|
US4605642A
(en)
*
|
1984-02-23 |
1986-08-12 |
The Salk Institute For Biological Studies |
CRF antagonists
|
|
US5063245A
(en)
*
|
1990-03-28 |
1991-11-05 |
Nova Pharmaceutical Corporation |
Corticotropin-releasing factor antagonism compounds
|
|
JPH09507746A
(ja)
*
|
1993-10-27 |
1997-08-12 |
アテナ ニューロサイエンシズ,インコーポレイティド |
Swedish変異を有するAPP対立遺伝子を含有するトランスジェニック動物
|
|
US5877399A
(en)
*
|
1994-01-27 |
1999-03-02 |
Johns Hopkins University |
Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
|
|
DE4419849A1
(de)
|
1994-06-07 |
1995-12-14 |
Hoechst Ag |
Isoindolinpigmente
|
|
EP0765327B1
(en)
|
1994-06-16 |
1999-07-21 |
Pfizer Inc. |
Pyrazolo and pyrrolopyridines
|
|
DE19516804A1
(de)
|
1995-05-08 |
1996-11-14 |
Hoechst Ag |
Isoindolinpigmente auf Basis von Aminochinoxalindionen
|
|
AU6383396A
(en)
*
|
1995-06-07 |
1996-12-30 |
Athena Neurosciences, Inc. |
Beta-secretase, antibodies to beta-secretase, and assays for detecting beta-secretase inhibition
|
|
US6211235B1
(en)
*
|
1996-11-22 |
2001-04-03 |
Elan Pharmaceuticals, Inc. |
Compounds for inhibiting β-amyloid peptide release and/or its synthesis
|
|
GB9701684D0
(en)
|
1997-01-28 |
1997-03-19 |
Smithkline Beecham Plc |
Novel compounds
|
|
WO1999011643A1
(en)
|
1997-09-02 |
1999-03-11 |
Du Pont Pharmaceuticals Company |
Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (crh) antagonists, useful for treating cns and stress-related disorders
|
|
US5981168A
(en)
*
|
1998-05-15 |
1999-11-09 |
The University Of British Columbia |
Method and composition for modulating amyloidosis
|
|
KR20070013361A
(ko)
|
1998-09-24 |
2007-01-30 |
파마시아 앤드 업존 캄파니 엘엘씨 |
알츠하이머병 세크레타제
|
|
US6245884B1
(en)
*
|
1998-10-16 |
2001-06-12 |
Vivian Y. H. Hook |
Secretases related to alzheimer's dementia
|
|
JP4653318B2
(ja)
|
1999-02-10 |
2011-03-16 |
エラン ファーマシューティカルズ,インコーポレイテッド |
βセクレターゼ酵素組成物および方法
|
|
WO2000058479A1
(en)
|
1999-03-26 |
2000-10-05 |
Amgen Inc. |
Beta secretase genes and polypeptides
|
|
JP2003502342A
(ja)
|
1999-06-15 |
2003-01-21 |
エラン ファーマスーティカルズ インコーポレイテッド |
ベータ−セクレターゼのスタチン誘導テトラペプチド阻害剤
|
|
CA2374346C
(en)
|
1999-06-28 |
2010-06-22 |
Jordan J. N. Tang |
Inhibitors of memapsin 2 and use thereof
|
|
ATE431419T1
(de)
|
1999-09-23 |
2009-05-15 |
Pharmacia & Upjohn Co Llc |
Alzheimer krankheit sekretase, app (amyloid vorlaüfer-protein) substrate dafür und verwendungen
|
|
GB9924957D0
(en)
|
1999-10-21 |
1999-12-22 |
Smithkline Beecham Plc |
Novel treatment
|
|
JP2004502665A
(ja)
|
2000-06-30 |
2004-01-29 |
イーラン ファーマスーティカルズ、インコーポレイテッド |
アルツハイマー病を治療する化合物
|
|
US6846813B2
(en)
|
2000-06-30 |
2005-01-25 |
Pharmacia & Upjohn Company |
Compounds to treat alzheimer's disease
|
|
PE20020276A1
(es)
|
2000-06-30 |
2002-04-06 |
Elan Pharm Inc |
COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
|
|
US6696488B2
(en)
|
2000-08-11 |
2004-02-24 |
The Brigham And Women's Hospital, Inc. |
(Hydroxyethyl)ureas as inhibitors of alzheimer's β-amyloid production
|
|
WO2002025276A1
(en)
|
2000-09-22 |
2002-03-28 |
Wyeth |
Crystal structure of bace and uses thereof
|
|
EP2335701B1
(en)
|
2003-12-15 |
2012-07-11 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
|
US7592348B2
(en)
|
2003-12-15 |
2009-09-22 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
|
CA2561267A1
(en)
|
2004-03-30 |
2005-10-20 |
Merck & Co., Inc. |
2-aminothiazole compounds useful as aspartyl protease inhibitors
|
|
JP2008502687A
(ja)
|
2004-06-14 |
2008-01-31 |
タケダ サン ディエゴ インコーポレイテッド |
キナーゼ阻害剤
|
|
ATE423121T1
(de)
|
2004-06-16 |
2009-03-15 |
Wyeth Corp |
Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitoren
|
|
ES2332659T3
(es)
*
|
2004-06-16 |
2010-02-10 |
Wyeth |
Derivados de amino-5,5-difenilimidazolona para la inhibicion de beta-secretasa.
|
|
TW200613272A
(en)
*
|
2004-08-13 |
2006-05-01 |
Astrazeneca Ab |
Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
|
|
JP2008513512A
(ja)
|
2004-09-21 |
2008-05-01 |
アサーシス, インク. |
Crth2受容体拮抗作用を示すインドール酢酸およびこれらの使用
|
|
US20090221579A1
(en)
|
2004-10-15 |
2009-09-03 |
Jeffrey Scott Albert |
Substituted Amino-Compounds and Uses Thereof
|
|
JP2008516946A
(ja)
|
2004-10-15 |
2008-05-22 |
アストラゼネカ・アクチエボラーグ |
置換されたアミノ−ピリミドンおよびそれらの使用
|
|
JP2008523139A
(ja)
|
2004-12-14 |
2008-07-03 |
アストラゼネカ・アクチエボラーグ |
置換アミノピリジン類及びその使用
|
|
CN101103034A
(zh)
*
|
2005-01-14 |
2008-01-09 |
惠氏公司 |
抑制β-分泌酶的氨基-咪唑酮
|
|
MX2007011234A
(es)
|
2005-03-14 |
2007-11-12 |
Transtech Pharma Inc |
Derivados de benzazol, composiciones y metodos de uso en la forma de inhibidores de b-secretasa.
|
|
JP2008543844A
(ja)
|
2005-06-14 |
2008-12-04 |
シェーリング コーポレイション |
アスパルチルプロテアーゼ阻害剤
|
|
AR054618A1
(es)
|
2005-06-14 |
2007-07-04 |
Schering Corp |
Compuestos de azetidina y su uso como inhibidores de proteasas
|
|
CA2610828A1
(en)
*
|
2005-06-14 |
2006-12-28 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors, preparation and use thereof
|
|
AR054510A1
(es)
|
2005-06-14 |
2007-06-27 |
Schering Corp |
Compuestos heterociclicos como inhibidores de aspartil proteasas y composiciones farmaceuticas que los comprenden.
|
|
CN101228163A
(zh)
|
2005-06-14 |
2008-07-23 |
先灵公司 |
天冬氨酰蛋白酶抑制剂
|
|
MX2007016185A
(es)
*
|
2005-06-14 |
2008-03-07 |
Schering Corp |
Inhibidores de aspartil proteasa heterociclicos macrociclicos.
|
|
EP1896448A1
(en)
*
|
2005-06-30 |
2008-03-12 |
Wyeth |
AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION
|
|
TW200738683A
(en)
*
|
2005-06-30 |
2007-10-16 |
Wyeth Corp |
Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
|
|
US8211904B2
(en)
|
2005-07-18 |
2012-07-03 |
Merck, Sharp & Dohme Corp. |
Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US7601751B2
(en)
*
|
2005-09-01 |
2009-10-13 |
Bristol-Myers Squibb Company |
Indole acetic acid acyl guanidines as β-secretase inhibitors
|
|
EP2612854B1
(en)
|
2005-10-25 |
2015-04-29 |
Shionogi&Co., Ltd. |
Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors
|
|
ATE478070T1
(de)
*
|
2005-10-27 |
2010-09-15 |
Schering Corp |
Heterozyklische aspartyl-proteasehemmer
|
|
EP1943246A1
(en)
*
|
2005-10-31 |
2008-07-16 |
Schering Corporation |
Aspartyl protease inhibitors
|
|
TW200804290A
(en)
|
2005-11-15 |
2008-01-16 |
Astrazeneca Ab |
Compounds and uses thereof
|
|
US20080318985A1
(en)
|
2005-11-15 |
2008-12-25 |
Astrazeneca Ab |
Novel 2-Aminopyrimidinone Or 2-Aminopyridinone Derivatives and Their Use
|
|
JP2009515949A
(ja)
|
2005-11-15 |
2009-04-16 |
アストラゼネカ・アクチエボラーグ |
新規な2−アミノピリミジノン誘導体およびそれらの使用
|
|
CN101360722A
(zh)
|
2005-11-15 |
2009-02-04 |
阿斯利康(瑞典)有限公司 |
新颖的2-氨基嘧啶衍生物及其用途
|
|
WO2007058601A1
(en)
|
2005-11-21 |
2007-05-24 |
Astrazeneca Ab |
Novel 2-amino-imidazole-4-one compounds and their use in the manufacture of a medicament to be used in the treatment of cognitive impairment, alzheimer’s disease, neurodegeneration and dementia
|
|
TW200734311A
(en)
|
2005-11-21 |
2007-09-16 |
Astrazeneca Ab |
New compounds
|
|
AR058381A1
(es)
|
2005-12-19 |
2008-01-30 |
Astrazeneca Ab |
Compuestos derivados de 2-aminopiridin-4-onas y una composicion farmaceutica
|
|
JP2009532464A
(ja)
|
2006-04-05 |
2009-09-10 |
アストラゼネカ・アクチエボラーグ |
2−アミノピリミジン−4−オン及びAβ−関連の病理を治療又は予防するためのその使用
|
|
TW200808751A
(en)
|
2006-04-13 |
2008-02-16 |
Astrazeneca Ab |
New compounds
|
|
EP2032542A2
(en)
|
2006-06-12 |
2009-03-11 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
|
TW200815443A
(en)
|
2006-06-14 |
2008-04-01 |
Astrazeneca Ab |
Novel compounds I
|
|
TW200808796A
(en)
|
2006-06-14 |
2008-02-16 |
Astrazeneca Ab |
New compounds III
|
|
TW200815447A
(en)
|
2006-06-14 |
2008-04-01 |
Astrazeneca Ab |
Novel compounds IV
|
|
TW200815449A
(en)
|
2006-06-14 |
2008-04-01 |
Astrazeneca Ab |
Novel compounds II
|
|
TW200815349A
(en)
*
|
2006-06-22 |
2008-04-01 |
Astrazeneca Ab |
New compounds
|
|
WO2008063114A1
(en)
|
2006-11-20 |
2008-05-29 |
Astrazeneca Ab |
Amino- imidazolones and their use as medicament for treating cognitive impairment alzheimer disease, neurodegeneration and dementia
|
|
TW200831484A
(en)
|
2006-12-20 |
2008-08-01 |
Astrazeneca Ab |
New compounds
|
|
TW200831091A
(en)
|
2006-12-20 |
2008-08-01 |
Astrazeneca Ab |
New compounds
|
|
WO2008076043A1
(en)
|
2006-12-20 |
2008-06-26 |
Astrazeneca Ab |
Novel 2-amino-5,5-diaryl-imidazol-4-ones
|
|
TW200902499A
(en)
*
|
2007-05-15 |
2009-01-16 |
Astrazeneca Ab |
New compounds
|
|
TW200902503A
(en)
|
2007-05-15 |
2009-01-16 |
Astrazeneca Ab |
New compounds
|
|
WO2009005470A1
(en)
*
|
2007-07-05 |
2009-01-08 |
Astrazeneca Ab |
Aryl and heteroaryl substituted isoindole derivatives as bace inhibitors
|
|
WO2009005471A1
(en)
|
2007-07-05 |
2009-01-08 |
Astrazeneca Ab |
Aryl and heteroaryl substituted isoindole derivatives as bace inhibitors
|
|
US20100125081A1
(en)
*
|
2008-11-14 |
2010-05-20 |
Astrazeneca Ab |
New compounds 574
|
|
US20100125087A1
(en)
*
|
2008-11-14 |
2010-05-20 |
Astrazeneca Ab |
New compounds 575
|
|
WO2011044185A2
(en)
|
2009-10-08 |
2011-04-14 |
Schering Corporation |
Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use
|
|
UA108363C2
(uk)
|
2009-10-08 |
2015-04-27 |
|
Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
|
|
WO2011044184A1
(en)
|
2009-10-08 |
2011-04-14 |
Schering Corporation |
Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use
|
|
WO2011044187A1
(en)
|
2009-10-08 |
2011-04-14 |
Schering Corporation |
Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|