ATE240747T1 - Galaktose-bindende lektine konjugate mit clostridiale neurotoxine ,wie analgetika - Google Patents

Galaktose-bindende lektine konjugate mit clostridiale neurotoxine ,wie analgetika

Info

Publication number
ATE240747T1
ATE240747T1 AT98946571T AT98946571T ATE240747T1 AT E240747 T1 ATE240747 T1 AT E240747T1 AT 98946571 T AT98946571 T AT 98946571T AT 98946571 T AT98946571 T AT 98946571T AT E240747 T1 ATE240747 T1 AT E240747T1
Authority
AT
Austria
Prior art keywords
galactose
pain
agents
analgesics
conjugates
Prior art date
Application number
AT98946571T
Other languages
English (en)
Inventor
Michael John Duggan
John Andrew Chaddock
Original Assignee
Speywood Lab Ltd
Microbiological Res Authority
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speywood Lab Ltd, Microbiological Res Authority filed Critical Speywood Lab Ltd
Application granted granted Critical
Publication of ATE240747T1 publication Critical patent/ATE240747T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT98946571T 1997-10-08 1998-10-07 Galaktose-bindende lektine konjugate mit clostridiale neurotoxine ,wie analgetika ATE240747T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9721189.0A GB9721189D0 (en) 1997-10-08 1997-10-08 Analgesic conjugates
PCT/GB1998/003001 WO1999017806A1 (en) 1997-10-08 1998-10-07 Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics

Publications (1)

Publication Number Publication Date
ATE240747T1 true ATE240747T1 (de) 2003-06-15

Family

ID=10820129

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98946571T ATE240747T1 (de) 1997-10-08 1998-10-07 Galaktose-bindende lektine konjugate mit clostridiale neurotoxine ,wie analgetika

Country Status (13)

Country Link
US (2) US7052702B1 (de)
EP (1) EP0996468B1 (de)
JP (1) JP4629225B2 (de)
AT (1) ATE240747T1 (de)
AU (1) AU741456B2 (de)
CA (1) CA2306350C (de)
DE (1) DE69814858T2 (de)
DK (1) DK0996468T3 (de)
ES (1) ES2198750T3 (de)
GB (1) GB9721189D0 (de)
PT (1) PT996468E (de)
WO (1) WO1999017806A1 (de)
ZA (1) ZA989138B (de)

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Also Published As

Publication number Publication date
US7052702B1 (en) 2006-05-30
DE69814858D1 (de) 2003-06-26
PT996468E (pt) 2003-09-30
US20060121056A1 (en) 2006-06-08
GB9721189D0 (en) 1997-12-03
DE69814858T2 (de) 2004-03-11
CA2306350A1 (en) 1999-04-15
JP2001518522A (ja) 2001-10-16
EP0996468B1 (de) 2003-05-21
US7452543B2 (en) 2008-11-18
DK0996468T3 (da) 2003-09-15
JP4629225B2 (ja) 2011-02-09
EP0996468A1 (de) 2000-05-03
ES2198750T3 (es) 2004-02-01
ZA989138B (en) 1999-05-27
AU741456B2 (en) 2001-11-29
AU9357498A (en) 1999-04-27
WO1999017806A1 (en) 1999-04-15
CA2306350C (en) 2008-09-02

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