JP2009532464A5 - - Google Patents
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- Publication number
- JP2009532464A5 JP2009532464A5 JP2009504154A JP2009504154A JP2009532464A5 JP 2009532464 A5 JP2009532464 A5 JP 2009532464A5 JP 2009504154 A JP2009504154 A JP 2009504154A JP 2009504154 A JP2009504154 A JP 2009504154A JP 2009532464 A5 JP2009532464 A5 JP 2009532464A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethyl
- phenyl
- amino
- compound according
- dihydropyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 19
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000001309 chloro group Chemical group Cl* 0.000 claims 6
- 208000024827 Alzheimer disease Diseases 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 3
- 230000007170 pathology Effects 0.000 claims 3
- -1 2-chloro-3-fluoropyridin-4-yl Chemical group 0.000 claims 2
- 102100021257 Beta-secretase 1 Human genes 0.000 claims 2
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- FYFDLWYDQWXFFV-UHFFFAOYSA-N 2-amino-6-[2-[3-(2-chloropyridin-4-yl)phenyl]ethyl]-3,6-dimethyl-5h-pyrimidin-4-one;hydrochloride Chemical compound Cl.C1C(=O)N(C)C(N)=NC1(C)CCC1=CC=CC(C=2C=C(Cl)N=CC=2)=C1 FYFDLWYDQWXFFV-UHFFFAOYSA-N 0.000 claims 1
- DQBYENAGOOFEDB-UHFFFAOYSA-N 2-amino-6-[2-[3-(5-chloro-2-fluoropyridin-3-yl)phenyl]ethyl]-3,6-dimethyl-5h-pyrimidin-4-one;hydrochloride Chemical compound Cl.C1C(=O)N(C)C(N)=NC1(C)CCC1=CC=CC(C=2C(=NC=C(Cl)C=2)F)=C1 DQBYENAGOOFEDB-UHFFFAOYSA-N 0.000 claims 1
- MUCSUPOQULHCOG-UHFFFAOYSA-N 2-amino-6-[2-[3-(6-methoxypyridin-2-yl)phenyl]ethyl]-3,6-dimethyl-5h-pyrimidin-4-one;hydrochloride Chemical compound Cl.COC1=CC=CC(C=2C=C(CCC3(C)N=C(N)N(C)C(=O)C3)C=CC=2)=N1 MUCSUPOQULHCOG-UHFFFAOYSA-N 0.000 claims 1
- VJKUYZOIHBOZJZ-UHFFFAOYSA-N 2-amino-6-[3-(2-chloro-5-fluoropyridin-4-yl)phenyl]-3,6-dimethyl-5h-pyrimidin-4-one;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1C(=O)N(C)C(N)=NC1(C)C1=CC=CC(C=2C(=CN=C(Cl)C=2)F)=C1 VJKUYZOIHBOZJZ-UHFFFAOYSA-N 0.000 claims 1
- FJXGOLBWWIMBMK-UHFFFAOYSA-N 2-amino-6-[3-(2-chloropyridin-4-yl)phenyl]-3,6-dimethyl-5h-pyrimidin-4-one;hydrochloride Chemical compound Cl.C1C(=O)N(C)C(N)=NC1(C)C1=CC=CC(C=2C=C(Cl)N=CC=2)=C1 FJXGOLBWWIMBMK-UHFFFAOYSA-N 0.000 claims 1
- KYHJQTPARKOBLO-UHFFFAOYSA-N 2-amino-6-[3-(2-fluoropyridin-3-yl)phenyl]-3,6-dimethyl-5h-pyrimidin-4-one Chemical compound C1C(=O)N(C)C(N)=NC1(C)C1=CC=CC(C=2C(=NC=CC=2)F)=C1 KYHJQTPARKOBLO-UHFFFAOYSA-N 0.000 claims 1
- MMPSUYCCVVGYFQ-UHFFFAOYSA-N 2-amino-6-[3-(5-bromopyridin-3-yl)phenyl]-3,6-dimethyl-5h-pyrimidin-4-one Chemical compound C1C(=O)N(C)C(N)=NC1(C)C1=CC=CC(C=2C=C(Br)C=NC=2)=C1 MMPSUYCCVVGYFQ-UHFFFAOYSA-N 0.000 claims 1
- GIYJMSBIQIMWIQ-UHFFFAOYSA-N 2-amino-6-[3-(5-chloro-2-fluoropyridin-3-yl)phenyl]-3,6-dimethyl-5h-pyrimidin-4-one;hydrochloride Chemical compound Cl.C1C(=O)N(C)C(N)=NC1(C)C1=CC=CC(C=2C(=NC=C(Cl)C=2)F)=C1 GIYJMSBIQIMWIQ-UHFFFAOYSA-N 0.000 claims 1
- XHXSWOSWALHHSS-UHFFFAOYSA-N 2-amino-6-[3-(5-methoxypyridin-3-yl)phenyl]-3,6-dimethyl-5h-pyrimidin-4-one;hydrochloride Chemical compound Cl.COC1=CN=CC(C=2C=C(C=CC=2)C2(C)N=C(N)N(C)C(=O)C2)=C1 XHXSWOSWALHHSS-UHFFFAOYSA-N 0.000 claims 1
- IJODUZYOFYIXBG-UHFFFAOYSA-N 2-amino-6-[3-(6-fluoro-5-methylpyridin-3-yl)phenyl]-3,6-dimethyl-5h-pyrimidin-4-one;hydrochloride Chemical compound Cl.C1C(=O)N(C)C(N)=NC1(C)C1=CC=CC(C=2C=C(C)C(F)=NC=2)=C1 IJODUZYOFYIXBG-UHFFFAOYSA-N 0.000 claims 1
- BZSXYTVEBZJHNV-UHFFFAOYSA-N 5-[3-(2-amino-1,4-dimethyl-6-oxo-5h-pyrimidin-4-yl)phenyl]pyridine-3-carbonitrile;hydrochloride Chemical compound Cl.N1=C(N)N(C)C(=O)CC1(C)C1=CC=CC(C=2C=C(C=NC=2)C#N)=C1 BZSXYTVEBZJHNV-UHFFFAOYSA-N 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
- 206010059245 Angiopathy Diseases 0.000 claims 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 208000011990 Corticobasal Degeneration Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010036631 Presenile dementia Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- RDNKNNZIBZRSSK-UHFFFAOYSA-N acetic acid;2-amino-6-[3-(2,3-dichloropyridin-4-yl)phenyl]-3,6-dimethyl-5h-pyrimidin-4-one Chemical compound CC(O)=O.C1C(=O)N(C)C(N)=NC1(C)C1=CC=CC(C=2C(=C(Cl)N=CC=2)Cl)=C1 RDNKNNZIBZRSSK-UHFFFAOYSA-N 0.000 claims 1
- VJELGZWMXNXQJN-UHFFFAOYSA-N acetic acid;2-amino-6-[3-(5-bromo-2-fluoropyridin-3-yl)phenyl]-3,6-dimethyl-5h-pyrimidin-4-one Chemical compound CC(O)=O.C1C(=O)N(C)C(N)=NC1(C)C1=CC=CC(C=2C(=NC=C(Br)C=2)F)=C1 VJELGZWMXNXQJN-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78954006P | 2006-04-05 | 2006-04-05 | |
| PCT/SE2007/000322 WO2007114771A1 (en) | 2006-04-05 | 2007-04-04 | 2-AMINOPYRIMIDIN-4-ONES AND THEIR USE FOR TREATING OR PREVENTING Aβ-RELATED PATHOLOGIES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009532464A JP2009532464A (ja) | 2009-09-10 |
| JP2009532464A5 true JP2009532464A5 (enExample) | 2010-05-20 |
Family
ID=38563950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009504154A Pending JP2009532464A (ja) | 2006-04-05 | 2007-04-04 | ２−アミノピリミジン−４−オン及びＡβ−関連の病理を治療又は予防するためのその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090099217A1 (enExample) |
| EP (1) | EP2004630A4 (enExample) |
| JP (1) | JP2009532464A (enExample) |
| CN (1) | CN101460480A (enExample) |
| WO (1) | WO2007114771A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| CA2575340A1 (en) | 2004-07-28 | 2006-02-09 | Schering Corporation | Macrocyclic beta-secretase inhibitors |
| US8722708B2 (en) | 2005-06-14 | 2014-05-13 | Merck Sharp & Dohme Inc. | Substituted isoindolines as aspartyl protease inhibitors |
| WO2006138264A2 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
| ES2537898T3 (es) | 2005-10-25 | 2015-06-15 | Shionogi & Co., Ltd. | Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1 |
| CA2653650A1 (en) * | 2006-06-12 | 2007-12-21 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
| FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
| EP2151435A4 (en) | 2007-04-24 | 2011-09-14 | Shionogi & Co | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| AU2008245082B8 (en) | 2007-04-24 | 2012-09-13 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
| AU2009239536C1 (en) | 2008-04-22 | 2012-12-13 | Merck Sharp & Dohme Corp. | Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use |
| TWI431004B (zh) * | 2008-05-02 | 2014-03-21 | Lilly Co Eli | Ｂａｃｅ抑制劑 |
| US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
| MX2011002705A (es) | 2008-09-11 | 2011-09-09 | Amgen Inc | Compuestos con anillos espiro-triciclicos como moduladores de beta-secretasas y metodos de uso. |
| WO2010047372A1 (ja) | 2008-10-22 | 2010-04-29 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害活性を有する２－アミノピリミジン－４－オンおよび２－アミノピリジン誘導体 |
| MX2011004680A (es) | 2008-11-06 | 2011-05-25 | Astrazeneca Ab | Moduladores de beta amiloide. |
| TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
| GB0912777D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydropyrimidone derivatives |
| GB0912778D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| WO2011044185A2 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
| WO2011044184A1 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
| WO2011044187A1 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| RU2012129168A (ru) | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | Производные оксазина |
| US8497264B2 (en) | 2010-03-15 | 2013-07-30 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| MX2012010658A (es) | 2010-03-15 | 2012-12-05 | Amgen Inc | Compuestos de anillo espiro tetraciclico como moduladores de beta-secretasa. |
| EA201291366A1 (ru) * | 2010-06-09 | 2013-04-30 | Янссен Фармацевтика Нв | Производные 5-амино-3,6-дигидро-1h-пиразин-2-она в качестве ингибиторов бета-секретазы (bace) |
| AR081587A1 (es) | 2010-06-09 | 2012-10-03 | Janssen Pharmaceutica Nv | DERIVADOS DE 5,6-DIHIDRO-2H-[1,4]OXAZIN-3-IL-AMINA UTILES COMO INHIBIDORES DE LA b-SECRETASA (BACE) |
| SG186408A1 (en) * | 2010-06-28 | 2013-01-30 | Janssen Pharmaceutica Nv | 3-amino-5, 6-dihydro-1h-pyrazin-2-one derivatives useful for the treatment of alzheimer's disease and other forms of dementia |
| CA2816285A1 (en) | 2010-10-29 | 2012-05-03 | Shionogi & Co., Ltd. | Naphthyridine derivative |
| US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
| WO2012071279A1 (en) | 2010-11-23 | 2012-05-31 | Amgen Inc. | Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use |
| ES2648143T3 (es) | 2010-12-22 | 2017-12-28 | Janssen Pharmaceutica Nv | Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8-ilamina útiles como inhibidores de la beta-secretasa (BACE) |
| GB201100181D0 (en) | 2011-01-06 | 2011-02-23 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| GB201101139D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| GB201101140D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| EP2665716B1 (en) | 2011-01-21 | 2017-03-08 | Eisai R&D Management Co., Ltd. | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives |
| US9346827B2 (en) | 2011-02-07 | 2016-05-24 | Amgen Inc. | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use |
| WO2012112462A1 (en) | 2011-02-15 | 2012-08-23 | Amgen Inc. | Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use |
| US9346811B2 (en) | 2011-03-01 | 2016-05-24 | Janssen Pharmaceutica Nv | 6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine derivatives useful as inhibitors of beta-secretase (BACE) |
| JP5853035B2 (ja) | 2011-03-09 | 2016-02-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ | β−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な３，４−ジヒドロ−ピロロ［１，２−ａ］ピラジン−１−イルアミン誘導体 |
| EP2694521B1 (en) | 2011-04-07 | 2015-11-25 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| WO2012138734A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤 |
| RU2014111055A (ru) | 2011-08-22 | 2015-09-27 | Мерк Шарп И Доум Корп. | 2-спирозамещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов bace, композиции и их применение |
| WO2013044092A1 (en) | 2011-09-21 | 2013-03-28 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| ES2745539T3 (es) | 2012-03-19 | 2020-03-02 | Buck Inst Res Aging | Inhibidores de BACE específicos de APP (ASBI) y uso de los mismos |
| WO2014062553A1 (en) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| EP2908825B1 (en) | 2012-10-17 | 2018-04-18 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
| US9725469B2 (en) | 2012-11-15 | 2017-08-08 | Amgen, Inc. | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| EP3653609B1 (en) | 2013-02-12 | 2024-04-03 | Buck Institute for Research on Aging | Hydantoins that modulate bace-mediated app processing |
| KR102243134B1 (ko) | 2013-06-12 | 2021-04-22 | 얀센 파마슈티카 엔.브이. | 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-5,6-디하이드로이미다조[1,5-a]피라진 유도체 |
| EP3008067B1 (en) | 2013-06-12 | 2017-03-29 | Janssen Pharmaceutica N.V. | 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2h)-one derivatives as inhibitors of beta-secretase (bace) |
| BR112015030597A2 (pt) | 2013-06-12 | 2017-07-25 | Janssen Pharmaceutica Nv | derivados 4-amino-6-fenil-6,7-di-hidro[1,2,3]triazolo[1,5-a]pirazina como inibidores de beta-secretase (bace) |
| JP2017538753A (ja) | 2014-12-18 | 2017-12-28 | ヤンセン ファーマシューティカ エヌ．ベー． | ２，３，４，５−テトラヒドロピリジン−６−アミンおよび３，４−ジヒドロ−２Ｈ−ピロール−５−アミンの化合物のβセクレターゼ阻害剤 |
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| AR023052A1 (es) * | 1998-09-25 | 2002-09-04 | Mitsuharu Yoshimura Milton | Derivados de pirimidona |
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| US20030114445A1 (en) * | 2001-06-15 | 2003-06-19 | Chengxin Zhi | N3-substituted 6-anilinopyrimidines and methods to treat-Gram-positive bacterial and mycoplasmal infections |
| US6951875B2 (en) * | 2001-10-29 | 2005-10-04 | Hoffmann-La Roche Inc. | Conjugated aromatic compounds with a pyridine substituent |
| US7592348B2 (en) * | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| CA2548388A1 (en) * | 2003-12-15 | 2005-06-30 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US20090221579A1 (en) * | 2004-10-15 | 2009-09-03 | Jeffrey Scott Albert | Substituted Amino-Compounds and Uses Thereof |
| CN101084198A (zh) * | 2004-10-15 | 2007-12-05 | 阿斯利康(瑞典)有限公司 | 取代的氨基－嘧啶酮及其用途 |
| CA2609562A1 (en) * | 2005-06-14 | 2006-12-28 | Schering Corporation | Macrocyclic heterocyclic aspartyl protease inhibitors |
| US7759353B2 (en) * | 2005-06-14 | 2010-07-20 | Schering Corporation | Substituted spiro iminopyrimidinones as aspartyl protease inhibitors, compositions, and methods of treatment |
| CN101296926A (zh) * | 2005-10-27 | 2008-10-29 | 先灵公司 | 天冬氨酰蛋白酶抑制剂 |
| CN101351460A (zh) * | 2005-10-31 | 2009-01-21 | 先灵公司 | 天冬氨酰蛋白酶抑制剂 |
-
2007
- 2007-04-04 JP JP2009504154A patent/JP2009532464A/ja active Pending
- 2007-04-04 CN CNA2007800209481A patent/CN101460480A/zh active Pending
- 2007-04-04 EP EP07747988A patent/EP2004630A4/en not_active Withdrawn
- 2007-04-04 US US12/295,959 patent/US20090099217A1/en not_active Abandoned
- 2007-04-04 WO PCT/SE2007/000322 patent/WO2007114771A1/en not_active Ceased