MX2016008247A - Derivados de acido heteroaril butanoico como inhibidores de lta4h. - Google Patents
Derivados de acido heteroaril butanoico como inhibidores de lta4h.Info
- Publication number
- MX2016008247A MX2016008247A MX2016008247A MX2016008247A MX2016008247A MX 2016008247 A MX2016008247 A MX 2016008247A MX 2016008247 A MX2016008247 A MX 2016008247A MX 2016008247 A MX2016008247 A MX 2016008247A MX 2016008247 A MX2016008247 A MX 2016008247A
- Authority
- MX
- Mexico
- Prior art keywords
- acid derivatives
- butanoic acid
- heteroaryl butanoic
- lta4h
- lta4h inhibitors
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C—CHEMISTRY; METALLURGY
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención describe derivados novedosos de ácido heteroaril butanóico que son buenos candidatos a fármacos especialmente, en relación con la leucotrieno A4 hidrolasa (LTA4H). La presente invención también se relaciona con composiciones farmacéuticas que comprenden dichos derivados novedosos de ácido heteroaril butanóico, métodos de uso de dichos compuestos en el tratamiento de varias enfermedades y trastornos y procesos para la preparación de tales compuestos novedosos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13199138 | 2013-12-20 | ||
EP14181155 | 2014-08-15 | ||
PCT/IB2014/067086 WO2015092740A1 (en) | 2013-12-20 | 2014-12-18 | Heteroaryl butanoic acid derivatives as lta4h inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016008247A true MX2016008247A (es) | 2016-10-21 |
Family
ID=52434892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016008247A MX2016008247A (es) | 2013-12-20 | 2014-12-18 | Derivados de acido heteroaril butanoico como inhibidores de lta4h. |
Country Status (38)
Country | Link |
---|---|
US (4) | US9981926B2 (es) |
EP (1) | EP3083564B1 (es) |
JP (1) | JP6500024B2 (es) |
KR (2) | KR102368958B1 (es) |
CN (1) | CN105829286B (es) |
AP (1) | AP2016009301A0 (es) |
AU (1) | AU2014369180B2 (es) |
BR (1) | BR112016011170B1 (es) |
CA (1) | CA2927564C (es) |
CL (1) | CL2016001255A1 (es) |
CR (1) | CR20160279A (es) |
CU (1) | CU24360B1 (es) |
CY (1) | CY1120715T1 (es) |
DK (1) | DK3083564T3 (es) |
EA (1) | EA034436B1 (es) |
EC (1) | ECSP16062173A (es) |
ES (1) | ES2690790T3 (es) |
GT (1) | GT201600132A (es) |
HR (1) | HRP20181506T1 (es) |
HU (1) | HUE039615T2 (es) |
IL (1) | IL245011B (es) |
LT (1) | LT3083564T (es) |
MX (1) | MX2016008247A (es) |
MY (1) | MY180165A (es) |
NZ (1) | NZ719169A (es) |
PE (1) | PE20160899A1 (es) |
PH (1) | PH12016500814A1 (es) |
PL (1) | PL3083564T3 (es) |
PT (1) | PT3083564T (es) |
RS (1) | RS57642B1 (es) |
SG (1) | SG11201602787YA (es) |
SI (1) | SI3083564T1 (es) |
SV (1) | SV2016005230A (es) |
TN (1) | TN2016000127A1 (es) |
UA (1) | UA117498C2 (es) |
UY (1) | UY36178A (es) |
WO (1) | WO2015092740A1 (es) |
ZA (1) | ZA201602445B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017175185A1 (en) | 2016-04-08 | 2017-10-12 | Novartis Ag | Heteroaryl butanoic acid derivatives as lta4h inhibitors |
CN112469439A (zh) | 2018-05-15 | 2021-03-09 | 万能溶剂有限公司 | 用白三烯a4水解酶调节剂治疗衰老相关性疾病 |
MA53388A (fr) | 2018-07-25 | 2021-06-02 | Novartis Ag | Inhibiteurs d'inflammasome nlrp3 |
TWI810338B (zh) * | 2018-07-31 | 2023-08-01 | 瑞士商諾華公司 | Lta4h抑制劑的晶型 |
EP3878836A4 (en) * | 2018-11-07 | 2022-08-10 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR THE PREPARATION OF O-SUBSTITUTED SERIN DERIVATIVES |
MX2021008303A (es) | 2019-01-11 | 2021-10-13 | Novartis Ag | Inhibidores de lta4h para el tratamiento de la hidradenitis supurativa. |
US10610280B1 (en) | 2019-02-02 | 2020-04-07 | Ayad K. M. Agha | Surgical method and apparatus for destruction and removal of intraperitoneal, visceral, and subcutaneous fat |
AR119731A1 (es) | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
WO2021044351A1 (en) | 2019-09-06 | 2021-03-11 | Novartis Ag | Methods of treating liver disease using lta4h inhibitors |
BR112023002031A2 (pt) | 2020-08-14 | 2023-03-07 | Novartis Ag | Derivados de espiropiperidinila substituídos por heteroarila e usos farmacêuticos dos mesmos |
US11932630B2 (en) | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
US20240067627A1 (en) | 2022-08-03 | 2024-02-29 | Novartis Ag | Nlrp3 inflammasome inhibitors |
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ATE63553T1 (de) | 1986-08-21 | 1991-06-15 | Pfizer | Chinazolindione und pyridopyrimidindione. |
US5272167A (en) | 1986-12-10 | 1993-12-21 | Schering Corporation | Pharmaceutically active compounds |
US4851423A (en) | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
US5750532A (en) | 1986-12-10 | 1998-05-12 | Schering Corporation | Pharmaceutically active compounds |
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