PL3153504T3 - Sposoby otrzymywania naładowanych środków sieciujących - Google Patents
Sposoby otrzymywania naładowanych środków sieciującychInfo
- Publication number
- PL3153504T3 PL3153504T3 PL16186412T PL16186412T PL3153504T3 PL 3153504 T3 PL3153504 T3 PL 3153504T3 PL 16186412 T PL16186412 T PL 16186412T PL 16186412 T PL16186412 T PL 16186412T PL 3153504 T3 PL3153504 T3 PL 3153504T3
- Authority
- PL
- Poland
- Prior art keywords
- preparation
- methods
- charged crosslinkers
- crosslinkers
- charged
- Prior art date
Links
- 239000004971 Cross linker Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
- C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
- C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
- C07C305/06—Hydrogenosulfates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/36—Sulfur-, selenium-, or tellurium-containing compounds
- C08K5/37—Thiols
- C08K5/372—Sulfides, e.g. R-(S)x-R'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Polyamides (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42135710P | 2010-12-09 | 2010-12-09 | |
| PCT/US2011/063944 WO2012078868A1 (en) | 2010-12-09 | 2011-12-08 | Methods for the preparation of charged crosslinkers |
| EP11846704.2A EP2648510B1 (en) | 2010-12-09 | 2011-12-08 | Methods for the preparation of charged crosslinkers |
| EP16186412.9A EP3153504B1 (en) | 2010-12-09 | 2011-12-08 | Methods for the preparation of charged crosslinkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3153504T3 true PL3153504T3 (pl) | 2019-04-30 |
Family
ID=46207513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16186412T PL3153504T3 (pl) | 2010-12-09 | 2011-12-08 | Sposoby otrzymywania naładowanych środków sieciujących |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US8598362B2 (pl) |
| EP (2) | EP2648510B1 (pl) |
| KR (1) | KR101959578B1 (pl) |
| CN (2) | CN103260406B (pl) |
| CY (1) | CY1121055T1 (pl) |
| DK (1) | DK3153504T3 (pl) |
| ES (2) | ES2702926T3 (pl) |
| HR (1) | HRP20182026T1 (pl) |
| HU (1) | HUE041699T2 (pl) |
| IL (3) | IL226795A (pl) |
| LT (1) | LT3153504T (pl) |
| PL (1) | PL3153504T3 (pl) |
| PT (1) | PT3153504T (pl) |
| RS (1) | RS58033B1 (pl) |
| SG (3) | SG10202005580RA (pl) |
| SI (1) | SI3153504T1 (pl) |
| SM (1) | SMT201800666T1 (pl) |
| TR (1) | TR201819440T4 (pl) |
| WO (1) | WO2012078868A1 (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3153504T3 (pl) * | 2010-12-09 | 2019-04-30 | Immunogen Inc | Sposoby otrzymywania naładowanych środków sieciujących |
| JP6026305B2 (ja) | 2013-02-04 | 2016-11-16 | 古河電気工業株式会社 | 標識抗体の製造方法 |
| WO2014210267A1 (en) | 2013-06-28 | 2014-12-31 | Immunogen, Inc. | Purification of intermediates used in the preparation of heterobifunctional linkers |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| CN106414465B (zh) | 2014-02-28 | 2021-11-16 | 杭州多禧生物科技有限公司 | 带电荷链接体及其在共轭反应上的应用 |
| CN104892748B (zh) * | 2014-03-04 | 2018-12-21 | 深圳翰宇药业股份有限公司 | 人类松弛素-2衍生物以及由其制备人类松弛素-2的方法 |
| JP7350313B2 (ja) | 2016-12-16 | 2023-09-26 | ブルーフィン バイオメディシン， インコーポレイテッド | 抗ｃｕｂドメイン含有タンパク質１（ｃｄｃｐ１）抗体、抗体薬物コンジュゲート、およびその使用方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1926422A (en) | 1930-12-29 | 1933-09-12 | Fred C Armbruster | Pipe joint |
| DE800410C (de) * | 1948-10-02 | 1950-11-06 | Basf Ag | Verfahren zur Herstellung von Lactonsulfonsaeuren |
| US2822387A (en) * | 1955-12-07 | 1958-02-04 | Universal Oil Prod Co | Method of producing sulfonated alkanes |
| US3418290A (en) * | 1965-10-18 | 1968-12-24 | Du Pont | Sulfonated caprolactones and polymerization with 2,2-dialkyl-3-propiolactones |
| US4244885A (en) * | 1977-12-08 | 1981-01-13 | Yeda Research And Development Co. Ltd. | α-Substituted-3-(halomethyl)-4-hydroxybenzeneacetic acids |
| US4563304A (en) | 1981-02-27 | 1986-01-07 | Pharmacia Fine Chemicals Ab | Pyridine compounds modifying proteins, polypeptides or polysaccharides |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| DK0563475T3 (da) | 1992-03-25 | 2000-09-18 | Immunogen Inc | Konjugater af cellebindende midler og derivater af CC-1065 |
| CA2130723C (en) | 1993-09-03 | 2006-01-31 | Wilhelm Quittmann | Process for preparing y-mercaptocarboxylic acid derivatives |
| DE19609338A1 (de) * | 1996-03-11 | 1997-09-18 | Hoechst Ag | Benzothioxanthen-Farbstoffe, ihre Herstellung und ihre Verwendung |
| NZ517772A (en) | 1999-11-24 | 2004-03-26 | Immunogen Inc | Cytotoxic agents comprising taxanes and their therapeutic use |
| US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
| US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
| WO2003094845A2 (en) | 2002-05-08 | 2003-11-20 | Bristol-Myers Squibb Company | Pyridine-based thyroid receptor ligands |
| DE60336149D1 (de) * | 2002-08-16 | 2011-04-07 | Immunogen Inc | Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| EP1688415A1 (en) | 2004-12-07 | 2006-08-09 | Aventis Pharma S.A. | Cytotoxic agents comprising new C-2 modified taxanes |
| HUE034763T2 (en) | 2008-04-30 | 2018-02-28 | Immunogen Inc | Crosslinkers and their use |
| CN102083461B (zh) | 2008-04-30 | 2014-09-17 | 伊缪诺金公司 | 有效的偶联物和亲水性连接体 |
| SG173152A1 (en) | 2009-02-05 | 2011-08-29 | Immunogen Inc | Novel benzodiazepine derivatives |
| PL3153504T3 (pl) * | 2010-12-09 | 2019-04-30 | Immunogen Inc | Sposoby otrzymywania naładowanych środków sieciujących |
-
2011
- 2011-12-08 PL PL16186412T patent/PL3153504T3/pl unknown
- 2011-12-08 SG SG10202005580RA patent/SG10202005580RA/en unknown
- 2011-12-08 TR TR2018/19440T patent/TR201819440T4/tr unknown
- 2011-12-08 SM SM20180666T patent/SMT201800666T1/it unknown
- 2011-12-08 ES ES16186412T patent/ES2702926T3/es active Active
- 2011-12-08 CN CN201180059248.XA patent/CN103260406B/zh not_active Expired - Fee Related
- 2011-12-08 WO PCT/US2011/063944 patent/WO2012078868A1/en not_active Ceased
- 2011-12-08 RS RS20181471A patent/RS58033B1/sr unknown
- 2011-12-08 CN CN201610836137.XA patent/CN107011253B/zh not_active Expired - Fee Related
- 2011-12-08 SI SI201131636T patent/SI3153504T1/sl unknown
- 2011-12-08 DK DK16186412.9T patent/DK3153504T3/en active
- 2011-12-08 SG SG2013035555A patent/SG190214A1/en unknown
- 2011-12-08 US US13/315,005 patent/US8598362B2/en not_active Expired - Fee Related
- 2011-12-08 KR KR1020137015769A patent/KR101959578B1/ko not_active Expired - Fee Related
- 2011-12-08 LT LTEP16186412.9T patent/LT3153504T/lt unknown
- 2011-12-08 SG SG10201509886YA patent/SG10201509886YA/en unknown
- 2011-12-08 EP EP11846704.2A patent/EP2648510B1/en active Active
- 2011-12-08 ES ES11846704.2T patent/ES2602118T3/es active Active
- 2011-12-08 EP EP16186412.9A patent/EP3153504B1/en active Active
- 2011-12-08 HU HUE16186412A patent/HUE041699T2/hu unknown
- 2011-12-08 PT PT16186412T patent/PT3153504T/pt unknown
-
2013
- 2013-06-06 IL IL226795A patent/IL226795A/en active IP Right Grant
- 2013-10-03 US US14/045,151 patent/US8921566B2/en active Active
-
2014
- 2014-11-12 US US14/539,361 patent/US9242936B2/en active Active
-
2015
- 2015-07-28 IL IL240200A patent/IL240200A/en active IP Right Grant
- 2015-07-28 IL IL240201A patent/IL240201A0/en unknown
- 2015-12-15 US US14/969,720 patent/US9663492B2/en not_active Expired - Fee Related
-
2017
- 2017-04-25 US US15/496,775 patent/US10112925B2/en active Active
-
2018
- 2018-12-03 HR HRP20182026TT patent/HRP20182026T1/hr unknown
- 2018-12-10 CY CY181101315T patent/CY1121055T1/el unknown
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