CN103153307A - 用作faah调节剂的噁唑衍生物 - Google Patents
用作faah调节剂的噁唑衍生物 Download PDFInfo
- Publication number
- CN103153307A CN103153307A CN201180019926XA CN201180019926A CN103153307A CN 103153307 A CN103153307 A CN 103153307A CN 201180019926X A CN201180019926X A CN 201180019926XA CN 201180019926 A CN201180019926 A CN 201180019926A CN 103153307 A CN103153307 A CN 103153307A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- optionally
- halo
- hydroxyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- CQXWLCATAHVHQA-WUKNDPDISA-N CC(/C(/N)=C(/OC(c(cc1)ccc1F)=C)\Sc(cc1)ncc1Cl)O Chemical compound CC(/C(/N)=C(/OC(c(cc1)ccc1F)=C)\Sc(cc1)ncc1Cl)O CQXWLCATAHVHQA-WUKNDPDISA-N 0.000 description 1
- YUSXZVMNIJTWAS-UHFFFAOYSA-N COC(c(cc1)ccc1NCc(nc(-c(cc1)ccc1F)[o]1)c1Sc(cc1)ncc1Cl)=O Chemical compound COC(c(cc1)ccc1NCc(nc(-c(cc1)ccc1F)[o]1)c1Sc(cc1)ncc1Cl)=O YUSXZVMNIJTWAS-UHFFFAOYSA-N 0.000 description 1
- KWRULUOYSXLFRE-UHFFFAOYSA-N CS(N(CC1)CCC1NCc(nc(-c(cc1)ccc1F)[o]1)c1Sc(cc1)ncc1Cl)(=O)=O Chemical compound CS(N(CC1)CCC1NCc(nc(-c(cc1)ccc1F)[o]1)c1Sc(cc1)ncc1Cl)(=O)=O KWRULUOYSXLFRE-UHFFFAOYSA-N 0.000 description 1
- RTWKBVLODZHIRF-UHFFFAOYSA-N Clc(cc1)ccc1Sc1c(COc2ccc3[nH]ncc3c2)nc(C2CCOCC2)[o]1 Chemical compound Clc(cc1)ccc1Sc1c(COc2ccc3[nH]ncc3c2)nc(C2CCOCC2)[o]1 RTWKBVLODZHIRF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/46—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32669510P | 2010-04-22 | 2010-04-22 | |
| US61/326,695 | 2010-04-22 | ||
| PCT/US2011/032842 WO2011133447A1 (en) | 2010-04-22 | 2011-04-18 | Oxazole derivatives useful as modulators of faah |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103153307A true CN103153307A (zh) | 2013-06-12 |
Family
ID=44834467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180019926XA Pending CN103153307A (zh) | 2010-04-22 | 2011-04-18 | 用作faah调节剂的噁唑衍生物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9073879B2 (enExample) |
| EP (1) | EP2593102B1 (enExample) |
| JP (1) | JP5856606B2 (enExample) |
| CN (1) | CN103153307A (enExample) |
| AU (1) | AU2011242961B2 (enExample) |
| BR (1) | BR112012023971A2 (enExample) |
| CA (1) | CA2794724A1 (enExample) |
| WO (1) | WO2011133447A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| MX2014015265A (es) | 2012-06-14 | 2015-08-12 | Basf Se | Metodos plaguicidas que utilizan compuestos de 3-piridiltiazol sustituido y derivados para combatir plagas de animales. |
| MX363708B (es) | 2013-10-14 | 2019-03-29 | Eisai R&D Man Co Ltd | Compuestos de quinolina selectivamente sustituidos. |
| SG10201704327RA (en) | 2013-10-14 | 2017-06-29 | Eisai R&D Man Co Ltd | Selectively substituted quinoline compounds |
| EP3322419B1 (en) | 2015-07-15 | 2025-09-03 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| EP3725788A1 (en) | 2019-04-15 | 2020-10-21 | Bayer AG | Novel heteroaryl-substituted aminoalkyl azole compounds as pesticides |
| CN114502545B (zh) | 2019-07-23 | 2024-06-28 | 拜耳公司 | 作为农药的新的杂芳基-三唑化合物 |
| TW202136248A (zh) | 2019-11-25 | 2021-10-01 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基-三唑化合物 |
| US20230148601A1 (en) | 2020-02-18 | 2023-05-18 | Bayer Aktiengesellschaft | Novel heteroaryl-triazole compounds as pesticides |
| TWI891782B (zh) | 2020-05-06 | 2025-08-01 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基三唑化合物 |
| KR20240051198A (ko) | 2021-08-25 | 2024-04-19 | 바이엘 악티엔게젤샤프트 | 농약제로서 신규 피라지닐-트리아졸 화합물 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009154785A2 (en) * | 2008-06-19 | 2009-12-23 | The Scripps Research Institute | C4-substituted alpha-keto oxazoles |
| WO2010017079A1 (en) * | 2008-08-04 | 2010-02-11 | Merck & Co., Inc. | Oxazole derivatives useful as inhibitors of faah |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8268817B2 (en) * | 2006-09-08 | 2012-09-18 | The Scripps Research Institute | Substituted oxazole ketone modulators of fatty acid amide hydrolase |
| WO2008100977A2 (en) * | 2007-02-14 | 2008-08-21 | N.V. Organon | Carbamates therapeutic release agents as amidase inhibitors |
| AU2008260496A1 (en) * | 2007-05-31 | 2008-12-11 | The Scripps Research Institute | Tricyclic inhibitors of fatty acid amide hydrolase |
-
2011
- 2011-04-18 WO PCT/US2011/032842 patent/WO2011133447A1/en not_active Ceased
- 2011-04-18 AU AU2011242961A patent/AU2011242961B2/en not_active Ceased
- 2011-04-18 JP JP2013506203A patent/JP5856606B2/ja not_active Expired - Fee Related
- 2011-04-18 BR BR112012023971A patent/BR112012023971A2/pt not_active IP Right Cessation
- 2011-04-18 US US13/635,286 patent/US9073879B2/en active Active
- 2011-04-18 CA CA2794724A patent/CA2794724A1/en not_active Abandoned
- 2011-04-18 EP EP11772492.2A patent/EP2593102B1/en active Active
- 2011-04-18 CN CN201180019926XA patent/CN103153307A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009154785A2 (en) * | 2008-06-19 | 2009-12-23 | The Scripps Research Institute | C4-substituted alpha-keto oxazoles |
| WO2010017079A1 (en) * | 2008-08-04 | 2010-02-11 | Merck & Co., Inc. | Oxazole derivatives useful as inhibitors of faah |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011242961B2 (en) | 2015-09-24 |
| US20130012526A1 (en) | 2013-01-10 |
| JP2013525356A (ja) | 2013-06-20 |
| EP2593102A1 (en) | 2013-05-22 |
| EP2593102B1 (en) | 2017-06-07 |
| BR112012023971A2 (pt) | 2016-11-29 |
| WO2011133447A1 (en) | 2011-10-27 |
| US9073879B2 (en) | 2015-07-07 |
| JP5856606B2 (ja) | 2016-02-10 |
| EP2593102A4 (en) | 2013-12-04 |
| AU2011242961A1 (en) | 2012-09-27 |
| CA2794724A1 (en) | 2011-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103153307A (zh) | 用作faah调节剂的噁唑衍生物 | |
| JP5698666B2 (ja) | Ｆａａｈの阻害剤として有用なオキサゾール誘導体 | |
| CN102917704A (zh) | 可用作faah调节剂的噁唑衍生物 | |
| JP2011523959A (ja) | Ｆａａｈの阻害剤として有用なイミダゾール誘導体 | |
| US20110021531A1 (en) | Oxazole derivatives useful as inhibitors of faah | |
| JP2013525490A (ja) | Ｆａａｈのモジュレータとして有用なアザインドール誘導体 | |
| JP5667093B2 (ja) | Ｆａａｈの調節剤およびｆａａｈ造影剤として有用なイミダゾール誘導体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130612 |