AR024306A1 - Preparacion farmaceutica que contiene una neurotoxina botulinica. - Google Patents
Preparacion farmaceutica que contiene una neurotoxina botulinica.Info
- Publication number
- AR024306A1 AR024306A1 ARP000102818A ARP000102818A AR024306A1 AR 024306 A1 AR024306 A1 AR 024306A1 AR P000102818 A ARP000102818 A AR P000102818A AR P000102818 A ARP000102818 A AR P000102818A AR 024306 A1 AR024306 A1 AR 024306A1
- Authority
- AR
- Argentina
- Prior art keywords
- neurotoxin
- pharmaceutical preparation
- preparation containing
- botulinic
- neurotoxins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Preparacion farmacéutica que contiene una de las neurotoxinas botulínicas de Clostridium Botulinum de los tipos A, B, C, D, E, F o G o una mezcla de dos omás de estas neurotoxinas, caracterizada porque la neurotoxina, o bien la mezcla de neurotoxinaestá libre de proteínas complejizantes que junto con lasneurotoxinas forman de manera natural los complejos de neurotoxina botulínica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19925739A DE19925739A1 (de) | 1999-06-07 | 1999-06-07 | Therapeutikum mit einem Botulinum-Neurotoxin |
Publications (1)
Publication Number | Publication Date |
---|---|
AR024306A1 true AR024306A1 (es) | 2002-09-25 |
Family
ID=7910318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000102818A AR024306A1 (es) | 1999-06-07 | 2000-06-07 | Preparacion farmaceutica que contiene una neurotoxina botulinica. |
Country Status (27)
Country | Link |
---|---|
US (3) | US7964199B1 (es) |
EP (1) | EP1185291B2 (es) |
JP (2) | JP2003505343A (es) |
KR (1) | KR100466407B1 (es) |
CN (2) | CN101062009A (es) |
AR (1) | AR024306A1 (es) |
AT (1) | ATE258803T1 (es) |
AU (1) | AU774590B2 (es) |
CA (1) | CA2376193C (es) |
CO (1) | CO5170431A1 (es) |
CZ (1) | CZ20014351A3 (es) |
DE (3) | DE19925739A1 (es) |
DK (1) | DK1185291T3 (es) |
EA (1) | EA004202B1 (es) |
ES (1) | ES2215056T5 (es) |
GE (1) | GEP20043200B (es) |
HK (1) | HK1047403A1 (es) |
HU (1) | HUP0201530A3 (es) |
IL (2) | IL146974A0 (es) |
MX (1) | MXPA01012540A (es) |
NO (1) | NO20015964L (es) |
PL (1) | PL198958B1 (es) |
PT (1) | PT1185291E (es) |
TW (1) | TWI251492B (es) |
UA (1) | UA72253C2 (es) |
WO (1) | WO2000074703A2 (es) |
ZA (1) | ZA200110074B (es) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19925739A1 (de) | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
US20080038274A1 (en) | 1999-09-23 | 2008-02-14 | Foster Keith A | Inhibition of secretion from non-neuronal cells |
US7838008B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating diverse cancers |
US7838007B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating mammary gland disorders |
US6821520B2 (en) | 2000-02-15 | 2004-11-23 | Allergan, Inc. | Clostridial toxin therapy for Hashimoto's thyroiditis |
JP2003009897A (ja) | 2001-07-03 | 2003-01-14 | Keiji Oguma | ボツリヌス毒素の分離・精製法 |
US6688311B2 (en) | 2002-03-14 | 2004-02-10 | Allergan, Inc. | Method for determining effect of a clostridial toxin upon a muscle |
US7140371B2 (en) | 2002-03-14 | 2006-11-28 | Allergan, Inc. | Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins |
US20050163809A1 (en) * | 2002-03-29 | 2005-07-28 | Ryuji Kaji | Remedy for hypermyotonia |
US7691394B2 (en) * | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
EP2272340B1 (en) * | 2002-08-19 | 2018-03-14 | Ira Sanders | Botulinum toxin |
US20120114697A1 (en) | 2002-08-19 | 2012-05-10 | Ira Sanders | Treatment of holocrine gland dysfunction with clostridia neurotoxins |
US7824693B2 (en) | 2002-08-19 | 2010-11-02 | Ira Sanders | Treatment of fine wrinkles with clostridia neurotoxins |
US8071550B2 (en) | 2003-03-03 | 2011-12-06 | Allergan, Inc. | Methods for treating uterine disorders |
JP2007528352A (ja) * | 2003-03-06 | 2007-10-11 | ボツリヌム・トクシン・リサーチ・アソシエイツ・インコーポレイテッド | 洞炎に関連する慢性の顔面痛および頭痛のボツリヌス毒素での治療 |
US6838434B2 (en) * | 2003-05-02 | 2005-01-04 | Allergan, Inc. | Methods for treating sinus headache |
EP1640017A1 (en) * | 2003-06-20 | 2006-03-29 | Santen Pharmaceutical Co., Ltd. | Remedies for diseases with hypermyotonia |
US6974579B2 (en) * | 2004-01-08 | 2005-12-13 | Allergan, Inc. | Methods for treating vascular disorders |
WO2005120546A2 (en) | 2004-03-03 | 2005-12-22 | Essentia Biosystems, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
LT2985039T (lt) | 2004-03-03 | 2018-11-12 | Revance Therapeutics, Inc. | Botulino toksinų vietinis taikymas ir jų įvedimas per odą |
GB2416122A (en) * | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
US7879341B2 (en) * | 2004-07-26 | 2011-02-01 | Merz Pharma Gmbh & Co. Kgaa | Therapeutic composition with a botulinum neurotoxin |
US7429386B2 (en) | 2004-09-03 | 2008-09-30 | Allergan, Inc. | Stretch mark treatment |
US7179474B2 (en) | 2004-09-03 | 2007-02-20 | Allergan, Inc. | Methods for treating a buttock deformity |
US20060067950A1 (en) * | 2004-09-27 | 2006-03-30 | Merz Pharma Gmbh & Co. Kgaa | Clostridial neurotoxins for use in wound healing |
ES2420430T3 (es) * | 2005-03-03 | 2013-08-23 | Allergan, Inc. | Sistema libre de productos de origen animal y procedimiento de purificación de una toxina botulínica |
JP2008531732A (ja) | 2005-03-03 | 2008-08-14 | ルバンス セラピュティックス インク. | ボツリヌス毒素の局所塗布及び経皮送達のための組成物及び方法 |
US7419675B2 (en) | 2005-05-26 | 2008-09-02 | Allergan, Inc. | Method for treating peritoneal adhesions |
ES2326916T3 (es) * | 2005-06-17 | 2009-10-21 | MERZ PHARMA GMBH & CO. KGAA | Aparato y metodo para la produccion de compuestos biologicamente activos por fermentacion. |
WO2007059528A2 (en) | 2005-11-17 | 2007-05-24 | Revance Therapeutics, Inc. | Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins |
EP1834962A1 (de) | 2006-03-15 | 2007-09-19 | Biotecon Therapeutics GmbH | PEGyliertes mutiertes Clostridium botulinum Toxin |
AR061669A1 (es) * | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
US10792344B2 (en) | 2006-06-29 | 2020-10-06 | Merz Pharma Gmbh & Co. Kgaa | High frequency application of botulinum toxin therapy |
KR20100020972A (ko) * | 2007-06-01 | 2010-02-23 | 메르츠 파마 게엠베하 운트 코. 카가아 | 보툴리늄 톡신의 신경독 성분에 기초한 온도-안정한 근육 이완제를 제공하는 방법 |
EP2048156A1 (en) * | 2007-10-12 | 2009-04-15 | Merz Pharma GmbH & Co.KGaA | Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin |
DE102007038015A1 (de) * | 2007-08-10 | 2009-02-19 | Hefter, Harald, Prof. Dr. med. Dr. rer. nat. | Verwendung eines Neurotoxins |
US9161970B2 (en) * | 2007-12-12 | 2015-10-20 | Allergan, Inc. | Dermal filler |
EP2072057A1 (en) | 2007-12-21 | 2009-06-24 | Merz Pharma GmbH & Co.KGaA | Early administration of Botulinum toxin in the treatment of cerebrovascular event and spinal cord injury |
EP2072039A1 (en) * | 2007-12-21 | 2009-06-24 | Merz Pharma GmbH & Co.KGaA | Use of a neurotoxic component of Clostridium botulinum toxin complex to reduce or prevent side effects |
CN101965403B (zh) * | 2008-01-29 | 2013-07-03 | 株式会社抗体研究所 | A型肉毒杆菌毒素中和组合物及人抗a型肉毒杆菌毒素抗体 |
US9107815B2 (en) * | 2008-02-22 | 2015-08-18 | Allergan, Inc. | Sustained release poloxamer containing pharmaceutical compositions |
NZ588029A (en) * | 2008-03-14 | 2012-12-21 | Allergan Inc | Immuno-based botulinum toxin serotype a activity assays |
EP2283849B1 (en) * | 2008-03-31 | 2016-05-04 | The Chemo-Sero-Therapeutic Research Institute | A2 botulinum neurotoxin for use in the treatment of muscle overactivity in the presence of type a1 neutralising antibodies |
EP2337790B1 (en) | 2008-08-29 | 2016-07-13 | Merz Pharma GmbH & Co. KGaA | Clostridial neurotoxins with altered persistency |
DK2161033T3 (da) | 2008-09-09 | 2013-08-05 | Susanne Dr Grafe | Botulinustoxin til at indføre midlertidig infertilitet i et hvirveldyr (f.eks. et menneske) |
CN101386648B (zh) * | 2008-09-25 | 2012-05-30 | 中国人民解放军军事医学科学院微生物流行病研究所 | 抗b型肉毒神经毒素中和性单克隆抗体、其制备方法及用途 |
WO2010096134A1 (en) | 2008-12-04 | 2010-08-26 | Botulinum Toxin Research Associates, Inc. | Extended length botulinum toxin formulation for human or mammalian use |
EP2248518B1 (en) | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
US8129139B2 (en) | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
JP2011074025A (ja) * | 2009-09-30 | 2011-04-14 | Chemo-Sero-Therapeutic Research Inst | ボツリヌス毒素の精製方法 |
PT2490986T (pt) | 2009-10-21 | 2018-11-13 | Revance Therapeutics Inc | Métodos e sistemas para purificar neurotoxina botulínica não complexada |
KR101134146B1 (ko) * | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
AU2011316111B2 (en) | 2010-10-12 | 2015-05-28 | Merz Pharma Gmbh & Co. Kgaa | Formulation suitable for stabilizing proteins, which is free of mammalian excipients |
AU2012276512B2 (en) * | 2011-06-27 | 2016-04-21 | Sang Duck Kim | Pharmaceutical composition for treating scars on the skin, and method for treating scars on the skin using same |
US9393291B2 (en) | 2012-04-12 | 2016-07-19 | Botulinum Toxin Research Associates, Inc. | Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds |
JP6517800B2 (ja) * | 2013-07-30 | 2019-05-22 | メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン | ボツリヌス毒素の高純度神経毒成分の製造方法とその使用 |
US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
US9901627B2 (en) | 2014-07-18 | 2018-02-27 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
EP3285800B1 (en) * | 2015-04-24 | 2019-09-18 | Consiglio Nazionale Delle Ricerche | A new therapeutic use of the botulinum neurotoxin serotype a |
KR101775682B1 (ko) * | 2015-11-30 | 2017-09-06 | 주식회사 대웅 | 보툴리눔 독소의 제조방법 |
ES2755815T3 (es) | 2016-09-13 | 2020-04-23 | Allergan Inc | Composiciones de toxina de Clostridium no proteicas estabilizadas |
KR102463881B1 (ko) | 2016-10-04 | 2022-11-07 | (주)메디톡스 | 보툴리눔 독소 함유 용액으로부터 보툴리눔 독소를 분리하는 방법 |
EP3600221A4 (en) * | 2017-03-22 | 2021-01-13 | Bonti, Inc. | BOTULINUM NEUROTOXINS FOR USE IN THERAPY |
WO2018172264A1 (en) | 2017-03-24 | 2018-09-27 | Merz Pharma Gmbh & Co. Kgaa | Improved use of botulinum neurotoxin in the treatment of sialorrhea |
US11191819B2 (en) | 2018-08-28 | 2021-12-07 | Ira Sanders | Skin therapeutics |
EP3860640A1 (en) | 2018-10-02 | 2021-08-11 | Merz Pharma GmbH & Co. KGaA | Novel uses of botulinum neurotoxin for treating lipoedema |
JP2022521237A (ja) | 2019-02-21 | 2022-04-06 | メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン | 振戦治療のためのボツリヌス神経毒素の新規用途 |
BR112022023413A2 (pt) | 2020-06-05 | 2022-12-20 | Merz Pharma Gmbh & Co Kgaa | Tratamento de rugas faciais com toxina botulínica de alta dose e baixo volume |
TW202400122A (zh) | 2022-02-28 | 2024-01-01 | 德商梅茲製藥有限兩合公司 | 肉毒桿菌毒素用於降低皮膚毛孔尺寸及/或皮脂產生之用途、以及降低皮膚毛孔尺寸及/或皮脂產生的方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0699078B1 (en) | 1993-05-14 | 2005-01-05 | Stephen S. Arnon | A method to prevent side effects and insensitivity to the therapeutic uses of toxins |
CA2164626C (en) * | 1993-06-10 | 2004-11-23 | K. Roger Aoki | Multiple botulinum toxins for treating neuromuscular disorders and conditions |
EP0737074B1 (en) | 1993-12-28 | 2001-08-01 | Allergan Sales, Inc. | Botulinum toxins for treating hyperhydrosis |
US5766605A (en) * | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
DK0758900T3 (da) | 1994-05-09 | 2002-07-29 | William J Binder | Botulinumtoksin til reduktion af migræne-hovedpinesmerter |
AU2907695A (en) | 1994-08-08 | 1996-03-07 | Wisconsin Alumni Research Foundation | Purification and pharmaceutical compositions containing type g botulinum neurotoxin |
US5512547A (en) * | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
US5756468A (en) | 1994-10-13 | 1998-05-26 | Wisconsin Alumni Research Foundation | Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation |
DK0773788T3 (da) * | 1995-06-06 | 2003-09-01 | Allergan Inc | Forbedrede præparater og fremgangsmåder til kemodenervering under anvendelse af neurotoxiner |
US5939070A (en) * | 1996-10-28 | 1999-08-17 | Wisconsin Alumni Research Foundation | Hybrid botulinal neurotoxins |
PT1011695E (pt) * | 1997-07-15 | 2006-07-31 | Univ Colorado | Utilizacao de terapia com neurotoxina para tratamento de doencas da prostata |
TW574036B (en) * | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
DE19856897A1 (de) * | 1998-12-10 | 2000-06-15 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum zur Unterdrückung von Schnarchgeräuschen |
DE19925739A1 (de) | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
US6358917B1 (en) * | 1999-08-24 | 2002-03-19 | Jean D. A. Carruthers | Cosmetic use of botulinum toxin for treatment of downturned mouth |
US6787517B1 (en) * | 2000-12-29 | 2004-09-07 | Allergan, Inc. | Agent and methods for treating pain |
DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
AU2010267963B2 (en) * | 2009-07-02 | 2015-09-24 | Merz Pharma Gmbh & Co. Kgaa | Neurotoxins exhibiting shortened biological activity |
-
1999
- 1999-06-07 DE DE19925739A patent/DE19925739A1/de not_active Withdrawn
-
2000
- 2000-05-26 DE DE10081516T patent/DE10081516D2/de not_active Ceased
- 2000-05-26 EA EA200200017A patent/EA004202B1/ru not_active IP Right Cessation
- 2000-05-26 KR KR10-2001-7015668A patent/KR100466407B1/ko not_active IP Right Cessation
- 2000-05-26 US US10/018,373 patent/US7964199B1/en not_active Expired - Lifetime
- 2000-05-26 WO PCT/DE2000/001777 patent/WO2000074703A2/de active IP Right Grant
- 2000-05-26 JP JP2001501237A patent/JP2003505343A/ja active Pending
- 2000-05-26 GE GEAP20006278A patent/GEP20043200B/en unknown
- 2000-05-26 AU AU58047/00A patent/AU774590B2/en not_active Ceased
- 2000-05-26 ES ES00943666T patent/ES2215056T5/es not_active Expired - Lifetime
- 2000-05-26 HU HU0201530A patent/HUP0201530A3/hu unknown
- 2000-05-26 EP EP00943666A patent/EP1185291B2/de not_active Expired - Lifetime
- 2000-05-26 UA UA2002010181A patent/UA72253C2/uk unknown
- 2000-05-26 CN CNA2007101102394A patent/CN101062009A/zh active Pending
- 2000-05-26 MX MXPA01012540A patent/MXPA01012540A/es active IP Right Grant
- 2000-05-26 CA CA002376193A patent/CA2376193C/en not_active Expired - Fee Related
- 2000-05-26 PL PL352468A patent/PL198958B1/pl not_active IP Right Cessation
- 2000-05-26 DK DK00943666T patent/DK1185291T3/da active
- 2000-05-26 AT AT00943666T patent/ATE258803T1/de active
- 2000-05-26 PT PT00943666T patent/PT1185291E/pt unknown
- 2000-05-26 CN CNB008086419A patent/CN100389820C/zh not_active Expired - Fee Related
- 2000-05-26 DE DE50005208T patent/DE50005208D1/de not_active Expired - Lifetime
- 2000-05-26 CZ CZ20014351A patent/CZ20014351A3/cs unknown
- 2000-05-26 IL IL14697400A patent/IL146974A0/xx active IP Right Grant
- 2000-06-07 AR ARP000102818A patent/AR024306A1/es unknown
- 2000-06-07 CO CO00042309A patent/CO5170431A1/es not_active Application Discontinuation
- 2000-08-24 TW TW089111212A patent/TWI251492B/zh not_active IP Right Cessation
-
2001
- 2001-12-06 ZA ZA200110074A patent/ZA200110074B/xx unknown
- 2001-12-06 NO NO20015964A patent/NO20015964L/no unknown
- 2001-12-06 IL IL146974A patent/IL146974A/en not_active IP Right Cessation
-
2002
- 2002-12-06 HK HK02108892.0A patent/HK1047403A1/xx not_active IP Right Cessation
-
2007
- 2007-05-16 JP JP2007130686A patent/JP2007238627A/ja not_active Withdrawn
-
2011
- 2011-05-11 US US13/068,439 patent/US20110217287A1/en not_active Abandoned
- 2011-11-23 US US13/303,973 patent/US8398998B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR024306A1 (es) | Preparacion farmaceutica que contiene una neurotoxina botulinica. | |
CY1108007T1 (el) | Φαρμακευτικες συνθεσεις βοτουλινικης τοξινης | |
ES2068202T3 (es) | Composicion liquida suavizante para prendas de ropa. | |
AR020934A1 (es) | Compuestos trombopoyeticos | |
EA200000449A1 (ru) | Модифицированные витамины к-зависимые полипептиды | |
NO20022998D0 (no) | Farmasöytiske preparater som tilveiebringer foröket konsentrasjon av medikament | |
EA199800946A1 (ru) | Концентрированный препарат антител | |
ATE240747T1 (de) | Galaktose-bindende lektine konjugate mit clostridiale neurotoxine ,wie analgetika | |
CY1105465T1 (el) | Μορφη δοσολογιας πepιλαμβανουσα υγρο σκευασμα | |
DE68911780T2 (de) | Nicht-reziproke optische Anordnung. | |
DE59009451D1 (de) | Colestyramin als lipidsenker enthaltende präparate. | |
DE69616936D1 (de) | Stabile, gelatinüberzogene Aspirintabletten | |
DE69828038D1 (de) | Lipidkomplexe von sehr unlöslichen platinkomplexen | |
ES2194003T3 (es) | Huperzina a racemica. | |
BR0109846A (pt) | Uso de uma composição que compreende um anticorpo ou um fragmento de ligação de antìgeno deste, e conjunto | |
BR9509172A (pt) | Proteina de via de complemento nativa sequéncia de dna construção de dna conjugado uso de uma proteína processo para reduzir proteina de via de complemento em um mamifero e formulação farmacéutica | |
DE68918847T2 (de) | Stabile pharmazeutische zusammensetzung. | |
TR200100455T2 (tr) | Nimesulid içeren topikal farmasötik bileşimler | |
ATE131066T1 (de) | Mittel zur hemmung von hiv-proteasen. | |
DE60132609D1 (de) | Optischer isolator mit niedrigen einfügeverlusten | |
DK258889A (da) | Farmaceutisk praeparat indeholdende en ace-inhibitor og en kaliumkanalmodulator, dets fremstilling og anvendelse | |
AR009819A1 (es) | Inhibidores de la proteasa proteinicos estabilizados y sus variantes | |
ATE401084T1 (de) | Torasemid enthaltende lagerstabile pharmazeutische zubereitungen | |
PT952975E (pt) | Compostos bi-aromaticos ligados por um radical hetero-etinileno e composicoes farmaceuticas e cosmeticas que os contem | |
DK1343896T3 (da) | Lille syreoplöseligt sporeprotein og anvendelser deraf |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |