|
BE788516A
(fr)
|
1971-09-10 |
1973-03-07 |
Lonza Ag |
Procede de fabrication d'esters alcoxyacetylacetiques
|
|
GB1528382A
(en)
|
1974-12-26 |
1978-10-11 |
Teijin Ltd |
Cyclopentene diols and acyl esters thereof and processes for their preparation
|
|
DE2658401A1
(de)
|
1976-12-23 |
1978-07-06 |
Merck Patent Gmbh |
Cyclopentan-1-amine, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
|
|
US4575694A
(en)
|
1984-03-05 |
1986-03-11 |
Allied Corporation |
Coaxial connector
|
|
DE3900735A1
(de)
|
1989-01-12 |
1990-07-26 |
Hoechst Ag |
Neue mehrfunktionelle (alpha)-diazo-(beta)-ketoester, verfahren zu ihrer herstellung und deren verwendung
|
|
US6703396B1
(en)
|
1990-02-01 |
2004-03-09 |
Emory University |
Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
|
|
US5204466A
(en)
|
1990-02-01 |
1993-04-20 |
Emory University |
Method and compositions for the synthesis of bch-189 and related compounds
|
|
US5914331A
(en)
|
1990-02-01 |
1999-06-22 |
Emory University |
Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
|
|
DE4014649A1
(de)
|
1990-05-08 |
1991-11-14 |
Hoechst Ag |
Neue mehrfunktionelle verbindungen mit (alpha)-diazo-ss-ketoester- und sulfonsaeureester-einheiten, verfahren zu ihrer herstellung und deren verwendung
|
|
GB9301000D0
(en)
|
1993-01-20 |
1993-03-10 |
Glaxo Group Ltd |
Chemical compounds
|
|
US5922695A
(en)
|
1996-07-26 |
1999-07-13 |
Gilead Sciences, Inc. |
Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
|
|
SE9702772D0
(sv)
|
1997-07-22 |
1997-07-22 |
Astra Pharma Prod |
Novel compounds
|
|
US5935946A
(en)
|
1997-07-25 |
1999-08-10 |
Gilead Sciences, Inc. |
Nucleotide analog composition and synthesis method
|
|
AU1403099A
(en)
|
1997-11-14 |
1999-06-07 |
Merck & Co., Inc. |
Alpha-1a adrenergic receptor antagonists
|
|
CN1325385A
(zh)
|
1998-11-09 |
2001-12-05 |
詹姆斯·布莱克基金有限公司 |
胃泌素和缩胆囊素受体配体
|
|
GB2345058A
(en)
|
1998-12-01 |
2000-06-28 |
Cerebrus Pharm Ltd |
Hydroxypyridone compounds useful in the treatment of oxidative damage to the central nervous system
|
|
ID29027A
(id)
|
1998-12-25 |
2001-07-26 |
Shionogi & Co |
Turunan-turunan heteroaromatik yang mempunyai aktivitas penghambatan terhadap integrase hiv
|
|
AU2001262732A1
(en)
|
2000-06-14 |
2001-12-24 |
Shionogi And Co., Ltd. |
Inhibitor for enzyme having two divalent metal ions as active centers
|
|
JP4338192B2
(ja)
|
2001-08-10 |
2009-10-07 |
塩野義製薬株式会社 |
抗ウイルス剤
|
|
NZ532018A
(en)
|
2001-10-03 |
2004-12-24 |
Ucb S |
Pyrrolidinone derivatives
|
|
HU230248B1
(hu)
|
2001-10-26 |
2015-11-30 |
Msd Italia S.R.L. |
N-szubsztituált hidroxipirimidinon-karboxamid HIV-integráz inhibitorok
|
|
DE60231425D1
(de)
|
2001-11-13 |
2009-04-16 |
Shiseido Co Ltd |
Azabicycloverbindung, matrixmetallproteaseinhibitor und zubereitung für haut
|
|
AU2003248872A1
(en)
|
2002-07-09 |
2004-01-23 |
Bristol-Myers Squibb Company |
Hiv integrase inhibitors
|
|
EP1549315A4
(en)
|
2002-09-11 |
2007-05-23 |
Merck & Co Inc |
DIHYDROXYPYRIDOPYRAZINE-1,6-DION COMPOUNDS AS HIV INTEGRASE INHIBITORS
|
|
US7176220B2
(en)
|
2002-11-20 |
2007-02-13 |
Japan Tobacco Inc. |
4-oxoquinoline compound and use thereof as pharmaceutical agent
|
|
SI1583542T1
(sl)
|
2003-01-14 |
2008-12-31 |
Gilead Sciences Inc |
Sestavki in postopki za kombinacijsko antivirusnoterapijo
|
|
TW200510425A
(en)
|
2003-08-13 |
2005-03-16 |
Japan Tobacco Inc |
Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
|
|
TW200528440A
(en)
|
2003-10-31 |
2005-09-01 |
Fujisawa Pharmaceutical Co |
2-cyanopyrrolidinecarboxamide compound
|
|
AU2005211349A1
(en)
|
2004-01-30 |
2005-08-18 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
N-benzyl-3,4-dihyroxypyridine-2-carboxamide and N-benzyl-2,3-dihydroxypyridine-4-carboxamide compounds useful as HIV integrase inhibitors
|
|
CN101014574A
(zh)
|
2004-03-09 |
2007-08-08 |
默克公司 |
Hiv整合酶抑制剂
|
|
WO2005110399A2
(en)
|
2004-04-29 |
2005-11-24 |
The Regents Of The University Of California |
Zinc-binding groups for metalloprotein inhibitors
|
|
EP1755586A2
(en)
|
2004-04-29 |
2007-02-28 |
The Regents of the University of California |
Hydroxypyridinone, hydroxypyridinethione, pyrone, and thiopyrone metalloprotein inhibitors
|
|
JP4824673B2
(ja)
|
2004-05-07 |
2011-11-30 |
メルク・シャープ・エンド・ドーム・コーポレイション |
Hivインテグラーゼ阻害剤
|
|
US7273859B2
(en)
|
2004-05-12 |
2007-09-25 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors: cyclic pyrimidinone compounds
|
|
US7531554B2
(en)
|
2004-05-20 |
2009-05-12 |
Japan Tobacco Inc. |
4-oxoquinoline compound and use thereof as HIV integrase inhibitor
|
|
MY134672A
(en)
|
2004-05-20 |
2007-12-31 |
Japan Tobacco Inc |
Stable crystal of 4-oxoquinoline compound
|
|
EP1758581A1
(en)
|
2004-05-21 |
2007-03-07 |
Japan Tobacco, Inc. |
Combinations comprising a 4-isoquinolone derivative and anti-hiv agents
|
|
EP1790638B1
(en)
|
2004-09-15 |
2013-04-03 |
Shionogi Co., Ltd. |
Carbamoylpyridone derivative having hiv integrase inhibitory activity
|
|
WO2006066414A1
(en)
|
2004-12-23 |
2006-06-29 |
Virochem Pharma Inc. |
Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase
|
|
ATE516026T1
(de)
|
2005-02-21 |
2011-07-15 |
Shionogi & Co |
Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung
|
|
DK1874117T3
(da)
|
2005-04-28 |
2013-09-23 |
Viiv Healthcare Co |
Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet
|
|
AR057023A1
(es)
|
2005-05-16 |
2007-11-14 |
Gilead Sciences Inc |
Compuestos heterociclicos con propiedades inhibidoras de hiv-integrasa
|
|
JP2009502964A
(ja)
|
2005-07-27 |
2009-01-29 |
ギリアード サイエンシーズ, インコーポレイテッド |
Hivを阻害するための抗ウイルス性ホスホン酸結合体
|
|
JP5131689B2
(ja)
|
2005-10-27 |
2013-01-30 |
塩野義製薬株式会社 |
Hivインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体
|
|
AP2702A
(en)
|
2005-12-30 |
2013-07-23 |
Gilead Sciences Inc |
Methods for improving the pharmacokinetics of HIV integrase inhibitors
|
|
US7601844B2
(en)
|
2006-01-27 |
2009-10-13 |
Bristol-Myers Squibb Company |
Piperidinyl derivatives as modulators of chemokine receptor activity
|
|
US20090018162A1
(en)
|
2006-02-01 |
2009-01-15 |
Yuji Matsuzaki |
Use of 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or salt thereof for treating retrovirus infection
|
|
WO2007102499A1
(ja)
|
2006-03-06 |
2007-09-13 |
Japan Tobacco Inc. |
4-オキソキノリン化合物の製造方法
|
|
JP4669040B2
(ja)
|
2006-03-06 |
2011-04-13 |
日本たばこ産業株式会社 |
4−オキソキノリン化合物の製造方法
|
|
US7893055B2
(en)
|
2006-06-28 |
2011-02-22 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
WO2008010953A2
(en)
|
2006-07-19 |
2008-01-24 |
University Of Georgia Research Foundation, Inc. |
Pyridinone diketo acids: inhibitors of hiv replication in combination therapy
|
|
CN101528749B
(zh)
|
2006-09-07 |
2013-07-31 |
工业研究有限公司 |
核苷磷酸化酶和水解酶的无环胺抑制剂
|
|
AU2007296555B2
(en)
|
2006-09-12 |
2012-07-12 |
Gilead Sciences, Inc. |
Process and intermediates for preparing integrase inhibitors
|
|
US20100216834A1
(en)
|
2006-10-18 |
2010-08-26 |
Isaacs Richard C A |
Hiv integrase inhibitors
|
|
BRPI0807581A2
(pt)
|
2007-02-23 |
2014-07-01 |
Gilead Science, Inc. |
Moduladores de propriedades farmacocinéticas de produtos terapêuticos
|
|
US20080280945A1
(en)
|
2007-05-09 |
2008-11-13 |
Sachin Lohani |
Crystalline forms of an HIV integrase inhibitor
|
|
CN101743004A
(zh)
|
2007-06-29 |
2010-06-16 |
吉里德科学公司 |
治疗用组合物及其用途
|
|
NZ582086A
(en)
|
2007-06-29 |
2012-07-27 |
Gilead Sciences Inc |
Therapeutic compositions and the use thereof
|
|
AU2008282273A1
(en)
|
2007-07-31 |
2009-02-05 |
Limerick Biopharma, Inc. |
Pyrone analog compositions and methods
|
|
AR068403A1
(es)
|
2007-09-11 |
2009-11-18 |
Gilead Sciences Inc |
Proceso e intermediarios para la preparacion de inhibidores de integrasa
|
|
NZ585226A
(en)
|
2007-11-16 |
2012-08-31 |
Gilead Sciences Inc |
Inhibitors of human immunodeficiency virus replication
|
|
GB0803019D0
(en)
|
2008-02-19 |
2008-03-26 |
Btg Int Ltd |
Fluorinated compounds
|
|
US8129398B2
(en)
|
2008-03-19 |
2012-03-06 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
WO2010011813A1
(en)
|
2008-07-23 |
2010-01-28 |
Alkermes, Inc. |
Complex of trospium and pharmaceutical compositions thereof
|
|
SI2320908T1
(sl)
|
2008-07-25 |
2014-05-30 |
Viiv Healthcare Company |
Predzdravila dolutegravirja
|
|
WO2010011818A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
PT2660239T
(pt)
|
2008-07-25 |
2017-02-24 |
Shionogi & Co |
Compostos químicos como intermediários sintéticos
|
|
WO2010011819A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
WO2010011815A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
WO2010011816A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
EP2376453B1
(en)
|
2008-12-11 |
2019-11-20 |
VIIV Healthcare Company |
Intermediates for carbamoylpyridone hiv integrase inhibitors
|
|
MX351942B
(es)
|
2008-12-11 |
2017-11-03 |
Shionogi & Co |
Sintesis de inhibidores de integrasa de vih de carbamoil-piridona e intermediarios.
|
|
US8835461B2
(en)
|
2009-03-26 |
2014-09-16 |
Shionogi & Co., Ltd. |
Substituted 3-hydroxy-4-pyridone derivative
|
|
TWI518084B
(zh)
|
2009-03-26 |
2016-01-21 |
鹽野義製藥股份有限公司 |
哌喃酮與吡啶酮衍生物之製造方法
|
|
US8338441B2
(en)
|
2009-05-15 |
2012-12-25 |
Gilead Sciences, Inc. |
Inhibitors of human immunodeficiency virus replication
|
|
PL2444400T3
(pl)
|
2009-06-15 |
2018-08-31 |
Shionogi & Co., Ltd. |
Podstawiona policykliczna pochodna karbamoilopirydonowa
|
|
US8637674B2
(en)
|
2009-09-02 |
2014-01-28 |
Ewha University-Industry Collaboration Foundation |
Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same
|
|
RS54123B1
(sr)
|
2010-01-27 |
2015-12-31 |
Viiv Healthcare Company |
Terapeutska kombinacija koja sadrži dolutegravir, abacavir i lamivudine
|
|
US10065950B2
(en)
|
2010-02-26 |
2018-09-04 |
Japan Tobacco Inc. |
Substituted thiazoles as HIV integrase inhibitors
|
|
TWI582097B
(zh)
|
2010-03-23 |
2017-05-11 |
Viiv醫療保健公司 |
製備胺甲醯吡啶酮衍生物及中間體之方法
|
|
US20130165489A1
(en)
|
2010-05-03 |
2013-06-27 |
The Trustees Of The University Of Pennsylvania |
Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof
|
|
SG186821A1
(en)
|
2010-07-02 |
2013-02-28 |
Gilead Sciences Inc |
2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds
|
|
AP2013006706A0
(en)
|
2010-07-02 |
2013-02-28 |
Gilead Sciences Inc |
Napht-2-ylacetic acid derivatives to treat AIDS
|
|
EP2595986A2
(en)
|
2010-07-14 |
2013-05-29 |
Addex Pharma SA |
Novel 2-amino-4-pyrazolyl-thiazole derivatives and their use as allosteric modulators of metabotropic glutamate receptors
|
|
PT3456721T
(pt)
|
2010-08-05 |
2021-05-04 |
Shionogi & Co |
Método de produção de compostos possuindo atividade inibitória de integrase de vih
|
|
US8987441B2
(en)
|
2010-09-24 |
2015-03-24 |
Shionogi & Co., Ltd. |
Substituted polycyclic carbamoyl pyridone derivative prodrug
|
|
WO2012106534A2
(en)
|
2011-02-02 |
2012-08-09 |
The Regents Of The University Of California |
Hiv integrase inhibitors
|
|
SG194512A1
(en)
|
2011-04-21 |
2013-12-30 |
Gilead Sciences Inc |
Benzothiazole compounds and their pharmaceutical use
|
|
WO2012151361A1
(en)
|
2011-05-03 |
2012-11-08 |
Concert Pharmaceuticals Inc. |
Carbamoylpyridone derivatives
|
|
US9328075B2
(en)
|
2011-05-05 |
2016-05-03 |
St. Jude Children's Research Hospital |
Pyrimidinone compounds and methods for treating influenza
|
|
ES2553449T3
(es)
|
2011-07-06 |
2015-12-09 |
Gilead Sciences, Inc. |
Compuestos para el tratamiento de VIH
|
|
CN102863512B
(zh)
|
2011-07-07 |
2016-04-20 |
上海泓博智源医药技术有限公司 |
抗病毒化合物
|
|
ES2613180T3
(es)
|
2011-09-14 |
2017-05-23 |
Mapi Pharma Limited |
Forma amorfa de la sal sódica dolutegravir
|
|
AU2012321762A1
(en)
|
2011-10-12 |
2014-04-17 |
Shionogi & Co., Ltd. |
Polycyclic pyridone derivative having integrase-inhibiting activity
|
|
US9643974B2
(en)
|
2011-12-12 |
2017-05-09 |
Bayer Intellectual Property Gmbh |
Amino-substituted imidazopyridazines
|
|
CN105121418A
(zh)
|
2012-04-20 |
2015-12-02 |
吉利德科学公司 |
苯并噻唑-6-基乙酸衍生物及其治疗hiv感染的用途
|
|
WO2014008636A1
(en)
|
2012-07-11 |
2014-01-16 |
Merck Sharp & Dohme Corp. |
Macrocyclic compounds as hiv integrase inhibitors
|
|
US20150166520A1
(en)
|
2012-07-20 |
2015-06-18 |
Merck Sharp & Dohme Corp. |
Amido-substituted pyrimidinone derivatives useful for the treatment of hiv infection
|
|
EP2877469A4
(en)
|
2012-07-25 |
2016-04-06 |
Merck Sharp & Dohme |
SUBSTITUTED NAPHTHYRIDEINDION DERIVATIVES AS HIV INTEGRASE INHIBITORS
|
|
AU2013296289B2
(en)
|
2012-08-03 |
2017-10-05 |
Gilead Sciences, Inc. |
Process and intermediates for preparing integrase inhibitors
|
|
PE20150953A1
(es)
|
2012-11-08 |
2015-06-20 |
Bristol Myers Squibb Co |
Compuestos de piridilo sustituidos con heteroarilo utiles como moduladores de cinasa
|
|
SG11201503807TA
(en)
|
2012-12-14 |
2015-06-29 |
Glaxosmithkline Llc |
Pharmaceutical compositions
|
|
WO2014099586A1
(en)
*
|
2012-12-17 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
4-pyridinonetriazine derivatives as hiv integrase inhibitors
|
|
SI2822954T1
(sl)
|
2012-12-21 |
2016-07-29 |
Gilead Sciences, Inc. |
Policiklične karbamoilpiridonske spojine in njihova farmacevtska uporaba
|
|
US20140221355A1
(en)
|
2012-12-21 |
2014-08-07 |
Gilead Sciences, Inc. |
Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
|
|
WO2014100077A1
(en)
|
2012-12-21 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
Gastro-retentive formulations
|
|
EP2940019B1
(en)
|
2012-12-27 |
2018-03-28 |
Japan Tobacco Inc. |
SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND MEDICINAL USE THEREOF AS HIV INTEGRASE INHIBITOR
|
|
EP3008044B1
(en)
|
2013-06-13 |
2018-11-21 |
Merck Sharp & Dohme Corp. |
Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
|
|
NO2865735T3
(enExample)
*
|
2013-07-12 |
2018-07-21 |
|
|
|
PT3019503T
(pt)
*
|
2013-07-12 |
2017-11-27 |
Gilead Sciences Inc |
Compostos carbamoílpiridona- policíclicos e seu uso para o tratamento de infecções por hiv
|
|
WO2015039348A1
(en)
*
|
2013-09-23 |
2015-03-26 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
AU2014324829B2
(en)
|
2013-09-27 |
2017-09-07 |
Merck Sharp & Dohme Corp. |
Substituted Quinolizine Derivatives useful as HIV integrase inhibitors
|
|
US20150146340A1
(en)
|
2013-11-26 |
2015-05-28 |
Qualcomm Incorporated |
Multilayer ceramic capacitor including at least one slot
|
|
WO2015089847A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Spirocyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
US9856271B2
(en)
|
2014-01-21 |
2018-01-02 |
Laurus Labs Limited |
Process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof
|