MX2017015496A - Fosforilacion selectiva sin disolvente. - Google Patents
Fosforilacion selectiva sin disolvente.Info
- Publication number
- MX2017015496A MX2017015496A MX2017015496A MX2017015496A MX2017015496A MX 2017015496 A MX2017015496 A MX 2017015496A MX 2017015496 A MX2017015496 A MX 2017015496A MX 2017015496 A MX2017015496 A MX 2017015496A MX 2017015496 A MX2017015496 A MX 2017015496A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- solvent free
- selective solvent
- salts
- preparation
- Prior art date
Links
- 230000026731 phosphorylation Effects 0.000 title 1
- 238000006366 phosphorylation reaction Methods 0.000 title 1
- 239000002904 solvent Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- PUEDDPCUCPRQNY-ZYUZMQFOSA-N D-ribosylnicotinate Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1[N+]1=CC=CC(C([O-])=O)=C1 PUEDDPCUCPRQNY-ZYUZMQFOSA-N 0.000 abstract 1
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 abstract 1
- 238000001311 chemical methods and process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020956 nicotinamide riboside Nutrition 0.000 abstract 1
- 239000011618 nicotinamide riboside Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
- C07H1/04—Introducing polyphosphoric acid radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Se proporciona un proceso sintético para la preparación de análogos fosforilados de ribósido de nicotinamida ("NR") que tienen la fórmula (I), o sales de los mismos, y derivados reducidos o modificados de los mismos, que tienen la fórmula (II), en la que X-, Yl, Y2, Z', Z2, n, RI, R2, R3, R4, R5, R6 y R7 son como se definen en el presente documento. La presente divulgación también se refiere a la preparación de análogos fosforilados de ribósido de ácido nicotínico ("NAR") que tienen la fórmula (I), o sales de los mismos, y derivados reducidos o modificados de los mismos, que tienen la fórmula (II). Generalmente, se emplean condiciones sin disolvente usando técnicas mecano-químicas apropiadas como se describen. (I) (II).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562171138P | 2015-06-04 | 2015-06-04 | |
| PCT/US2016/035729 WO2016196941A1 (en) | 2015-06-04 | 2016-06-03 | Selective solvent free phosphorylation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017015496A true MX2017015496A (es) | 2018-08-01 |
Family
ID=57441978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017015496A MX2017015496A (es) | 2015-06-04 | 2016-06-03 | Fosforilacion selectiva sin disolvente. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20160355539A1 (es) |
| EP (1) | EP3302059A4 (es) |
| JP (1) | JP2018517709A (es) |
| KR (1) | KR20180033465A (es) |
| CN (1) | CN107846883A (es) |
| AU (1) | AU2016271481A1 (es) |
| BR (1) | BR112017025969A2 (es) |
| CA (1) | CA2987986A1 (es) |
| MX (1) | MX2017015496A (es) |
| WO (1) | WO2016196941A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017024255A1 (en) | 2015-08-05 | 2017-02-09 | Metrobiotech, Llc | Nicotinamide mononucleotide derivatives and their uses |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| WO2018089830A1 (en) | 2016-11-11 | 2018-05-17 | The Queen's University Of Belfast | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| CA3044814A1 (en) | 2016-11-29 | 2018-06-07 | Charles M. Brenner | Use of nad precursors for improving maternal health and/or offspring health |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| LT3606929T (lt) * | 2017-04-05 | 2021-10-25 | Cornell University | Beta-nikotinatinato esterio nukleotidai ir jų gamybos būdai |
| CN108976259A (zh) * | 2017-06-01 | 2018-12-11 | 上海凯赛生物技术研发中心有限公司 | 一种磷酸吡哆醛的合成方法 |
| US11286274B2 (en) | 2017-06-19 | 2022-03-29 | Mitopower Llc | Nicotinamide riboside derivatives and their uses |
| AU2019214858B2 (en) | 2018-01-30 | 2023-02-02 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| EP3794005A1 (en) * | 2018-05-15 | 2021-03-24 | Jumpstart Fertility Pty Ltd | Inorganic salts of nicotinic acid mononucleotide as anti-aging agents |
| JP7432585B2 (ja) * | 2018-05-15 | 2024-02-16 | ジャンプスタート ファーティリティ ピーティーワイ リミテッド | 抗加齢剤としてのニコチン酸モノヌクレオチド及びニコチンアミドモノヌクレオチドのアミノ酸塩 |
| WO2020072497A1 (en) * | 2018-10-01 | 2020-04-09 | Cornell University | Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof |
| WO2020131578A2 (en) | 2018-12-17 | 2020-06-25 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
| CN110483601A (zh) * | 2019-08-12 | 2019-11-22 | 上海龙翔生物医药开发有限公司 | 制备β-烟酸胺单核苷酸的方法及其应用 |
| IL308577A (en) | 2021-05-27 | 2024-01-01 | Metro Int Biotech Llc | Crystalline solids of nicotinic acid mononucleotides and their esters and methods for their preparation and use |
| WO2023147161A2 (en) * | 2022-01-31 | 2023-08-03 | New Frontier Bio, Inc. | Nicotinate and nicotinamide riboside-based compounds and derivatives thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1042839A (en) * | 1963-12-19 | 1966-09-14 | Asahi Chemical Ind | Production of 5'-nucleotides |
| US6730812B2 (en) * | 2002-02-06 | 2004-05-04 | Iowa State University Research Foundation, Inc. | Solvent-free mechanochemical preparation of phosphonium salts, phosphorus ylides, and olefins |
| WO2012004917A1 (ja) * | 2010-07-06 | 2012-01-12 | Kaminishi Hidenori | 神経突起伸長剤 |
-
2016
- 2016-06-03 CA CA2987986A patent/CA2987986A1/en not_active Abandoned
- 2016-06-03 MX MX2017015496A patent/MX2017015496A/es unknown
- 2016-06-03 BR BR112017025969A patent/BR112017025969A2/pt not_active Application Discontinuation
- 2016-06-03 CN CN201680043503.4A patent/CN107846883A/zh active Pending
- 2016-06-03 US US15/172,662 patent/US20160355539A1/en not_active Abandoned
- 2016-06-03 JP JP2017563123A patent/JP2018517709A/ja active Pending
- 2016-06-03 WO PCT/US2016/035729 patent/WO2016196941A1/en active Application Filing
- 2016-06-03 AU AU2016271481A patent/AU2016271481A1/en not_active Abandoned
- 2016-06-03 KR KR1020177037685A patent/KR20180033465A/ko unknown
- 2016-06-03 EP EP16804531.8A patent/EP3302059A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2987986A1 (en) | 2016-12-08 |
| EP3302059A1 (en) | 2018-04-11 |
| EP3302059A4 (en) | 2018-10-03 |
| BR112017025969A2 (pt) | 2018-08-07 |
| AU2016271481A1 (en) | 2017-12-14 |
| JP2018517709A (ja) | 2018-07-05 |
| US20160355539A1 (en) | 2016-12-08 |
| CN107846883A (zh) | 2018-03-27 |
| KR20180033465A (ko) | 2018-04-03 |
| WO2016196941A1 (en) | 2016-12-08 |
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