MX349969B - Metodos de preparación de ribósido de nicotinamida y sus derivados. - Google Patents

Metodos de preparación de ribósido de nicotinamida y sus derivados.

Info

Publication number
MX349969B
MX349969B MX2016001211A MX2016001211A MX349969B MX 349969 B MX349969 B MX 349969B MX 2016001211 A MX2016001211 A MX 2016001211A MX 2016001211 A MX2016001211 A MX 2016001211A MX 349969 B MX349969 B MX 349969B
Authority
MX
Mexico
Prior art keywords
substituted
unsubstituted
derivatives
methods
nicotinamide riboside
Prior art date
Application number
MX2016001211A
Other languages
English (en)
Other versions
MX2016001211A (es
Inventor
Migaud Marie
Redpath Philip
CROSSEY Kerri
Doherty Mark
Original Assignee
Univ Belfast
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Belfast filed Critical Univ Belfast
Publication of MX2016001211A publication Critical patent/MX2016001211A/es
Publication of MX349969B publication Critical patent/MX349969B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se refiere a métodos para preparar ribósido de nicotinamida y sus derivados. En un aspecto, la invención se refiere a un método para preparar un compuesto de la fórmula (I), en donde n es 0 o 1; m es 0 o 1; Y es O o S; R1 se selecciona entre H, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido, arilo sustituido o no sustituido, amino primario o secundario sustituido o no sustituido, y azido sustituido o no sustituido; R2-R5, que pueden ser iguales o diferentes, se seleccionan cada uno independientemente entre H, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido, y arilo sustituido o no sustituido; y X- es un anión, seleccionado de un anión de un ácido carboxílico sustituido o no sustituido, un haluro, un sulfonato sustituido o no sustituido, un fosfato sustituido o no sustituido, un sulfato sustituido o no sustituido, un carbonato sustituido o no sustituido, y un carbamato sustituido o no sustituido.
MX2016001211A 2013-07-29 2014-07-24 Metodos de preparación de ribósido de nicotinamida y sus derivados. MX349969B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1313465.5A GB201313465D0 (en) 2013-07-29 2013-07-29 Methods of preparing nicotinamide riboside and derivatives thereof
PCT/EP2014/065971 WO2015014722A1 (en) 2013-07-29 2014-07-24 Methods of preparing nicotinamide riboside and derivatives thereof

Publications (2)

Publication Number Publication Date
MX2016001211A MX2016001211A (es) 2016-10-28
MX349969B true MX349969B (es) 2017-08-23

Family

ID=49167061

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016001211A MX349969B (es) 2013-07-29 2014-07-24 Metodos de preparación de ribósido de nicotinamida y sus derivados.

Country Status (14)

Country Link
US (6) US10000519B2 (es)
EP (2) EP3027635B1 (es)
JP (1) JP6208352B2 (es)
KR (2) KR102303966B1 (es)
CN (2) CN108707174A (es)
AU (4) AU2014298629B2 (es)
BR (1) BR112016001774B1 (es)
CA (2) CA3192957A1 (es)
ES (1) ES2652654T3 (es)
GB (1) GB201313465D0 (es)
HK (2) HK1218918A1 (es)
MX (1) MX349969B (es)
WO (1) WO2015014722A1 (es)
ZA (1) ZA201802315B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201313465D0 (en) 2013-07-29 2013-09-11 Queens University Of The Belfast Methods of preparing nicotinamide riboside and derivatives thereof
WO2015186068A1 (en) * 2014-06-02 2015-12-10 Glaxosmithkline Intellectual Property (No.2) Limited Preparation and use of crystalline beta-d-nicotinamide riboside
US10485814B2 (en) 2014-06-06 2019-11-26 Glaxosmithkline Intellectual Property (No. 2) Limited Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof
WO2016014927A2 (en) * 2014-07-24 2016-01-28 W.R. Grace & Co.-Conn. Crystalline form of nicotinamide riboside
KR102629310B1 (ko) 2015-03-09 2024-01-24 더블유.알. 그레이스 앤드 캄파니-콘. 니코틴아미드 리보사이드의 결정 형태
EP3271370B1 (en) 2015-03-16 2023-06-21 Chromadex Inc. Nicotinic acid riboside or nicotinamide riboside compositions, reduced derivatives thereof, and the use thereof
WO2017011788A1 (en) 2015-07-15 2017-01-19 Cornell University Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
WO2017024255A1 (en) 2015-08-05 2017-02-09 Metrobiotech, Llc Nicotinamide mononucleotide derivatives and their uses
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
US10611790B2 (en) * 2015-11-02 2020-04-07 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
US11248018B2 (en) 2016-02-23 2022-02-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Process for preparation of nicotinamide riboside (NR) and cosmetic composition comprising (NR and a phosphate-binding agent
CA3017254C (en) 2016-03-16 2023-08-22 ChromaDex Inc. B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof
WO2017184885A1 (en) 2016-04-20 2017-10-26 ChromaDex Inc. Use of nicotinic acid riboside or nicotinamide ribosite derivatives, and reduced derivatives thereof, as nad+increasing precursors
WO2017218580A1 (en) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Synthetic methods for the preparation of nicotinamide riboside and related compounds
GB2553001A (en) * 2016-08-19 2018-02-21 The Queen's Univ Of Belfast Lactone intermediates of nicotinamide riboside and nicotinate riboside
US10689411B2 (en) 2016-11-11 2020-06-23 The Queen's University Of Belfast Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
CA3044814A1 (en) 2016-11-29 2018-06-07 Charles M. Brenner Use of nad precursors for improving maternal health and/or offspring health
WO2018236814A2 (en) 2017-06-19 2018-12-27 Gangadhara Ganapati NICOTINAMIDE RIBOSID DERIVATIVES AND USES THEREOF
JP2020526511A (ja) * 2017-06-30 2020-08-31 エリジウム・ヘルス・インコーポレイテッド ニコチンアミドリボシドの合成方法
CN112020363A (zh) 2017-12-22 2020-12-01 益力舒健康公司 烟酰胺核苷氯化物的结晶形式
WO2019122084A1 (en) 2017-12-22 2019-06-27 Stemtek Therapeutics, S.L. Process for the preparation of nicotinamide riboside chloride derivatives
AU2019214858B2 (en) 2018-01-30 2023-02-02 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
CN110283221A (zh) * 2018-03-19 2019-09-27 药源药物化学（上海）有限公司 杂环化合物的制备和纯化方法
CN110452277A (zh) * 2018-05-07 2019-11-15 明特奇点医疗科技(成都)有限公司 一种烟酰胺核糖的制备方法
US20210196742A1 (en) * 2018-05-22 2021-07-01 Jumpstart Fertility Pty Ltd Amino acid salts of nicotinic acid ribosides as anti-aging agents
CN108774278A (zh) * 2018-09-10 2018-11-09 张洪喜 一种制备尼克酰胺核苷盐的方法
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
WO2020131578A2 (en) 2018-12-17 2020-06-25 Mitopower Llc Nicotinyl riboside compounds and their uses
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
US20220324899A1 (en) * 2019-08-14 2022-10-13 Metro International Biotech, Llc Compounds and compositions for differential modulation of nicotinamide adenine dinucleotide
CN110642897B (zh) * 2019-09-27 2021-04-06 武汉一若生物材料有限公司 一种β-烟酰胺核糖氯化物的制备方法
CN110658224B (zh) * 2019-10-15 2022-11-22 中国中医科学院中药研究所 一种氢核磁定量分析技术测定nmn绝对含量的方法
CN111153953A (zh) * 2020-01-07 2020-05-15 杭州洁汉化工有限公司 一种烟酰胺核糖氯化物的高效合成方法
CN111454311B (zh) * 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
CN111647032B (zh) * 2020-06-29 2023-02-24 上海舒泽生物科技研究所 一种β-烟酰胺单核苷酸的合成方法
CN111848710A (zh) * 2020-08-20 2020-10-30 深圳市迪克曼科技开发有限公司 烟酰胺核糖及其还原态、盐的制备方法
EP4214217B1 (en) * 2020-09-15 2024-09-18 Société des Produits Nestlé S.A. Methods for producing dihydronicotinamide riboside from nicotinamide riboside chloride
CN112851730B (zh) * 2021-01-08 2023-02-21 厦门瑞林药业有限公司 一种nmn中间体nr氯化物合成方法
WO2022233923A1 (en) 2021-05-04 2022-11-10 Bohan & Co As. A process for synthesis of nicotinamide riboside chloride (nrcl)
KR20240020716A (ko) 2021-05-27 2024-02-15 메트로 인터내셔널 바이오테크 엘엘씨 니코틴산 모노뉴클레오타이드 및 이의 에스터의 결정질 고체 및 제조 및 사용 방법
WO2023166160A1 (en) 2022-03-04 2023-09-07 Bohan & Co As. Process for synthesis of 1,4-dihydronicotinamide riboside (nrh) from nicotinamide-beta-riboside triacetate chloride (nra-cl)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4115514B2 (ja) 1991-10-23 2008-07-09 キャンサー・リサーチ・キヤンペーン・テクノロジー・リミテツド Ｃｂ １９５４およびその類似体を細胞障害性の形態に還元するための細菌のニトロリダクターゼ
US6689760B1 (en) * 2000-07-10 2004-02-10 Enzrel Inc. Anti-mycobacterial compositions
EP3730507A1 (en) * 2005-11-18 2020-10-28 Cornell Research Foundation, Inc. Nicotinoyl riboside and nicotinamide riboside compositions for use in reducing toxicity induced by hmg-coa reductase inhibitors
US9603862B2 (en) * 2009-12-14 2017-03-28 Cornell University Activation and activators of SIRT5
GB201313465D0 (en) 2013-07-29 2013-09-11 Queens University Of The Belfast Methods of preparing nicotinamide riboside and derivatives thereof

Also Published As

Publication number Publication date
AU2014298629A1 (en) 2016-02-11
EP3027635B1 (en) 2017-09-20
HK1255037A1 (zh) 2019-08-02
US20180186824A1 (en) 2018-07-05
CN108707174A (zh) 2018-10-26
US10000519B2 (en) 2018-06-19
ES2652654T3 (es) 2018-02-05
AU2020201254B2 (en) 2022-05-26
KR102414886B1 (ko) 2022-07-01
CN105636973B (zh) 2018-06-01
ZA201802315B (en) 2023-02-22
EP3027635A1 (en) 2016-06-08
AU2018211238A1 (en) 2018-08-16
US20240239831A1 (en) 2024-07-18
US11981698B2 (en) 2024-05-14
JP2016530248A (ja) 2016-09-29
CA3192957A1 (en) 2015-02-05
US10815262B2 (en) 2020-10-27
US20200291055A1 (en) 2020-09-17
BR112016001774A8 (pt) 2020-01-21
AU2020201254A1 (en) 2020-03-12
WO2015014722A1 (en) 2015-02-05
HK1218918A1 (zh) 2017-03-17
KR20160043974A (ko) 2016-04-22
US20220259250A1 (en) 2022-08-18
CA2918955C (en) 2023-05-09
AU2022203196B2 (en) 2023-11-23
KR102303966B1 (ko) 2021-09-24
US11584770B2 (en) 2023-02-21
CN105636973A (zh) 2016-06-01
US20160168184A1 (en) 2016-06-16
MX2016001211A (es) 2016-10-28
BR112016001774B1 (pt) 2021-06-22
JP6208352B2 (ja) 2017-10-04
EP3321274A1 (en) 2018-05-16
AU2014298629B2 (en) 2018-08-16
AU2022203196A1 (en) 2022-06-02
KR20210038718A (ko) 2021-04-07
US20240101588A1 (en) 2024-03-28
NZ716277A (en) 2021-03-26
GB201313465D0 (en) 2013-09-11
BR112016001774A2 (pt) 2017-08-01
CA2918955A1 (en) 2015-02-05

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