili polimorf, naznačen time da
R1 je C4-8 alkil supstituiran s hidroksilom,
R2 je vodik, halogen, hidroksil, amin, C1-7alkil, C1-7 alkilamino, C1-6alkoksi, (C1-4)alkoksi-(C1-4)alkil, C3-6cikloalkil, C4-7heterocikal, aromatski biciklički heterocikal, arilalkil, heteroaril, heteroarilalkil, karboksilni amid, karboksilni ester svaki od kojih je proizvoljno supstituiran s jednim ili više supstituenata koji su neovisno odabrani iz skupa koji čine halogen, hidroksil, amino, C1-6 alkil, di-(C1-6)alkilamino, C1-6 alkilamino, C1-6 alkil, C1-6alkoksi, C3-6 cikloalkil, karboksilna kiselina, karboksilni ester, karboksilni amid, heterocikal, aril, alkenil, alkinil, arilalkil, heteroaril, heteroarilalkil ili nitril,
R3 je vodik, halogen, hidroksil, amin, C1-7alkil, C1-7alkenil, C1-7alkinil, C1-7 alkilamino, C1-6alkoksi, (C1-4)alkoksi-(C1-4)alkil, C3-6cikloalkil, C4-7heterocikal, aromatski biciklički heterocikal, arilalkil, heteroaril, heteroarilalkil, ariloksi, heteroariloksi, keton, nitril svaki od kojih je proizvoljno supstituiran s jednim ili više supstituenata koji su neovisno odabrani iz skupa koji čine halogen, hidroksil, amino, C1-6 alkil, di-(C1-6)alkilamino, C1-6 alkilamino, C1-6 alkil, C1-6 alkoksi, C3-6 cikloalkil, karboksilna kiselina, karboksilni ester, karboksilni amid, heterocikal, aril, alkenil, alkinil, arilalkil, heteroaril, heteroarilalkil ili nitril,
R4 je vodik, halogen, hidroksil, amin, C1-7alkil, C1-7 alkilamino, C1-6alkoksi, (C1-4)alkoksi-(C1-4)alkil, C3-6cikloalkil, C4-7heterocikal, biciklički heterocikal, arilalkil, heteroarilalkil, ariloksi, heteroariloksi svaki od kojih je proizvoljno supstituiran s jednim ili više supstituenata koji su neovisno odabrani iz skupa koji čine halogen, hidroksil, amino, C1-6 alkil, di-(C1-6)alkilamino, C1-6 alkilamino, C1-6 alkil, C1-6 alkoksi, C3-6 cikloalkil, karboksilna kiselina, karboksilni ester, karboksilni amid, heterocikal, aril, alkenil, alkinil, arilalkil, heteroaril, heteroarilalkil ili nitril, i
R5 je vodik, fluor, klor ili metil pod uvjetom da
R2, R3, R4, i R5 ne mogu svi biti H.
2. Spoj s formulom (I) prema zahtjevu 1 naznačen time da R1 je jedan od slijedećih:
[image]
[image]
3. Spoj s formulom (I) prema zahtjevu 1 ili 2 naznačen time da R5 je vodik ili fluor.
4. Spoj ako formula (I) prema zahtjevima 1-3 ima strukturu
[image]
5. Farmaceutski pripravak naznačen time da sadrži spoj s formulom (I) ili njegovu farmaceutski prihvatljivu sol, solvat ili polimorf prema jednom od zahtjeva 1-4 zajedno s jednim ili više farmaceutski prihvatljivih pomoćnih sredstava, sredstava za razrjeđivanje ili nosača.
6. Spoj s formulom (I) ili njegova farmaceutski prihvatljiva sol, solvat ili polimorf prema jednom od zahtjeva 1-4 ili farmaceutski pripravak prema zahtjevu 5 naznačen time da je za uporabu kao lijek.
7. Spoj s formulom (I) ili njegova farmaceutski prihvatljiva sol, solvat ili polimorf prema jednom od zahtjeva 1-4, ili farmaceutski pripravak prema zahtjevu 5 naznačen time da je za uporabu za liječenje poremećaja u kojem je uključena modulacija TLR7 i/ili TLR8.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11166538 | 2011-05-18 | ||
EP12721852.7A EP2709989B8 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
PCT/EP2012/059234 WO2012156498A1 (en) | 2011-05-18 | 2012-05-18 | Quinazoline derivatives for the treatment of viral infections and further diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20180447T1 true HRP20180447T1 (hr) | 2018-04-20 |
Family
ID=44849923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20180447TT HRP20180447T1 (hr) | 2011-05-18 | 2018-03-16 | Derivati kinazolina za liječenje virusnih infekcija i drugih bolesti |
Country Status (29)
Country | Link |
---|---|
US (1) | US8916575B2 (hr) |
EP (1) | EP2709989B8 (hr) |
JP (1) | JP6050329B2 (hr) |
KR (2) | KR102119700B1 (hr) |
AU (1) | AU2012258220B2 (hr) |
BR (1) | BR112013029537B1 (hr) |
CA (1) | CA2835229C (hr) |
CL (1) | CL2013003313A1 (hr) |
CY (1) | CY1120429T1 (hr) |
DK (1) | DK2709989T3 (hr) |
EA (1) | EA028254B1 (hr) |
ES (1) | ES2663601T3 (hr) |
HR (1) | HRP20180447T1 (hr) |
HU (1) | HUE036220T2 (hr) |
IL (1) | IL228906A (hr) |
LT (1) | LT2709989T (hr) |
ME (1) | ME02986B (hr) |
MX (1) | MX347966B (hr) |
MY (1) | MY166557A (hr) |
NO (1) | NO2709989T3 (hr) |
PH (1) | PH12019502269A1 (hr) |
PL (1) | PL2709989T3 (hr) |
PT (1) | PT2709989T (hr) |
RS (1) | RS57023B1 (hr) |
SG (1) | SG194852A1 (hr) |
SI (1) | SI2709989T1 (hr) |
UA (1) | UA114476C2 (hr) |
WO (1) | WO2012156498A1 (hr) |
ZA (1) | ZA201308746B (hr) |
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KR101481164B1 (ko) * | 2008-01-30 | 2015-01-09 | 주식회사 미래셀바이오 | 체세포 유래 다능성 줄기세포의 제조 방법 |
SI3330257T1 (sl) | 2011-04-08 | 2020-07-31 | Janssen Sciences Ireland Unlimited Company | Derivati pirimidina za zdravljenje virusnih okužb |
ES2690082T3 (es) | 2011-11-09 | 2018-11-19 | Janssen Sciences Ireland Uc | Derivados de purina para el tratamiento de infecciones virales |
MX360718B (es) | 2012-07-13 | 2018-11-13 | Janssen Sciences Ireland Uc | Purinas macrocíclicas para el tratamiento de infecciones víricas. |
US9499549B2 (en) | 2012-10-10 | 2016-11-22 | Janssen Sciences Ireland Uc | Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases |
JP6297055B2 (ja) | 2012-11-16 | 2018-03-20 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染症の治療のための複素環置換2−アミノ−キナゾリン誘導体 |
KR102300861B1 (ko) | 2013-02-21 | 2021-09-10 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체 |
JP6336036B2 (ja) | 2013-03-29 | 2018-06-06 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染治療のための大環状デアザプリノン |
SG11201509520QA (en) | 2013-05-24 | 2015-12-30 | Janssen Sciences Ireland Uc | Pyridone derivatives for the treatment of viral infections and further diseases |
WO2014207082A1 (en) | 2013-06-27 | 2014-12-31 | Janssen R&D Ireland | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases |
MY179503A (en) * | 2013-07-30 | 2020-11-09 | Janssen Sciences Ireland Uc | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections |
EP3097102B1 (en) * | 2015-03-04 | 2017-10-18 | Gilead Sciences, Inc. | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
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2018
- 2018-03-16 HR HRP20180447TT patent/HRP20180447T1/hr unknown
- 2018-03-20 CY CY20181100320T patent/CY1120429T1/el unknown
-
2019
- 2019-10-01 PH PH12019502269A patent/PH12019502269A1/en unknown
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