ES2448870T3 - Derivados de quinolina como inhibidores de PARP - Google Patents
Derivados de quinolina como inhibidores de PARP Download PDFInfo
- Publication number
- ES2448870T3 ES2448870T3 ES08841176.4T ES08841176T ES2448870T3 ES 2448870 T3 ES2448870 T3 ES 2448870T3 ES 08841176 T ES08841176 T ES 08841176T ES 2448870 T3 ES2448870 T3 ES 2448870T3
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- Prior art keywords
- hydrogen
- alkyl
- alkyloxy
- formula
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012661 PARP inhibitor Substances 0.000 title description 27
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 title description 27
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title description 2
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 245
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 130
- 239000001257 hydrogen Substances 0.000 claims abstract description 130
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 85
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 55
- -1 cyano, hydroxyl Chemical group 0.000 claims abstract description 51
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 51
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 50
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 38
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 36
- 150000003839 salts Chemical class 0.000 claims abstract description 31
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract description 28
- 125000001424 substituent group Chemical group 0.000 claims abstract description 22
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 17
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 17
- 125000000815 N-oxide group Chemical group 0.000 claims abstract description 16
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 15
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 14
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 13
- 150000002367 halogens Chemical class 0.000 claims abstract description 13
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims abstract description 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 13
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract description 10
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- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract description 8
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims abstract description 8
- 125000002431 aminoalkoxy group Chemical group 0.000 claims abstract description 8
- 125000004966 cyanoalkyl group Chemical group 0.000 claims abstract description 3
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07119417 | 2007-10-26 | ||
| EP07119417 | 2007-10-26 | ||
| PCT/EP2008/064243 WO2009053373A1 (en) | 2007-10-26 | 2008-10-22 | Quinolinone derivatives as parp inhibitors |
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| ES2448870T3 true ES2448870T3 (es) | 2014-03-17 |
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|---|---|---|---|
| ES08841176.4T Active ES2448870T3 (es) | 2007-10-26 | 2008-10-22 | Derivados de quinolina como inhibidores de PARP |
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| US (1) | US8404713B2 (enExample) |
| EP (1) | EP2215075B1 (enExample) |
| JP (1) | JP5525447B2 (enExample) |
| ES (1) | ES2448870T3 (enExample) |
| PL (1) | PL2215075T3 (enExample) |
| WO (1) | WO2009053373A1 (enExample) |
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| JP4806353B2 (ja) * | 2003-12-05 | 2011-11-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ポリ（ａｄｐ−リボース）ポリメラーゼインヒビターとしての６−置換２−キノリノンおよび２−キノキサリノン |
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| US8153633B2 (en) * | 2007-06-25 | 2012-04-10 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
-
2008
- 2008-10-22 WO PCT/EP2008/064243 patent/WO2009053373A1/en not_active Ceased
- 2008-10-22 US US12/681,790 patent/US8404713B2/en active Active
- 2008-10-22 ES ES08841176.4T patent/ES2448870T3/es active Active
- 2008-10-22 EP EP08841176.4A patent/EP2215075B1/en active Active
- 2008-10-22 JP JP2010530433A patent/JP5525447B2/ja not_active Expired - Fee Related
- 2008-10-22 PL PL08841176T patent/PL2215075T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2215075B1 (en) | 2013-12-11 |
| WO2009053373A1 (en) | 2009-04-30 |
| US20100222348A1 (en) | 2010-09-02 |
| JP5525447B2 (ja) | 2014-06-18 |
| JP2011500758A (ja) | 2011-01-06 |
| PL2215075T3 (pl) | 2014-04-30 |
| EP2215075A1 (en) | 2010-08-11 |
| US8404713B2 (en) | 2013-03-26 |
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