|
US2856420A
(en)
|
1955-12-15 |
1958-10-14 |
Minnesota Mining & Mfg |
Perfluoro- and perfluorochlorocarboxylic acid esters of amino alcohols
|
|
FR1391300A
(fr)
*
|
1963-03-25 |
1965-03-05 |
Ici Ltd |
Organopolysiloxanes nouveaux et leur procédé de fabrication
|
|
US3340299A
(en)
|
1964-03-27 |
1967-09-05 |
Air Reduction |
Tetrasubstituted ethylene diamines
|
|
GB1277947A
(en)
|
1968-08-22 |
1972-06-14 |
Armour Ind Chem Co |
Compositions and method for controlling insect pests
|
|
US4491583A
(en)
|
1970-08-07 |
1985-01-01 |
Pfizer Inc. |
Interferon induction in animals by amines
|
|
US3729564A
(en)
|
1970-12-16 |
1973-04-24 |
Pfizer |
N-secondary alkyl alkanediamines and derivatives thereof as anti-inflammatory agents
|
|
JPS5122416B2
(enExample)
|
1972-11-11 |
1976-07-09 |
|
|
|
JPS5718088B2
(enExample)
|
1972-06-22 |
1982-04-14 |
|
|
|
DE2633615C3
(de)
|
1976-07-27 |
1981-08-13 |
Bayer Ag, 5090 Leverkusen |
Verfahren zum Färben von synthetischen Polyamid-Fasermaterialien
|
|
DE3010599A1
(de)
|
1979-03-22 |
1980-10-09 |
Continental Pharma |
Derivate von glycinamid, deren herstellung und verwendung
|
|
EP0025083B1
(de)
*
|
1979-09-10 |
1982-02-03 |
EPROVA Aktiengesellschaft |
Verfahren zur Herstellung von Serinol und Serinolderivaten
|
|
US4883751A
(en)
|
1986-05-28 |
1989-11-28 |
New York University |
Specific immunoassay for heparin
|
|
US5858980A
(en)
|
1990-03-30 |
1999-01-12 |
Autoimmune, Inc. |
Peptide fragments of myelin basic protein
|
|
JP2588339B2
(ja)
|
1992-06-02 |
1997-03-05 |
花王株式会社 |
新規ジアミノジエステル及びその製造法
|
|
US6197553B1
(en)
|
1994-07-15 |
2001-03-06 |
Merck & Co., Inc. |
Method for large scale plasmid purification
|
|
FR2727679B1
(fr)
|
1994-12-05 |
1997-01-03 |
Rhone Poulenc Rorer Sa |
Nouveaux agents de transfection et leurs applications pharmaceutiques
|
|
ATE285477T1
(de)
|
1995-06-07 |
2005-01-15 |
Inex Pharmaceutical Corp |
Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
|
|
US5981501A
(en)
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
|
US7422902B1
(en)
|
1995-06-07 |
2008-09-09 |
The University Of British Columbia |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US5705385A
(en)
|
1995-06-07 |
1998-01-06 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
CA2227373A1
(en)
|
1995-07-21 |
1997-02-06 |
Promega Biosciences, Inc. |
Novel amide-based cationic lipids
|
|
DE19605175A1
(de)
|
1996-02-13 |
1997-08-14 |
Sourovoi Andrej Dr |
Lipidverbindungen und deren Verwendung
|
|
JP3792289B2
(ja)
*
|
1996-03-26 |
2006-07-05 |
花王株式会社 |
新規第４級アンモニウム塩及びその製造方法、並びにそれを含有する毛髪化粧料
|
|
JPH103643A
(ja)
|
1996-06-12 |
1998-01-06 |
Fuji Photo Film Co Ltd |
ディスク状磁気記録媒体
|
|
KR20000049089A
(ko)
|
1996-10-11 |
2000-07-25 |
인피늄 홀딩스 비.브이. |
연료 조성물
|
|
CA2217550A1
(en)
|
1996-10-22 |
1998-04-22 |
F. Hoffmann-La Roche Ag |
Cationic lipids for gene therapy
|
|
US6884430B1
(en)
|
1997-02-10 |
2005-04-26 |
Aventis Pharma S.A. |
Formulation of stabilized cationic transfection agent(s) /nucleic acid particles
|
|
US5965542A
(en)
|
1997-03-18 |
1999-10-12 |
Inex Pharmaceuticals Corp. |
Use of temperature to control the size of cationic liposome/plasmid DNA complexes
|
|
US5756785A
(en)
|
1997-03-21 |
1998-05-26 |
Lambent Technologies, Inc. |
Guerbet betaines
|
|
FR2763943B1
(fr)
|
1997-05-28 |
1999-07-09 |
Rhone Poulenc Rorer Sa |
Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
|
|
US6395713B1
(en)
|
1997-07-23 |
2002-05-28 |
Ribozyme Pharmaceuticals, Inc. |
Compositions for the delivery of negatively charged molecules
|
|
AU751434B2
(en)
|
1997-12-23 |
2002-08-15 |
Inex Pharmaceuticals Corporation |
Polyamide oligomers
|
|
US6410328B1
(en)
|
1998-02-03 |
2002-06-25 |
Protiva Biotherapeutics Inc. |
Sensitizing cells to compounds using lipid-mediated gene and compound delivery
|
|
US6986902B1
(en)
|
1998-04-28 |
2006-01-17 |
Inex Pharmaceuticals Corporation |
Polyanionic polymers which enhance fusogenicity
|
|
US6013813A
(en)
|
1998-06-17 |
2000-01-11 |
Hansotech Inc |
Guerbet based sorbitan esters
|
|
US6333433B1
(en)
|
1998-11-09 |
2001-12-25 |
Council Of Scientific Industrial Research |
Process for synthesis of novel cationic amphiphiles containing N-hydroxyalkl group for intracellular delivery of biologically active molecules
|
|
AU1830200A
(en)
|
1998-11-25 |
2000-06-13 |
Vanderbilt University |
Cationic liposomes for gene transfer
|
|
US5919743A
(en)
|
1998-12-28 |
1999-07-06 |
Petroferm Inc. |
Guerbet branched quaternary compounds in personal care applications
|
|
US7112337B2
(en)
|
1999-04-23 |
2006-09-26 |
Alza Corporation |
Liposome composition for delivery of nucleic acid
|
|
US6211140B1
(en)
|
1999-07-26 |
2001-04-03 |
The Procter & Gamble Company |
Cationic charge boosting systems
|
|
ATE289630T1
(de)
|
1999-09-09 |
2005-03-15 |
Curevac Gmbh |
Transfer von mrnas unter verwendung von polykationischen verbindungen
|
|
GB9930533D0
(en)
|
1999-12-23 |
2000-02-16 |
Mitsubishi Tokyo Pharm Inc |
Nucleic acid delivery
|
|
JP2001338416A
(ja)
|
2000-05-25 |
2001-12-07 |
Sony Corp |
ディスク状磁気記録媒体
|
|
US20040142474A1
(en)
|
2000-09-14 |
2004-07-22 |
Expression Genetics, Inc. |
Novel cationic lipopolymer as a biocompatible gene delivery agent
|
|
JP4111856B2
(ja)
|
2002-04-12 |
2008-07-02 |
昭和電工株式会社 |
安定化されたアスコルビン酸誘導体
|
|
DE60334618D1
(de)
|
2002-06-28 |
2010-12-02 |
Protiva Biotherapeutics Inc |
Verfahren und vorrichtung zur herstellung von liposomen
|
|
DE10229872A1
(de)
|
2002-07-03 |
2004-01-29 |
Curevac Gmbh |
Immunstimulation durch chemisch modifizierte RNA
|
|
US6620794B1
(en)
|
2002-07-08 |
2003-09-16 |
Colonial Chemical Inc. |
Guerbet functionalized phospholipids
|
|
JP4004976B2
(ja)
|
2003-03-03 |
2007-11-07 |
独立行政法人科学技術振興機構 |
フラーレン誘導体
|
|
CN101291653B
(zh)
|
2003-07-16 |
2012-06-27 |
普洛体维生物治疗公司 |
脂质包封的干扰rna
|
|
DE10335833A1
(de)
|
2003-08-05 |
2005-03-03 |
Curevac Gmbh |
Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie
|
|
KR101164256B1
(ko)
|
2003-09-15 |
2012-07-10 |
프로티바 바이오쎄라퓨틱스, 인코포레이티드 |
폴리에틸렌글리콜 개질된 지질 화합물 및 그의 용도
|
|
EP1694329A4
(en)
|
2003-11-26 |
2009-06-03 |
Aton Pharma Inc |
DIAMOND AND IMINODIACETIC ACID HYDROXAMINIC DERIVATIVES
|
|
DE602005018043D1
(de)
|
2004-05-17 |
2010-01-14 |
Tekmira Pharmaceuticals Corp |
Liposomale formulierungen mit dihydrosphingomyelin und verfahren zu ihrer verwendung
|
|
EP1781593B1
(en)
|
2004-06-07 |
2011-12-14 |
Protiva Biotherapeutics Inc. |
Cationic lipids and methods of use
|
|
EP1766035B1
(en)
|
2004-06-07 |
2011-12-07 |
Protiva Biotherapeutics Inc. |
Lipid encapsulated interfering rna
|
|
DE102004042546A1
(de)
|
2004-09-02 |
2006-03-09 |
Curevac Gmbh |
Kombinationstherapie zur Immunstimulation
|
|
KR100699279B1
(ko)
|
2005-04-28 |
2007-03-23 |
학교법인 포항공과대학교 |
당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법
|
|
EP1912679A4
(en)
|
2005-06-15 |
2009-07-29 |
Massachusetts Inst Technology |
AMINOUS LIPIDS AND ITS USES
|
|
WO2007012191A1
(en)
|
2005-07-27 |
2007-02-01 |
Protiva Biotherapeutics, Inc. |
Systems and methods for manufacturing liposomes
|
|
RS63964B1
(sr)
|
2005-08-23 |
2023-03-31 |
Univ Pennsylvania |
Rnk koja sadrži modifikovane nukleozide i postupci za njenu upotrebu
|
|
JP4681425B2
(ja)
|
2005-11-15 |
2011-05-11 |
花王株式会社 |
毛髪弾性改善剤
|
|
GB2433928B
(en)
|
2006-01-07 |
2009-10-14 |
Shane Richard Wootton |
Apparatus for producing material by a chemical reaction
|
|
DE102006035618A1
(de)
|
2006-07-31 |
2008-02-07 |
Curevac Gmbh |
Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz
|
|
EP2695608B1
(en)
|
2006-10-03 |
2016-11-23 |
Arbutus Biopharma Corporation |
Lipid containing formulations
|
|
DE102007001370A1
(de)
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
|
WO2009030254A1
(en)
|
2007-09-04 |
2009-03-12 |
Curevac Gmbh |
Complexes of rna and cationic peptides for transfection and for immunostimulation
|
|
WO2009046739A1
(en)
|
2007-10-09 |
2009-04-16 |
Curevac Gmbh |
Composition for treating prostate cancer (pca)
|
|
CA2910760C
(en)
|
2007-12-04 |
2019-07-09 |
Muthiah Manoharan |
Targeting lipids
|
|
CA2711236A1
(en)
|
2008-01-02 |
2009-07-16 |
Alnylam Pharmaceuticals, Inc. |
Screening method for selected amino lipid-containing compositions
|
|
CA2711240C
(en)
|
2008-01-02 |
2021-10-26 |
Alnylam Pharmaceuticals, Inc. |
Liver screening method
|
|
CA2710534C
(en)
|
2008-01-31 |
2018-09-04 |
Curevac Gmbh |
Nucleic acids of formula (i) (nuglxmgnnv)a and derivatives thereof as an immunostimulating agent/adjuvant
|
|
WO2009126933A2
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
CA2721333C
(en)
|
2008-04-15 |
2020-12-01 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for nucleic acid delivery
|
|
WO2009132131A1
(en)
|
2008-04-22 |
2009-10-29 |
Alnylam Pharmaceuticals, Inc. |
Amino lipid based improved lipid formulation
|
|
WO2010037408A1
(en)
|
2008-09-30 |
2010-04-08 |
Curevac Gmbh |
Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
|
|
JP5777519B2
(ja)
|
2008-10-09 |
2015-09-09 |
テクミラ ファーマシューティカルズ コーポレイション |
改良されたアミノ脂質および核酸の送達方法
|
|
WO2010048536A2
(en)
|
2008-10-23 |
2010-04-29 |
Alnylam Pharmaceuticals, Inc. |
Processes for preparing lipids
|
|
US20120009222A1
(en)
|
2008-10-27 |
2012-01-12 |
Massachusetts Institute Of Technology |
Modulation of the immune response
|
|
WO2010054384A1
(en)
|
2008-11-10 |
2010-05-14 |
Alnylam Pharmaceuticals, Inc. |
Lipids and compositions for the delivery of therapeutics
|
|
DK2355851T3
(en)
|
2008-11-10 |
2018-06-25 |
Arbutus Biopharma Corp |
Newly known lipids and compositions for release of therapeutic agents
|
|
CN102231950A
(zh)
|
2008-11-17 |
2011-11-02 |
安龙制药公司 |
用于核酸递送系统的可释放聚合脂质
|
|
US20120101148A1
(en)
|
2009-01-29 |
2012-04-26 |
Alnylam Pharmaceuticals, Inc. |
lipid formulation
|
|
CA3045126A1
(en)
|
2009-05-05 |
2010-11-11 |
Arbutus Biopharma Corporation |
Methods of delivering oligonucleotides to immune cells
|
|
CA2760776C
(en)
|
2009-05-05 |
2019-07-09 |
Alnylam Pharmaceuticals, Inc. |
Lipid compositions for the delivery of therapeutic agents
|
|
CA2764609C
(en)
|
2009-06-10 |
2018-10-02 |
Alnylam Pharmaceuticals, Inc. |
Improved cationic lipid of formula i
|
|
US9051567B2
(en)
|
2009-06-15 |
2015-06-09 |
Tekmira Pharmaceuticals Corporation |
Methods for increasing efficacy of lipid formulated siRNA
|
|
WO2011000106A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Improved cationic lipids and methods for the delivery of therapeutic agents
|
|
JP5766188B2
(ja)
|
2009-07-01 |
2015-08-19 |
プロチバ バイオセラピューティクス インコーポレイティッド |
固形腫瘍に治療剤を送達するための脂質製剤
|
|
US9018187B2
(en)
|
2009-07-01 |
2015-04-28 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
WO2011005799A2
(en)
|
2009-07-06 |
2011-01-13 |
Novartis Ag |
Self replicating rna molecules and uses thereof
|
|
US20120264810A1
(en)
|
2009-09-22 |
2012-10-18 |
The University Of British Columbia |
Compositions and methods for enhancing cellular uptake and intracellular delivery of lipid particles
|
|
EP2496700B1
(en)
|
2009-11-04 |
2017-03-01 |
The University Of British Columbia |
Nucleic acid-containing lipid particles and related methods
|
|
EP2506879A4
(en)
|
2009-12-01 |
2014-03-19 |
Protiva Biotherapeutics Inc |
PREPARATIONS OF SNALP CONTAINING ANTIOXIDANTS
|
|
CA2783372C
(en)
|
2009-12-07 |
2019-07-16 |
Muthiah Manoharan |
Compositions for nucleic acid delivery
|
|
AU2010330814B2
(en)
*
|
2009-12-18 |
2017-01-12 |
Acuitas Therapeutics Inc. |
Methods and compositions for delivery of nucleic acids
|
|
WO2011076807A2
(en)
|
2009-12-23 |
2011-06-30 |
Novartis Ag |
Lipids, lipid compositions, and methods of using them
|
|
US9408914B2
(en)
|
2010-04-28 |
2016-08-09 |
Kyowa Hakko Kirin Co., Ltd. |
Cationic lipid
|
|
WO2011136369A1
(ja)
|
2010-04-28 |
2011-11-03 |
協和発酵キリン株式会社 |
カチオン性脂質
|
|
US9254327B2
(en)
|
2010-05-10 |
2016-02-09 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
|
EP2569276B1
(en)
|
2010-05-12 |
2021-02-24 |
Arbutus Biopharma Corporation |
Novel cationic lipids and methods of use thereof
|
|
US8865675B2
(en)
|
2010-05-12 |
2014-10-21 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing apolipoprotein B
|
|
JP2013531634A
(ja)
|
2010-05-24 |
2013-08-08 |
メルク・シャープ・エンド・ドーム・コーポレイション |
オリゴヌクレオチド送達のための新規なアミノアルコールカチオン性脂質
|
|
CA2800401C
(en)
|
2010-06-03 |
2020-09-15 |
Alnylam Pharmaceuticals, Inc. |
Biodegradable lipids for the delivery of active agents
|
|
US9006417B2
(en)
|
2010-06-30 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
|
US20130323269A1
(en)
|
2010-07-30 |
2013-12-05 |
Muthiah Manoharan |
Methods and compositions for delivery of active agents
|
|
WO2012019630A1
(en)
|
2010-08-13 |
2012-02-16 |
Curevac Gmbh |
Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
|
|
US8466122B2
(en)
|
2010-09-17 |
2013-06-18 |
Protiva Biotherapeutics, Inc. |
Trialkyl cationic lipids and methods of use thereof
|
|
BR122022001262B1
(pt)
|
2010-11-15 |
2022-09-27 |
Life Technologies Corporation |
Compostos de transfecção contendo amina e complexo de transfecção
|
|
AU2011254003B2
(en)
*
|
2010-12-22 |
2013-05-16 |
Kabushiki Kaisha Toshiba |
Acid gas absorbent, acid gas removal method, and acid gas removal device
|
|
WO2012089225A1
(en)
|
2010-12-29 |
2012-07-05 |
Curevac Gmbh |
Combination of vaccination and inhibition of mhc class i restricted antigen presentation
|
|
WO2012116715A1
(en)
|
2011-03-02 |
2012-09-07 |
Curevac Gmbh |
Vaccination in newborns and infants
|
|
WO2012113413A1
(en)
|
2011-02-21 |
2012-08-30 |
Curevac Gmbh |
Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates
|
|
WO2012116714A1
(en)
|
2011-03-02 |
2012-09-07 |
Curevac Gmbh |
Vaccination in elderly patients
|
|
JP2014511687A
(ja)
|
2011-03-31 |
2014-05-19 |
モデルナ セラピューティクス インコーポレイテッド |
工学操作された核酸の送達および製剤
|
|
WO2012133737A1
(ja)
|
2011-03-31 |
2012-10-04 |
公益財団法人地球環境産業技術研究機構 |
架橋性アミン化合物、該化合物を用いた高分子膜及びその製造方法
|
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
|
US20140243391A1
(en)
|
2011-07-22 |
2014-08-28 |
Centre National De La Recherche Scientifique |
Phospholipid-detergent conjugates and uses thereof
|
|
WO2013016058A1
(en)
|
2011-07-22 |
2013-01-31 |
Merck Sharp & Dohme Corp. |
Novel bis-nitrogen containing cationic lipids for oligonucleotide delivery
|
|
US9126966B2
(en)
|
2011-08-31 |
2015-09-08 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use thereof
|
|
CA2848417C
(en)
|
2011-09-21 |
2023-05-02 |
Sangamo Biosciences, Inc. |
Methods and compositions for regulation of transgene expression
|
|
AU2012315965A1
(en)
|
2011-09-27 |
2014-04-03 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted PEGylated lipids
|
|
ES2897565T3
(es)
|
2011-10-18 |
2022-03-01 |
Dicerna Pharmaceuticals Inc |
Lípidos catiónicos de amina y uso de los mismos
|
|
MX363734B
(es)
|
2011-10-27 |
2019-03-29 |
Massachusetts Inst Technology |
Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco.
|
|
JP2013095755A
(ja)
|
2011-11-02 |
2013-05-20 |
Kyowa Hakko Kirin Co Ltd |
カチオン性脂質
|
|
EP3988537A1
(en)
|
2011-12-07 |
2022-04-27 |
Alnylam Pharmaceuticals, Inc. |
Biodegradable lipids for the delivery of active agents
|
|
US20140308304A1
(en)
|
2011-12-07 |
2014-10-16 |
Alnylam Pharmaceuticals, Inc. |
Lipids for the delivery of active agents
|
|
JP6305343B2
(ja)
|
2011-12-07 |
2018-04-04 |
アルニラム・ファーマシューティカルズ・インコーポレーテッド |
活性薬剤の送達のための分岐アルキルおよびシクロアルキルを末端とする生分解性脂質
|
|
EP2792368A4
(en)
|
2011-12-12 |
2015-09-30 |
Kyowa Hakko Kirin Co Ltd |
LIPID NANOPARTICLES WITH COMBINATIONS OF CATIONIC LIPIDES
|
|
KR20140102759A
(ko)
|
2011-12-16 |
2014-08-22 |
모더나 세라퓨틱스, 인코포레이티드 |
변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
|
|
EP2623121A1
(en)
|
2012-01-31 |
2013-08-07 |
Bayer Innovation GmbH |
Pharmaceutical composition comprising a polymeric carrier cargo complex and an antigen
|
|
WO2013113325A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Negatively charged nucleic acid comprising complexes for immunostimulation
|
|
WO2013113326A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
|
|
WO2013120499A1
(en)
|
2012-02-15 |
2013-08-22 |
Curevac Gmbh |
Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
|
|
WO2013120497A1
(en)
|
2012-02-15 |
2013-08-22 |
Curevac Gmbh |
Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
|
|
WO2013120498A1
(en)
|
2012-02-15 |
2013-08-22 |
Curevac Gmbh |
Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen
|
|
CN102604115B
(zh)
|
2012-02-22 |
2013-07-10 |
天津大学 |
羧甲基壳聚糖季铵盐/pamam核壳纳米粒及制备方法
|
|
NZ700075A
(en)
|
2012-02-24 |
2016-05-27 |
Protiva Biotherapeutics Inc |
Trialkyl cationic lipids and methods of use thereof
|
|
WO2013143555A1
(en)
|
2012-03-26 |
2013-10-03 |
Biontech Ag |
Rna formulation for immunotherapy
|
|
CN104220599A
(zh)
|
2012-03-27 |
2014-12-17 |
库瑞瓦格有限责任公司 |
人工核酸分子
|
|
CN108929880A
(zh)
|
2012-03-27 |
2018-12-04 |
库瑞瓦格股份公司 |
包含5′toputr的人工核酸分子
|
|
RU2658490C2
(ru)
|
2012-03-27 |
2018-06-21 |
Кьюрвак Аг |
Искусственные молекулы нуклеиновых кислот для улучшенной экспрессии белков или пептидов
|
|
US9446132B2
(en)
|
2012-03-27 |
2016-09-20 |
Sima Therapeutics, Inc. |
Diether based biodegradable cationic lipids for siRNA delivery
|
|
US20150306249A1
(en)
|
2012-05-25 |
2015-10-29 |
Curevac Gmbh |
Reversible immobilization and/or controlled release of nucleic acid containing nanoparticles by (biodegradable) polymer coatings
|
|
US9415109B2
(en)
|
2012-07-06 |
2016-08-16 |
Alnylam Pharmaceuticals, Inc. |
Stable non-aggregating nucleic acid lipid particle formulations
|
|
CA2884870C
(en)
|
2012-08-13 |
2022-03-29 |
Massachusetts Institute Of Technology |
Amine-containing lipidoids and uses thereof
|
|
AU2013355258A1
(en)
|
2012-12-07 |
2015-06-11 |
Alnylam Pharmaceuticals, Inc. |
Improved nucleic acid lipid particle formulations
|
|
CN105073135A
(zh)
|
2013-02-22 |
2015-11-18 |
库瑞瓦格有限责任公司 |
疫苗接种和抑制pd-1途径的组合
|
|
KR102205278B1
(ko)
*
|
2013-03-14 |
2021-01-22 |
다이서나 파마수이티컬, 인크. |
음이온성 약제를 제형화하는 방법
|
|
US20160030527A1
(en)
|
2013-03-14 |
2016-02-04 |
The Trustees Of The University Of Pennsylvania |
Compositions and Methods for Treatment of Stroke
|
|
WO2014160243A1
(en)
|
2013-03-14 |
2014-10-02 |
The Trustees Of The University Of Pennsylvania |
Purification and purity assessment of rna molecules synthesized with modified nucleosides
|
|
US9693958B2
(en)
|
2013-03-15 |
2017-07-04 |
Cureport, Inc. |
Methods and devices for preparation of lipid nanoparticles
|
|
SG11201510747RA
(en)
|
2013-08-21 |
2016-03-30 |
Curevac Ag |
Method for increasing expression of rna-encoded proteins
|
|
SG11201510746WA
(en)
|
2013-08-21 |
2016-03-30 |
Curevac Ag |
Respiratory syncytial virus (rsv) vaccine
|
|
MX2016002153A
(es)
|
2013-08-21 |
2017-03-01 |
Curevac Ag |
Composicion y vacuna para tratar cancer de prostata.
|
|
AU2014310935B2
(en)
|
2013-08-21 |
2019-11-21 |
CureVac SE |
Combination vaccine
|
|
BR112016001192A2
(pt)
|
2013-08-21 |
2017-08-29 |
Curevac Ag |
Vacina contra a raiva
|
|
ES2806575T3
(es)
|
2013-11-01 |
2021-02-18 |
Curevac Ag |
ARN modificado con propiedades inmunoestimuladoras disminuidas
|
|
US9593077B2
(en)
|
2013-11-18 |
2017-03-14 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
|
WO2015101414A2
(en)
|
2013-12-30 |
2015-07-09 |
Curevac Gmbh |
Artificial nucleic acid molecules
|
|
JP6584414B2
(ja)
|
2013-12-30 |
2019-10-02 |
キュアバック アーゲー |
人工核酸分子
|
|
WO2015123576A2
(en)
|
2014-02-17 |
2015-08-20 |
The Brigham And Women's Hospital, Inc. |
Targeted nanoparticle compositions and methods of their use to treat obesity
|
|
EP3556353A3
(en)
|
2014-02-25 |
2020-03-18 |
Merck Sharp & Dohme Corp. |
Lipid nanoparticle vaccine adjuvants and antigen delivery systems
|
|
WO2015149944A2
(en)
|
2014-04-01 |
2015-10-08 |
Curevac Gmbh |
Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
|
|
RU2021109685A
(ru)
|
2014-04-23 |
2021-04-13 |
МОДЕРНАТиЭкс, ИНК. |
Вакцины на основе нуклеиновых кислот
|
|
US10309541B2
(en)
|
2014-05-22 |
2019-06-04 |
Flowserve S.R.L. |
Guide element for a valve actuator and actuator provided with said guide element
|
|
IL289934B2
(en)
|
2014-06-25 |
2023-04-01 |
Acuitas Therapeutics Inc |
Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
|
WO2016010840A1
(en)
|
2014-07-16 |
2016-01-21 |
Novartis Ag |
Method of encapsulating a nucleic acid in a lipid nanoparticle host
|
|
JP6339884B2
(ja)
|
2014-07-17 |
2018-06-06 |
富士フイルム株式会社 |
イミダゾール化合物およびそれを含有するリポソーム
|
|
AP2016009615A0
(en)
*
|
2014-07-22 |
2016-12-31 |
Boehringer Ingelheim Int |
Heterocyclic carboxylic acids as activators of soluble guanylate cyclase
|
|
US9816074B2
(en)
|
2014-07-25 |
2017-11-14 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
|
EP4241784A3
(en)
|
2014-12-12 |
2023-11-15 |
CureVac SE |
Artificial nucleic acid molecules for improved protein expression
|
|
EP3233113A1
(en)
|
2014-12-16 |
2017-10-25 |
CureVac AG |
Ebolavirus and marburgvirus vaccines
|
|
KR102580696B1
(ko)
|
2014-12-30 |
2023-09-19 |
큐어백 에스이 |
신규 인공 핵산 분자
|
|
CN104876831B
(zh)
|
2015-04-03 |
2017-05-17 |
苏州圣诺生物医药技术有限公司 |
脂质修饰精胺衍生物及利用该衍生物制备的脂质体
|
|
EP4353257A3
(en)
|
2015-04-13 |
2024-08-07 |
CureVac Manufacturing GmbH |
Method for producing rna compositions
|
|
WO2016168469A1
(en)
|
2015-04-17 |
2016-10-20 |
The Regents Of The University Of California |
Fatty acid analogs and methods of use thereof
|
|
EP3289083A4
(en)
|
2015-04-27 |
2018-12-19 |
The Trustees Of The University Of Pennsylvania |
Nucleoside-modified rna for inducing an adaptive immune response
|
|
AU2016264027A1
(en)
|
2015-05-15 |
2017-08-31 |
Curevac Ag |
Prime-boost regimens involving administration of at least one mRNA construct
|
|
EP3310384A1
(en)
|
2015-06-17 |
2018-04-25 |
CureVac AG |
Vaccine composition
|
|
CN114085198A
(zh)
|
2015-06-29 |
2022-02-25 |
爱康泰生治疗公司 |
用于递送核酸的脂质和脂质纳米颗粒制剂
|
|
EP3331555A1
(en)
|
2015-08-05 |
2018-06-13 |
CureVac AG |
Epidermal mrna vaccine
|
|
WO2017025120A1
(en)
|
2015-08-07 |
2017-02-16 |
Curevac Ag |
Process for the in vivo production of rna in a host cell
|
|
WO2017036580A1
(en)
|
2015-08-28 |
2017-03-09 |
Curevac Ag |
Artificial nucleic acid molecules
|
|
WO2017048770A1
(en)
|
2015-09-15 |
2017-03-23 |
Regulus Therapeutics, Inc. |
Systems, compositions, and methods for formulating nucleic acid compositions
|
|
EP3350157B1
(en)
|
2015-09-17 |
2022-01-05 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of therapeutic agents
|
|
RS63986B1
(sr)
|
2015-10-28 |
2023-03-31 |
Acuitas Therapeutics Inc |
Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
|
|
EP3373965A1
(en)
|
2015-11-09 |
2018-09-19 |
CureVac AG |
Rotavirus vaccines
|
|
EP4582098A3
(en)
|
2015-11-09 |
2025-12-24 |
CureVac SE |
Optimized nucleic acid molecules
|
|
SI3394030T1
(sl)
|
2015-12-22 |
2022-04-29 |
Modernatx, Inc. |
Sestave za doziranje sredstev v celice
|
|
WO2017117528A1
(en)
|
2015-12-30 |
2017-07-06 |
Acuitas Therapeutics, Inc. |
Lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
|
SG11201806340YA
(en)
|
2016-02-17 |
2018-09-27 |
Curevac Ag |
Zika virus vaccine
|
|
US20170266292A1
(en)
|
2016-03-21 |
2017-09-21 |
The Research Foundation For The State University Of New York |
Lipidic compound-telodendrimer hybrid nanoparticles and methods of making and uses thereof
|
|
SMT202500211T1
(it)
|
2016-03-30 |
2025-07-22 |
Intellia Therapeutics Inc |
Formulazioni di nanoparticelle lipidiche per componenti crispr/cas
|
|
EP4487869A3
(en)
|
2016-04-22 |
2025-07-30 |
CureVac SE |
Rna encoding a tumor antigen
|
|
US20180126003A1
(en)
|
2016-05-04 |
2018-05-10 |
Curevac Ag |
New targets for rna therapeutics
|
|
CN109152735B
(zh)
|
2016-05-09 |
2022-03-11 |
阿斯利康(瑞典)有限公司 |
包含亲脂性抗炎剂的脂质纳米颗粒及其使用方法
|
|
US20190298657A1
(en)
|
2016-05-18 |
2019-10-03 |
Modernatx, Inc. |
Polynucleotides Encoding Acyl-CoA Dehydrogenase, Very Long-Chain for the Treatment of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency
|
|
IL317855A
(en)
|
2016-10-26 |
2025-02-01 |
Acuitas Therapeutics Inc |
mRNA vaccines with lipid nanoparticles
|
|
US20190274968A1
(en)
|
2016-10-27 |
2019-09-12 |
The Trustees Of The University Of Pennsylvania |
Nucleoside-modified rna for inducing an adaptive immune response
|
|
AU2017374042C1
(en)
|
2016-12-09 |
2024-07-11 |
Acuitas Therapeutics, Inc. |
Delivery of target specific nucleases
|
|
WO2018191657A1
(en)
|
2017-04-13 |
2018-10-18 |
Acuitas Therapeutics, Inc. |
Lipids for delivery of active agents
|
|
WO2018191719A1
(en)
|
2017-04-13 |
2018-10-18 |
Acuitas Therapeutics, Inc. |
Lipid delivery of therapeutic agents to adipose tissue
|
|
WO2018200943A1
(en)
|
2017-04-28 |
2018-11-01 |
Acuitas Therapeutics, Inc. |
Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
|
US12029790B2
(en)
|
2017-07-31 |
2024-07-09 |
Ohio State Innovation Foundation |
Biomimetic nanomaterials and uses thereof
|
|
WO2019036008A1
(en)
|
2017-08-16 |
2019-02-21 |
Acuitas Therapeutics, Inc. |
LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS
|
|
WO2019036028A1
(en)
|
2017-08-17 |
2019-02-21 |
Acuitas Therapeutics, Inc. |
LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS
|
|
WO2019036030A1
(en)
|
2017-08-17 |
2019-02-21 |
Acuitas Therapeutics, Inc. |
LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
|
|
WO2019089828A1
(en)
|
2017-10-31 |
2019-05-09 |
Acuitas Therapeutics, Inc. |
Lamellar lipid nanoparticles
|
|
EP4613367A1
(en)
|
2018-09-21 |
2025-09-10 |
Acuitas Therapeutics, Inc. |
Systems and methods for manufacturing lipid nanoparticles and liposomes
|
|
AU2019361129A1
(en)
|
2018-10-18 |
2021-05-20 |
Acuitas Therapeutics, Inc. |
Lipids for lipid nanoparticle delivery of active agents
|
|
CA3125485A1
(en)
|
2019-01-11 |
2020-07-16 |
Acuitas Therapeutics, Inc. |
Lipids for lipid nanoparticle delivery of active agents
|
|
DK4182297T3
(da)
|
2020-07-16 |
2025-12-01 |
Acuitas Therapeutics Inc |
Kationiske lipider til brug i lipid-nanopartikler
|