MX364529B - Nuevos ligandos del receptor de estrógeno. - Google Patents

Nuevos ligandos del receptor de estrógeno.

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Publication number
MX364529B
MX364529B MX2014001386A MX2014001386A MX364529B MX 364529 B MX364529 B MX 364529B MX 2014001386 A MX2014001386 A MX 2014001386A MX 2014001386 A MX2014001386 A MX 2014001386A MX 364529 B MX364529 B MX 364529B
Authority
MX
Mexico
Prior art keywords
estrogen receptor
receptor ligands
novel estrogen
novel
carbamate
Prior art date
Application number
MX2014001386A
Other languages
English (en)
Other versions
MX2014001386A (es
Inventor
Cheng Aiping
Garg Neeraj
Krüger Lars
Löfstedt Joakim
Koch Eva
Koehler Konrad
Hagberg Lars
Nöteberg Daniel
Original Assignee
Karobio Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karobio Ab filed Critical Karobio Ab
Publication of MX2014001386A publication Critical patent/MX2014001386A/es
Publication of MX364529B publication Critical patent/MX364529B/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract

Se describen los compuestos de fórmula (I) o un éster, una amida, un carbamato o una sal farmacéuticamente aceptable de los mismos, que incluyen una sal de tal éster, tal amida o tal carbamato, en los cuales R1 a R9 tienen los significados de acuerdo con lo definido en la especificación, los cuales son útiles como ligandos del receptor de estrógeno.
MX2014001386A 2011-08-04 2012-08-02 Nuevos ligandos del receptor de estrógeno. MX364529B (es)

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GBGB1113538.1A GB201113538D0 (en) 2011-08-04 2011-08-04 Novel estrogen receptor ligands
PCT/EP2012/065134 WO2013017654A1 (en) 2011-08-04 2012-08-02 Novel estrogen receptor ligands

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016036721A1 (en) 2014-09-02 2016-03-10 The Regents Of The University Of California Estrogen receptor ligand treatment for neurodegenerative diseases
BR112017024481B1 (pt) 2015-05-14 2020-11-17 The Wistar Institute Of Anatomy And Biology composto inibidor de ebna1, composição farmacêutica compreendendo dito composto e usos terapêuticos do mesmo
CN112543634A (zh) 2018-05-17 2021-03-23 威斯达研究所 Ebna1抑制剂晶体形式及其制备和使用方法
CN109796372B (zh) * 2019-03-13 2020-03-10 中国科学院化学研究所 一种制备多取代烯基脒的方法
BR112022000986A2 (pt) * 2019-07-19 2022-03-08 Adama Makhteshim Ltd Processos para preparar bifenilaminas e produzir compostos de interesse agroquímico e usos de ligantes de bifenilfosfinas no preparo dos mesmos

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519675A (en) 1964-06-01 1970-07-07 Upjohn Co 1,2-diphenyl-3,4-dihydronaphthalenes and 2,3-diphenylindenes
CH986269A4 (es) 1969-06-27 1970-12-31
US3799943A (en) 1971-06-23 1974-03-26 Sterling Drug Inc 1,2-diphenylindoles
BE787488A (fr) 1971-08-12 1973-02-12 Ciba Geigy Nouveau procede de preparation de nouvelles pentanones polycycliques
US3878225A (en) 1973-03-01 1975-04-15 Hoechst Co American Condensed pyrroles bearing an N-phenyl substituent
US4182764A (en) 1973-10-11 1980-01-08 Merck & Co., Inc. Tetrazole derivatives of [1-oxo-2-aryl or thienyl-2-substituted-5-indanyloxy(or thio)]alkanoic acids
US4056624A (en) 1976-05-14 1977-11-01 American Hoechst Corporation Method of treating dermal inflammation
DE2909754A1 (de) 1979-03-13 1980-09-18 Thomae Gmbh Dr K Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel
JPS5726653A (en) 1980-05-09 1982-02-12 Ciba Geigy Ag Substituted phenyl ether
US5096919A (en) 1989-01-05 1992-03-17 Ciba-Geigy Corporation Pyrrolylphenyl-substituted hydroxamic acid derivatives
DE4117512A1 (de) 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
GB9224517D0 (en) 1992-11-23 1993-01-13 British Tech Group Controlling plant growth
PL313973A1 (en) 1993-10-12 1996-08-05 Du Pont Merck Pharma 1 n-alkyl-n-arylopyrimidin amines and their derivatives
US5691376A (en) 1994-02-17 1997-11-25 American Home Products Corporation Substituted biphenyl derivatives
CA2144669A1 (en) 1994-03-29 1995-09-30 Kozo Akasaka Biphenyl derivatives
WO1995027692A1 (en) 1994-04-08 1995-10-19 Smithkline Beecham Corporation Subtituted biphenyl tnf inhibitors
DE4412983A1 (de) 1994-04-15 1995-10-19 Basf Ag Phenolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung, insbesondere in der nichtlinearen Optik
DE4426625A1 (de) 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
US5693647A (en) 1994-12-22 1997-12-02 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
FR2744445B1 (fr) * 1996-02-01 1998-10-02 Roussel Uclaf Composes biphenyles nouveaux et/ou a titre de medicament, compositions pharmaceutiques les contenant, leur procede de preparation et les intermediaires de ce procede
US5998402A (en) 1996-04-19 1999-12-07 American Home Products Corporation 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
CA2219269A1 (en) 1996-10-29 1998-04-29 Novartis Ag Novel herbicides
HRP20000778B1 (en) 1998-05-15 2004-10-31 Wyeth Corp 2-phenyl-1-/4-(2-aminoethoxy)-benzyl/-indole in combination with estrogens
WO2000000487A1 (en) 1998-06-30 2000-01-06 Eli Lilly And Company 5-ht1f agonists
GB9816575D0 (en) 1998-07-31 1998-09-30 Zeneca Ltd Novel compounds
EP1102753B1 (en) 1998-08-07 2007-02-28 Novartis Vaccines and Diagnostics, Inc. Pyrazoles as estrogen receptor modulators
WO2000019994A1 (en) 1998-10-02 2000-04-13 Board Of Trustees Of The University Of Illinois Estrogen receptor ligands
US6380185B1 (en) 1999-03-04 2002-04-30 American Home Products Corporation N-substituted benzoyl indoles as estrogenic agents
AU4327600A (en) 1999-04-02 2000-10-23 Du Pont Pharmaceuticals Company Aryl sulfonyls as factor xa inhibitors
SK15902001A3 (sk) * 1999-05-04 2002-11-06 American Home Products Corporation Deriváty tiooxindolu
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
AU2001258784A1 (en) 2000-05-22 2001-12-03 Takeda Chemical Industries Ltd. Tyrosine phosphatase inhibitors
EP2258694A1 (en) 2001-03-16 2010-12-08 Abbott Laboratories Amines as histamine-3 receptor ligands and their therapeutic applications
EP1421061A4 (en) 2001-08-17 2004-12-22 Incyte San Diego Inc OXIME DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA AND HYPERCHOLESTEROLEMIA
US6903238B2 (en) 2001-12-13 2005-06-07 Wyeth Substituted indenones as estrogenic agents
US6774248B2 (en) 2001-12-18 2004-08-10 Wyeth Substituted 2-phenyl benzofurans as estrogenic agents
JP4399265B2 (ja) 2001-12-21 2010-01-13 ヴァーナリス（ケンブリッジ）リミテッド ３，４−ジアリールピラゾール、および癌の治療におけるそれらの使用
US6835745B2 (en) 2002-01-15 2004-12-28 Wyeth Phenyl substituted thiophenes as estrogenic agents
EP1472216A2 (en) 2002-02-07 2004-11-03 Axys Pharmaceuticals Novel bicyclic hydroxamates as inhibitors of histone deacetylase
US20030220377A1 (en) 2002-05-08 2003-11-27 Richard Chesworth Indole compounds and their use as estrogen agonists/antagonists
DK1569901T3 (da) 2002-12-10 2009-02-16 Wyeth Corp Aryl-, aryloxy- og alkoxysubstituerede 1H-indol-3-yl-glyoxylsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1)
GB0229618D0 (en) 2002-12-19 2003-01-22 Cancer Rec Tech Ltd Pyrazole compounds
JP4567596B2 (ja) 2003-02-14 2010-10-20 キッセイ薬品工業株式会社 アミノアルコール誘導体、それを含有する医薬組成物およびそれらの用途
TWI335218B (en) 2003-02-19 2011-01-01 Panion & Bf Biotech Inc Ferric organic compounds, uses thereof and methods of making same
AU2003901647A0 (en) 2003-04-04 2003-05-01 Fujisawa Pharmaceutical Co., Ltd. Novel Condensed Furan Compounds and Pharmaceutical Use Thereof
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
ATE452121T1 (de) * 2003-04-23 2010-01-15 Japan Tobacco Inc Casr-antagonist
US7279600B2 (en) 2003-05-02 2007-10-09 Wyeth Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents
AU2004241246A1 (en) 2003-05-16 2004-12-02 Wyeth Aryl-carbaldehyde oxime derivatives and their use as estrogenic agents
US7250440B2 (en) 2003-08-12 2007-07-31 Wyeth (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents
EP1663959A4 (en) 2003-09-05 2007-10-31 Univ North Carolina NEW AMIDINE COMPOUNDS FOR THE TREATMENT OF MICROBIAL INFECTIONS
CN1925855B (zh) 2003-12-19 2010-06-16 普莱希科公司 开发Ret调节剂的化合物和方法
ITMI20040874A1 (it) 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori Derivati indolici ed azaindolici con azione antitumorale
JP2008506702A (ja) 2004-07-14 2008-03-06 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するための方法
WO2006081034A2 (en) 2004-12-23 2006-08-03 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
BRPI0519459A2 (pt) 2004-12-31 2009-01-27 Aventis Pharma Inc uso de certos compostos de bifenila para proteÇço dos neurânios e oligodendràcitos no tratamento da esclerose méltipla (em)
US8093302B2 (en) 2005-02-15 2012-01-10 Eli Lilly And Company Substituted tetralins as selective estrogen receptor-β agonists
US8999289B2 (en) 2005-03-22 2015-04-07 President And Fellows Of Harvard College Treatment of protein degradation disorders
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US20070021495A1 (en) 2005-07-25 2007-01-25 Katzenellenbogen John A Sulfonamides as selective estrogen receptor
SI1945622T1 (sl) 2005-10-11 2012-05-31 Univ Pittsburgh Izotopično markirane spojine benzfurana kot označevalne snovi za amiloidogenske proteine
AR056690A1 (es) 2005-10-14 2007-10-17 Athersys Inc Derivados de indol como inhibidores de indol como inhibidores del receptor 3 de histamina para el tartamiento de trastornos del sueno y cognitivos obesidad y otros trastornos de snc
EP1779848A1 (en) 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
HRP20130058T1 (hr) 2006-01-24 2013-02-28 Eli Lilly & Company Indolsulfonamidni modulatori progesteronskih receptora
CN101415674A (zh) 2006-02-16 2009-04-22 先灵公司 作为erk抑制剂的吡咯烷衍生物
EP1889617A1 (en) 2006-07-11 2008-02-20 Freie Universität Berlin Triphenyl modified 5-membered heterocycles and their use as anticancer and antiflammatory agents
WO2008011557A2 (en) 2006-07-20 2008-01-24 Borchardt Allen J Heteroaryl inhibitors of rho kinase
WO2008064830A1 (en) 2006-11-27 2008-06-05 Ucb Pharma, S.A. Bicyclic and heterobicyclic derivatives, processes for preparing them and their pharmaceutical uses
WO2008082839A2 (en) 2006-12-29 2008-07-10 Abbott Laboratories Pim kinase inhibitors as cancer chemotherapeutics
CA2674318A1 (en) 2007-01-05 2008-07-17 Novartis Ag Cyclized derivatives as eg-5 inhibitors
JP5107589B2 (ja) 2007-02-13 2012-12-26 旭化成株式会社 インドール誘導体
EP2133331A4 (en) 2007-04-11 2011-06-22 Kissei Pharmaceutical FIVE-GLASS HETEROCYCLIC DERIVATIVE AND ITS USE IN MEDICAL PURPOSES
US20100210524A1 (en) 2007-07-20 2010-08-19 Theresa Apelqvist Novel estrogen receptor ligands
JP2010535738A (ja) 2007-08-08 2010-11-25 ノイロサーチ アクティーゼルスカブ ニコチン性アセチルコリン受容体の調節物質として有用な新規１，２，３−トリアゾール誘導体
EP2252799B1 (en) 2008-02-12 2014-06-11 Parker-Hannifin Corporation Flow management system for hydraulic work machine
GB0806074D0 (en) 2008-04-03 2008-05-14 Karobio Ab Novel estrogen receptor ligands
GB0806656D0 (en) 2008-04-11 2008-05-14 Karobio Ab Novel estrogen receptor ligands
GB2459133A (en) 2008-04-11 2009-10-14 Karobio Ab Therapeutic 2-(4-substituted-phenyl)-3-(cyclyl containing)-5-hydroxy-benzo[b]thiophene derivatives as estrogen receptor ligands
PT2276732E (pt) * 2008-04-16 2015-09-28 Karobio Ab Novos ligandos do recetor de estrogénio
BRPI0822522A2 (pt) 2008-04-23 2018-06-05 Chroma Therapeutics Ltd Inibidores da proteína quinase ikk-beta serina- treonina
HUE043090T2 (hu) 2008-06-09 2019-08-28 Univ Muenchen Ludwig Maximilians Gyógyszerek fehérjék aggregálódásának gátlására olyan betegségeknél, amelyek fehérje-aggregálódással és/vagy neurodegeneratív megbetegedésekkel függnek össze
CA2729220A1 (en) * 2008-06-25 2009-12-30 Envivo Pharmaceuticals, Inc. Di-substituted phenyl compounds
GB0817221D0 (en) 2008-09-19 2008-10-29 Karobio Ab Novel estrogen receptor ligands
MX2011005218A (es) * 2008-12-22 2011-06-01 Pola Chem Ind Inc Inhibidor de produccion de malanina.
GB0917571D0 (en) 2009-10-07 2009-11-25 Karobio Ab Novel estrogen receptor ligands
IN2012DN02556A (es) 2009-10-07 2015-08-28 Karobio Ab
ES2744219T3 (es) 2009-10-07 2020-02-24 Karo Pharma Ab Ligandos del receptor de estrógeno
JP5505616B2 (ja) 2009-12-08 2014-05-28 凸版印刷株式会社 気体分析装置
WO2012022776A1 (en) 2010-08-19 2012-02-23 Karo Bio Ab Substituted thiopenes or furans as estrogen receptor ligands
GB201105979D0 (en) 2011-04-07 2011-05-18 Karobio Ab Novel estrogen receptor ligands

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AU2012292033A1 (en) 2014-02-27
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ZA201400708B (en) 2015-12-23
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CA2842719C (en) 2019-11-05
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