JP2013525490A5 - - Google Patents
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- Publication number
- JP2013525490A5 JP2013525490A5 JP2013509201A JP2013509201A JP2013525490A5 JP 2013525490 A5 JP2013525490 A5 JP 2013525490A5 JP 2013509201 A JP2013509201 A JP 2013509201A JP 2013509201 A JP2013509201 A JP 2013509201A JP 2013525490 A5 JP2013525490 A5 JP 2013525490A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydroxyl
- optionally substituted
- halo
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 98
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 73
- 125000005843 halogen group Chemical group 0.000 claims 45
- 125000001424 substituent group Chemical group 0.000 claims 39
- 229910052739 hydrogen Inorganic materials 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 23
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 22
- 125000003118 aryl group Chemical group 0.000 claims 22
- 239000001257 hydrogen Substances 0.000 claims 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 18
- -1 hydroxy, phenyl Chemical group 0.000 claims 16
- 125000004429 atom Chemical group 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 10
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000004043 oxo group Chemical group O=* 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 229910003827 NRaRb Inorganic materials 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 2
- 102100027297 Fatty acid 2-hydroxylase Human genes 0.000 claims 2
- 101000937693 Homo sapiens Fatty acid 2-hydroxylase Proteins 0.000 claims 2
- 101000918494 Homo sapiens Fatty-acid amide hydrolase 1 Proteins 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33197410P | 2010-05-06 | 2010-05-06 | |
| US61/331,974 | 2010-05-06 | ||
| PCT/US2011/035091 WO2011140164A1 (en) | 2010-05-06 | 2011-05-04 | Aza-indole derivatives useful as modulators of faah |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013525490A JP2013525490A (ja) | 2013-06-20 |
| JP2013525490A5 true JP2013525490A5 (enExample) | 2014-06-05 |
Family
ID=44904047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013509201A Pending JP2013525490A (ja) | 2010-05-06 | 2011-05-04 | Ｆａａｈのモジュレータとして有用なアザインドール誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20130059850A1 (enExample) |
| EP (1) | EP2566481A4 (enExample) |
| JP (1) | JP2013525490A (enExample) |
| CN (1) | CN102917707A (enExample) |
| AU (1) | AU2011248175A1 (enExample) |
| BR (1) | BR112012028055A2 (enExample) |
| CA (1) | CA2797281A1 (enExample) |
| WO (1) | WO2011140164A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201411236D0 (en) | 2014-06-25 | 2014-08-06 | Takeda Pharmaceutical | Novel compounds |
| DK3362449T3 (da) * | 2015-10-13 | 2021-07-19 | Inst Nat Sante Rech Med | Sibirilin-derivater til anvendelse til at forebygge og/eller behandle lidelser associeret med cellulær nekroptose |
| CA3036776A1 (en) * | 2016-09-16 | 2018-03-22 | Sumitomo Chemical Company, Limited | Heterocyclic compound, and harmful-arthropod-controlling agent containing same |
| CN109589325B (zh) * | 2019-02-19 | 2019-11-26 | 牡丹江医学院 | 一种用于治疗肠炎的药物组合物及其制备方法 |
| CA3137091A1 (en) * | 2019-06-17 | 2020-12-24 | Ucb Pharma Gmbh | N-(phenyl)-indole-3-sulfonamide derivatives and related compounds as gpr17 modulators for treating cns disorders such as multiple sclerosis |
| CN111743864B (zh) * | 2020-08-05 | 2022-04-01 | 牡丹江医学院 | 一种体育外伤喷雾剂及其制备方法 |
| CN112159423A (zh) * | 2020-11-03 | 2021-01-01 | 凯美克(上海)医药科技有限公司 | 1H-吡咯并[2,3-b]吡啶-2-硼酸频哪醇酯的合成方法 |
| WO2022157392A1 (en) * | 2021-01-25 | 2022-07-28 | Seabelife | Use of indole, 6- and 7-azaindole derivatives as inhibitors of ferroptosis regulated cell death |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH574441A5 (enExample) * | 1973-06-14 | 1976-04-15 | Ciba Geigy Ag | |
| JPS5239672A (en) * | 1975-09-26 | 1977-03-28 | Sankyo Co Ltd | Process for preparing indole-2-allyl-3- thioeter compounds |
| IL84796A (en) * | 1986-12-17 | 1992-03-29 | Merck Frosst Canada Inc | Substituted n-benzyl-indoles and pharmaceutical compositions containing them |
| US5095031A (en) * | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
| US5527819A (en) * | 1991-09-06 | 1996-06-18 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
| CA2156420A1 (en) * | 1993-02-24 | 1994-09-01 | Theresa M. Williams | Inhibitors of hiv reverse transcriptase |
| FR2705346B1 (fr) * | 1993-05-18 | 1995-08-11 | Union Pharma Scient Appl | Nouveaux dérivés de pipéridinyl thio indole, leurs procédés de préparation, compositions pharmaceutiques les contenant, utiles notamment comme antalgiques . |
| ATE340792T1 (de) * | 2002-02-01 | 2006-10-15 | Hoffmann La Roche | Substituierte indole als alpha-1 agonisten |
| UA78999C2 (en) * | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
| TW200403243A (en) * | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| US6800655B2 (en) * | 2002-08-20 | 2004-10-05 | Sri International | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents |
| MXPA05008441A (es) * | 2003-02-14 | 2005-10-19 | Wyeth Corp | Derivados de heterociclil-3-sulfonilindazol o azaindazol como ligandos de 5-hidroxitriptamina-6. |
| CA2573362A1 (en) * | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| CA2577511A1 (en) * | 2004-08-19 | 2006-03-02 | Aventis Pharmaceuticals Inc. | 3-arylthioindole-2-carboxamide derivatives and analogs thereof as inhibitors of casein kinase ie |
| GB2422831A (en) * | 2005-02-04 | 2006-08-09 | Oxagen Ltd | Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor |
| MX2007016463A (es) * | 2005-06-22 | 2008-03-04 | Plexxikon Inc | Derivados de pirrolo [2,3-b] piridina como inhibidores de proteina cinasa. |
| EP1998766A2 (en) * | 2005-12-16 | 2008-12-10 | Ironwood Pharmaceuticals, Inc. | Useful indole compounds |
| US20090118503A1 (en) * | 2007-06-20 | 2009-05-07 | Kevin Sprott | Faah inhibitors |
| EA201001330A1 (ru) * | 2008-02-22 | 2011-04-29 | Айрм Ллк | Соединения и композиции в качестве модуляторов активности gpr119 |
| ES2543599T3 (es) * | 2008-04-16 | 2015-08-20 | Karo Bio Ab | Nuevos ligandos de receptor de estrógeno |
-
2011
- 2011-05-04 BR BR112012028055A patent/BR112012028055A2/pt not_active IP Right Cessation
- 2011-05-04 AU AU2011248175A patent/AU2011248175A1/en not_active Abandoned
- 2011-05-04 US US13/696,520 patent/US20130059850A1/en not_active Abandoned
- 2011-05-04 CA CA2797281A patent/CA2797281A1/en not_active Abandoned
- 2011-05-04 JP JP2013509201A patent/JP2013525490A/ja active Pending
- 2011-05-04 CN CN2011800228440A patent/CN102917707A/zh active Pending
- 2011-05-04 WO PCT/US2011/035091 patent/WO2011140164A1/en not_active Ceased
- 2011-05-04 EP EP11778226.8A patent/EP2566481A4/en not_active Withdrawn