CY1118920T1 - Ενωσεις πιπεραζινης- πιπεριδινης ως αναστολεις του ιου ηπατιτιδας c - Google Patents

Ενωσεις πιπεραζινης- πιπεριδινης ως αναστολεις του ιου ηπατιτιδας c

Info

Publication number
CY1118920T1
CY1118920T1 CY20171100520T CY171100520T CY1118920T1 CY 1118920 T1 CY1118920 T1 CY 1118920T1 CY 20171100520 T CY20171100520 T CY 20171100520T CY 171100520 T CY171100520 T CY 171100520T CY 1118920 T1 CY1118920 T1 CY 1118920T1
Authority
CY
Cyprus
Prior art keywords
compounds
virus
inhibitors
piperazine
piperidine compounds
Prior art date
Application number
CY20171100520T
Other languages
English (en)
Inventor
Daniel D Long
Robert Murray Mckinnell
Orden Lori Jean Van
Gavin Ogawa
Donna Wilton
Original Assignee
Theravance Biopharma R&D Ip, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip, Llc filed Critical Theravance Biopharma R&D Ip, Llc
Publication of CY1118920T1 publication Critical patent/CY1118920T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Abstract

Η εφεύρεση παρέχει ενώσεις του χημικού τύπου (I) όπου οι μεταβλητές ορίζονται στην περιγραφή, ή ένα φαρμακευτικώς αποδεκτά άλατα αυτών, οι οποίες είναι αναστολείς της αντιγραφής (πολλαπλασιασμού) του ιού της ηπατίτιδας C. Η εφεύρεση παρέχει επίσης φαρμακευτικές συνθέσεις που περιέχουν τέτοιες ενώσεις, μεθόδους χρήσης τέτοιων ενώσεων για την θεραπευτική αντιμετώπιση ιογενών λοιμώξεων από ηπατίτιδα C, και διαδικασίες και ενδιάμεσα προϊόντα χρήσιμα για την παρασκευή τέτοιων ενώσεων.
CY20171100520T 2012-04-25 2017-05-17 Ενωσεις πιπεραζινης- πιπεριδινης ως αναστολεις του ιου ηπατιτιδας c CY1118920T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261637959P 2012-04-25 2012-04-25
US201361774033P 2013-03-07 2013-03-07
PCT/US2013/037920 WO2013163262A1 (en) 2012-04-25 2013-04-24 Piperazine-piperidine compounds as hepatitis c virus inhibitors

Publications (1)

Publication Number Publication Date
CY1118920T1 true CY1118920T1 (el) 2018-01-10

Family

ID=48237291

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100520T CY1118920T1 (el) 2012-04-25 2017-05-17 Ενωσεις πιπεραζινης- πιπεριδινης ως αναστολεις του ιου ηπατιτιδας c

Country Status (17)

Country Link
US (1) US9206159B2 (el)
EP (1) EP2850075B1 (el)
JP (1) JP6069491B2 (el)
CN (1) CN104302639B (el)
CA (1) CA2869640C (el)
CY (1) CY1118920T1 (el)
DK (1) DK2850075T3 (el)
ES (1) ES2624846T3 (el)
HR (1) HRP20170471T1 (el)
HU (1) HUE032173T2 (el)
LT (1) LT2850075T (el)
ME (1) ME02682B (el)
PL (1) PL2850075T3 (el)
PT (1) PT2850075T (el)
RS (1) RS55864B1 (el)
SI (1) SI2850075T1 (el)
WO (1) WO2013163262A1 (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108794454B (zh) * 2017-04-27 2023-08-15 广东东阳光药业股份有限公司 一种咪唑环化合物的制备方法
CN107814789B8 (zh) * 2017-11-27 2021-01-01 常州寅盛药业有限公司 一种达卡他韦起始原料的合成方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007115805A2 (en) * 2006-04-05 2007-10-18 European Molecular Biology Laboratory (Embl) Aurora kinase inhibitors
US8329159B2 (en) 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7659270B2 (en) 2006-08-11 2010-02-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8303944B2 (en) 2006-08-11 2012-11-06 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8147818B2 (en) 2008-02-13 2012-04-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2010094977A1 (en) 2009-02-23 2010-08-26 Arrow Therapeutics Limited Novel biphenyl compounds useful for the treatment of hepatitis c
EP2398474A4 (en) 2009-02-23 2012-12-05 Presidio Pharmaceuticals Inc HCV NS5A SHEMMER
US8796466B2 (en) 2009-03-30 2014-08-05 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
NZ619205A (en) 2009-05-13 2015-04-24 Gilead Pharmasset Llc Antiviral compounds
US8344155B2 (en) 2009-09-04 2013-01-01 Glaxosmith Kline Llc Chemical compounds
EP2475256A4 (en) 2009-09-11 2013-06-05 Enanta Pharm Inc HEPATITIS C-VIRUS HEMMER
US8822700B2 (en) 2009-09-11 2014-09-02 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
EP2475254A4 (en) * 2009-09-11 2013-05-22 Enanta Pharm Inc HEPATITIS C-VIRUS HEMMER
US20110274648A1 (en) 2009-11-11 2011-11-10 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
EP2512480A4 (en) 2009-12-14 2013-05-15 Enanta Pharm Inc HEPATITIS C-VIRUS HEMMER
US8377980B2 (en) 2009-12-16 2013-02-19 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
AU2010336355A1 (en) 2009-12-24 2012-07-05 Vertex Pharmaceuticals Incorporated Analogues for the treatment or prevention of flavivirus infections
WO2011091446A1 (en) 2010-01-22 2011-07-28 Glaxosmithkline Llc Chemical compounds
PE20130062A1 (es) 2010-03-09 2013-02-28 Merck Sharp & Dohme Compuestos de sililo triciclicos fusionados para el tratamiento de enfermedades virales
US8778938B2 (en) 2010-06-04 2014-07-15 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
US20120195857A1 (en) 2010-08-12 2012-08-02 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
WO2012048421A1 (en) 2010-10-14 2012-04-19 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
EP2635571B1 (en) * 2010-11-04 2015-08-12 Theravance Biopharma R&D IP, LLC Novel inhibitors of hepatitis c virus
US8552047B2 (en) 2011-02-07 2013-10-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
KR20140091036A (ko) 2011-11-03 2014-07-18 세라밴스 인코포레이티드 단편 [2-[4-(바이페닐-4-일)-1h-이미다조-2-일]피롤리딘-1-카르보닐메틸]아민을 포함하는 간상 c형 간염 바이러스 억제제
JP6069492B2 (ja) * 2012-04-25 2017-02-01 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｃ型肝炎ウイルス阻害剤

Also Published As

Publication number Publication date
EP2850075B1 (en) 2017-02-22
JP2015514807A (ja) 2015-05-21
CN104302639B (zh) 2017-03-29
SI2850075T1 (sl) 2017-06-30
PT2850075T (pt) 2017-05-02
RS55864B1 (sr) 2017-08-31
US20130287730A1 (en) 2013-10-31
JP6069491B2 (ja) 2017-02-01
CA2869640A1 (en) 2013-10-31
ME02682B (me) 2017-06-20
HUE032173T2 (en) 2017-09-28
DK2850075T3 (en) 2017-05-22
PL2850075T3 (pl) 2017-08-31
LT2850075T (lt) 2017-05-10
US9206159B2 (en) 2015-12-08
CA2869640C (en) 2018-03-20
ES2624846T3 (es) 2017-07-17
WO2013163262A1 (en) 2013-10-31
CN104302639A (zh) 2015-01-21
EP2850075A1 (en) 2015-03-25
HRP20170471T1 (hr) 2017-06-02

Similar Documents

Publication Publication Date Title
CY1121418T1 (el) Παρεμποδιστες ιου ηπατιτιδας c
CY1122279T1 (el) Ενωσεις ναφθυριδινης αναστολεις κινασης jak
CY1123324T1 (el) Παραγωγα πυριμιδινης για τη θεραπευτικη αντιμετωπιση ιογενων λοιμωξεων
CY1121972T1 (el) Mono- ή διυποκατεστημενα ινδολια ως αναστολεις του αναδιπλασιασμου του ιου του δαγκειου πυρετου
PH12015501881A1 (en) Amide compounds for the treatment of hiv
CY1121706T1 (el) Ενωσεις υποκατασταθεισες διυδροϊσοκινολινονης
CY1119056T1 (el) Παραγωγα 2',4',-διφθορο-2'-μεθυλ υποκατεστημενου νουκλεοσιδιου ως αναστολεις αντιγραφης hcv rna
NZ729150A (en) Antiretroviral agents
CY1119620T1 (el) Αναστολεις νεπριλυσινης
EA201890731A1 (ru) Модуляторы корового белка гепатита b
CY1121874T1 (el) Παραγωγα μονο- ή διυποκατεστημενου ινδολιου ως αναστολεις του αναδιπλασιασμου του ιου του δαγκειου πυρετου
NZ631726A (en) Therapeutic compounds for the treatment of viral infections
MX2016013689A (es) Compuestos 4-amino-imidazoquinolina.
BR112014030639A2 (pt) inibidores macrocíclicos de vírus flaviviridae
BR112014030630A2 (pt) inibidores macrocíclicos de vírus flaviviridae
NZ631738A (en) (hetero) arylacetamide derivatives as antiretroviral agents
CY1117105T1 (el) Ενωσεις πυριδαζινονης και χρηση τους ως αναστολεις του daao
EA201791776A1 (ru) Замещенные циклофаны для использования при лечении инфекции вгс
EA201500383A1 (ru) Производные 1,2,4-триазина для лечения вирусных инфекций
BR112014010401A8 (pt) Inibidores do vírus da hepatite c rod-like que contêm o fragmento {2-[4-(bifenil-4-il)-1h-imidazo-2-il] pirrolidina-1-carbonilmetil}amina
CY1118399T1 (el) Ενωσεις βενζοφουρανιου για την θεραπεια μολυνσεων ιου ηπατιτιδας c
CY1122077T1 (el) Νεα δακτυλιωμενα φαινοξυακεταμιδια
CY1121063T1 (el) Αναστολεις της συνθασης της αλδοστερονης
EA201692358A1 (ru) Производные изоиндолина для применения в лечении вирусной инфекции
CY1121650T1 (el) Αναστολεις συνθασης αλδοστερονης