ATE478070T1 - Heterozyklische aspartyl-proteasehemmer - Google Patents
Heterozyklische aspartyl-proteasehemmerInfo
- Publication number
- ATE478070T1 ATE478070T1 AT06817385T AT06817385T ATE478070T1 AT E478070 T1 ATE478070 T1 AT E478070T1 AT 06817385 T AT06817385 T AT 06817385T AT 06817385 T AT06817385 T AT 06817385T AT E478070 T1 ATE478070 T1 AT E478070T1
- Authority
- AT
- Austria
- Prior art keywords
- protease inhibitors
- aspartyl protease
- heterocyclic aspartyl
- heterocyclic
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73062205P | 2005-10-27 | 2005-10-27 | |
PCT/US2006/041716 WO2007050721A2 (en) | 2005-10-27 | 2006-10-25 | Heterocyclic aspartyl protease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE478070T1 true ATE478070T1 (de) | 2010-09-15 |
Family
ID=37873175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06817385T ATE478070T1 (de) | 2005-10-27 | 2006-10-25 | Heterozyklische aspartyl-proteasehemmer |
Country Status (13)
Country | Link |
---|---|
US (3) | US7763606B2 (de) |
EP (1) | EP1940828B1 (de) |
JP (1) | JP2009513656A (de) |
CN (1) | CN101296926A (de) |
AR (1) | AR057983A1 (de) |
AT (1) | ATE478070T1 (de) |
CA (1) | CA2626976A1 (de) |
DE (1) | DE602006016314D1 (de) |
ES (1) | ES2349433T3 (de) |
HK (1) | HK1119680A1 (de) |
PE (1) | PE20070531A1 (de) |
TW (1) | TW200803847A (de) |
WO (1) | WO2007050721A2 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
WO2006041405A1 (en) * | 2004-10-15 | 2006-04-20 | Astrazeneca Ab | Substituted amino-pyrimidones and uses thereof |
JP2008516945A (ja) * | 2004-10-15 | 2008-05-22 | アストラゼネカ・アクチエボラーグ | 置換されたアミノ化合物およびそれらの使用 |
WO2006065204A1 (en) * | 2004-12-14 | 2006-06-22 | Astrazeneca Ab | Substituted aminopyridines and uses thereof |
US8722708B2 (en) | 2005-06-14 | 2014-05-13 | Merck Sharp & Dohme Inc. | Substituted isoindolines as aspartyl protease inhibitors |
ATE482214T1 (de) | 2005-06-14 | 2010-10-15 | Schering Corp | Aspartylproteasehemmer |
TWI332005B (en) | 2005-06-14 | 2010-10-21 | Schering Corp | Aspartyl protease inhibitors |
US20080318985A1 (en) * | 2005-11-15 | 2008-12-25 | Astrazeneca Ab | Novel 2-Aminopyrimidinone Or 2-Aminopyridinone Derivatives and Their Use |
CN101360720A (zh) * | 2005-11-15 | 2009-02-04 | 阿斯利康(瑞典)有限公司 | 新颖的2-氨基嘧啶酮衍生物及其用途 |
TW200734311A (en) * | 2005-11-21 | 2007-09-16 | Astrazeneca Ab | New compounds |
JP2009520686A (ja) * | 2005-11-21 | 2009-05-28 | アストラゼネカ・アクチエボラーグ | 新規な2−アミノ−イミダゾール−4−オン化合物並びに認知障害、アルツハイマー病、神経変性及び認知症の治療に使用する医薬の製造におけるその使用 |
AR058381A1 (es) * | 2005-12-19 | 2008-01-30 | Astrazeneca Ab | Compuestos derivados de 2-aminopiridin-4-onas y una composicion farmaceutica |
EP2004630A4 (de) * | 2006-04-05 | 2010-05-19 | Astrazeneca Ab | 2-aminopyrimidin-4-one und ihre verwendung zur behandlung bzw. prävention a-bedingter pathologien |
US8168641B2 (en) | 2006-06-12 | 2012-05-01 | Schering Corporation | Aspartyl protease inhibitors |
US20080051420A1 (en) * | 2006-06-14 | 2008-02-28 | Astrazeneca Ab | New Compounds 317 |
TW200815447A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds IV |
TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
TW200831484A (en) * | 2006-12-20 | 2008-08-01 | Astrazeneca Ab | New compounds |
TW200902503A (en) * | 2007-05-15 | 2009-01-16 | Astrazeneca Ab | New compounds |
TW200902499A (en) * | 2007-05-15 | 2009-01-16 | Astrazeneca Ab | New compounds |
CA2698341A1 (en) | 2007-09-06 | 2009-03-12 | Schering Corporation | Gamma secretase modulators |
JP2011503002A (ja) | 2007-11-05 | 2011-01-27 | シェーリング コーポレイション | γセクレターゼ調節剤 |
WO2009076352A1 (en) | 2007-12-11 | 2009-06-18 | Schering Corporation | Gamma secretase modulators |
AU2009239535A1 (en) | 2008-04-22 | 2009-10-29 | Schering Corporation | Thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use |
AU2009314049B2 (en) | 2008-11-13 | 2015-03-05 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
TW201020244A (en) * | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
WO2010056195A1 (en) * | 2008-11-14 | 2010-05-20 | Astrazeneca Ab | New compounds 575 |
US20100125081A1 (en) * | 2008-11-14 | 2010-05-20 | Astrazeneca Ab | New compounds 574 |
JP2012513399A (ja) | 2008-12-22 | 2012-06-14 | シェーリング コーポレイション | γ−セクレターゼ調節剤 |
AU2009330234A1 (en) | 2008-12-22 | 2011-07-07 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
US20120245158A1 (en) | 2009-06-16 | 2012-09-27 | Xianhai Huang | Gamma secretase modulators |
EP2443118A1 (de) | 2009-06-16 | 2012-04-25 | Schering Corporation | Gammasekretasemodulatoren |
EP2443121A2 (de) | 2009-06-16 | 2012-04-25 | Schering Corporation | Gammasekretasemodulatoren |
EP2281824A1 (de) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Furan-Imidazolon-Derivate zur Behandlung von kognitiven, neurodegenerativen oder neuronalen Erkrankungen oder Funktionsstörungen |
EP2485590B1 (de) | 2009-10-08 | 2015-01-07 | Merck Sharp & Dohme Corp. | Heterozyklische pentafluorsulfur-imin-verbindungen als bace-1-hemmer sowie zusammensetzungen damit und ihre verwendung |
US8563543B2 (en) | 2009-10-08 | 2013-10-22 | Merck Sharp & Dohme Corp. | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
US8569310B2 (en) | 2009-10-08 | 2013-10-29 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions and their use |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
WO2012069428A1 (en) | 2010-11-22 | 2012-05-31 | Noscira, S.A. | Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions |
WO2012138734A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
WO2012138590A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
BR112014004181A2 (pt) | 2011-08-22 | 2017-06-13 | Merck Sharp & Dohme | composto, composição farmacêutica, e, método de tratamento, prevenção, e / ou retardo do início de uma doença ou patologia |
AU2013235422B2 (en) | 2012-03-19 | 2016-12-15 | Buck Institute For Research On Aging | APP specific BACE inhibitors (ASBIs) and uses thereof |
WO2014062549A1 (en) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
EP2908824B1 (de) | 2012-10-17 | 2018-05-02 | Merck Sharp & Dohme Corp. | Tricyclische substituierte thiadiazindioxidverbindungen als bace-hemmer, zusammensetzungen und deren verwendung |
US9489013B2 (en) | 2012-12-20 | 2016-11-08 | Merck Sharp & Dohme Corp. | C6-azaspiro iminothiadiazine dioxides as bace inhibitors, compositions, and their use |
WO2014099788A1 (en) | 2012-12-21 | 2014-06-26 | Merck Sharp & Dohme Corp. | C5-spiro iminothiadiazine dioxides as bace inhibitors |
EP2956443B1 (de) | 2013-02-12 | 2019-09-25 | Buck Institute For Research On Aging | Hydantoine als modulatoren von bace-vermittelter app-verarbeitung |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH511863A (de) | 1967-04-13 | 1971-08-31 | Ciba Geigy Ag | Verfahren zur Herstellung von 2,4-Benzdiazepinen |
EP0118171B1 (de) | 1983-03-04 | 1989-03-22 | Arco Chemical Technology, Inc. | Herstellung polyurethanbildender Komponenten mit freien Isocyanat- oder Hydroxygruppen |
US4550169A (en) * | 1983-11-21 | 1985-10-29 | American Cyanamid Company | Platinum chelates of 2-hydrazino-azoles |
CA2104060A1 (en) | 1992-11-10 | 1994-05-11 | Robert Ed Johnson | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents |
WO2002074719A2 (en) | 2001-03-15 | 2002-09-26 | The Johns Hopkins University | Inhibitors of plasmepsins |
JP4283681B2 (ja) * | 2002-03-04 | 2009-06-24 | アンブリリア バイオファーマ インコーポレーテッド | Hivアスパルチルプロテアーゼ阻害剤としての尿素誘導体 |
JP4790624B2 (ja) * | 2003-11-21 | 2011-10-12 | ジョンズ ホプキンス ユニバーシティ | 生体分子パーティションモチーフ及びそれらの使用 |
JP5020638B2 (ja) | 2003-12-15 | 2012-09-05 | シェーリング コーポレイション | 複素環式アスパルチルプロテアーゼインヒビター |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7759353B2 (en) | 2005-06-14 | 2010-07-20 | Schering Corporation | Substituted spiro iminopyrimidinones as aspartyl protease inhibitors, compositions, and methods of treatment |
CA2610829A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | The preparation and use of compounds as aspartyl protease inhibitors |
TWI332005B (en) | 2005-06-14 | 2010-10-21 | Schering Corp | Aspartyl protease inhibitors |
-
2006
- 2006-10-25 US US11/586,151 patent/US7763606B2/en active Active
- 2006-10-25 PE PE2006001297A patent/PE20070531A1/es not_active Application Discontinuation
- 2006-10-25 DE DE602006016314T patent/DE602006016314D1/de active Active
- 2006-10-25 EP EP06817385A patent/EP1940828B1/de active Active
- 2006-10-25 JP JP2008537928A patent/JP2009513656A/ja not_active Ceased
- 2006-10-25 CA CA002626976A patent/CA2626976A1/en not_active Abandoned
- 2006-10-25 AT AT06817385T patent/ATE478070T1/de not_active IP Right Cessation
- 2006-10-25 AR ARP060104660A patent/AR057983A1/es not_active Application Discontinuation
- 2006-10-25 WO PCT/US2006/041716 patent/WO2007050721A2/en active Application Filing
- 2006-10-25 ES ES06817385T patent/ES2349433T3/es active Active
- 2006-10-25 CN CNA2006800398031A patent/CN101296926A/zh active Pending
- 2006-10-26 TW TW095139559A patent/TW200803847A/zh unknown
-
2008
- 2008-10-24 HK HK08111732.2A patent/HK1119680A1/xx not_active IP Right Cessation
-
2010
- 2010-06-07 US US12/794,858 patent/US8012960B2/en active Active
-
2011
- 2011-07-27 US US13/191,978 patent/US8202854B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2007050721A2 (en) | 2007-05-03 |
US8202854B2 (en) | 2012-06-19 |
US8012960B2 (en) | 2011-09-06 |
CN101296926A (zh) | 2008-10-29 |
TW200803847A (en) | 2008-01-16 |
CA2626976A1 (en) | 2007-05-03 |
US20110280867A1 (en) | 2011-11-17 |
DE602006016314D1 (de) | 2010-09-30 |
US7763606B2 (en) | 2010-07-27 |
EP1940828A2 (de) | 2008-07-09 |
HK1119680A1 (en) | 2009-03-13 |
JP2009513656A (ja) | 2009-04-02 |
ES2349433T3 (es) | 2011-01-03 |
AR057983A1 (es) | 2008-01-09 |
US20100247519A1 (en) | 2010-09-30 |
PE20070531A1 (es) | 2007-07-13 |
US20070099898A1 (en) | 2007-05-03 |
WO2007050721A3 (en) | 2007-06-14 |
EP1940828B1 (de) | 2010-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |