JP2018515525A5 - - Google Patents
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- JP2018515525A5 JP2018515525A5 JP2017559003A JP2017559003A JP2018515525A5 JP 2018515525 A5 JP2018515525 A5 JP 2018515525A5 JP 2017559003 A JP2017559003 A JP 2017559003A JP 2017559003 A JP2017559003 A JP 2017559003A JP 2018515525 A5 JP2018515525 A5 JP 2018515525A5
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- hydrogen
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- 0 CC(C)c1c(*)nn[n]1 Chemical compound CC(C)c1c(*)nn[n]1 0.000 description 25
- JPDPRXXLFYTTRV-UHFFFAOYSA-N CC(C)c1c(C)[o]nc1C Chemical compound CC(C)c1c(C)[o]nc1C JPDPRXXLFYTTRV-UHFFFAOYSA-N 0.000 description 4
- VTYLNNZBVOSGTA-UHFFFAOYSA-N CC(C)c([n](C)nn1)c1OC Chemical compound CC(C)c([n](C)nn1)c1OC VTYLNNZBVOSGTA-UHFFFAOYSA-N 0.000 description 3
- DWVFSQVBDSMYJA-UHFFFAOYSA-N CC(C)c([nH]nn1)c1OC Chemical compound CC(C)c([nH]nn1)c1OC DWVFSQVBDSMYJA-UHFFFAOYSA-N 0.000 description 2
- FMSYGTJKIDOBPH-UHFFFAOYSA-N CCc1c(C(C)C)[nH]nn1 Chemical compound CCc1c(C(C)C)[nH]nn1 FMSYGTJKIDOBPH-UHFFFAOYSA-N 0.000 description 2
- MRFNWSQNINZIIA-UHFFFAOYSA-O CC(C)C1=C(C)N(C)N[NH2+]1 Chemical compound CC(C)C1=C(C)N(C)N[NH2+]1 MRFNWSQNINZIIA-UHFFFAOYSA-O 0.000 description 1
- VSNWPYLQRCUJJC-UHFFFAOYSA-O CC(C)C1=C(C)N=N[NH2+]1 Chemical compound CC(C)C1=C(C)N=N[NH2+]1 VSNWPYLQRCUJJC-UHFFFAOYSA-O 0.000 description 1
- MMTJVWTXKUNWCZ-UHFFFAOYSA-N CC(C)c1c(C)nn[n]1C Chemical compound CC(C)c1c(C)nn[n]1C MMTJVWTXKUNWCZ-UHFFFAOYSA-N 0.000 description 1
- UJKAFNFFPBCHLA-UHFFFAOYSA-N CCC1=C(C(C)C)NNN1C Chemical compound CCC1=C(C(C)C)NNN1C UJKAFNFFPBCHLA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562159991P | 2015-05-12 | 2015-05-12 | |
| US62/159,991 | 2015-05-12 | ||
| US15/150,492 US9725449B2 (en) | 2015-05-12 | 2016-05-10 | Tricyclic compounds as anticancer agents |
| US15/150,492 | 2016-05-10 | ||
| PCT/US2016/031707 WO2016183118A1 (en) | 2015-05-12 | 2016-05-11 | Tricyclic compounds as anticancer agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515525A JP2018515525A (ja) | 2018-06-14 |
| JP2018515525A5 true JP2018515525A5 (enExample) | 2019-06-13 |
| JP6843767B2 JP6843767B2 (ja) | 2021-03-17 |
Family
ID=56117957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559003A Active JP6843767B2 (ja) | 2015-05-12 | 2016-05-11 | 抗がん剤としての三環式化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9725449B2 (enExample) |
| EP (1) | EP3294739B1 (enExample) |
| JP (1) | JP6843767B2 (enExample) |
| CN (1) | CN107709322B (enExample) |
| ES (1) | ES2746131T3 (enExample) |
| TW (1) | TW201713657A (enExample) |
| UY (1) | UY36677A (enExample) |
| WO (1) | WO2016183118A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102238012B1 (ko) * | 2016-01-20 | 2021-04-09 | 닝보 웬다 파르마 테크놀로지 엘티디 | 브로모도메인 억제제인 카르볼린 유도체 |
| WO2017133681A1 (zh) * | 2016-02-05 | 2017-08-10 | 正大天晴药业集团股份有限公司 | 溴区结构域蛋白抑制剂的三环类化合物及其制备、药物组合物和用途 |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| CN111356695B (zh) * | 2017-10-27 | 2022-12-30 | 北京加科思新药研发有限公司 | 新的三环化合物 |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| JP7168245B2 (ja) * | 2018-06-25 | 2022-11-09 | ジャコバイオ ファーマスーティカルズ カンパニー リミテッド | 三環式化合物 |
| PE20210642A1 (es) | 2018-07-13 | 2021-03-23 | Gilead Sciences Inc | Inhibidores de pd-1/pd-l1 |
| WO2020200284A1 (zh) * | 2019-04-04 | 2020-10-08 | 上海华汇拓医药科技有限公司 | 三环类化合物制备方法及其在医药领域的应用 |
| US10947253B2 (en) | 2019-08-05 | 2021-03-16 | Ankh Life Sciences Limited | Fused polycyclic dimers |
| BR112022007208A2 (pt) * | 2019-10-30 | 2022-07-26 | Janssen Sciences Ireland Unlimited Co | Síntese de 3-nitro-n-(2,2,2-trifluoroetil)-4-piridinamina |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
| AU2022211285A1 (en) * | 2021-01-22 | 2023-08-17 | Jingrui Biopharma Co., Ltd. | Tricyclic compounds as anticancer agents |
| WO2024099441A1 (en) * | 2022-11-11 | 2024-05-16 | Jingrui Biopharma (Shandong) Co., Ltd. | Bromodomain and extra-terminal (bet) protein degrader |
| US12173005B1 (en) | 2023-12-21 | 2024-12-24 | King Faisal University | Pyrimido[1′,6′:1,5]pyrazolo[4,3-b][1,7]naphthyridine compounds as CK2 inhibitors |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE504828C2 (sv) | 1990-04-11 | 1997-05-12 | Sandvik Ab | Hammaranordning där kolv och borrkrona har omvänd design relativt varandra vad gäller impedans |
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| JP5238936B2 (ja) | 2005-03-25 | 2013-07-17 | ジーアイティーアール，インク． | Ｇｉｔｒ結合分子およびその使用 |
| DK1879573T3 (da) | 2005-05-10 | 2013-02-25 | Incyte Corp | Modulatorer af indolamin 2,3-dioxygenase og fremgangsmåder til anvendelse deraf |
| KR101704734B1 (ko) | 2005-07-01 | 2017-02-09 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| ES2540561T3 (es) | 2005-12-20 | 2015-07-10 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| CA2663057C (en) | 2006-09-19 | 2015-12-08 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| PT2175884T (pt) | 2007-07-12 | 2016-09-21 | Gitr Inc | Terapias de combinação empregando moléculas de ligação a gitr |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
| WO2009073620A2 (en) | 2007-11-30 | 2009-06-11 | Newlink Genetics | Ido inhibitors |
| AU2008343932B2 (en) * | 2007-12-19 | 2013-08-15 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| MX356367B (es) | 2008-12-09 | 2018-05-25 | Genentech Inc | Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t. |
| CN102257076B (zh) | 2008-12-18 | 2014-07-30 | 纳幕尔杜邦公司 | 具有新颜料的粉末涂料组合物 |
| IN2015DN02826A (enExample) | 2009-09-03 | 2015-09-11 | Merck Sharp & Dohme | |
| EP2493862B1 (en) | 2009-10-28 | 2016-10-05 | Newlink Genetics Corporation | Imidazole derivatives as ido inhibitors |
| DK2510010T3 (en) | 2009-12-10 | 2015-12-14 | Hoffmann La Roche | Antibodies that bind to human CSF1R extracellular domain 4 and their use |
| DK2542256T3 (da) | 2010-03-04 | 2019-08-26 | Macrogenics Inc | Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf |
| RU2617971C2 (ru) | 2010-03-05 | 2017-04-28 | Ф.Хоффманн-Ля Рош Аг | Антитела против csf-1r человека и их применение |
| CN102918061B (zh) | 2010-03-05 | 2016-06-08 | 霍夫曼-拉罗奇有限公司 | 针对人csf-1r的抗体及其用途 |
| EP3943154A1 (en) | 2010-05-04 | 2022-01-26 | Five Prime Therapeutics, Inc. | Antibodies that bind csf1r |
| NZ729044A (en) | 2010-09-09 | 2020-07-31 | Pfizer | 4-1bb binding molecules |
| US8580399B2 (en) | 2011-04-08 | 2013-11-12 | Universal Display Corporation | Substituted oligoazacarbazoles for light emitting diodes |
| NO2694640T3 (enExample) | 2011-04-15 | 2018-03-17 | ||
| CA2833636A1 (en) | 2011-04-20 | 2012-10-26 | Amplimmune, Inc. | Antibodies and other molecules that bind b7-h1 and pd-1 |
| KR20140068883A (ko) | 2011-09-28 | 2014-06-09 | 이데미쓰 고산 가부시키가이샤 | 유기 전계 발광 소자용 재료 및 이를 사용한 유기 전계 발광 소자 |
| BR112014012819B1 (pt) | 2011-11-28 | 2022-08-16 | Merck Patent Gmbh | Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição |
| MX356337B (es) | 2011-12-15 | 2018-05-23 | Hoffmann La Roche | Anticuerpos contra csf-1r humano y sus usos. |
| MX2014008961A (es) | 2012-02-06 | 2014-10-14 | Genentech Inc | Composiciones y metodos para utilizar inhibidores de csf1r. |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| KR20150018533A (ko) | 2012-05-11 | 2015-02-23 | 파이브 프라임 테라퓨틱스, 인크. | 콜로니 자극 인자 1 수용체(csf1r)에 결속하는 항체들에 의한 질병 상태의 치료 방법 |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| CN107759690A (zh) | 2012-08-31 | 2018-03-06 | 戊瑞治疗有限公司 | 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
| UA115576C2 (uk) | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | Похідні бензимідазолу як антагоністи ер4 |
| EP2961747B1 (en) | 2013-02-27 | 2017-11-15 | Bristol-Myers Squibb Company | Carbazole compounds useful as bromodomain inhibitors |
| US9492460B2 (en) | 2013-02-27 | 2016-11-15 | Bristol-Myers Squibb Company | Carbazole compounds useful as bromodomain inhibitors |
| EP2970312B1 (en) | 2013-03-11 | 2017-11-15 | The Regents of The University of Michigan | Bet bromodomain inhibitors and therapeutic methods using the same |
| EA201990240A1 (ru) | 2013-12-24 | 2019-06-28 | Бристол-Маерс Сквибб Компани | Новые трициклические соединения в качестве противораковых средств |
| US9458156B2 (en) | 2014-12-23 | 2016-10-04 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
| US10662193B2 (en) | 2014-01-21 | 2020-05-26 | Ac Immune Sa | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins |
| US9580430B2 (en) | 2014-02-28 | 2017-02-28 | The Regents Of The University Of Michigan | 9H-pyrimido[4,5-B]indoles and related analogs as BET bromodomain inhibitors |
-
2016
- 2016-05-10 US US15/150,492 patent/US9725449B2/en active Active
- 2016-05-11 UY UY0001036677A patent/UY36677A/es unknown
- 2016-05-11 CN CN201680039269.8A patent/CN107709322B/zh active Active
- 2016-05-11 JP JP2017559003A patent/JP6843767B2/ja active Active
- 2016-05-11 ES ES16728765T patent/ES2746131T3/es active Active
- 2016-05-11 EP EP16728765.5A patent/EP3294739B1/en active Active
- 2016-05-11 TW TW105114608A patent/TW201713657A/zh unknown
- 2016-05-11 WO PCT/US2016/031707 patent/WO2016183118A1/en not_active Ceased
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