BR112016001774A2 - métodos de preparação de ribosídeo de nicotinamida e seus derivados - Google Patents

métodos de preparação de ribosídeo de nicotinamida e seus derivados

Info

Publication number
BR112016001774A2
BR112016001774A2 BR112016001774A BR112016001774A BR112016001774A2 BR 112016001774 A2 BR112016001774 A2 BR 112016001774A2 BR 112016001774 A BR112016001774 A BR 112016001774A BR 112016001774 A BR112016001774 A BR 112016001774A BR 112016001774 A2 BR112016001774 A2 BR 112016001774A2
Authority
BR
Brazil
Prior art keywords
substituted
unsubstituted
derivatives
methods
alkenyl
Prior art date
Application number
BR112016001774A
Other languages
English (en)
Other versions
BR112016001774A8 (pt
Inventor
CROSSEY Kerri
Migaud Marie
Doherty Mark
Redpath Philip
Original Assignee
The Queens Univ Of Belfast
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB1313465.5A priority Critical patent/GB201313465D0/en
Application filed by The Queens Univ Of Belfast filed Critical The Queens Univ Of Belfast
Priority to PCT/EP2014/065971 priority patent/WO2015014722A1/en
Publication of BR112016001774A2 publication Critical patent/BR112016001774A2/pt
Publication of BR112016001774A8 publication Critical patent/BR112016001774A8/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048Pyridine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • C07H1/06Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Abstract

a invenção refere-se a métodos de preparação do ribosídeo de nicotinamida e seus derivados. por um lado, a invenção se refere a um método de preparação de um composto de fórmula (i), onde n é 0 ou 1; m é 0 ou 1; y é o ou s; r1 é selecionado de h, alquil substituído ou não substituído, alqueno substituído ou não substituído, alquenil substituído ou não substituído, aril substituído ou não substituído, amino primário ou secundário substituído ou não substituído e azido substituído ou não substituído; r2-r5, que podem ser iguais ou diferentes, são cada um selecionado independentemente a partir de h, alquil substituído ou não substituído, alquenil substituído ou não substituído, alquenil substituído ou não substituído e aril substituído ou não substituído; e x– é um ânion, selecionado a partir de um ânion de um ácido carboxílico substituído ou não substituído, um haleto, um sulfonato substituído ou não substituído, um fosfato substituído ou não substituído, um sulfato substituído ou não substituído, um carbonato substituído ou não substituído e um carbamato substituído ou não substituído.
BR112016001774A 2013-07-29 2014-07-24 método para o preparo de um composto BR112016001774A8 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB1313465.5A GB201313465D0 (en) 2013-07-29 2013-07-29 Methods of preparing nicotinamide riboside and derivatives thereof
PCT/EP2014/065971 WO2015014722A1 (en) 2013-07-29 2014-07-24 Methods of preparing nicotinamide riboside and derivatives thereof

Publications (2)

Publication Number Publication Date
BR112016001774A2 true BR112016001774A2 (pt) 2017-08-01
BR112016001774A8 BR112016001774A8 (pt) 2020-01-21

Family

ID=49167061

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016001774A BR112016001774A8 (pt) 2013-07-29 2014-07-24 método para o preparo de um composto

Country Status (13)

Country Link
US (2) US10000519B2 (pt)
EP (2) EP3027635B1 (pt)
JP (1) JP6208352B2 (pt)
KR (1) KR20160043974A (pt)
CN (2) CN108707174A (pt)
AU (3) AU2014298629B2 (pt)
BR (1) BR112016001774A8 (pt)
CA (1) CA2918955A1 (pt)
ES (1) ES2652654T3 (pt)
GB (1) GB201313465D0 (pt)
HK (1) HK1218918A1 (pt)
MX (1) MX349969B (pt)
WO (1) WO2015014722A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016015997A (es) * 2014-06-02 2017-04-05 Glaxosmithkline Intellectual Property (No 2) Ltd Preparacion y uso de beta-d-nicotinamida ribosido cristalina.
MX2016016071A (es) 2014-06-06 2017-07-11 Glaxosmithkline Intellectual Property (No 2) Ltd Analogos de ribosido de nicotinamida y composiciones farmaceuticas y usos de los mismos.
ES2776395T3 (es) * 2014-07-24 2020-07-30 Grace W R & Co Forma cristalina de ribósido de nicotinamida
BR112017019409A2 (pt) * 2015-03-09 2018-04-24 Grace W R & Co forma cristalina de ribosídeo de nicotinamida
AU2016233247A1 (en) * 2015-03-16 2017-09-21 ChromaDex Inc. Nicotinic acid riboside or nicotinamide riboside compositions, reduced derivatives thereof, and the use thereof
US10392414B2 (en) 2015-07-15 2019-08-27 Cornell University Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
CN108137639A (zh) 2015-08-05 2018-06-08 麦德龙国际生物科技有限责任公司 烟酰胺单核苷酸衍生物及其用途
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
WO2017079195A1 (en) * 2015-11-02 2017-05-11 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
US20190055275A1 (en) 2016-02-23 2019-02-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Process for preparation of nicotinamide riboside (nr) and cosmetic composition comprising (nr and a phosphate-binding agent
WO2017161165A1 (en) * 2016-03-16 2017-09-21 ChromaDex Inc. B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof
KR20190008246A (ko) * 2016-04-20 2019-01-23 크로마덱스 아이엔씨. Nad+ 증가용 전구체로서 니코틴산 리보사이드 또는 니코틴아미드 리보사이트 유도체 및 이의 환원된 유도체의 용도
WO2017218580A1 (en) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Synthetic methods for the preparation of nicotinamide riboside and related compounds
GB2553001A (en) * 2016-08-19 2018-02-21 The Queen's Univ Of Belfast Lactone intermediates of nicotinamide riboside and nicotinate riboside
US9975915B1 (en) 2016-11-11 2018-05-22 The Queen's University Of Belfast Crystalline forms of nicotinoyl ribosides, modified derivatives thereof, and phosphorylated analogs thereof, and methods of preparation thereof
WO2019122084A1 (en) 2017-12-22 2019-06-27 Stemtek Therapeutics, S.L. Process for the preparation of nicotinamide riboside chloride derivatives
CN110452277A (zh) * 2018-05-07 2019-11-15 明特奇点医疗科技(成都)有限公司 一种烟酰胺核糖的制备方法
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
CN110642897A (zh) * 2019-09-27 2020-01-03 武汉一若生物材料有限公司 一种β-烟酰胺核糖氯化物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU681337B2 (en) 1991-10-23 1997-08-28 Cancer Research Campaign Technology Limited Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form
US6689760B1 (en) 2000-07-10 2004-02-10 Enzrel Inc. Anti-mycobacterial compositions
WO2007061798A2 (en) * 2005-11-18 2007-05-31 Cornell Research Foundation, Inc. Nicotinoyl riboside compositions and methods of use
US9603862B2 (en) 2009-12-14 2017-03-28 Cornell University Activation and activators of SIRT5

Also Published As

Publication number Publication date
AU2014298629B2 (en) 2018-08-16
JP2016530248A (ja) 2016-09-29
EP3027635B1 (en) 2017-09-20
MX2016001211A (es) 2016-10-28
KR20160043974A (ko) 2016-04-22
US20160168184A1 (en) 2016-06-16
CA2918955A1 (en) 2015-02-05
CN105636973B (zh) 2018-06-01
US20180186824A1 (en) 2018-07-05
JP6208352B2 (ja) 2017-10-04
ES2652654T3 (es) 2018-02-05
CN108707174A (zh) 2018-10-26
AU2018211238A1 (en) 2018-08-16
WO2015014722A1 (en) 2015-02-05
MX349969B (es) 2017-08-23
US10000519B2 (en) 2018-06-19
AU2014298629A1 (en) 2016-02-11
BR112016001774A8 (pt) 2020-01-21
AU2020201254A1 (en) 2020-03-12
GB201313465D0 (en) 2013-09-11
EP3027635A1 (en) 2016-06-08
EP3321274A1 (en) 2018-05-16
CN105636973A (zh) 2016-06-01
HK1218918A1 (zh) 2017-03-17

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notice of approval relating to section 229 industrial property law