TR201819440T4 - Yüklü çapraz bağlayıcıların hazırlanmasına yönelik yöntemler. - Google Patents

Yüklü çapraz bağlayıcıların hazırlanmasına yönelik yöntemler. Download PDF

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Publication number
TR201819440T4
TR201819440T4 TR2018/19440T TR201819440T TR201819440T4 TR 201819440 T4 TR201819440 T4 TR 201819440T4 TR 2018/19440 T TR2018/19440 T TR 2018/19440T TR 201819440 T TR201819440 T TR 201819440T TR 201819440 T4 TR201819440 T4 TR 201819440T4
Authority
TR
Turkey
Prior art keywords
methods
preparing charged
charged crosslinkers
crosslinkers
preparing
Prior art date
Application number
TR2018/19440T
Other languages
English (en)
Inventor
Li Wei
Zhao Robert
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of TR201819440T4 publication Critical patent/TR201819440T4/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/06—Hydrogenosulfates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/36—Sulfur-, selenium-, or tellurium-containing compounds
    • C08K5/37—Thiols
    • C08K5/372—Sulfides, e.g. R-(S)x-R'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Pyridine Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Polyamides (AREA)

Abstract

Bir sülfonik asit kısmını taşıyan yüklü çapraz bağlayıcıların hazırlanmasına yönelik prosesler açıklanır. Bu prosedürler, ayrıca isteğe bağlı olarak ortaya çıkan ürünlerin temel olarak tek bir tuz formuna dönüştürülmesi yöntemini içerir.
TR2018/19440T 2010-12-09 2011-12-08 Yüklü çapraz bağlayıcıların hazırlanmasına yönelik yöntemler. TR201819440T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42135710P 2010-12-09 2010-12-09

Publications (1)

Publication Number Publication Date
TR201819440T4 true TR201819440T4 (tr) 2019-01-21

Family

ID=46207513

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/19440T TR201819440T4 (tr) 2010-12-09 2011-12-08 Yüklü çapraz bağlayıcıların hazırlanmasına yönelik yöntemler.

Country Status (18)

Country Link
US (5) US8598362B2 (tr)
EP (2) EP2648510B1 (tr)
KR (1) KR101959578B1 (tr)
CN (2) CN107011253B (tr)
CY (1) CY1121055T1 (tr)
DK (1) DK3153504T3 (tr)
ES (2) ES2602118T3 (tr)
HR (1) HRP20182026T1 (tr)
HU (1) HUE041699T2 (tr)
IL (3) IL226795A (tr)
LT (1) LT3153504T (tr)
PL (1) PL3153504T3 (tr)
PT (1) PT3153504T (tr)
RS (1) RS58033B1 (tr)
SG (3) SG10202005580RA (tr)
SI (1) SI3153504T1 (tr)
TR (1) TR201819440T4 (tr)
WO (1) WO2012078868A1 (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10202005580RA (en) * 2010-12-09 2020-07-29 Immunogen Inc Methods for the preparation of charged crosslinkers
JP6026305B2 (ja) * 2013-02-04 2016-11-16 古河電気工業株式会社 標識抗体の製造方法
WO2014210267A1 (en) 2013-06-28 2014-12-31 Immunogen, Inc. Purification of intermediates used in the preparation of heterobifunctional linkers
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
US10464955B2 (en) * 2014-02-28 2019-11-05 Hangzhou Dac Biotech Co., Ltd. Charged linkers and their uses for conjugation
CN104892748B (zh) * 2014-03-04 2018-12-21 深圳翰宇药业股份有限公司 人类松弛素-2衍生物以及由其制备人类松弛素-2的方法

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AU2003225305A1 (en) 2002-05-08 2003-11-11 Bristol-Myers Squibb Company Pyridine-based thyroid receptor ligands
DE60336149D1 (de) * 2002-08-16 2011-04-07 Immunogen Inc Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
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SG189811A1 (en) * 2008-04-30 2013-05-31 Immunogen Inc Cross-linkers and their uses
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SG10202005580RA (en) * 2010-12-09 2020-07-29 Immunogen Inc Methods for the preparation of charged crosslinkers

Also Published As

Publication number Publication date
HRP20182026T1 (hr) 2019-02-22
EP2648510B1 (en) 2016-08-31
US8598362B2 (en) 2013-12-03
CN107011253A (zh) 2017-08-04
CY1121055T1 (el) 2019-12-11
IL240200A (en) 2017-02-28
US10112925B2 (en) 2018-10-30
CN107011253B (zh) 2021-01-15
KR101959578B1 (ko) 2019-03-18
IL240200A0 (en) 2015-09-24
PT3153504T (pt) 2018-12-27
HUE041699T2 (hu) 2019-05-28
US8921566B2 (en) 2014-12-30
SG10201509886YA (en) 2016-01-28
US20120165537A1 (en) 2012-06-28
PL3153504T3 (pl) 2019-04-30
CN103260406A (zh) 2013-08-21
SI3153504T1 (sl) 2019-03-29
ES2702926T3 (es) 2019-03-06
US9242936B2 (en) 2016-01-26
KR20130124336A (ko) 2013-11-13
EP3153504B1 (en) 2018-09-26
LT3153504T (lt) 2019-02-11
US20140135502A1 (en) 2014-05-15
ES2602118T3 (es) 2017-02-17
US20160272616A1 (en) 2016-09-22
US20150166482A1 (en) 2015-06-18
SG190214A1 (en) 2013-06-28
IL226795A (en) 2015-08-31
US20170327486A1 (en) 2017-11-16
EP2648510A4 (en) 2014-05-07
CN103260406B (zh) 2016-10-19
EP3153504A1 (en) 2017-04-12
IL240201A0 (en) 2015-09-24
WO2012078868A1 (en) 2012-06-14
US9663492B2 (en) 2017-05-30
EP2648510A1 (en) 2013-10-16
DK3153504T3 (en) 2019-01-07
RS58033B1 (sr) 2019-02-28
SG10202005580RA (en) 2020-07-29

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