CY1121055T1 - Μεθοδος για την παρασκευη φορτισμενων διασυνδετων - Google Patents

Μεθοδος για την παρασκευη φορτισμενων διασυνδετων

Info

Publication number
CY1121055T1
CY1121055T1 CY181101315T CY181101315T CY1121055T1 CY 1121055 T1 CY1121055 T1 CY 1121055T1 CY 181101315 T CY181101315 T CY 181101315T CY 181101315 T CY181101315 T CY 181101315T CY 1121055 T1 CY1121055 T1 CY 1121055T1
Authority
CY
Cyprus
Prior art keywords
interconnectors
charged
manufacture
methods
converting
Prior art date
Application number
CY181101315T
Other languages
English (en)
Inventor
Wei Li
Robert Zhao
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of CY1121055T1 publication Critical patent/CY1121055T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/06—Hydrogenosulfates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/36—Sulfur-, selenium-, or tellurium-containing compounds
    • C08K5/37—Thiols
    • C08K5/372—Sulfides, e.g. R-(S)x-R'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyamides (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)

Abstract

Αποκαλύπτονται μέθοδοι για την παρασκευή φορτισμένων διασυνδετών που φέρουν ένα τμήμα σουλφονικού οξέος. Οι διαδικασίες αυτές επίσης ενδεχομένως περιλαμβάνουν μεθόδους μετατροπής των προκυπτόντων προϊόντων σε μορφή ουσιαστικά ενός μονού άλατος.
CY181101315T 2010-12-09 2018-12-10 Μεθοδος για την παρασκευη φορτισμενων διασυνδετων CY1121055T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42135710P 2010-12-09 2010-12-09
PCT/US2011/063944 WO2012078868A1 (en) 2010-12-09 2011-12-08 Methods for the preparation of charged crosslinkers
EP11846704.2A EP2648510B1 (en) 2010-12-09 2011-12-08 Methods for the preparation of charged crosslinkers

Publications (1)

Publication Number Publication Date
CY1121055T1 true CY1121055T1 (el) 2019-12-11

Family

ID=46207513

Family Applications (1)

Application Number Title Priority Date Filing Date
CY181101315T CY1121055T1 (el) 2010-12-09 2018-12-10 Μεθοδος για την παρασκευη φορτισμενων διασυνδετων

Country Status (18)

Country Link
US (5) US8598362B2 (el)
EP (2) EP2648510B1 (el)
KR (1) KR101959578B1 (el)
CN (2) CN103260406B (el)
CY (1) CY1121055T1 (el)
DK (1) DK3153504T3 (el)
ES (2) ES2602118T3 (el)
HR (1) HRP20182026T1 (el)
HU (1) HUE041699T2 (el)
IL (3) IL226795A (el)
LT (1) LT3153504T (el)
PL (1) PL3153504T3 (el)
PT (1) PT3153504T (el)
RS (1) RS58033B1 (el)
SG (3) SG10202005580RA (el)
SI (1) SI3153504T1 (el)
TR (1) TR201819440T4 (el)
WO (1) WO2012078868A1 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103260406B (zh) * 2010-12-09 2016-10-19 伊缪诺金公司 制备带电荷交联剂的方法
JP6026305B2 (ja) 2013-02-04 2016-11-16 古河電気工業株式会社 標識抗体の製造方法
WO2014210267A1 (en) 2013-06-28 2014-12-31 Immunogen, Inc. Purification of intermediates used in the preparation of heterobifunctional linkers
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
ES2960619T3 (es) 2014-02-28 2024-03-05 Hangzhou Dac Biotech Co Ltd Enlazadores cargados y sus usos para la conjugación
CN104892748B (zh) * 2014-03-04 2018-12-21 深圳翰宇药业股份有限公司 人类松弛素-2衍生物以及由其制备人类松弛素-2的方法

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US1926422A (en) 1930-12-29 1933-09-12 Fred C Armbruster Pipe joint
DE800410C (de) 1948-10-02 1950-11-06 Basf Ag Verfahren zur Herstellung von Lactonsulfonsaeuren
US2822387A (en) * 1955-12-07 1958-02-04 Universal Oil Prod Co Method of producing sulfonated alkanes
US3418290A (en) * 1965-10-18 1968-12-24 Du Pont Sulfonated caprolactones and polymerization with 2,2-dialkyl-3-propiolactones
US4244885A (en) * 1977-12-08 1981-01-13 Yeda Research And Development Co. Ltd. α-Substituted-3-(halomethyl)-4-hydroxybenzeneacetic acids
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US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
EP0563475B1 (en) 1992-03-25 2000-05-31 Immunogen Inc Cell binding agent conjugates of derivatives of CC-1065
CA2130723C (en) * 1993-09-03 2006-01-31 Wilhelm Quittmann Process for preparing y-mercaptocarboxylic acid derivatives
DE19609338A1 (de) * 1996-03-11 1997-09-18 Hoechst Ag Benzothioxanthen-Farbstoffe, ihre Herstellung und ihre Verwendung
ATE349438T1 (de) 1999-11-24 2007-01-15 Immunogen Inc Cytotoxische wirkstoffe enthaltend taxane und deren therapeutische anwendung
US6716821B2 (en) 2001-12-21 2004-04-06 Immunogen Inc. Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
US6756397B2 (en) 2002-04-05 2004-06-29 Immunogen, Inc. Prodrugs of CC-1065 analogs
AU2003225305A1 (en) 2002-05-08 2003-11-11 Bristol-Myers Squibb Company Pyridine-based thyroid receptor ligands
AU2003259163B2 (en) * 2002-08-16 2008-07-03 Immunogen, Inc. Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
EP1688415A1 (en) 2004-12-07 2006-08-09 Aventis Pharma S.A. Cytotoxic agents comprising new C-2 modified taxanes
EP2276506A4 (en) 2008-04-30 2014-05-07 Immunogen Inc EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
US8236319B2 (en) 2008-04-30 2012-08-07 Immunogen, Inc. Cross-linkers and their uses
RU2545080C2 (ru) 2009-02-05 2015-03-27 Иммьюноджен, Инк. Новые производные бензодиазепина
CN103260406B (zh) 2010-12-09 2016-10-19 伊缪诺金公司 制备带电荷交联剂的方法

Also Published As

Publication number Publication date
IL240201A0 (en) 2015-09-24
US20160272616A1 (en) 2016-09-22
IL240200A0 (en) 2015-09-24
EP2648510A4 (en) 2014-05-07
IL226795A (en) 2015-08-31
PT3153504T (pt) 2018-12-27
KR101959578B1 (ko) 2019-03-18
SI3153504T1 (sl) 2019-03-29
DK3153504T3 (en) 2019-01-07
US20140135502A1 (en) 2014-05-15
US20170327486A1 (en) 2017-11-16
TR201819440T4 (tr) 2019-01-21
SG10201509886YA (en) 2016-01-28
US8598362B2 (en) 2013-12-03
CN103260406A (zh) 2013-08-21
CN107011253A (zh) 2017-08-04
RS58033B1 (sr) 2019-02-28
EP3153504A1 (en) 2017-04-12
ES2602118T3 (es) 2017-02-17
CN107011253B (zh) 2021-01-15
ES2702926T3 (es) 2019-03-06
US10112925B2 (en) 2018-10-30
SG10202005580RA (en) 2020-07-29
CN103260406B (zh) 2016-10-19
HUE041699T2 (hu) 2019-05-28
US20120165537A1 (en) 2012-06-28
EP3153504B1 (en) 2018-09-26
WO2012078868A1 (en) 2012-06-14
US9663492B2 (en) 2017-05-30
LT3153504T (lt) 2019-02-11
EP2648510A1 (en) 2013-10-16
PL3153504T3 (pl) 2019-04-30
US8921566B2 (en) 2014-12-30
EP2648510B1 (en) 2016-08-31
US9242936B2 (en) 2016-01-26
IL240200A (en) 2017-02-28
HRP20182026T1 (hr) 2019-02-22
SG190214A1 (en) 2013-06-28
US20150166482A1 (en) 2015-06-18
KR20130124336A (ko) 2013-11-13

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