SI3464336T1 - Spojine - Google Patents

Spojine

Info

Publication number
SI3464336T1
SI3464336T1 SI201731129T SI201731129T SI3464336T1 SI 3464336 T1 SI3464336 T1 SI 3464336T1 SI 201731129 T SI201731129 T SI 201731129T SI 201731129 T SI201731129 T SI 201731129T SI 3464336 T1 SI3464336 T1 SI 3464336T1
Authority
SI
Slovenia
Prior art keywords
compounds
Prior art date
Application number
SI201731129T
Other languages
English (en)
Inventor
Leen H. Kawas
Jasbir Singh
Lansing Joseph Stewart
William R. Baker
Original Assignee
Athira Pharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Athira Pharma, Inc. filed Critical Athira Pharma, Inc.
Publication of SI3464336T1 publication Critical patent/SI3464336T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0217Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -C(=O)-C-N-C(=O)-N-C-C(=O)-
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
SI201731129T 2016-06-01 2017-06-01 Spojine SI3464336T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662344305P 2016-06-01 2016-06-01
EP17807519.8A EP3464336B1 (en) 2016-06-01 2017-06-01 Compounds
PCT/US2017/035547 WO2017210489A1 (en) 2016-06-01 2017-06-01 Compounds

Publications (1)

Publication Number Publication Date
SI3464336T1 true SI3464336T1 (sl) 2022-06-30

Family

ID=60478958

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201731129T SI3464336T1 (sl) 2016-06-01 2017-06-01 Spojine

Country Status (14)

Country Link
US (2) US11021514B2 (sl)
EP (2) EP4067368A1 (sl)
JP (3) JP2019525947A (sl)
CN (3) CN116655730A (sl)
AU (3) AU2017273857B2 (sl)
CA (1) CA3026074A1 (sl)
DK (1) DK3464336T3 (sl)
ES (1) ES2912035T3 (sl)
HR (1) HRP20220479T1 (sl)
LT (1) LT3464336T (sl)
PL (1) PL3464336T3 (sl)
RS (1) RS63143B1 (sl)
SI (1) SI3464336T1 (sl)
WO (1) WO2017210489A1 (sl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019525947A (ja) 2016-06-01 2019-09-12 エムスリー・バイオテクノロジー・インコーポレイテッドM3 Biotechnology, Inc. 化合物
KR20240038980A (ko) * 2021-07-23 2024-03-26 아티라 파마, 인코포레이티드 파킨슨병 및/또는 루이체 질환 또는 장애(들)의 치료 방법
WO2023215376A1 (en) 2022-05-04 2023-11-09 Athira Pharma, Inc. Methods of treating neuropathies
WO2023215378A1 (en) 2022-05-04 2023-11-09 Athira Pharma, Inc. Methods of treating fibrosis
WO2023215377A1 (en) 2022-05-04 2023-11-09 Athira Pharma, Inc. Methods of treating neuroinflammatory conditions
CN114907288B (zh) * 2022-05-13 2023-12-08 中国医学科学院医药生物技术研究所 硝基苯类化合物在制备铜绿假单胞菌群体感应抑制剂中的应用

Family Cites Families (238)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639456A (en) 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
GB8311286D0 (en) 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
DE3320175A1 (de) 1983-06-03 1984-12-06 Boehringer Mannheim Gmbh, 6800 Mannheim Aminosaeure- bzw. peptidderivate, verfahren zu deren herstellung und verwendung als arzneimittel
US4477440A (en) 1983-09-14 1984-10-16 Merck & Co., Inc. Renin inhibitors containing an n-terminal disulfide cycle
EP0163237A3 (en) 1984-05-29 1988-04-27 Merck & Co. Inc. Di- and tri-peptidal renin inhibitors
JPS63503380A (ja) 1986-01-16 1988-12-08 アボット・ラボラトリーズ ペプチド類似体
US5378691A (en) 1988-04-14 1995-01-03 Merck Patent Gesellschaft Mit Beschrankter Haftung Amino acid derivatives
WO1990002137A1 (en) 1988-08-19 1990-03-08 The Upjohn Company Renin inhibitory peptides containing suleptanic acid or derivatives thereof
US5180816A (en) 1988-08-24 1993-01-19 Centocor One vial method for labeling protein/linker conjugates with technetium-99M
EP0444156A4 (en) 1988-11-21 1992-12-09 Abbott Laboratories Method for treating vascular diseases
DE3912829A1 (de) 1989-04-19 1990-10-25 Bayer Ag Verwendung von renininhibitorischen peptiden als mittel gegen retroviren
DE4004820A1 (de) 1989-08-05 1991-04-25 Bayer Ag Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE3915361A1 (de) 1989-05-11 1990-11-15 Merck Patent Gmbh Cyclopeptide
US5240913A (en) 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
AU641215B2 (en) 1990-02-13 1993-09-16 Merrell Dow Pharmaceuticals Inc. Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
US5284828A (en) 1990-05-14 1994-02-08 Fujisawa Pharmaceutical Co. Ltd. Peptide compound and its preparation
AU648140B2 (en) 1991-02-01 1994-04-14 Virtual Drug Development, Inc. Reverse antimicrobial peptides and antimicrobial compositions
US5190924A (en) 1991-02-13 1993-03-02 Boc Health Care, Inc. Peptide amides and amide dimers useful as muscle relaxants
US5382569A (en) 1991-05-16 1995-01-17 Warner-Lambert Company Endotherlin antagonists
JP3294610B2 (ja) 1991-05-16 2002-06-24 ワーナー−ランバート・コンパニー エンドセリン拮抗剤
US5190922A (en) 1991-06-04 1993-03-02 Abbott Laboratories Terminally modified tri-, tetra- and pentapeptide anaphylatoxin receptor ligands
DE69226820T2 (de) 1991-06-21 1999-05-12 Merck & Co Inc Peptidylderivate als Inhibitoren von Interleukin-1B-konvertierenden Enzymen
DE4122885A1 (de) 1991-07-11 1993-01-21 Hoechst Ag Verfahren zur diastereoselektiven reduktiven pinakol-kupplung von homochiralen (alpha)-aminoaldehyden
EP0533226A3 (en) 1991-08-16 1993-08-18 Merck & Co. Inc. Novel chromophore containing compounds
US6348570B1 (en) 1991-08-16 2002-02-19 Merck & Co., Inc. Chromophore containing compounds and their use in determining interleukin-1β convertase activity
US5223535A (en) 1991-10-29 1993-06-29 G. D. Searle & Co. Propargyl glycine amino propargyl diol compounds for treatment of hypertension
US5227401A (en) 1991-10-29 1993-07-13 G. D. Searle & Co. Ethynyl alanine amino diol compounds for treatment of hypertension
JPH05117169A (ja) 1991-10-29 1993-05-14 Mitsubishi Kasei Corp クロロメチルケトンの製法
WO1993012076A1 (en) 1991-12-13 1993-06-24 Corvas International Inc. Reagents for automated synthesis of peptide analogs
EP0547699A1 (en) 1991-12-19 1993-06-23 Merck & Co. Inc. Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme
JPH05178890A (ja) 1991-12-26 1993-07-20 Banyu Pharmaceut Co Ltd エンドセリン拮抗性化合物
WO1993014777A1 (en) 1992-01-31 1993-08-05 Merck & Co., Inc. PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
ES2118940T3 (es) 1992-02-21 1998-10-01 Merck & Co Inc Peptidil-derivados utiles como inhibidores de la enzima conversora de la interleucina-1 beta.
US5430062A (en) 1992-05-21 1995-07-04 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
CA2136220A1 (en) 1992-05-21 1993-11-25 Mark S. Cushman Stilbene derivatives as anticancer agents
EP0647239A4 (en) 1992-06-24 1997-07-02 Univ Washington ANGIOTENSIN IV PEPTIDES, AND RECEPTOR.
HUT72614A (en) 1992-09-24 1996-05-28 Chiron Corp Synthesis of n-substituted oligomers
EP0600832A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Diaminobenzoe- und Diaminophthalsäurederivate und ihre Verfahren als Proteinkinase-Inhibitoren
IL107719A0 (en) 1992-12-21 1994-02-27 Du Pont Imidazolones their manufacture and their use as herbicides
JPH06192199A (ja) 1992-12-25 1994-07-12 Mitsubishi Kasei Corp ケトン誘導体
AU6491294A (en) 1993-03-26 1994-10-24 Warner-Lambert Company Inhibitors of endothelin converting enzyme
DE4311021A1 (de) 1993-03-31 1994-10-27 Diagnostikforschung Inst Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel
WO1994028012A1 (en) 1993-05-28 1994-12-08 Warner-Lambert Company Hydroxamate inhibitors of endothelin converting enzyme
US5854388A (en) 1993-06-24 1998-12-29 Washington State University Research Foundation Angiotensin IV peptides and receptor
DE4321306A1 (de) 1993-06-26 1995-01-05 Sanol Arznei Schwarz Gmbh Disulfide
GB9323165D0 (en) 1993-11-10 1994-01-05 Chiros Ltd Compounds
DE4345062A1 (de) 1993-12-31 1995-07-13 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von Viruserkrankungen
US5686419A (en) 1994-01-21 1997-11-11 Georgia Tech Research Corp. Basic α-aminoalkylphosphonate derivatives
GB2292149A (en) 1994-08-09 1996-02-14 Ferring Res Ltd Peptide inhibitors of pro-interleukin-1beta converting enzyme
US20010046668A1 (en) 1994-10-21 2001-11-29 G.D. Searle & Co. Fluorescence polarization method for determining protease activity
US5840698A (en) 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5831004A (en) 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
AU3935895A (en) 1994-11-24 1996-06-17 Takeda Chemical Industries Ltd. Alpha-ketoamide derivatives as cathepsin l inhibitor
EP0731107A1 (en) 1995-02-13 1996-09-11 Takeda Chemical Industries, Ltd. Production of aldehyde derivatives
JPH08262673A (ja) 1995-03-22 1996-10-11 Fuji Photo Film Co Ltd 銀塩拡散転写法による画像形成方法
US5798442A (en) 1995-04-21 1998-08-25 Merck Frosst Canada, Inc. Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases
EP0822983A4 (en) 1995-04-21 2004-12-15 Merck & Co Inc apopain
EP0838471A4 (en) 1995-07-07 2000-07-26 Sagami Chem Res PEPTIDE DERIVATIVES AND AGONISTS OF THE ANGIOTENSIN IV RECEPTOR
GB9517060D0 (en) * 1995-08-17 1995-10-25 Ciba Geigy Ag Acylated oligopeptide derivatives
US5763576A (en) 1995-10-06 1998-06-09 Georgia Tech Research Corp. Tetrapeptide α-ketoamides
WO1997016410A1 (en) 1995-10-30 1997-05-09 Merck & Co., Inc. Novel inhibitors of peptide binding to mhc class ii proteins
US5817757A (en) 1995-10-30 1998-10-06 Merck & Co., Inc. Inhibitors of peptide binding to MHO class II proteins
US6121489A (en) 1996-03-05 2000-09-19 Trega Biosciences, Inc. Selectively N-alkylated peptidomimetic combinatorial libraries and compounds therein
WO1997040071A1 (en) 1996-04-19 1997-10-30 Novo Nordisk A/S Compounds with growth hormone releasing properties
SE9603468D0 (sv) 1996-09-23 1996-09-23 Astra Ab New compounds
SE9603461D0 (sv) 1996-09-23 1996-09-23 Astra Ab New compounds
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
SI9600371B (sl) 1996-12-18 2005-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Etilidenski derivati tricikličnih karbapenemov
WO1998029435A1 (en) 1996-12-27 1998-07-09 Boehringer Ingelheim (Canada) Ltd. Peptidomimetic inhibitors of the human cytomegalovirus protease
GB2324529A (en) 1997-02-21 1998-10-28 Merck & Co Inc A combinatorial library based on a tetrapeptide substituted with aminomethylcoumarin for characterizing proteases
RU2200154C2 (ru) 1997-12-12 2003-03-10 Дайичи Файн Кемикал Ко., Лтд. Новые ингибиторы металлопротеиназ
CA2225325A1 (en) 1997-12-19 1999-06-19 The University Of British Columbia Hemiasterlin analogs
US6468977B1 (en) 1998-03-02 2002-10-22 Apotex Inc. Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes
GB9806815D0 (en) 1998-03-30 1998-05-27 Hoffmann La Roche Amino acid derivatives
US6022696A (en) 1998-04-02 2000-02-08 Washington State University Research Foundation Methods of identifying agonists or antagonists of angiotensin IV
GB9809664D0 (en) 1998-05-06 1998-07-01 Hoffmann La Roche a-Ketoamide derivatives
US6242563B1 (en) 1998-07-20 2001-06-05 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Peptide analogues
WO2000005260A1 (en) 1998-07-20 2000-02-03 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Peptide analogues of pacap
US6140342A (en) 1998-09-17 2000-10-31 Pfizer Inc. Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
GB9828074D0 (en) * 1998-12-18 1999-02-17 Glaxo Group Ltd Therapeutically useful compounds
JP2000250182A (ja) 1999-03-04 2000-09-14 Fuji Photo Film Co Ltd カラー拡散転写写真画像形成方法
EP1059302A1 (en) 1999-06-08 2000-12-13 Aventis Pharma Deutschland GmbH Factor VIIa inhibitors
DE19947154A1 (de) 1999-10-01 2001-10-04 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
US20060233748A1 (en) 2002-09-13 2006-10-19 Ahmed Merzouk Mimetics of interleukin-8 and methods of using them in the prevention, treatment, diagnosis, and ameliorization of symptoms of a disease
US20070116669A1 (en) 2002-09-13 2007-05-24 Chemokine Therapeutics Corporation Interferon-inducible protein-10 (IP-10 or CXCL10) chemokine analogs for the treatment of human diseases
US20070160574A1 (en) 2000-04-12 2007-07-12 Ahmed Merzouk Design of CXC chemokine analogs for the treatment of human diseases
WO2001079263A1 (fr) 2000-04-14 2001-10-25 Nippon Shinyaku Co., Ltd. Derives peptidiques et compositions medicinales
JP2002145898A (ja) 2000-11-09 2002-05-22 Ajinomoto Co Inc 新規グリチルレチン酸誘導体及び甘味剤
FR2816509B1 (fr) 2000-11-15 2004-02-06 Sod Conseils Rech Applic Association d'inhibiteurs de calpaine et de piegeurs des formes reactives de l'oxygene
JP2003040784A (ja) 2001-01-31 2003-02-13 Japan Science & Technology Corp 血糖降下剤
EP1351992B1 (en) 2001-01-16 2011-03-02 Ramot at Tel Aviv University Ltd. Hybrid peptides for treatment of bacteremia and septicemia
WO2002095007A2 (en) 2001-05-23 2002-11-28 Dendreon San Diego Llc Conjugates activated by cell surface proteases and therapeutic uses thereof
AR037938A1 (es) 2001-12-21 2004-12-22 Syngenta Participations Ag Derivados de avermectina b1 que tienen un substituyente de aminosulfoniloxilo en la posicion 4''
KR100948278B1 (ko) 2002-02-07 2010-03-18 히토시 엔도 방향족 아미노산 유도체 및 의약 조성물
US20040001801A1 (en) 2002-05-23 2004-01-01 Corvas International, Inc. Conjugates activated by cell surface proteases and therapeutic uses thereof
US8013014B2 (en) 2002-07-05 2011-09-06 Georgia Tech Research Corporation Aza-peptide epoxides
US7056947B2 (en) 2002-07-05 2006-06-06 Georgia Tech Research Corp. Aza-peptide epoxides
AU2003248888A1 (en) 2002-07-09 2004-01-23 Palatin Technologies, Inc. Peptide composition for treatment of sexual dysfunction
WO2004018644A2 (en) 2002-08-26 2004-03-04 Wisconsin Alumni Research Foundation HETEROGENEOUS FOLDAMERS CONTAINING α, β, AND/OR Ϝ-AMINO ACIDS
US20050214859A1 (en) 2003-03-03 2005-09-29 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
DE10320453A1 (de) 2003-05-08 2004-11-25 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Bioisostere von Actinonin
PT1648998E (pt) * 2003-07-18 2014-11-04 Amgen Inc Agentes de ligação específica ao factor de crescimento do hepatócito
MXPA06001501A (es) 2003-08-07 2006-09-04 Enkam Pharmaceuticals As Compuestos que comprenden lpa.
US7118747B2 (en) 2003-09-30 2006-10-10 Pacific Northwest Biotechnology Inc. AT4 receptor ligands as angiogenic, anti-angiogenic, and anti-tumor agents
SE0302853D0 (sv) 2003-10-29 2003-10-29 Astrazeneca Ab Chemical compounds
AU2005214388A1 (en) 2004-02-18 2005-09-01 Georgia Tech Research Corporation Propenoyl hydrazides
JP4502115B2 (ja) 2004-04-23 2010-07-14 信越化学工業株式会社 含窒素有機化合物、化学増幅型レジスト材料及びパターン形成方法
EP1740614A2 (en) 2004-04-30 2007-01-10 Theraptosis S.A. Caspase-2 inhibitors and their biological applications
WO2005113580A1 (en) 2004-05-21 2005-12-01 Pfizer Inc. Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis
US20060063803A1 (en) 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
US7521427B2 (en) 2004-11-09 2009-04-21 Georgia Tech Research Corporation Peptidyl allyl sulfones
WO2006061714A2 (en) 2004-12-09 2006-06-15 Pfizer Inc. Anticoronaviral compounds and compositions, their pharmaceutical uses and materials for their synthesis
DE102005044319A1 (de) 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
US7790745B2 (en) 2005-10-21 2010-09-07 Bristol-Myers Squibb Company Tetrahydroisoquinoline LXR Modulators
GB0522061D0 (en) 2005-10-28 2005-12-07 Glaxo Group Ltd Chemical process
US7705009B2 (en) 2005-11-22 2010-04-27 Hoffman-La Roche Inc. 4-aminopyrimidine-5-thione derivatives
US20080090760A2 (en) 2005-12-09 2008-04-17 Todd Hembrough Compositions and Methods for Inhibiting Cellular Proliferation
JP5079265B2 (ja) 2006-06-13 2012-11-21 ポリプラスチックス株式会社 安定化ポリアセタール樹脂の製造方法
EP1873527A1 (en) 2006-06-30 2008-01-02 Schwarz Pharma Ag Method for identifying CRMP modulators
CN101466390B (zh) 2006-06-15 2014-03-12 优时比制药有限公司 用于治疗难治性癫痫持续状态的肽类化合物
EA027836B1 (ru) 2006-06-15 2017-09-29 ЮСиБи ФАРМА ГМБХ Фармацевтическая комбинация для профилактики, облегчения и/или лечения приступов эпилепсии и ее применение
WO2007150053A2 (en) 2006-06-22 2007-12-27 Biosurface Engineering Technologies, Inc. Composition and method for delivery of bmp-2 amplifier/co-activator for enhancement of osteogenesis
US9066901B2 (en) 2006-07-07 2015-06-30 Washington State University C-Met receptor regulation by angiotensin IV (AT4) receptor ligands
US8236761B2 (en) 2006-07-07 2012-08-07 Washington State University Research Foundation C-Met receptor regulation by angiotensin IV (AT4) receptor ligands
US7910555B2 (en) 2006-07-07 2011-03-22 Washington State University Research Foundation C-Met receptor regulation by angiotensin IV (AT4 ) receptor ligands
EP1961765A1 (en) 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
EP1932852B1 (en) 2006-12-15 2010-02-24 Giuseppe Campiani Novel taxane related peptides and uses thereof
EP1977765A1 (en) 2007-04-03 2008-10-08 Diatos Peptide prodrugs
US20110002855A1 (en) 2007-06-25 2011-01-06 Neurogen Corporation Piperazinyl oxoalkyl tetrahydro-beta-carbolines and related analogues
WO2009003861A1 (en) 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag Imidazole derivatives as ccr2 receptor antagonists
AU2008307158A1 (en) 2007-10-01 2009-04-09 F. Hoffmann-La Roche Ag N-heterocyclic biaryl carboxamides as CCR receptor antagonists
WO2009059002A2 (en) 2007-10-30 2009-05-07 The Regents Of The University Of Michigan Office Of Technology Transfer Macrocyclization of compounds from solid support using thioesterases
EP2083009A1 (de) 2008-01-22 2009-07-29 Grünenthal GmbH Substituierte Tethrahydroimidazopyridin-Verbindungen und deren Verwendung in Arzneimitteln
US9096649B2 (en) 2008-02-08 2015-08-04 Northern Antibiotics Ltd. Polymyxin derivatives and uses thereof
JP2011511076A (ja) 2008-02-08 2011-04-07 エイルロン セラピューティクス,インコーポレイテッド 治療用ペプチド模倣大環状分子
WO2009105782A1 (en) 2008-02-21 2009-08-27 Sequoia Pharmaceuticals, Inc. Hiv protease inhibitor and cytochrome p450 inhibitor combinations
KR101247840B1 (ko) 2008-02-22 2013-03-26 에프. 호프만-라 로슈 아게 아밀로이드 베타 조절제
CN102036956A (zh) 2008-03-21 2011-04-27 柯罗瑞恩制药有限公司 取代的吡咯烷和哌啶化合物、它们的衍生物、以及用于治疗疼痛的方法
US8367680B2 (en) 2008-03-28 2013-02-05 Wisconsin Alumni Research Foundation Antibacterial small molecules and methods for their synthesis
US8440827B2 (en) 2008-07-31 2013-05-14 Duke University Photolabile caged transition metal complexes and methods of using the same
EP2331112A1 (en) 2008-08-19 2011-06-15 Ferring B.V. Peptidic pth receptor agonists
US8772229B2 (en) 2008-10-03 2014-07-08 The Johns Hopkins University Methods for synthesis and uses of inhibitors of ghrelin O-acyltransferase as potential therapeutic agents for obesity and diabetes
EP2349285B1 (en) 2008-10-10 2016-03-23 Dara Biosciences, Inc. Nanoemulsions comprising Spicamycin derivatives for use in the treatment of pain
US8697632B2 (en) 2008-12-19 2014-04-15 Indiana University Research And Technology Corporation Amide based insulin prodrugs
MX2011006527A (es) 2008-12-19 2011-08-17 Univ Indiana Res & Tech Corp Agentes medicinales unidos a dipeptido.
US8835602B2 (en) 2009-03-06 2014-09-16 Indian Institute Of Science Templates for nucleation and propagation of peptide secondary structure
HUE052510T2 (hu) 2009-05-27 2021-05-28 Ptc Therapeutics Inc Módszerek a rák és a nem daganatos állapotok kezelésére
WO2010138659A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating brain tumors
US20120202801A1 (en) 2009-05-27 2012-08-09 Liangxian Cao Methods for treating breast cancer
US20120157401A1 (en) 2009-05-27 2012-06-21 Ptc Therapeutics, Inc. Methods for treating neurofibromatosis
US8697662B2 (en) 2009-05-27 2014-04-15 Ptc Therapeutics, Inc. Methods for treating Kaposi sarcoma
US8703726B2 (en) 2009-05-27 2014-04-22 Ptc Therapeutics, Inc. Methods for treating prostate conditions
WO2010151644A2 (en) 2009-06-26 2010-12-29 Brandeis University Antineoplastic hydrogels, and enzyme-instructed preparations thereof
CN102471327A (zh) 2009-07-21 2012-05-23 吉里德科学公司 黄病毒科病毒的抑制剂
KR101768661B1 (ko) 2009-09-25 2017-08-16 샤이어 오펀 테라피즈 게엠베하 신규한 npr-b 길항제
US8551938B2 (en) 2009-09-25 2013-10-08 Alcon Research, Ltd. NPR-B agonists
WO2011075471A2 (en) 2009-12-18 2011-06-23 Alcon Research, Ltd. Novel npr-b agonists and methods of use for the treatment of c-type natriuretic peptide-mediated disorders
PL2523950T3 (pl) 2010-01-15 2017-09-29 Gilead Sciences, Inc. Inhibitory wirusów flaviviridae
GB201013513D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
WO2012026988A2 (en) 2010-08-27 2012-03-01 New York University Dendrimeric peptides, pharmaceutical compositions and methods of using the same
EP2428503B1 (de) 2010-09-10 2014-12-10 Justus-Liebig-Universität Gießen Synthese von tripodalen Catecholderivaten mit einem flexiblen Grundgerüst zur Funktionalisierung von Oberflächen
US8685916B2 (en) 2011-03-09 2014-04-01 Signature Therapeutics, Inc. Opioid prodrugs with heterocyclic linkers
AU2012225337B2 (en) 2011-03-09 2016-04-28 Signature Therapeutics, Inc. Active agent prodrugs with heterocyclic linkers
WO2012138599A2 (en) 2011-04-02 2012-10-11 Washington State University Research Foundation Hepatocyte growth factor mimics as therapeutic agents
US9051351B2 (en) * 2011-04-02 2015-06-09 Washington State University Hepatocyte growth factor mimics as therapeutic agents
CN102838523A (zh) 2011-06-23 2012-12-26 南开大学 抗肠病毒71(ev71)戊内酰胺类化合物及其制备方法和用途
GB201110938D0 (en) 2011-06-27 2011-08-10 Iti Scotland Ltd Compounds
ES2876939T3 (es) 2011-08-30 2021-11-15 Res & Innovation Uk Péptidos penetradores de células que tienen un dominio hidrófobo central
CN113149869A (zh) 2011-10-27 2021-07-23 麻省理工学院 能够形成药物包封微球的在n末端上官能化的氨基酸衍生物
KR20140132367A (ko) 2012-02-16 2014-11-17 알큐엑스 파마슈티컬스, 인크. 선형 펩티드 항생제
WO2013128003A1 (en) 2012-03-01 2013-09-06 Novo Nordisk A/S N-terminally modified oligopeptides and uses thereof
US20140094413A1 (en) * 2012-04-02 2014-04-03 Washington State University Hepatocyte growth factor (hgf) mimics as therapeutic agents
CA2869309C (en) 2012-04-05 2021-02-09 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase and combination therapies thereof
JO3109B1 (ar) 2012-05-10 2017-09-20 Ferring Bv منبهات لمستقبلات v1a
MX2014013752A (es) 2012-05-11 2014-12-08 Abbvie Inc Inhibidores de nampt.
WO2013170115A1 (en) 2012-05-11 2013-11-14 Abbvie Inc. Pyridazine and pyridine derivatives as nampt inhibitors
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
AR092873A1 (es) 2012-09-26 2015-05-06 Cadila Healthcare Ltd Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon
WO2014067746A1 (en) 2012-11-01 2014-05-08 Evonik Industries Ag Process for the enzymatic formation of amide bonds
US20150306232A1 (en) 2012-11-08 2015-10-29 Brandeis University Hydrogelators comprising d-amino acids
UA111925C2 (uk) 2012-12-11 2016-06-24 Федора Фармасьютікалз Інк. БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ
EP2746262A1 (en) 2012-12-19 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds for combating phytopathogenic fungi
MA38496B2 (fr) 2013-03-15 2021-01-29 Regeneron Pharma Molécules biologiquement actives, leurs conjugués, et utilisations thérapeutiques
KR20150132362A (ko) 2013-03-15 2015-11-25 에이다에레이타, 리미티드 파트너쉽 Pcsk9의 소분자 조절물질 및 그것의 사용 방법
US8957078B2 (en) 2013-03-15 2015-02-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
AU2014262621B2 (en) 2013-05-08 2018-03-01 Baylor College Of Medicine STAT6 inhibitors
CN105324121A (zh) 2013-06-24 2016-02-10 三井有限公司 组合使用并治疗癌症患者亚群的肽和肽模拟物
WO2015023898A1 (en) 2013-08-14 2015-02-19 Rqx Pharmaceuticals, Inc. Linear peptide antibiotcs
EP3068495B1 (en) 2013-11-15 2019-02-27 PCR Technology Holdings, LC Retinoid double conjugate compounds, compositions thereof, and methods for treating of skin conditions
US9676784B2 (en) 2013-12-20 2017-06-13 Laboratorios Del Dr. Esteve S.A. Fused imidazolyl derivatives, their preparation and use as medicaments
JP6295702B2 (ja) 2014-02-14 2018-03-20 東洋インキScホールディングス株式会社 反応性単量体、およびそれを用いた重合性組成物
EP2910236B1 (de) 2014-02-24 2020-02-12 Ivoclar Vivadent AG Dentalmaterialien auf der Basis von geruchsarmen Thiolen
US20170191031A1 (en) 2014-04-30 2017-07-06 University Of Oslo Systems and methods for stem cell differentiation
WO2015173970A1 (ja) 2014-05-15 2015-11-19 ジェイファーマ株式会社 抗悪性腫瘍剤組成物
US9475854B2 (en) * 2014-05-23 2016-10-25 Washington State University Lead compound for otoprotection: targeting HGF signaling with dihexa
JP6158754B2 (ja) 2014-06-04 2017-07-05 信越化学工業株式会社 レジスト下層膜形成用組成物、及びパターン形成方法
EP3164476A1 (en) 2014-07-03 2017-05-10 Novozymes A/S Improved stabilization of non-protease enzyme
TWI515225B (zh) 2014-07-10 2016-01-01 國立交通大學 胜肽分子材料
EP2975046A1 (en) 2014-07-16 2016-01-20 The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth Novel compounds
CN106661034B (zh) 2014-08-15 2019-11-29 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
US10385107B2 (en) 2014-09-24 2019-08-20 Indiana Univeresity Researc and Technology Corporation Lipidated amide-based insulin prodrugs
US9388214B2 (en) 2014-11-05 2016-07-12 Ferring B.V. V1A receptor agonists
US10400230B2 (en) 2014-12-19 2019-09-03 Novozymes A/S Protease variants and polynucleotides encoding same
EP3250209B1 (en) 2015-01-30 2023-09-13 Lieber Institute For Brain Development Comt inhibiting methods and compositions
ES2806206T3 (es) 2015-03-11 2021-02-16 Chia Tai Tianqing Pharmaceutical Group Co Ltd Derivado de 2-hidrógeno pirazol sustituido que sirve como fármaco anticanceroso
AU2016235590B2 (en) 2015-03-23 2020-09-17 Polyphor Ag Beta-hairpin peptidomimetics
CN104788537B (zh) 2015-03-31 2018-03-13 中国科学院长春应用化学研究所 一种四肽化合物及其制备方法和应用
HUE061954T2 (hu) 2015-05-01 2023-09-28 Ironwood Pharmaceuticals Inc Vastagbél tisztítására és gyomor-bélrendszeri rendellenességek kezelésére szolgáló készítmények
WO2016182898A1 (en) 2015-05-08 2016-11-17 Xenoport, Inc. Methods of use for monomethyl fumarate and prodrugs thereof
EP3319978A1 (en) 2015-07-09 2018-05-16 Mimetogen Pharmaceuticals Inc. Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts
US20170022149A1 (en) 2015-07-25 2017-01-26 Mark Quang Nguyen Fumarate compounds, pharmaceutical compositions thereof, and methods of use
MX2018007451A (es) 2015-12-18 2018-11-09 Eisai R&D Man Co Ltd Inmunoglobulinas conjugadas con lisina c-terminal.
JP7022066B2 (ja) 2016-01-11 2022-02-17 シンデブルックス,インコーポレイティド 代謝機能不全によって引き起こされる腫瘍の治療
EP3408366B1 (en) 2016-01-28 2021-12-08 Novozymes A/S Method for cleaning a medical or dental instrument
US20190055283A1 (en) 2016-02-29 2019-02-21 Ohio State Innovation Foundation Aza-peptide aldehydes and ketones
US20190022165A1 (en) 2016-03-02 2019-01-24 Stealth Biotherapeutics Corp Methods and compositions for the treatment and prevention of pulmonary arterial hypertension
WO2017172881A1 (en) 2016-03-29 2017-10-05 Ohio State Innovation Foundation Thermogenic compositions and methods
EP3442955B1 (en) 2016-04-14 2021-09-29 The United States of America, as represented by the Secretary, Department of Health and Human Services Selective d3 dopamine receptor agonists and methods of their use
WO2017201433A1 (en) 2016-05-19 2017-11-23 Stealth Biotherapeutics Corp Compositions and methods for the prevention and treatment of mitochondrial myopathies
US20190218479A1 (en) 2016-05-31 2019-07-18 Novozymes A/S Stabilized Liquid Peroxide Compositions
JP2019525947A (ja) 2016-06-01 2019-09-12 エムスリー・バイオテクノロジー・インコーポレイテッドM3 Biotechnology, Inc. 化合物
EP3472179A1 (en) 2016-06-17 2019-04-24 Erasmus University Medical Center Rotterdam Geminoid lipopeptide compounds and their uses
US10398760B2 (en) 2016-06-30 2019-09-03 Gabriel Rusanescu Method of treating pain using agents that promote neuronal differentiation
EP3486231B1 (en) 2016-07-12 2020-05-20 Guangdong Raynovent Biotech Co., Ltd. Pyrrolidine derivative serving as ppar agonist
WO2018014862A1 (zh) 2016-07-22 2018-01-25 南京明德新药研发股份有限公司 S1p1激动剂及其应用
WO2018035615A1 (en) 2016-08-26 2018-03-01 Thrasos Therapeutics Inc. Compositions and methods for the treatment of inflammatory bowel diseases
WO2018035617A1 (en) 2016-08-26 2018-03-01 Thrasos Therapeutics Inc. Antibiotic carrier conjugates for the treatment of kidney infections
US9611297B1 (en) 2016-08-26 2017-04-04 Thrasos Therapeutics Inc. Compositions and methods for the treatment of cast nephropathy and related conditions
JP6733050B2 (ja) 2016-09-15 2020-07-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ripk2の阻害剤としてのヘテロアリールカルボキサミド化合物
WO2018060216A1 (en) 2016-09-29 2018-04-05 Novozymes A/S Use of enzyme for washing, method for washing and warewashing composition
EP3342779A1 (en) 2016-12-27 2018-07-04 Zedira GmbH Inhibitors of transglutaminases
EP3345917B1 (en) 2017-01-05 2021-11-17 Bacoba AG Antiprotozoal compounds
JP2020505352A (ja) 2017-01-18 2020-02-20 プロタゴニスト セラピューティクス, インコーポレイテッド インターロイキン−23受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用
AU2018225825A1 (en) 2017-02-22 2019-09-12 Université de Montréal Novel minor histocompatibility antigens and uses thereof
US20210122781A1 (en) 2017-03-24 2021-04-29 Agency For Science, Technology And Research Stapled peptides
US10738082B2 (en) 2017-04-07 2020-08-11 University Of South Florida One-bead-two-compound macrocyclic library and methods of preparation and use
US20180340008A1 (en) 2017-05-24 2018-11-29 Bioxiness Pharmaceuticals, Inc. Antibiotic oligopeptide mimetics
CN108117582A (zh) 2017-12-30 2018-06-05 浙江大学 大环环氧酮肽类化合物及其制备方法和医药用途

Also Published As

Publication number Publication date
US11021514B2 (en) 2021-06-01
CN116655730A (zh) 2023-08-29
ES2912035T3 (es) 2022-05-24
AU2017273857B2 (en) 2021-08-19
JP2023036883A (ja) 2023-03-14
AU2021266222A1 (en) 2021-12-02
EP3464336A1 (en) 2019-04-10
CN109563144B (zh) 2023-03-28
AU2021266222B2 (en) 2023-10-05
US20210340176A1 (en) 2021-11-04
JP2022051738A (ja) 2022-04-01
CA3026074A1 (en) 2017-12-07
JP7203943B2 (ja) 2023-01-13
DK3464336T3 (da) 2022-05-09
EP3464336B1 (en) 2022-03-16
CN109563144A (zh) 2019-04-02
AU2017273857A1 (en) 2018-12-20
US20200010504A1 (en) 2020-01-09
EP3464336A4 (en) 2020-01-15
RS63143B1 (sr) 2022-05-31
EP4067368A1 (en) 2022-10-05
CN116731101A (zh) 2023-09-12
HRP20220479T1 (hr) 2022-05-27
JP2019525947A (ja) 2019-09-12
WO2017210489A1 (en) 2017-12-07
AU2023285937A1 (en) 2024-01-25
LT3464336T (lt) 2022-05-10
PL3464336T3 (pl) 2022-05-16

Similar Documents

Publication Publication Date Title
IL286839A (en) Propyne-indole compounds
GB201604647D0 (en) Novel compounds
GB201604638D0 (en) Novel compounds
GB201602854D0 (en) Novel compounds
GB201603779D0 (en) Novel compounds
GB201602934D0 (en) Compounds
GB201604027D0 (en) Compounds
GB201610854D0 (en) Compounds
GB201604020D0 (en) Compounds
GB201619694D0 (en) Compounds
GB201608777D0 (en) Compounds
IL263228A (en) Benzoxaborole compounds
GB201620119D0 (en) Compounds
SI3464336T1 (sl) Spojine
GB201604030D0 (en) Compounds
GB201604022D0 (en) Compounds
GB201613946D0 (en) Compounds
GB201713217D0 (en) Compounds
GB201621520D0 (en) Compounds
GB201604029D0 (en) Compounds
GB201601301D0 (en) Novel compounds
GB201622365D0 (en) Compounds
GB201622362D0 (en) Compounds
GB201604031D0 (en) Compounds
GB201600899D0 (en) Intermediate compounds