MA33559B1 - Composes bicycliques 5,6- heteroaryle contenant l'uree comme inhibiteurs de kinase. - Google Patents
Composes bicycliques 5,6- heteroaryle contenant l'uree comme inhibiteurs de kinase.Info
- Publication number
- MA33559B1 MA33559B1 MA34647A MA34647A MA33559B1 MA 33559 B1 MA33559 B1 MA 33559B1 MA 34647 A MA34647 A MA 34647A MA 34647 A MA34647 A MA 34647A MA 33559 B1 MA33559 B1 MA 33559B1
- Authority
- MA
- Morocco
- Prior art keywords
- kinase inhibitor
- contains urea
- tetrahydrate
- tetrahydrate contains
- urea
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne des composés d'urée contenant un groupe hétéroaryle 5,6-bicyclique de formule i ou ii et leur utilisation pour traiter des affections régulées par une protéine kinase telle que le vegfr2, c-met, le pdgfr², c-kit, le csflr ou epha2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23627409P | 2009-08-24 | 2009-08-24 | |
PCT/CN2010/076199 WO2011023081A1 (fr) | 2009-08-24 | 2010-08-20 | Composés d'urée contenant un groupe hétéroaryle 5,6-bicyclique |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33559B1 true MA33559B1 (fr) | 2012-09-01 |
Family
ID=43627250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34647A MA33559B1 (fr) | 2009-08-24 | 2012-02-22 | Composes bicycliques 5,6- heteroaryle contenant l'uree comme inhibiteurs de kinase. |
Country Status (19)
Country | Link |
---|---|
US (1) | US8648086B2 (fr) |
EP (1) | EP2470533A4 (fr) |
JP (1) | JP2013502444A (fr) |
KR (1) | KR20120089459A (fr) |
CN (1) | CN102066372B (fr) |
AU (1) | AU2010289143A1 (fr) |
BR (1) | BR112012003462A2 (fr) |
CA (1) | CA2769151A1 (fr) |
CO (1) | CO6491087A2 (fr) |
EA (1) | EA201290073A1 (fr) |
EC (1) | ECSP12011691A (fr) |
IL (1) | IL218114A0 (fr) |
IN (1) | IN2012DN01983A (fr) |
MA (1) | MA33559B1 (fr) |
MX (1) | MX2012002317A (fr) |
SG (1) | SG178092A1 (fr) |
TN (1) | TN2012000042A1 (fr) |
WO (1) | WO2011023081A1 (fr) |
ZA (1) | ZA201200890B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010045095A1 (fr) | 2008-10-14 | 2010-04-22 | Ning Xi | Composés et procédés d'utilisation |
KR20110133048A (ko) | 2009-03-21 | 2011-12-09 | 닝 시 | 아미노 에스테르 유도체, 그의 염 및 이용 방법 |
EP2611806A4 (fr) * | 2010-09-01 | 2014-05-07 | Ascepion Pharmaceuticals Inc | Composés hétérocycliques enrichis en deutérium en tant qu'inhibiteurs de kinases |
CA2819648C (fr) * | 2010-12-03 | 2018-05-01 | Epizyme, Inc. | Composes purines et 7-deazapurines substituees en tant que modulateurs d'enzymes epigeniques |
CN102408426B (zh) * | 2011-09-14 | 2013-07-10 | 湖南有色凯铂生物药业有限公司 | 取代的芳香脲类化合物及其作为抗癌药物的应用 |
FR2985257B1 (fr) * | 2011-12-28 | 2014-02-14 | Sanofi Sa | Composes dimeres agonistes des recepteurs des fgfs (fgfrs), leur procede de preparation et leur application en therapeutique |
CN103420895A (zh) * | 2012-05-18 | 2013-12-04 | 苏州爱斯鹏药物研发有限责任公司 | 一种4-氨基吲哚的制备方法 |
US20150284422A1 (en) | 2012-08-10 | 2015-10-08 | Epizyme, Inc. | Inhibitors of protein methyltransferase dot1l and methods of use thereof |
AU2013312319B2 (en) | 2012-09-06 | 2018-04-19 | Epizyme, Inc. | Method of treating leukemia |
US9738679B2 (en) | 2013-03-15 | 2017-08-22 | Epizyme, Inc. | Methods of synthesizing substituted purine compounds |
CN103613580B (zh) * | 2013-09-03 | 2016-02-10 | 遵义医学院 | 用于抗肿瘤药物的3-羟基吲哚-2-酮类化合物或其药学上能够接受的盐 |
CN106279154A (zh) * | 2016-08-02 | 2017-01-04 | 叶芳 | 一种7‑氮杂吲哚‑3‑甲醛的制备方法 |
CN108191874B (zh) * | 2018-01-16 | 2019-11-29 | 成都施贝康生物医药科技有限公司 | 一种C-Kit抑制剂及其应用 |
CN111518016B (zh) * | 2018-06-01 | 2022-02-25 | 厦门宝太生物科技股份有限公司 | 一种csf1r抑制剂中间体及其制备方法 |
US20210317461A1 (en) | 2018-08-09 | 2021-10-14 | Verseau Therapeutics, Inc. | Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof |
WO2022123319A1 (fr) * | 2020-12-11 | 2022-06-16 | Ildong Pharmaceutical Co., Ltd. | Agonistes de récepteurs opioïdes polarisés |
CR20230576A (es) | 2021-06-14 | 2024-04-05 | Scorpion Therapeutics Inc | Derivados de la urea que pueden ser utilizados para tratar el cáncer |
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DE3928177A1 (de) | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
GB9412719D0 (en) | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
GB9604361D0 (en) | 1996-02-29 | 1996-05-01 | Pharmacia Spa | 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors |
BR9807083A (pt) | 1997-01-23 | 2000-04-18 | Smithkline Beckman Corp | Antagonistas ao receptor de il-8 |
JP2002539119A (ja) * | 1999-03-08 | 2002-11-19 | バイエル アクチェンゲゼルシャフト | チアゾリルウレア誘導体および抗ウイルス剤としてのそれらの使用 |
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US6525067B1 (en) * | 1999-11-23 | 2003-02-25 | Pfizer Inc | Substituted heterocyclic derivatives |
US7074805B2 (en) | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
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AR054416A1 (es) | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
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EP1940844B1 (fr) * | 2005-10-28 | 2009-09-30 | Irm Llc | Composes et compositions utilises comme inhibiteurs des kinases des proteines |
CA2634787C (fr) | 2005-12-23 | 2014-10-21 | Smithkline Beecham Corporation | Inhibiteurs azaindoliques des kinases aurora |
US20090018156A1 (en) | 2006-02-01 | 2009-01-15 | Jun Tang | Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors |
CN101058561B (zh) * | 2006-04-19 | 2011-01-26 | 苏州爱斯鹏药物研发有限责任公司 | 用于抑制蛋白激酶的二苯脲衍生物及其组合物和用途 |
WO2008063888A2 (fr) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Composés modulant l'activité de c-fms et/ou de c-kit et utilisations associées |
WO2008079909A1 (fr) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Composés et méthodes de modulation des kinases, et indications connexes |
PE20121126A1 (es) | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
WO2008125014A1 (fr) * | 2007-04-13 | 2008-10-23 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. | Composés d'urée, leurs procédés de préparation et leurs utilisations pharmaceutiques |
-
2010
- 2010-08-20 EA EA201290073A patent/EA201290073A1/ru unknown
- 2010-08-20 CA CA2769151A patent/CA2769151A1/fr not_active Abandoned
- 2010-08-20 SG SG2012004917A patent/SG178092A1/en unknown
- 2010-08-20 AU AU2010289143A patent/AU2010289143A1/en not_active Abandoned
- 2010-08-20 CN CN201080001560.9A patent/CN102066372B/zh not_active Expired - Fee Related
- 2010-08-20 KR KR1020127006772A patent/KR20120089459A/ko not_active Application Discontinuation
- 2010-08-20 BR BR112012003462A patent/BR112012003462A2/pt not_active Application Discontinuation
- 2010-08-20 WO PCT/CN2010/076199 patent/WO2011023081A1/fr active Application Filing
- 2010-08-20 MX MX2012002317A patent/MX2012002317A/es not_active Application Discontinuation
- 2010-08-20 IN IN1983DEN2012 patent/IN2012DN01983A/en unknown
- 2010-08-20 EP EP10811241A patent/EP2470533A4/fr not_active Withdrawn
- 2010-08-20 US US12/922,527 patent/US8648086B2/en not_active Expired - Fee Related
- 2010-08-20 JP JP2012525875A patent/JP2013502444A/ja active Pending
-
2012
- 2012-01-26 TN TNP2012000042A patent/TN2012000042A1/en unknown
- 2012-01-26 CO CO12012075A patent/CO6491087A2/es not_active Application Discontinuation
- 2012-02-06 ZA ZA2012/00890A patent/ZA201200890B/en unknown
- 2012-02-14 IL IL218114A patent/IL218114A0/en unknown
- 2012-02-22 MA MA34647A patent/MA33559B1/fr unknown
- 2012-02-23 EC ECSP12011691 patent/ECSP12011691A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP12011691A (es) | 2012-04-30 |
IN2012DN01983A (fr) | 2015-07-24 |
EP2470533A1 (fr) | 2012-07-04 |
CA2769151A1 (fr) | 2011-03-03 |
EA201290073A1 (ru) | 2013-01-30 |
BR112012003462A2 (pt) | 2016-02-23 |
KR20120089459A (ko) | 2012-08-10 |
CN102066372A (zh) | 2011-05-18 |
MX2012002317A (es) | 2012-06-25 |
CO6491087A2 (es) | 2012-07-31 |
IL218114A0 (en) | 2012-04-30 |
US20120122895A1 (en) | 2012-05-17 |
US8648086B2 (en) | 2014-02-11 |
TN2012000042A1 (en) | 2013-09-19 |
ZA201200890B (en) | 2012-10-31 |
AU2010289143A1 (en) | 2012-02-16 |
JP2013502444A (ja) | 2013-01-24 |
EP2470533A4 (fr) | 2013-01-23 |
SG178092A1 (en) | 2012-03-29 |
WO2011023081A1 (fr) | 2011-03-03 |
CN102066372B (zh) | 2014-09-17 |
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EA201000149A1 (ru) | Производные 1-фенил-2-пиридинилалкиловых спиртов в качестве ингибиторов фосфодиэстераз | |
MA34896B1 (fr) | Inhibiteurs du virus de l'hepatite c | |
MA30435B1 (fr) | Inhibiteurs de protéase de type nitrile spirocyclique | |
MA31336B1 (fr) | Inhibiteurs de pi3k alpha a base de pyridopyrimidinone | |
MA43409B1 (fr) | Composés polycycliques à utiliser en tant qu'inhibiteurs de la tyrosine kinase de bruton | |
TN2009000329A1 (fr) | DERIVES DE 2-AMINO-5,7-DIHYDRO-6H-PYRROLO[3,4-d]-PYRIMIDINE SERVANT D'INHBITEURS DE HSP-90 POUR LE TRAITEMENT DU CANCER | |
MA39170A1 (fr) | Composes inhibiteurs de sérine/thréonine kinase pour leurs utilisations dans le traitement du cancer | |
MA31834B1 (fr) | 5-[(3,3,3-trifluoro-2-hydroxy-1-arylpropyl)amino]-1h-quinolin-2-ones, leur procédé de production et leur utilisation comme anti-inflammatoires | |
MA37384B1 (fr) | Nouveaux dérivés de thiénopyrimidine, leurs procédés de préparation et leurs utilisations thérapeutiques. | |
MA39048B1 (fr) | Nouveaux inhibiteurs de la dgat2 | |
MA34098B1 (fr) | Utilisation de nouveaux inhibiteurs pan-cdk pour le traitement de tumeurs | |
MA38410A1 (fr) | Composés d'azétidinyloxyphénylpyrrolidine |