JP2014520809A5 - - Google Patents
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- Publication number
- JP2014520809A5 JP2014520809A5 JP2014519122A JP2014519122A JP2014520809A5 JP 2014520809 A5 JP2014520809 A5 JP 2014520809A5 JP 2014519122 A JP2014519122 A JP 2014519122A JP 2014519122 A JP2014519122 A JP 2014519122A JP 2014520809 A5 JP2014520809 A5 JP 2014520809A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- optionally substituted
- stereoisomers
- acceptable salt
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000001257 hydrogen Substances 0.000 claims description 74
- 229910052739 hydrogen Inorganic materials 0.000 claims description 74
- 150000001875 compounds Chemical class 0.000 claims description 59
- 239000000203 mixture Substances 0.000 claims description 52
- 150000003839 salts Chemical class 0.000 claims description 46
- 125000000217 alkyl group Chemical group 0.000 claims description 43
- 150000002431 hydrogen Chemical class 0.000 claims description 41
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 33
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
- 125000001153 fluoro group Chemical group F* 0.000 claims description 18
- 125000005843 halogen group Chemical group 0.000 claims description 18
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 11
- 241000124008 Mammalia Species 0.000 claims description 10
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 10
- 125000000623 heterocyclic group Chemical group 0.000 claims description 8
- 125000005415 substituted alkoxy group Chemical group 0.000 claims description 8
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 8
- 125000003107 substituted aryl group Chemical group 0.000 claims description 8
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 8
- 229960003638 dopamine Drugs 0.000 claims description 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 4
- 125000004442 acylamino group Chemical group 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 4
- 150000001768 cations Chemical class 0.000 claims description 4
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
- 125000004426 substituted alkynyl group Chemical group 0.000 claims description 4
- 206010012335 Dependence Diseases 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 229940002612 prodrug Drugs 0.000 claims description 3
- 239000000651 prodrug Substances 0.000 claims description 3
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 2
- LHRZBKAEDZUYNC-UHFFFAOYSA-N 2,6-dichloro-4-(2-methoxyethoxy)-n-[[4-(2-oxo-1h-pyridin-4-yl)phenyl]methyl]benzamide Chemical compound ClC1=CC(OCCOC)=CC(Cl)=C1C(=O)NCC1=CC=C(C2=CC(=O)NC=C2)C=C1 LHRZBKAEDZUYNC-UHFFFAOYSA-N 0.000 claims description 2
- CDCUWQFSGRLNTF-UHFFFAOYSA-N 2,6-dichloro-n-[[3-methyl-4-(2-oxo-1h-pyridin-4-yl)phenyl]methyl]benzamide Chemical compound C=1C=C(C2=CC(=O)NC=C2)C(C)=CC=1CNC(=O)C1=C(Cl)C=CC=C1Cl CDCUWQFSGRLNTF-UHFFFAOYSA-N 0.000 claims description 2
- LWYWZWJVXJWUFS-UHFFFAOYSA-N 2,6-dichloro-n-[[4-(2-methyl-6-oxo-1h-pyridin-4-yl)phenyl]methyl]benzamide Chemical compound O=C1NC(C)=CC(C=2C=CC(CNC(=O)C=3C(=CC=CC=3Cl)Cl)=CC=2)=C1 LWYWZWJVXJWUFS-UHFFFAOYSA-N 0.000 claims description 2
- MROYYAOBHCNTQW-UHFFFAOYSA-N 2,6-dichloro-n-[[4-(2-oxo-1h-pyridin-4-yl)phenyl]methyl]benzamide Chemical compound ClC1=CC=CC(Cl)=C1C(=O)NCC1=CC=C(C2=CC(=O)NC=C2)C=C1 MROYYAOBHCNTQW-UHFFFAOYSA-N 0.000 claims description 2
- ZTQCTWHLFXVYGO-UHFFFAOYSA-N 2,6-dimethyl-n-[[4-(2-oxo-1h-pyridin-4-yl)phenyl]methyl]benzamide Chemical compound CC1=CC=CC(C)=C1C(=O)NCC1=CC=C(C2=CC(=O)NC=C2)C=C1 ZTQCTWHLFXVYGO-UHFFFAOYSA-N 0.000 claims description 2
- ARCMHOCAICWNFM-UHFFFAOYSA-N 2,6-dimethyl-n-[[4-(2-oxopiperidin-4-yl)phenyl]methyl]benzamide Chemical compound CC1=CC=CC(C)=C1C(=O)NCC1=CC=C(C2CC(=O)NCC2)C=C1 ARCMHOCAICWNFM-UHFFFAOYSA-N 0.000 claims description 2
- SFVKNPJMMRPOCO-UHFFFAOYSA-N 2-chloro-3,6-difluoro-n-[[4-(2-oxo-1h-pyridin-4-yl)phenyl]methyl]benzamide Chemical compound FC1=CC=C(F)C(C(=O)NCC=2C=CC(=CC=2)C2=CC(=O)NC=C2)=C1Cl SFVKNPJMMRPOCO-UHFFFAOYSA-N 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 239000008896 Opium Substances 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 229960003920 cocaine Drugs 0.000 claims description 2
- 206010013663 drug dependence Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229960002715 nicotine Drugs 0.000 claims description 2
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 229960001027 opium Drugs 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 208000011117 substance-related disease Diseases 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- -1 4- {4-[(2,6 -Dichloro-benzoylamino) -methyl] -phenyl} -2-oxo-2H-pyridin-1-ylmethyl Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- SPADNYVJQZNTKZ-UHFFFAOYSA-N [4-[4-[[(2,6-dichlorobenzoyl)amino]methyl]phenyl]-2-oxopyridin-1-yl]methyl dihydrogen phosphate Chemical compound O=C1N(COP(O)(=O)O)C=CC(C=2C=CC(CNC(=O)C=3C(=CC=CC=3Cl)Cl)=CC=2)=C1 SPADNYVJQZNTKZ-UHFFFAOYSA-N 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161503923P | 2011-07-01 | 2011-07-01 | |
| US61/503,923 | 2011-07-01 | ||
| PCT/US2012/044809 WO2013006400A1 (en) | 2011-07-01 | 2012-06-29 | Compounds for the treatment of addiction |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014520809A JP2014520809A (ja) | 2014-08-25 |
| JP2014520809A5 true JP2014520809A5 (enExample) | 2015-07-23 |
| JP5943998B2 JP5943998B2 (ja) | 2016-07-05 |
Family
ID=46513858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519122A Expired - Fee Related JP5943998B2 (ja) | 2011-07-01 | 2012-06-29 | 嗜癖の処置のための化合物 |
Country Status (32)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| SI2707361T1 (sl) | 2011-05-10 | 2017-12-29 | Gilead Sciences, Inc. | Zlite heterociklične spojine kot modulatorji natrijevega kanala |
| TWI549944B (zh) | 2011-07-01 | 2016-09-21 | 吉李德科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (enExample) | 2011-07-01 | 2018-04-28 | ||
| TWI567061B (zh) | 2011-07-01 | 2017-01-21 | 吉李德科學股份有限公司 | 用於治療成癮之化合物 |
| CN105358531B (zh) * | 2013-03-14 | 2017-11-14 | 利兰-斯坦福大学初级学院的董事会 | 线粒体醛脱氢酶‑2调节剂和其使用方法 |
| EP3459958B1 (en) * | 2013-12-13 | 2024-08-07 | Vertex Pharmaceuticals Incorporated | Process and intermediates for preparing prodrugs of pyridone amides useful as modulators of sodium channels |
| US10077669B2 (en) | 2014-11-26 | 2018-09-18 | United Technologies Corporation | Non-metallic engine case inlet compression seal for a gas turbine engine |
| US10289971B2 (en) | 2015-02-13 | 2019-05-14 | Atlassian Pty Ltd | Issue and trigger rebalancing in a ranked issue management system |
| LT3500572T (lt) * | 2016-08-19 | 2023-02-10 | The University Of Bristol | Citizino dariniai, skirti priklausomybių gydymui |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| KR20200070273A (ko) * | 2017-10-16 | 2020-06-17 | 아미그달라 뉴로사이언시즈, 인크. | 중독을 예방하기 위한 병용 요법 |
| TWI796596B (zh) | 2018-02-13 | 2023-03-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| EP4029868A1 (en) | 2018-05-14 | 2022-07-20 | Gilead Sciences, Inc. | Mcl-1 inhibitors |
| MX2021000100A (es) | 2018-07-13 | 2021-03-25 | Gilead Sciences Inc | Inhibidores de muerte programada-1 (pd-1)/ ligando de muerte programada 1 (pd-l1). |
| EP3829562A1 (en) * | 2018-07-27 | 2021-06-09 | Amygdala Neurosciences, Inc. | Combination therapy for nicotine addiction |
| EP3863424A4 (en) * | 2018-10-12 | 2022-08-03 | Amygdala Neurosciences, Inc. | ADDICTION TREATMENT OF AN ALCOHOLIC PATIENT POPULATION |
| JP7158577B2 (ja) | 2018-10-24 | 2022-10-21 | ギリアード サイエンシーズ， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１阻害剤 |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| AU2023292243A1 (en) | 2022-06-14 | 2025-03-06 | Amygdala Neurosciences, Inc. | Aldh-2 inhibitor compounds and methods of use |
| JP2025520426A (ja) | 2022-06-14 | 2025-07-03 | アミグダラ ニューロサイエンシーズ， インコーポレイテッド | Ａｌｄｈ－２阻害化合物及び使用方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| US5204369A (en) | 1991-07-01 | 1993-04-20 | The Endowment For Research In Human Biology | Method for the inhibition of aldh-i useful in the treatment of alcohol dependence or alcohol abuse |
| WO1999058124A1 (en) | 1998-05-12 | 1999-11-18 | The Endowment For Research In Human Biology, Inc. | Methods and assays useful in the treatment of alcohol dependence or alcohol abuse |
| KR20060011785A (ko) | 2002-06-27 | 2006-02-03 | 디 인다우먼트 포 리써치 인 휴먼 바이올로지, 인크. | Ａｌｄｈ 억제에 유용한 화합물 |
| JP2004182657A (ja) * | 2002-12-04 | 2004-07-02 | Eisai Co Ltd | Ｈｄｌレベル上昇促進剤 |
| US20080004260A1 (en) * | 2006-06-29 | 2008-01-03 | Transcept Pharmaceuticals, Inc. | Compositions of 5-HT3 antagonists and dopamine D2 antagonists for treatment of dopamine-associated chronic conditions |
| MX2008015765A (es) | 2006-07-27 | 2009-03-26 | Cv Therapeutics Inc | Inhibidores de aldh-2 en el tratamiento de adiccion. |
| US20080207610A1 (en) | 2006-07-27 | 2008-08-28 | Jeff Zablocki | Aldh-2 inhibitors in the treatment of addiction |
| US8158810B2 (en) | 2006-07-27 | 2012-04-17 | Gilead Sciences, Inc. | ALDH-2 inhibitors in the treatment of addiction |
| US20110105602A2 (en) | 2007-03-08 | 2011-05-05 | Daria Mochly-Rosen | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof |
| BRPI0822129A2 (pt) | 2008-01-24 | 2015-06-23 | Gilead Palo Alto Inc | Inibidores de aldh-2c no tratamento de vício. |
| KR20110002492A (ko) | 2008-05-01 | 2011-01-07 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| CN102209541B (zh) | 2008-09-08 | 2016-05-18 | 小利兰·斯坦福大学托管委员会 | 醛脱氢酶活性调节剂和其使用方法 |
| US8389522B2 (en) * | 2008-10-28 | 2013-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase and methods of use thereof |
| UY33469A (es) * | 2010-06-29 | 2012-01-31 | Irm Llc Y Novartis Ag | Composiciones y metodos para modular la via de señalizacion de wnt |
| TWI567061B (zh) * | 2011-07-01 | 2017-01-21 | 吉李德科學股份有限公司 | 用於治療成癮之化合物 |
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2012
- 2012-06-26 TW TW101122794A patent/TWI567061B/zh not_active IP Right Cessation
- 2012-06-27 UY UY0001034165A patent/UY34165A/es not_active Application Discontinuation
- 2012-06-28 AR ARP120102331A patent/AR086792A1/es not_active Application Discontinuation
- 2012-06-29 SI SI201230340T patent/SI2726460T1/sl unknown
- 2012-06-29 PT PT127353944T patent/PT2726460E/pt unknown
- 2012-06-29 KR KR1020147002302A patent/KR101664915B1/ko not_active Expired - Fee Related
- 2012-06-29 BR BR112014000033A patent/BR112014000033A2/pt active Search and Examination
- 2012-06-29 EP EP12735394.4A patent/EP2726460B1/en active Active
- 2012-06-29 MD MDA20140009A patent/MD4436B1/ro not_active IP Right Cessation
- 2012-06-29 EP EP15184883.5A patent/EP2993170B1/en active Active
- 2012-06-29 PE PE2013002811A patent/PE20141067A1/es not_active Application Discontinuation
- 2012-06-29 PH PH1/2013/502674A patent/PH12013502674A1/en unknown
- 2012-06-29 PL PL12735394T patent/PL2726460T3/pl unknown
- 2012-06-29 WO PCT/US2012/044809 patent/WO2013006400A1/en not_active Ceased
- 2012-06-29 AU AU2012279332A patent/AU2012279332B2/en not_active Ceased
- 2012-06-29 JP JP2014519122A patent/JP5943998B2/ja not_active Expired - Fee Related
- 2012-06-29 CN CN201280032944.6A patent/CN103635460B/zh not_active Expired - Fee Related
- 2012-06-29 US US13/537,536 patent/US8558001B2/en active Active
- 2012-06-29 UA UAA201314148A patent/UA109199C2/ru unknown
- 2012-06-29 DK DK15184883.5T patent/DK2993170T3/da active
- 2012-06-29 ES ES15184883.5T patent/ES2656716T3/es active Active
- 2012-06-29 CA CA2840763A patent/CA2840763C/en active Active
- 2012-06-29 MX MX2013014938A patent/MX337611B/es active IP Right Grant
- 2012-06-29 KR KR1020167023967A patent/KR20160106207A/ko not_active Withdrawn
- 2012-06-29 EA EA201391635A patent/EA025573B1/ru not_active IP Right Cessation
- 2012-06-29 ES ES12735394.4T patent/ES2553829T3/es active Active
- 2012-06-29 AP AP2013007282A patent/AP3544A/xx active
- 2012-06-29 SG SG10201605355RA patent/SG10201605355RA/en unknown
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2013
- 2013-03-08 US US13/791,422 patent/US8575353B2/en active Active
- 2013-08-13 US US13/966,029 patent/US9000015B2/en active Active
- 2013-11-28 ZA ZA2013/08977A patent/ZA201308977B/en unknown
- 2013-12-13 CR CR20130659A patent/CR20130659A/es unknown
- 2013-12-16 CL CL2013003597A patent/CL2013003597A1/es unknown
- 2013-12-18 CO CO13295408A patent/CO6821964A2/es active IP Right Grant
- 2013-12-18 EC ECSP13013087 patent/ECSP13013087A/es unknown
- 2013-12-30 MA MA36629A patent/MA35404B1/fr unknown
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2014
- 2014-01-26 IL IL230657A patent/IL230657B/en active IP Right Grant
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2015
- 2015-03-16 US US14/659,042 patent/US9610299B2/en not_active Expired - Fee Related
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2017
- 2017-03-31 US US15/476,569 patent/US9987295B2/en active Active
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2018
- 2018-05-08 US US15/974,171 patent/US10507215B2/en not_active Expired - Fee Related