CN102917707A - 可用作faah调节剂的氮杂吲哚衍生物 - Google Patents

可用作faah调节剂的氮杂吲哚衍生物 Download PDF

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Publication number
CN102917707A
CN102917707A CN2011800228440A CN201180022844A CN102917707A CN 102917707 A CN102917707 A CN 102917707A CN 2011800228440 A CN2011800228440 A CN 2011800228440A CN 201180022844 A CN201180022844 A CN 201180022844A CN 102917707 A CN102917707 A CN 102917707A
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Prior art keywords
pyrrolo
thio
chlorophenyl
alkyl
pyridin
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CN2011800228440A
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Chinese (zh)
Inventor
A.M.瓦尔吉
P.G.南特梅特
K.P.穆尔
R.A.斯托尔
L.瓦萨洛
C.克里特索拉斯
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Publication of CN102917707A publication Critical patent/CN102917707A/zh
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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CN2011800228440A 2010-05-06 2011-05-04 可用作faah调节剂的氮杂吲哚衍生物 Pending CN102917707A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33197410P 2010-05-06 2010-05-06
US61/331974 2010-05-06
PCT/US2011/035091 WO2011140164A1 (en) 2010-05-06 2011-05-04 Aza-indole derivatives useful as modulators of faah

Publications (1)

Publication Number Publication Date
CN102917707A true CN102917707A (zh) 2013-02-06

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US (1) US20130059850A1 (enExample)
EP (1) EP2566481A4 (enExample)
JP (1) JP2013525490A (enExample)
CN (1) CN102917707A (enExample)
AU (1) AU2011248175A1 (enExample)
BR (1) BR112012028055A2 (enExample)
CA (1) CA2797281A1 (enExample)
WO (1) WO2011140164A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106488919A (zh) * 2014-06-25 2017-03-08 武田药品工业株式会社 3‑取代的2‑氨基吲哚衍生物
CN109589325A (zh) * 2019-02-19 2019-04-09 牡丹江医学院 一种用于治疗肠炎的药物组合物及其制备方法
CN111743864A (zh) * 2020-08-05 2020-10-09 牡丹江医学院 一种体育外伤喷雾剂及其制备方法
CN112159423A (zh) * 2020-11-03 2021-01-01 凯美克(上海)医药科技有限公司 1H-吡咯并[2,3-b]吡啶-2-硼酸频哪醇酯的合成方法
CN113993845A (zh) * 2019-06-17 2022-01-28 优时比制药有限公司 作为治疗cns障碍例如多发性硬化的gpr17调节剂的n-(苯基)-吲哚-3-磺酰胺衍生物和相关化合物

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3362449T3 (da) * 2015-10-13 2021-07-19 Inst Nat Sante Rech Med Sibirilin-derivater til anvendelse til at forebygge og/eller behandle lidelser associeret med cellulær nekroptose
CN110352192B (zh) * 2016-09-16 2023-03-24 住友化学株式会社 杂环化合物及含有其的有害节肢动物防治剂
JP2024506530A (ja) * 2021-01-25 2024-02-14 シービーライフ フェロトーシス制御性細胞死の阻害剤としてのインドール、６－および７－アザインドール誘導体の使用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1659166A (zh) * 2002-06-04 2005-08-24 惠氏公司 作为5－羟色胺－6配体的1－(氨基烷基)－3－磺酰基氮杂吲哚

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH574441A5 (enExample) * 1973-06-14 1976-04-15 Ciba Geigy Ag
JPS5239672A (en) * 1975-09-26 1977-03-28 Sankyo Co Ltd Process for preparing indole-2-allyl-3- thioeter compounds
IL84796A (en) * 1986-12-17 1992-03-29 Merck Frosst Canada Inc Substituted n-benzyl-indoles and pharmaceutical compositions containing them
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
US5527819A (en) * 1991-09-06 1996-06-18 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
BR9405737A (pt) * 1993-02-24 1995-12-05 Merck & Co Inc Composto processo de inibição de transcriptase reserva de HIV, processo de prevenção contra a infecção pelo HIV ou de tratamento da infecção pelo HIV, composição farmacêutica útil para a inibição da transcriptase reserva de HIV, e, útil para a prevenção ou tratamento de infecção pelo HIV ou para o tratamento da AIDS ou ARC
FR2705346B1 (fr) * 1993-05-18 1995-08-11 Union Pharma Scient Appl Nouveaux dérivés de pipéridinyl thio indole, leurs procédés de préparation, compositions pharmaceutiques les contenant, utiles notamment comme antalgiques .
BR0307406A (pt) * 2002-02-01 2004-12-28 Hoffmann La Roche Indóis substituìdos como agonistas alfa-1
TW200403243A (en) * 2002-07-18 2004-03-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
AU2004213375A1 (en) * 2003-02-14 2004-09-02 Wyeth Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-Hydroxytryptamine-6 ligands
US7361763B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
SI1791537T1 (sl) * 2004-08-19 2010-02-26 Aventis Pharma Inc 3-ariltioindol-2-karboksamidni derivati in njihovi analogi kot inhibitorji kazein-kinaze I
GB2422831A (en) * 2005-02-04 2006-08-09 Oxagen Ltd Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor
PL2395004T3 (pl) * 2005-06-22 2016-08-31 Plexxikon Inc Pochodne pirolo[2,3-b]pirydyny jako inhibitory kinazy białkowej
EP1998766A2 (en) * 2005-12-16 2008-12-10 Ironwood Pharmaceuticals, Inc. Useful indole compounds
TW201242961A (en) * 2007-06-20 2012-11-01 Ironwood Pharmaceuticals Inc FAAH inhibitors
MX2010009203A (es) * 2008-02-22 2010-11-10 Irm Llc Compuestos y composiciones como modulares de la actividad de gpr119.
PT2276732E (pt) * 2008-04-16 2015-09-28 Karobio Ab Novos ligandos do recetor de estrogénio

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1659166A (zh) * 2002-06-04 2005-08-24 惠氏公司 作为5－羟色胺－6配体的1－(氨基烷基)－3－磺酰基氮杂吲哚

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106488919A (zh) * 2014-06-25 2017-03-08 武田药品工业株式会社 3‑取代的2‑氨基吲哚衍生物
CN106488919B (zh) * 2014-06-25 2018-10-23 武田药品工业株式会社 3-取代的2-氨基吲哚衍生物
CN109589325A (zh) * 2019-02-19 2019-04-09 牡丹江医学院 一种用于治疗肠炎的药物组合物及其制备方法
CN109589325B (zh) * 2019-02-19 2019-11-26 牡丹江医学院 一种用于治疗肠炎的药物组合物及其制备方法
CN113993845A (zh) * 2019-06-17 2022-01-28 优时比制药有限公司 作为治疗cns障碍例如多发性硬化的gpr17调节剂的n-(苯基)-吲哚-3-磺酰胺衍生物和相关化合物
CN111743864A (zh) * 2020-08-05 2020-10-09 牡丹江医学院 一种体育外伤喷雾剂及其制备方法
CN112159423A (zh) * 2020-11-03 2021-01-01 凯美克(上海)医药科技有限公司 1H-吡咯并[2,3-b]吡啶-2-硼酸频哪醇酯的合成方法

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AU2011248175A1 (en) 2012-10-25
EP2566481A1 (en) 2013-03-13
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BR112012028055A2 (pt) 2019-09-24
US20130059850A1 (en) 2013-03-07

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