JP2017535561A5 - - Google Patents
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- JP2017535561A5 JP2017535561A5 JP2017526957A JP2017526957A JP2017535561A5 JP 2017535561 A5 JP2017535561 A5 JP 2017535561A5 JP 2017526957 A JP2017526957 A JP 2017526957A JP 2017526957 A JP2017526957 A JP 2017526957A JP 2017535561 A5 JP2017535561 A5 JP 2017535561A5
- Authority
- JP
- Japan
- Prior art keywords
- triazolo
- pyrrolo
- pyrimidin
- pyrazin
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims description 82
- 125000000217 alkyl group Chemical group 0.000 claims description 70
- -1 (5-methylpyrazin-2-yl) -2- (8- (3,3,4,4,4-pentafluorobutyl)-[1,2,4] Triazolo [1,5-a] pyrazin-6-yl) -5H-pyrrolo [2,3-d] pyrimidin-6 (7H) -one Chemical compound 0.000 claims description 53
- 125000005843 halogen group Chemical group 0.000 claims description 48
- 150000003839 salts Chemical class 0.000 claims description 38
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 30
- 125000003118 aryl group Chemical group 0.000 claims description 22
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 20
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 125000001072 heteroaryl group Chemical group 0.000 claims description 14
- 125000005842 heteroatom Chemical group 0.000 claims description 14
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 12
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 229910052717 sulfur Inorganic materials 0.000 claims description 10
- 206010016654 Fibrosis Diseases 0.000 claims description 8
- 206010019280 Heart failures Diseases 0.000 claims description 8
- 206010020772 Hypertension Diseases 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 8
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 6
- 206010002383 Angina Pectoris Diseases 0.000 claims description 6
- 201000001320 Atherosclerosis Diseases 0.000 claims description 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 6
- 206010052337 Diastolic dysfunction Diseases 0.000 claims description 6
- 206010048554 Endothelial dysfunction Diseases 0.000 claims description 6
- 208000010228 Erectile Dysfunction Diseases 0.000 claims description 6
- 208000006011 Stroke Diseases 0.000 claims description 6
- 208000007536 Thrombosis Diseases 0.000 claims description 6
- 239000000674 adrenergic antagonist Substances 0.000 claims description 6
- 208000006673 asthma Diseases 0.000 claims description 6
- 230000000747 cardiac effect Effects 0.000 claims description 6
- 208000020832 chronic kidney disease Diseases 0.000 claims description 6
- 230000007882 cirrhosis Effects 0.000 claims description 6
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 6
- 230000004064 dysfunction Effects 0.000 claims description 6
- 230000008694 endothelial dysfunction Effects 0.000 claims description 6
- 201000001881 impotence Diseases 0.000 claims description 6
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims description 6
- 208000010125 myocardial infarction Diseases 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 208000002815 pulmonary hypertension Diseases 0.000 claims description 6
- 208000037803 restenosis Diseases 0.000 claims description 6
- 206010020852 Hypertonia Diseases 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000005541 ACE inhibitor Substances 0.000 claims description 4
- 229940123338 Aldosterone synthase inhibitor Drugs 0.000 claims description 4
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 claims description 4
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 claims description 4
- 229940127291 Calcium channel antagonist Drugs 0.000 claims description 4
- 229940118365 Endothelin receptor antagonist Drugs 0.000 claims description 4
- 208000011514 Familial renal glucosuria Diseases 0.000 claims description 4
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 claims description 4
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims description 4
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 claims description 4
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 4
- 239000002170 aldosterone antagonist Substances 0.000 claims description 4
- 229940083712 aldosterone antagonist Drugs 0.000 claims description 4
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims description 4
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims description 4
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 claims description 4
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 4
- 239000002876 beta blocker Substances 0.000 claims description 4
- 239000000480 calcium channel blocker Substances 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 239000002934 diuretic Substances 0.000 claims description 4
- 230000001882 diuretic effect Effects 0.000 claims description 4
- 239000002308 endothelin receptor antagonist Substances 0.000 claims description 4
- 239000002792 enkephalinase inhibitor Substances 0.000 claims description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000002503 metabolic effect Effects 0.000 claims description 4
- 239000003607 modifier Substances 0.000 claims description 4
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims description 4
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 4
- 239000000810 peripheral vasodilating agent Substances 0.000 claims description 4
- 229960002116 peripheral vasodilator Drugs 0.000 claims description 4
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 claims description 4
- 239000004036 potassium channel stimulating agent Substances 0.000 claims description 4
- 208000007278 renal glycosuria Diseases 0.000 claims description 4
- 239000002461 renin inhibitor Substances 0.000 claims description 4
- 229940086526 renin-inhibitors Drugs 0.000 claims description 4
- 230000002889 sympathetic effect Effects 0.000 claims description 4
- 229940124549 vasodilator Drugs 0.000 claims description 4
- 239000003071 vasodilator agent Substances 0.000 claims description 4
- 210000004072 lung Anatomy 0.000 claims description 3
- LXAOHLADQYQDKZ-UHFFFAOYSA-N 2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(3,4-difluorophenyl)-5-methyl-3,7-dihydropyrrolo[2,3-d]pyrimidine-4,6-dione Chemical compound C(CCC)C=1C=2N(C=C(N=1)C=1N=C(C3=C(N=1)NC(C3(C)C1=CC(=C(C=C1)F)F)=O)O)N=CN=2 LXAOHLADQYQDKZ-UHFFFAOYSA-N 0.000 claims description 2
- DGRJGTKRMXRNLZ-UHFFFAOYSA-N 2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(3-fluorophenyl)-5-methyl-3,7-dihydropyrrolo[2,3-d]pyrimidine-4,6-dione Chemical compound C(CCC)C=1C=2N(C=C(N=1)C=1N=C(C3=C(N=1)NC(C3(C)C1=CC(=CC=C1)F)=O)O)N=CN=2 DGRJGTKRMXRNLZ-UHFFFAOYSA-N 0.000 claims description 2
- MJPGVZAWISUCPN-UHFFFAOYSA-N 2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(4-chloro-3-fluorophenyl)-5-methyl-3,7-dihydropyrrolo[2,3-d]pyrimidine-4,6-dione Chemical compound C(CCC)C=1C=2N(C=C(N=1)C=1N=C(C3=C(N=1)NC(C3(C)C1=CC(=C(C=C1)Cl)F)=O)O)N=CN=2 MJPGVZAWISUCPN-UHFFFAOYSA-N 0.000 claims description 2
- FQESNKDMJREXNR-UHFFFAOYSA-N 2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(4-chlorophenyl)-5-methyl-3,7-dihydropyrrolo[2,3-d]pyrimidine-4,6-dione Chemical compound C(CCC)C=1C=2N(C=C(N=1)C=1N=C(C3=C(N=1)NC(C3(C)C1=CC=C(C=C1)Cl)=O)O)N=CN=2 FQESNKDMJREXNR-UHFFFAOYSA-N 0.000 claims description 2
- HQVUQJDUKZCAKM-UHFFFAOYSA-N 2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(4-fluorophenyl)-5-methyl-3,7-dihydropyrrolo[2,3-d]pyrimidine-4,6-dione Chemical compound C(CCC)C=1C=2N(C=C(N=1)C=1N=C(C3=C(N=1)NC(C3(C)C1=CC=C(C=C1)F)=O)O)N=CN=2 HQVUQJDUKZCAKM-UHFFFAOYSA-N 0.000 claims description 2
- IRJDCCOPVWQZFS-UHFFFAOYSA-N 2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(5-chloropyridin-2-yl)-5-methyl-3,7-dihydropyrrolo[2,3-d]pyrimidine-4,6-dione Chemical compound C(CCC)C=1C=2N(C=C(N=1)C=1N=C(C3=C(N=1)NC(C3(C)C1=NC=C(C=C1)Cl)=O)O)N=CN=2 IRJDCCOPVWQZFS-UHFFFAOYSA-N 0.000 claims description 2
- BJTDMLIJOGMFAB-UHFFFAOYSA-N 2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(5-fluoropyridin-2-yl)-5-methyl-3,7-dihydropyrrolo[2,3-d]pyrimidine-4,6-dione Chemical compound C(CCC)C=1C=2N(C=C(N=1)C=1N=C(C3=C(N=1)NC(C3(C)C1=NC=C(C=C1)F)=O)O)N=CN=2 BJTDMLIJOGMFAB-UHFFFAOYSA-N 0.000 claims description 2
- TXAOYIUUKRNHIX-UHFFFAOYSA-N 2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-methyl-5-(5-methylpyridin-2-yl)-3,7-dihydropyrrolo[2,3-d]pyrimidine-4,6-dione Chemical compound C(CCC)C=1C=2N(C=C(N=1)C=1N=C(C3=C(N=1)NC(C3(C1=NC=C(C=C1)C)C)=O)O)N=CN=2 TXAOYIUUKRNHIX-UHFFFAOYSA-N 0.000 claims description 2
- NVAZGOBZBPOMHJ-UHFFFAOYSA-N 2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-methyl-5-[5-(trifluoromethyl)pyridin-2-yl]-3,7-dihydropyrrolo[2,3-d]pyrimidine-4,6-dione Chemical compound C(CCC)C=1C=2N(C=C(N=1)C=1N=C(C3=C(N=1)NC(C3(C1=NC=C(C=C1)C(F)(F)F)C)=O)O)N=CN=2 NVAZGOBZBPOMHJ-UHFFFAOYSA-N 0.000 claims description 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 2
- LMRDQTUJMDYOSF-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(3,4-difluorophenyl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C)C1=CC(=C(C=C1)F)F)=O LMRDQTUJMDYOSF-UHFFFAOYSA-N 0.000 claims description 2
- SMADCKIYUKQHTM-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(4-chloro-3-fluorophenyl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C)C1=CC(=C(C=C1)Cl)F)=O SMADCKIYUKQHTM-UHFFFAOYSA-N 0.000 claims description 2
- QKSIYKIUIRBJLO-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(4-chlorophenyl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C)C1=CC=C(C=C1)Cl)=O QKSIYKIUIRBJLO-UHFFFAOYSA-N 0.000 claims description 2
- RPLJYXSNLLLWJB-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(4-fluorophenyl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C)C1=CC=C(C=C1)F)=O RPLJYXSNLLLWJB-UHFFFAOYSA-N 0.000 claims description 2
- DKJKIOMNQFKWRU-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(5-chloropyridin-2-yl)-5-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C1CC1)C1=NC=C(C=C1)Cl)=O DKJKIOMNQFKWRU-UHFFFAOYSA-N 0.000 claims description 2
- AYDTWTCFOONFAW-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(5-chloropyridin-2-yl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C)C1=NC=C(C=C1)Cl)=O AYDTWTCFOONFAW-UHFFFAOYSA-N 0.000 claims description 2
- BYZFKKBSQNZUHA-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-(5-fluoropyridin-2-yl)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C)C1=NC=C(C=C1)F)=O BYZFKKBSQNZUHA-UHFFFAOYSA-N 0.000 claims description 2
- TZNMGNJFFQFDSN-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-cyclopropyl-5-(5-methylpyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C1=NC=C(C=C1)C)C1CC1)=O TZNMGNJFFQFDSN-UHFFFAOYSA-N 0.000 claims description 2
- ARPIPJLVHMRNTM-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-cyclopropyl-5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C=1OC(=NN=1)C(F)(F)F)C1CC1)=O ARPIPJLVHMRNTM-UHFFFAOYSA-N 0.000 claims description 2
- CFXHGGPGIWUSMF-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-cyclopropyl-5-[5-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C1=NC=C(C=C1)C(F)(F)F)C1CC1)=O CFXHGGPGIWUSMF-UHFFFAOYSA-N 0.000 claims description 2
- SQPXVCJKVFWNAT-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-cyclopropyl-5-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C1=NC=CC=C1)C1CC1)=O SQPXVCJKVFWNAT-UHFFFAOYSA-N 0.000 claims description 2
- IBLMKKUNVUEJPK-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-methyl-5-(5-methylpyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C1=NC=C(C=C1)C)C)=O IBLMKKUNVUEJPK-UHFFFAOYSA-N 0.000 claims description 2
- WKZLLIKBYCBIRD-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-methyl-5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C=1OC(=NN=1)C(F)(F)F)C)=O WKZLLIKBYCBIRD-UHFFFAOYSA-N 0.000 claims description 2
- GDSOLFAUGQUSPO-UHFFFAOYSA-N 4-amino-2-(8-butyl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-methyl-5-[5-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC)NC(C2(C1=NC=C(C=C1)C(F)(F)F)C)=O GDSOLFAUGQUSPO-UHFFFAOYSA-N 0.000 claims description 2
- FUIAWYATXWPXHA-UHFFFAOYSA-N 4-amino-5-(3,4-difluorophenyl)-5-methyl-2-[8-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[1,5-a]pyrazin-6-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCC(F)(F)F)NC(C2(C)C1=CC(=C(C=C1)F)F)=O FUIAWYATXWPXHA-UHFFFAOYSA-N 0.000 claims description 2
- UXFLSGRTDQWADO-UHFFFAOYSA-N 4-amino-5-(3,4-difluorophenyl)-5-methyl-2-[8-(4,4,4-trifluorobutyl)-[1,2,4]triazolo[1,5-a]pyrazin-6-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC(F)(F)F)NC(C2(C)C1=CC(=C(C=C1)F)F)=O UXFLSGRTDQWADO-UHFFFAOYSA-N 0.000 claims description 2
- DPINFZKMEZBXOX-UHFFFAOYSA-N 4-amino-5-(3-fluorophenyl)-5-methyl-2-[8-(3,3,4,4,4-pentafluorobutyl)-[1,2,4]triazolo[1,5-a]pyrazin-6-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCC(C(F)(F)F)(F)F)NC(C2(C)C1=CC(=CC=C1)F)=O DPINFZKMEZBXOX-UHFFFAOYSA-N 0.000 claims description 2
- NCRWABGVHDOFSY-UHFFFAOYSA-N 4-amino-5-(4-chloro-3-fluorophenyl)-5-cyclopropyl-2-[8-(4,4,4-trifluorobutyl)-[1,2,4]triazolo[1,5-a]pyrazin-6-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC(F)(F)F)NC(C2(C1CC1)C1=CC(=C(C=C1)Cl)F)=O NCRWABGVHDOFSY-UHFFFAOYSA-N 0.000 claims description 2
- ILAXOCFPUSBEAT-UHFFFAOYSA-N 4-amino-5-(4-chloro-3-fluorophenyl)-5-methyl-2-[8-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[1,5-a]pyrazin-6-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCC(F)(F)F)NC(C2(C)C1=CC(=C(C=C1)Cl)F)=O ILAXOCFPUSBEAT-UHFFFAOYSA-N 0.000 claims description 2
- JYDSMTRMKOUTQS-UHFFFAOYSA-N 4-amino-5-(4-chloro-3-fluorophenyl)-5-methyl-2-[8-(3,3,4,4,4-pentafluorobutyl)-[1,2,4]triazolo[1,5-a]pyrazin-6-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical group NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCC(C(F)(F)F)(F)F)NC(C2(C)C1=CC(=C(C=C1)Cl)F)=O JYDSMTRMKOUTQS-UHFFFAOYSA-N 0.000 claims description 2
- FQFPGEPRBPWOPZ-UHFFFAOYSA-N 4-amino-5-(4-chloro-3-fluorophenyl)-5-methyl-2-[8-(4,4,4-trifluorobutyl)-[1,2,4]triazolo[1,5-a]pyrazin-6-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC(F)(F)F)NC(C2(C)C1=CC(=C(C=C1)Cl)F)=O FQFPGEPRBPWOPZ-UHFFFAOYSA-N 0.000 claims description 2
- IYELZELRRUTSRM-UHFFFAOYSA-N 4-amino-5-(4-chlorophenyl)-5-cyclopropyl-2-[8-(4,4,4-trifluorobutyl)-[1,2,4]triazolo[1,5-a]pyrazin-6-yl]-7H-pyrrolo[2,3-d]pyrimidin-6-one Chemical compound NC=1C2=C(N=C(N=1)C=1N=C(C=3N(C=1)N=CN=3)CCCC(F)(F)F)NC(C2(C1CC1)C1=CC=C(C=C1)Cl)=O IYELZELRRUTSRM-UHFFFAOYSA-N 0.000 claims description 2
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| KR101404781B1 (ko) | 2007-06-28 | 2014-06-12 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 장치의 제조 방법 |
| US20090176778A1 (en) | 2007-08-10 | 2009-07-09 | Franz Ulrich Schmitz | Certain nitrogen containing bicyclic chemical entities for treating viral infections |
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-
2015
- 2015-11-13 TW TW104137596A patent/TW201625635A/zh unknown
- 2015-11-19 EP EP15801104.9A patent/EP3221319B1/en active Active
- 2015-11-19 CN CN201580063273.3A patent/CN107001389A/zh active Pending
- 2015-11-19 BR BR112017010551A patent/BR112017010551A2/pt not_active Application Discontinuation
- 2015-11-19 US US14/945,576 patent/US9822130B2/en active Active
- 2015-11-19 AU AU2015349888A patent/AU2015349888A1/en not_active Abandoned
- 2015-11-19 JP JP2017526957A patent/JP2017535561A/ja not_active Withdrawn
- 2015-11-19 WO PCT/US2015/061442 patent/WO2016081668A1/en not_active Ceased
- 2015-11-19 RU RU2017121278A patent/RU2017121278A/ru not_active Application Discontinuation
- 2015-11-19 CA CA2967965A patent/CA2967965A1/en not_active Abandoned
- 2015-11-19 MX MX2017006649A patent/MX2017006649A/es unknown
- 2015-11-19 KR KR1020177016515A patent/KR20170084299A/ko not_active Withdrawn
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