MA33662B1 - Composés de spiropipéridine et leur utilisation pharmaceutique pour le traitement du diabète - Google Patents
Composés de spiropipéridine et leur utilisation pharmaceutique pour le traitement du diabèteInfo
- Publication number
- MA33662B1 MA33662B1 MA34760A MA34760A MA33662B1 MA 33662 B1 MA33662 B1 MA 33662B1 MA 34760 A MA34760 A MA 34760A MA 34760 A MA34760 A MA 34760A MA 33662 B1 MA33662 B1 MA 33662B1
- Authority
- MA
- Morocco
- Prior art keywords
- diabetes
- treatment
- pharmaceutical use
- spiropiperidine compounds
- spiropiperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
L'invention porte sur un composé de la formule :(i) ou sur un sel de qualité pharmaceutique de celui-ci, ainsi que sur une composition pharmaceutique et sur un procédé pour traiter le diabète.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25183909P | 2009-10-15 | 2009-10-15 | |
US30333410P | 2010-02-11 | 2010-02-11 | |
PCT/US2010/052126 WO2011046851A1 (fr) | 2009-10-15 | 2010-10-11 | Composés de spiropipéridine et son utilisation pharmaceutique pour le traitement du diabète |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33662B1 true MA33662B1 (fr) | 2012-10-01 |
Family
ID=43719548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34760A MA33662B1 (fr) | 2009-10-15 | 2012-04-09 | Composés de spiropipéridine et leur utilisation pharmaceutique pour le traitement du diabète |
Country Status (24)
Country | Link |
---|---|
US (1) | US8383642B2 (fr) |
EP (1) | EP2488500A1 (fr) |
JP (1) | JP2013508279A (fr) |
KR (1) | KR20120051777A (fr) |
CN (1) | CN102574807A (fr) |
AR (1) | AR078522A1 (fr) |
AU (1) | AU2010307094A1 (fr) |
BR (1) | BR112012008889A2 (fr) |
CA (1) | CA2777775A1 (fr) |
CL (1) | CL2012000921A1 (fr) |
CO (1) | CO6531458A2 (fr) |
CR (1) | CR20120177A (fr) |
DO (1) | DOP2012000105A (fr) |
EA (1) | EA201270560A1 (fr) |
EC (1) | ECSP12011799A (fr) |
IL (1) | IL218344A0 (fr) |
MA (1) | MA33662B1 (fr) |
MX (1) | MX2012004420A (fr) |
NZ (1) | NZ598972A (fr) |
PE (1) | PE20121437A1 (fr) |
TN (1) | TN2012000152A1 (fr) |
TW (1) | TW201124415A (fr) |
WO (1) | WO2011046851A1 (fr) |
ZA (1) | ZA201202560B (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20110132575A (ko) | 2009-03-23 | 2011-12-08 | 그렌마크 파머수티칼스 에스. 아. | Trpa1 조절자로서 융합된 피리미딘디온 유도체 |
SI2411395T1 (sl) | 2009-03-23 | 2013-07-31 | Glenmark Pharmaceuticals S.A. | Furopirimidindionski derivati kot TRPA1 modulatorji |
AR078948A1 (es) | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
CN104710381A (zh) | 2009-12-25 | 2015-06-17 | 持田制药株式会社 | 新的3-羟基-5-芳基异噻唑衍生物 |
US9040525B2 (en) | 2010-10-08 | 2015-05-26 | Mochida Pharmaceutical Co., Ltd. | Cyclic amide derivative |
JP2014510525A (ja) | 2011-03-11 | 2014-05-01 | インターコンチネンタル グレート ブランズ エルエルシー | 多層菓子の形成システムおよび形成方法 |
WO2012147518A1 (fr) | 2011-04-27 | 2012-11-01 | 持田製薬株式会社 | Nouveau dérivé de 1-oxyde de 3-hydroxyisothiazole |
JPWO2012147516A1 (ja) | 2011-04-28 | 2014-07-28 | 持田製薬株式会社 | 環状アミド誘導体 |
AR087451A1 (es) * | 2011-08-17 | 2014-03-26 | Lilly Co Eli | Derivado de 1,2,3,4-tetrahidroquinolina util para tratamiento de diabetes |
WO2013139341A1 (fr) * | 2012-03-20 | 2013-09-26 | Syddansk Universitet | Modulateurs de récepteurs gpr120 |
WO2013185766A1 (fr) * | 2012-06-15 | 2013-12-19 | Syddansk Universitet | Modulateurs du récepteur gpr120 |
JP6322203B2 (ja) | 2012-11-16 | 2018-05-09 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | ジヒドロピラゾールgpr40モジュレーター |
KR101569522B1 (ko) * | 2013-04-18 | 2015-11-17 | 현대약품 주식회사 | 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
WO2015097713A1 (fr) * | 2013-11-14 | 2015-07-02 | Cadila Healthcare Limited | Nouveaux composés hétérocycliques |
US20150351889A1 (en) | 2014-06-05 | 2015-12-10 | Vivex Biomedical Inc. | Dynamic Biometric Mesh |
BR112017007720B1 (pt) * | 2014-10-17 | 2023-01-17 | Hyundai Pharm Co., Ltd. | Composição contendo derivado de ácido 3-(4-(benzilóxi)fenil)hex-4-inoico e outro princípio ativo para prevenir ou tratar doenças metabólicas |
CN109666027A (zh) * | 2017-10-17 | 2019-04-23 | 中国科学院上海药物研究所 | 一类酰胺结构的gpr40激动剂化合物及其用途 |
EP3737470B9 (fr) | 2018-01-08 | 2024-03-13 | Celon Pharma S.A. | Dérivés d'acides 3-phényl-4-hexinoïques en tant qu'agonistes de gpr40 |
IL300572A (en) | 2018-02-13 | 2023-04-01 | Gilead Sciences Inc | PD–1/PD–L1 inhibitors |
US10899735B2 (en) | 2018-04-19 | 2021-01-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
PE20210642A1 (es) | 2018-07-13 | 2021-03-23 | Gilead Sciences Inc | Inhibidores de pd-1/pd-l1 |
AU2019366355B2 (en) | 2018-10-24 | 2022-10-13 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
BR112022006546A2 (pt) | 2019-10-07 | 2022-08-30 | Kallyope Inc | Agonistas de gpr119 |
JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ,インク. | Ampkアクチベーター |
CA3183575A1 (fr) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Activateurs d'ampk |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60229736D1 (de) | 2001-04-18 | 2008-12-18 | Euro Celtique Sa | Spiroinden- und spiroindan-verbindungen |
EP1613601A4 (fr) * | 2003-04-04 | 2007-05-02 | Merck & Co Inc | Derives de spiropiperidine acyles utilises comme agonistes vis-a-vis du recepteur de melanocortine-4 |
US7504506B2 (en) | 2003-11-04 | 2009-03-17 | Elixir Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
US7834013B2 (en) | 2003-11-19 | 2010-11-16 | Glaxosmithkline Llc | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to GPR40 |
BRPI0508098A (pt) | 2004-02-27 | 2007-07-17 | Amgen Inc | compostos, composições farmacêuticas e métodos para uso no tratamento de distúrbios metabólicos |
WO2005095338A1 (fr) * | 2004-03-30 | 2005-10-13 | Takeda Pharmaceutical Company Limited | Dérivés de l’acide alkoxyphénylpropanoïque |
WO2007033002A1 (fr) | 2005-09-14 | 2007-03-22 | Amgen Inc. | Acides propanoïques 3-substitués par un groupement 4-hydroxyphényle à conformation contrainte pouvant être employés dans le traitement de troubles métaboliques |
AU2007292816B2 (en) | 2006-09-07 | 2011-11-17 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
NZ584161A (en) * | 2007-10-26 | 2011-12-22 | Japan Tobacco Inc | Spiro-ring compound and use thereof for medical purposes |
WO2009067202A1 (fr) | 2007-11-21 | 2009-05-28 | Janssen Pharmaceutica, N.V. | Spiropipéridines utilisables en tant qu'inhibiteurs de la tryptase |
AR078948A1 (es) | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
-
2010
- 2010-10-04 AR ARP100103604A patent/AR078522A1/es not_active Application Discontinuation
- 2010-10-06 TW TW099134098A patent/TW201124415A/zh unknown
- 2010-10-11 PE PE2012000492A patent/PE20121437A1/es not_active Application Discontinuation
- 2010-10-11 WO PCT/US2010/052126 patent/WO2011046851A1/fr active Application Filing
- 2010-10-11 CA CA2777775A patent/CA2777775A1/fr not_active Abandoned
- 2010-10-11 KR KR1020127009501A patent/KR20120051777A/ko not_active Application Discontinuation
- 2010-10-11 EP EP10793349A patent/EP2488500A1/fr not_active Withdrawn
- 2010-10-11 NZ NZ598972A patent/NZ598972A/xx not_active IP Right Cessation
- 2010-10-11 CN CN2010800462763A patent/CN102574807A/zh active Pending
- 2010-10-11 US US12/901,597 patent/US8383642B2/en not_active Expired - Fee Related
- 2010-10-11 BR BR112012008889A patent/BR112012008889A2/pt not_active IP Right Cessation
- 2010-10-11 MX MX2012004420A patent/MX2012004420A/es not_active Application Discontinuation
- 2010-10-11 JP JP2012534259A patent/JP2013508279A/ja not_active Withdrawn
- 2010-10-11 EA EA201270560A patent/EA201270560A1/ru unknown
- 2010-10-11 AU AU2010307094A patent/AU2010307094A1/en not_active Abandoned
-
2012
- 2012-02-27 IL IL218344A patent/IL218344A0/en unknown
- 2012-04-02 TN TNP2012000152A patent/TN2012000152A1/en unknown
- 2012-04-09 MA MA34760A patent/MA33662B1/fr unknown
- 2012-04-10 ZA ZA2012/02560A patent/ZA201202560B/en unknown
- 2012-04-12 CR CR20120177A patent/CR20120177A/es not_active Application Discontinuation
- 2012-04-12 CL CL2012000921A patent/CL2012000921A1/es unknown
- 2012-04-13 DO DO2012000105A patent/DOP2012000105A/es unknown
- 2012-04-13 EC ECSP12011799 patent/ECSP12011799A/es unknown
- 2012-04-20 CO CO12065315A patent/CO6531458A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PE20121437A1 (es) | 2012-10-26 |
CO6531458A2 (es) | 2012-09-28 |
KR20120051777A (ko) | 2012-05-22 |
BR112012008889A2 (pt) | 2019-09-24 |
CR20120177A (es) | 2012-06-06 |
EA201270560A1 (ru) | 2012-09-28 |
US20110092531A1 (en) | 2011-04-21 |
CA2777775A1 (fr) | 2011-04-21 |
NZ598972A (en) | 2013-06-28 |
CN102574807A (zh) | 2012-07-11 |
TN2012000152A1 (en) | 2013-12-12 |
WO2011046851A1 (fr) | 2011-04-21 |
ECSP12011799A (es) | 2012-07-31 |
AU2010307094A1 (en) | 2012-04-19 |
EP2488500A1 (fr) | 2012-08-22 |
IL218344A0 (en) | 2012-04-30 |
ZA201202560B (en) | 2013-09-25 |
CL2012000921A1 (es) | 2012-09-14 |
AR078522A1 (es) | 2011-11-16 |
MX2012004420A (es) | 2012-05-08 |
US8383642B2 (en) | 2013-02-26 |
JP2013508279A (ja) | 2013-03-07 |
DOP2012000105A (es) | 2013-01-31 |
TW201124415A (en) | 2011-07-16 |
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