ATE341615T1 - Auf der dreidimensionalen struktur von lta4 hydrolase basierender entwurf von arzneimitteln - Google Patents
Auf der dreidimensionalen struktur von lta4 hydrolase basierender entwurf von arzneimittelnInfo
- Publication number
- ATE341615T1 ATE341615T1 AT00913207T AT00913207T ATE341615T1 AT E341615 T1 ATE341615 T1 AT E341615T1 AT 00913207 T AT00913207 T AT 00913207T AT 00913207 T AT00913207 T AT 00913207T AT E341615 T1 ATE341615 T1 AT E341615T1
- Authority
- AT
- Austria
- Prior art keywords
- lta4
- hydrolase
- dimensional structure
- lta4 hydrolase
- present
- Prior art date
Links
- 102100022118 Leukotriene A-4 hydrolase Human genes 0.000 title abstract 4
- 108010072713 leukotriene A4 hydrolase Proteins 0.000 title abstract 4
- 238000009510 drug design Methods 0.000 title abstract 2
- UFPQIRYSPUYQHK-VRKJBCFNSA-N Leukotriene A4 Natural products CCCCCC=C/CC=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(=O)O UFPQIRYSPUYQHK-VRKJBCFNSA-N 0.000 abstract 2
- UFPQIRYSPUYQHK-WAQVJNLQSA-N leukotriene A4 Chemical compound CCCCC\C=C/C\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(O)=O UFPQIRYSPUYQHK-WAQVJNLQSA-N 0.000 abstract 2
- 108090000604 Hydrolases Proteins 0.000 abstract 1
- 229940124599 anti-inflammatory drug Drugs 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000002617 leukotrienes Chemical class 0.000 abstract 1
- 230000009456 molecular mechanism Effects 0.000 abstract 1
- 235000004252 protein component Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12211099P | 1999-02-26 | 1999-02-26 | |
| SE9900722A SE9900722D0 (sv) | 1999-02-26 | 1999-02-26 | Drug design based on the structure of LTA4 hydrolase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE341615T1 true ATE341615T1 (de) | 2006-10-15 |
Family
ID=26663520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00913207T ATE341615T1 (de) | 1999-02-26 | 2000-02-28 | Auf der dreidimensionalen struktur von lta4 hydrolase basierender entwurf von arzneimitteln |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7590494B1 (de) |
| EP (1) | EP1157101B1 (de) |
| AT (1) | ATE341615T1 (de) |
| AU (1) | AU3468300A (de) |
| DE (1) | DE60031096T2 (de) |
| WO (1) | WO2000050577A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7507531B2 (en) | 2002-10-17 | 2009-03-24 | Decode Genetics Chf. | Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction |
| US7851486B2 (en) | 2002-10-17 | 2010-12-14 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment |
| KR102368958B1 (ko) | 2013-12-20 | 2022-02-28 | 노파르티스 아게 | Lta4h 억제제로서의 헤테로아릴 부탄산 유도체 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5331573A (en) * | 1990-12-14 | 1994-07-19 | Balaji Vitukudi N | Method of design of compounds that mimic conformational features of selected peptides |
| US20040137518A1 (en) * | 2002-01-31 | 2004-07-15 | Lambert Millard Hurst | CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME |
-
2000
- 2000-02-28 AT AT00913207T patent/ATE341615T1/de not_active IP Right Cessation
- 2000-02-28 EP EP00913207A patent/EP1157101B1/de not_active Expired - Lifetime
- 2000-02-28 WO PCT/SE2000/000384 patent/WO2000050577A1/en not_active Ceased
- 2000-02-28 AU AU34683/00A patent/AU3468300A/en not_active Abandoned
- 2000-02-28 US US09/914,451 patent/US7590494B1/en not_active Expired - Fee Related
- 2000-02-28 DE DE60031096T patent/DE60031096T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000050577A1 (en) | 2000-08-31 |
| DE60031096D1 (de) | 2006-11-16 |
| EP1157101B1 (de) | 2006-10-04 |
| US7590494B1 (en) | 2009-09-15 |
| DE60031096T2 (de) | 2007-05-10 |
| AU3468300A (en) | 2000-09-14 |
| EP1157101A1 (de) | 2001-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |