ATE643T1 - Verfahren zur herstellung von serinol und serinolderivaten. - Google Patents
Verfahren zur herstellung von serinol und serinolderivaten.Info
- Publication number
- ATE643T1 ATE643T1 AT80103054T AT80103054T ATE643T1 AT E643 T1 ATE643 T1 AT E643T1 AT 80103054 T AT80103054 T AT 80103054T AT 80103054 T AT80103054 T AT 80103054T AT E643 T1 ATE643 T1 AT E643T1
- Authority
- AT
- Austria
- Prior art keywords
- serinol
- derivatives
- production
- dialkoxy
- cytostatic
- Prior art date
Links
- KJJPLEZQSCZCKE-UHFFFAOYSA-N 2-aminopropane-1,3-diol Chemical compound OCC(N)CO KJJPLEZQSCZCKE-UHFFFAOYSA-N 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- -1 -isopropyl halide Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001033 ether group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
- 230000001003 psychopharmacologic effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH818279 | 1979-09-10 | ||
| EP80103054A EP0025083B1 (de) | 1979-09-10 | 1980-06-02 | Verfahren zur Herstellung von Serinol und Serinolderivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE643T1 true ATE643T1 (de) | 1982-02-15 |
Family
ID=4336422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT80103054T ATE643T1 (de) | 1979-09-10 | 1980-06-02 | Verfahren zur herstellung von serinol und serinolderivaten. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4503252A (de) |
| EP (1) | EP0025083B1 (de) |
| JP (1) | JPS5839820B2 (de) |
| AT (1) | ATE643T1 (de) |
| DE (1) | DE3060177D1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3609978A1 (de) * | 1986-03-25 | 1987-10-01 | Merck Patent Gmbh | Verfahren zur herstellung von hydroxyaminen |
| DE3705384A1 (de) * | 1987-02-20 | 1988-09-01 | Goedecke Ag | 2-propylamin-derivate, verfahren zu deren herstellung sowie deren verwendung |
| JP2847265B2 (ja) * | 1990-08-01 | 1999-01-13 | ダイセル化学工業株式会社 | 高純度１−アミノ−２，３−プロパンジオ−ルおよびその製造方法 |
| DE4102394A1 (de) * | 1991-01-28 | 1992-07-30 | Hoechst Ag | Verfahren zur herstellung von dialkylaminopropandiol |
| GB9905771D0 (en) * | 1999-03-12 | 1999-05-05 | Isis Innovation | Compounds |
| US7989555B2 (en) * | 2007-05-21 | 2011-08-02 | Global Agritech, Inc. | Glycerol derivatives and methods of making same |
| DE102012104679A1 (de) | 2011-05-30 | 2012-12-06 | Westfälische Wilhelms-Universität Münster | Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli |
| US8653306B1 (en) | 2011-12-28 | 2014-02-18 | Penn A Kem LLC | Process for production of serinol and its bis-adduct |
| WO2014178082A1 (en) | 2013-05-03 | 2014-11-06 | Council Of Scientific & Industrial Research | Novel 2'/3'/5'-(r/s)-serinyl functionalized oligonucleotides |
| US12491261B2 (en) | 2016-10-26 | 2025-12-09 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| US12065396B2 (en) * | 2017-08-17 | 2024-08-20 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| CA3189338A1 (en) | 2020-07-16 | 2022-01-20 | Acuitas Therapeutics, Inc. | Cationic lipids for use in lipid nanoparticles |
| US20240199530A1 (en) | 2021-03-22 | 2024-06-20 | Bracco Imaging S.P.A. | Industrial synthesis of serinol |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2709169A (en) * | 1955-05-24 | X c chs | ||
| US2490385A (en) * | 1945-05-23 | 1949-12-06 | Heyden Chemical Corp | Production of aminoacetal |
| US2628254A (en) * | 1948-11-13 | 1953-02-10 | Gen Aniline & Film Corp | Process of producing amino acetals |
-
1980
- 1980-06-02 AT AT80103054T patent/ATE643T1/de not_active IP Right Cessation
- 1980-06-02 DE DE8080103054T patent/DE3060177D1/de not_active Expired
- 1980-06-02 EP EP80103054A patent/EP0025083B1/de not_active Expired
- 1980-08-26 JP JP55116518A patent/JPS5839820B2/ja not_active Expired
-
1982
- 1982-11-15 US US06/441,777 patent/US4503252A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5839820B2 (ja) | 1983-09-01 |
| JPS5640647A (en) | 1981-04-16 |
| DE3060177D1 (en) | 1982-03-11 |
| EP0025083A2 (de) | 1981-03-18 |
| EP0025083B1 (de) | 1982-02-03 |
| US4503252A (en) | 1985-03-05 |
| EP0025083A3 (en) | 1981-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |