MX2016012419A - Formas solidas de ibrutinib y procesos para la produccion de las mismas. - Google Patents
Formas solidas de ibrutinib y procesos para la produccion de las mismas.Info
- Publication number
- MX2016012419A MX2016012419A MX2016012419A MX2016012419A MX2016012419A MX 2016012419 A MX2016012419 A MX 2016012419A MX 2016012419 A MX2016012419 A MX 2016012419A MX 2016012419 A MX2016012419 A MX 2016012419A MX 2016012419 A MX2016012419 A MX 2016012419A
- Authority
- MX
- Mexico
- Prior art keywords
- ibrutinib
- production process
- solid forms
- forms
- process therefor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Se proporcionan polimorfos de ibrutinib, por ejemplo, las formas III, IV, V, VI, VII, VII y la Forma IX de ibrutinib cristalino y los procesos para producir estas formas cristalinas, ibrutinib amorfo estable y los procesos 5 para preparar el ibrutinib amorfo estable, composiciones farmac?uticas que comprenden estas formas y m?todos para usar estas formas cristalinas y amorfas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461971164P | 2014-03-27 | 2014-03-27 | |
US201462045869P | 2014-09-04 | 2014-09-04 | |
PCT/IL2015/000017 WO2015145415A2 (en) | 2014-03-27 | 2015-03-23 | Ibrutinib solid forms and production process therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016012419A true MX2016012419A (es) | 2016-11-30 |
Family
ID=54196519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016012419A MX2016012419A (es) | 2014-03-27 | 2015-03-23 | Formas solidas de ibrutinib y procesos para la produccion de las mismas. |
Country Status (7)
Country | Link |
---|---|
US (2) | US9884869B2 (es) |
EP (1) | EP3122753A4 (es) |
AU (1) | AU2015237744A1 (es) |
CA (1) | CA2941087A1 (es) |
IL (1) | IL247963A0 (es) |
MX (1) | MX2016012419A (es) |
WO (1) | WO2015145415A2 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA37711A1 (fr) | 2012-06-04 | 2017-05-31 | Pharmacyclics Inc | Formes cristallines d'un inhibiteur de tyrosine kinase de bruton |
CN106573002A (zh) | 2014-08-07 | 2017-04-19 | 药品循环有限责任公司 | 布鲁顿氏酪氨酸激酶抑制剂的新型制剂 |
WO2016079216A1 (en) * | 2014-11-20 | 2016-05-26 | Sandoz Ag | Physical forms of ibrutinib, a bruton's kinase inhibitor |
WO2016139588A1 (en) * | 2015-03-03 | 2016-09-09 | Dr. Reddy's Laboratories Limited | Polymorphs of ibrutinib |
BR122023020985A2 (pt) | 2015-03-03 | 2023-12-26 | Pharmacyclics Llc | Formulação de comprimido sólido de um inibidor de tirosina quinase de bruton |
WO2017029586A1 (en) * | 2015-08-19 | 2017-02-23 | Sun Pharmaceutical Industries Limited | Crystalline forms of ibrutinib |
US9834561B2 (en) | 2015-10-28 | 2017-12-05 | Scinopharm Taiwan, Ltd. | Process for preparing ibrutinib and its intermediates |
CN105622614B (zh) * | 2015-12-18 | 2021-02-26 | 重庆医药工业研究院有限责任公司 | 一种依鲁替尼无定型物及其制备方法 |
CN106905320A (zh) * | 2015-12-23 | 2017-06-30 | 杭州容立医药科技有限公司 | 一种适合药用的依鲁替尼及其制剂 |
CN106995445B (zh) * | 2016-01-22 | 2021-08-03 | 山东新时代药业有限公司 | 一种布鲁顿酪氨酸激酶抑制剂晶型及其制备方法 |
WO2017134588A1 (en) | 2016-02-04 | 2017-08-10 | Shilpa Medicare Limited | Process for the preparation of ibrutinib |
GB2558514A (en) * | 2016-02-09 | 2018-07-18 | Azad Pharmaceutical Ingredients Ag | Process for the synthesis of stable amorphous ibrutinib |
CN105646498A (zh) * | 2016-03-01 | 2016-06-08 | 孙霖 | 依鲁替尼晶型f及制备方法 |
CN105646499A (zh) * | 2016-03-01 | 2016-06-08 | 孙霖 | 依鲁替尼晶型g及制备方法 |
CN107286163A (zh) * | 2016-03-30 | 2017-10-24 | 上海星泰医药科技有限公司 | 一种依鲁替尼的新晶型及其制备方法 |
CZ2016196A3 (cs) | 2016-04-06 | 2017-10-18 | Zentiva, K.S. | Pevné formy Ibrutinibu |
CZ2016276A3 (cs) | 2016-05-11 | 2017-11-22 | Zentiva, K.S. | Pevné formy volné báze ibrutinibu |
CN106008529A (zh) * | 2016-08-08 | 2016-10-12 | 上海工程技术大学 | 一种依鲁替尼溶剂化物及其制备方法 |
US10183024B2 (en) | 2016-12-02 | 2019-01-22 | Apotex Inc. | Crystalline forms of ibrutinib |
WO2019070698A1 (en) | 2017-10-02 | 2019-04-11 | Johnson Matthey Public Limited Company | NEW FORMS OF IBRUTINIB |
CZ2017787A3 (cs) | 2017-12-08 | 2019-06-19 | Zentiva, K.S. | Farmaceutické kompozice obsahující ibrutinib |
WO2019195827A1 (en) | 2018-04-06 | 2019-10-10 | Johnson Matthey Public Limited Company | Novel form of ibrutinib |
WO2019211870A1 (en) | 2018-05-02 | 2019-11-07 | Cipla Limited | Polymorphic forms of ibrutinib |
BR112020022185A2 (pt) | 2018-05-03 | 2021-02-02 | Juno Therapeutics Inc | terapia de combinação de uma terapia de células t do receptor de antígeno quimérico (car) e um inibidor de quinase |
EP3575300A1 (en) | 2018-05-31 | 2019-12-04 | Apotex Inc. | Novel crystalline forms of ibrutinib |
EP3669867A1 (en) | 2018-12-21 | 2020-06-24 | Synthon B.V. | Pharmaceutical composition comprising ibrutinib |
US10688050B1 (en) | 2018-12-21 | 2020-06-23 | Synthon B.V. | Pharmaceutical composition comprising ibrutinib |
CN113135917A (zh) * | 2020-01-16 | 2021-07-20 | 北京赛思源生物医药技术有限公司 | 一种依鲁替尼的无定型物及其药用组合物 |
CN112630346B (zh) * | 2020-12-16 | 2022-11-01 | 河北合佳医药科技集团股份有限公司 | 一种伊布替尼中残留溶剂的定量分析方法 |
WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
WO2023242384A1 (en) | 2022-06-17 | 2023-12-21 | Krka, D.D., Novo Mesto | Crystalline form of ibrutinib |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS53165B (en) | 2007-03-14 | 2014-06-30 | Bionsil S.R.L. | BTK INHIBITORS FOR THE TREATMENT OF CHEMOTHERAPY-RESISTANT EPITHELIC TUMORS |
JP5369183B2 (ja) | 2008-07-16 | 2013-12-18 | ファーマサイクリックス,インク. | 固形腫瘍の治療用のブルートンのチロシンキナーゼの阻害剤 |
MA37711A1 (fr) * | 2012-06-04 | 2017-05-31 | Pharmacyclics Inc | Formes cristallines d'un inhibiteur de tyrosine kinase de bruton |
WO2014004707A1 (en) * | 2012-06-29 | 2014-01-03 | Principia Biopharma Inc. | Formulations comprising ibrutinib |
CN103694241A (zh) | 2013-11-27 | 2014-04-02 | 苏州晶云药物科技有限公司 | Pci-32765的新晶型a及其制备方法 |
-
2015
- 2015-03-23 MX MX2016012419A patent/MX2016012419A/es unknown
- 2015-03-23 CA CA2941087A patent/CA2941087A1/en not_active Abandoned
- 2015-03-23 WO PCT/IL2015/000017 patent/WO2015145415A2/en active Application Filing
- 2015-03-23 AU AU2015237744A patent/AU2015237744A1/en not_active Abandoned
- 2015-03-23 EP EP15770382.8A patent/EP3122753A4/en not_active Withdrawn
- 2015-03-23 US US15/128,856 patent/US9884869B2/en active Active
-
2016
- 2016-09-21 IL IL247963A patent/IL247963A0/en unknown
-
2017
- 2017-12-22 US US15/853,368 patent/US10280173B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3122753A4 (en) | 2017-11-29 |
US9884869B2 (en) | 2018-02-06 |
US10280173B2 (en) | 2019-05-07 |
AU2015237744A1 (en) | 2016-09-15 |
CA2941087A1 (en) | 2015-10-01 |
US20170226108A1 (en) | 2017-08-10 |
EP3122753A2 (en) | 2017-02-01 |
WO2015145415A2 (en) | 2015-10-01 |
IL247963A0 (en) | 2016-11-30 |
WO2015145415A3 (en) | 2015-11-19 |
US20180251463A1 (en) | 2018-09-06 |
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