CU24360B1 - Derivados de ácido heteroaril butanoico como inhibidores de lta4h - Google Patents

Derivados de ácido heteroaril butanoico como inhibidores de lta4h

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Publication number
CU24360B1
CU24360B1 CU2016000093A CU20160093A CU24360B1 CU 24360 B1 CU24360 B1 CU 24360B1 CU 2016000093 A CU2016000093 A CU 2016000093A CU 20160093 A CU20160093 A CU 20160093A CU 24360 B1 CU24360 B1 CU 24360B1
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CU
Cuba
Prior art keywords
lta4h
derivatives
acid
heteroaril
butanoic
Prior art date
Application number
CU2016000093A
Other languages
English (en)
Inventor
Birgit Bollbuck
Christian Markert
Wolfgang Miltz
Till Roehn
Original Assignee
Novartis Ag
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Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU24360B1 publication Critical patent/CU24360B1/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención describe derivados novedosos de ácido heteroaril butanoico que son buenos candidatos a fármacos especialmente, en relación con la leucotrieno A4 hidrolasa (LTA4H). La presente invención también se relaciona con composiciones farmacéuticas que comprenden dichos derivados novedosos de ácido heteroaril butanoico, métodos de uso de dichos compuestos en el tratamiento de varias enfermedades y trastomos y procesos para la preparación de tales compuestos novedosos.</p>
CU2016000093A 2013-12-20 2014-12-18 Derivados de ácido heteroaril butanoico como inhibidores de lta4h CU24360B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13199138 2013-12-20
EP14181155 2014-08-15
PCT/IB2014/067086 WO2015092740A1 (en) 2013-12-20 2014-12-18 Heteroaryl butanoic acid derivatives as lta4h inhibitors

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CU24360B1 true CU24360B1 (es) 2018-10-04

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EP (1) EP3083564B1 (es)
JP (1) JP6500024B2 (es)
KR (2) KR102368958B1 (es)
CN (1) CN105829286B (es)
AP (1) AP2016009301A0 (es)
AU (1) AU2014369180B2 (es)
BR (1) BR112016011170B1 (es)
CA (1) CA2927564C (es)
CL (1) CL2016001255A1 (es)
CR (1) CR20160279A (es)
CU (1) CU24360B1 (es)
CY (1) CY1120715T1 (es)
DK (1) DK3083564T3 (es)
EA (1) EA034436B1 (es)
EC (1) ECSP16062173A (es)
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GT (1) GT201600132A (es)
HR (1) HRP20181506T1 (es)
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PL (1) PL3083564T3 (es)
PT (1) PT3083564T (es)
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SG (1) SG11201602787YA (es)
SI (1) SI3083564T1 (es)
SV (1) SV2016005230A (es)
TN (1) TN2016000127A1 (es)
UA (1) UA117498C2 (es)
UY (1) UY36178A (es)
WO (1) WO2015092740A1 (es)
ZA (1) ZA201602445B (es)

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KR102368958B1 (ko) 2013-12-20 2022-02-28 노파르티스 아게 Lta4h 억제제로서의 헤테로아릴 부탄산 유도체
WO2017175185A1 (en) 2016-04-08 2017-10-12 Novartis Ag Heteroaryl butanoic acid derivatives as lta4h inhibitors
US11426399B2 (en) 2018-05-15 2022-08-30 Alkahest, Inc. Treatment of aging-associated disease with modulators of leukotriene A4 hydrolase
CN112424207B (zh) 2018-07-25 2024-03-19 诺华股份有限公司 Nlrp3炎性小体抑制剂
CA3105542A1 (en) * 2018-07-31 2020-02-06 Novartis Ag Crystalline forms of a lta4h inhibitor
KR102841441B1 (ko) 2018-11-07 2025-07-31 추가이 세이야쿠 가부시키가이샤 O-치환 세린 유도체의 제조 방법
KR102630669B1 (ko) * 2019-01-11 2024-01-30 노파르티스 아게 화농성 한선염 치료를 위한 lta4h 억제제
US10610280B1 (en) 2019-02-02 2020-04-07 Ayad K. M. Agha Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat
UY38687A (es) 2019-05-17 2023-05-15 Novartis Ag Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso
TW202122078A (zh) 2019-09-06 2021-06-16 瑞士商諾華公司 使用lta4h抑制劑治療肝臟疾病之方法
EP4196478A1 (en) 2020-08-14 2023-06-21 Novartis AG Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof
US11932630B2 (en) * 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
AU2022376563A1 (en) 2021-11-01 2023-12-07 Alkahest, Inc. Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases
UY40374A (es) 2022-08-03 2024-02-15 Novartis Ag Inhibidores de inflamasoma nlrp3

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