JP2018529731A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018529731A5 JP2018529731A5 JP2018516728A JP2018516728A JP2018529731A5 JP 2018529731 A5 JP2018529731 A5 JP 2018529731A5 JP 2018516728 A JP2018516728 A JP 2018516728A JP 2018516728 A JP2018516728 A JP 2018516728A JP 2018529731 A5 JP2018529731 A5 JP 2018529731A5
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- amino
- amine
- dimethylpentyl
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)CC(C*)(CO)N Chemical compound CC(C)CC(C*)(CO)N 0.000 description 2
- VRDXDROAZSDMSA-UHFFFAOYSA-N NC1(CO)CCC1 Chemical compound NC1(CO)CCC1 VRDXDROAZSDMSA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3169DE2015 | 2015-10-01 | ||
| IN3169/DEL/2015 | 2015-10-01 | ||
| PCT/US2016/054464 WO2017059080A1 (en) | 2015-10-01 | 2016-09-29 | Biaryl kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529731A JP2018529731A (ja) | 2018-10-11 |
| JP2018529731A5 true JP2018529731A5 (enExample) | 2019-11-07 |
| JP6864674B2 JP6864674B2 (ja) | 2021-04-28 |
Family
ID=57137279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516728A Active JP6864674B2 (ja) | 2015-10-01 | 2016-09-29 | ビアリールキナーゼ阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10246469B2 (enExample) |
| EP (1) | EP3356330B1 (enExample) |
| JP (1) | JP6864674B2 (enExample) |
| KR (1) | KR102707968B1 (enExample) |
| CN (1) | CN108290843B (enExample) |
| ES (1) | ES2767776T3 (enExample) |
| WO (1) | WO2017059080A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA028942B1 (ru) | 2014-04-02 | 2018-01-31 | Бристол-Майерс Сквибб Компани | Биарильные ингибиторы киназы |
| ES2765730T3 (es) | 2015-10-01 | 2020-06-10 | Bristol Myers Squibb Co | Inhibidores de biaril cinasa |
| CN108290843B (zh) | 2015-10-01 | 2021-08-24 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
| MY210039A (en) | 2018-10-30 | 2025-08-22 | Kronos Bio Inc | Compounds, compositions, and methods for modulating cdk9 activity |
| US12240838B2 (en) * | 2019-05-15 | 2025-03-04 | Biogen Ma Inc. | Inhibiting agents for Bruton's tyrosine kinase |
| MX2024000807A (es) * | 2021-07-15 | 2024-02-06 | Xizang Haisco Pharmaceutical Co Ltd | Inhibidor de aak1 y uso de este. |
| WO2023051749A1 (zh) * | 2021-09-30 | 2023-04-06 | 武汉人福创新药物研发中心有限公司 | Aak1抑制剂及其用途 |
| EP4507697A1 (en) * | 2022-04-15 | 2025-02-19 | Lexicon Pharmaceuticals, Inc. | Compounds and methods for treating spasticity |
| CN115894353B (zh) * | 2022-10-18 | 2025-08-29 | 山西永津集团有限公司 | 一种2,3-二氨基-4-溴吡啶的合成方法 |
| CN120202001A (zh) * | 2022-11-10 | 2025-06-24 | 西藏海思科制药有限公司 | 一种含aak1抑制剂的药物组合物 |
| CN120344529A (zh) * | 2022-12-13 | 2025-07-18 | 上海海雁医药科技有限公司 | 杂环取代的五并六元杂芳基衍生物、其药物组合物及应用与制备方法 |
| CN120641406A (zh) * | 2023-01-16 | 2025-09-12 | 上海海雁医药科技有限公司 | 杂环取代的含氮杂环衍生物、其药物组合物及应用与制备方法 |
| KR20250167096A (ko) | 2023-04-07 | 2025-11-28 | 앨리콘 파머슈티컬 컴퍼니 리미티드 | Aak1 억제제인 질소 함유 헤테로고리계 화합물 |
| CN118772152B (zh) * | 2023-04-07 | 2026-01-02 | 艾立康药业股份有限公司 | 作为aak1抑制剂的氮杂环类化合物 |
| CN116396241A (zh) * | 2023-04-12 | 2023-07-07 | 南京优氟医药科技有限公司 | 一种叔丁基（r）-4-乙基-2,2-二氧化物-1,2,3-氧杂噻唑烷-3-羧酸的制备方法 |
| WO2025092928A1 (zh) * | 2023-11-02 | 2025-05-08 | 西藏海思科制药有限公司 | 一种可抑制连接蛋白相关激酶1的化合物、制备及其用途 |
| WO2025225608A1 (en) * | 2024-04-23 | 2025-10-30 | Otsuka Pharmaceutical Co., Ltd. | Tetrahydropyrazolopyridine derivative |
| WO2025230262A1 (ko) * | 2024-04-29 | 2025-11-06 | 심플렉스 주식회사 | 신규한 헤테로아릴 유도체 및 이의 aak1 억제 용도 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US7348335B2 (en) | 2002-11-05 | 2008-03-25 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of JAK and other protein kinases |
| WO2007120593A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | Anilino-pyrimidine phenyl and benzothiophene analogs |
| MX2010005070A (es) | 2007-11-15 | 2010-05-24 | Angeletti P Ist Richerche Bio | Derivados de piridazinona como inhibidores de parp. |
| UA115326C2 (uk) * | 2012-02-29 | 2017-10-25 | Мейдзі Сейка Фарма Ко., Лтд. | Композиція для боротьби зі шкідниками, яка включає нове похідне імінопіридину |
| US8703953B2 (en) * | 2012-03-09 | 2014-04-22 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| HUE036040T2 (hu) | 2012-03-09 | 2018-06-28 | Lexicon Pharmaceuticals Inc | Adaptor-asszociált kináz 1 gátlása fájdalom kezelésére |
| US8901305B2 (en) | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| WO2014130258A1 (en) | 2013-02-22 | 2014-08-28 | Bristol-Myers Squibb Company | 5h-chromeno[3,4-c]pyridines as inhibitors of adaptor associated kinase 1 (aak1) |
| EP3019475A1 (en) | 2013-07-08 | 2016-05-18 | Bristol-Myers Squibb Company | Aryl amide kinase inhibitors |
| CN105683196B (zh) | 2013-09-11 | 2018-12-21 | 百时美施贵宝公司 | 基于芳基醚的激酶抑制剂 |
| CA2922506A1 (en) * | 2013-09-19 | 2015-03-26 | Basf Se | N-acylimino heterocyclic compounds |
| JP6276865B2 (ja) | 2014-01-29 | 2018-02-07 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | アリールラクタムキナーゼ阻害剤 |
| EA201691397A1 (ru) | 2014-01-31 | 2016-11-30 | Бристол-Майерс Сквибб Компани | Хинолиновые ингибиторы киназы |
| EA028942B1 (ru) * | 2014-04-02 | 2018-01-31 | Бристол-Майерс Сквибб Компани | Биарильные ингибиторы киназы |
| US20170239249A1 (en) | 2014-09-30 | 2017-08-24 | Bristol-Myers Squibb Company | Quinazoline-based kinase inhibitors |
| US10174044B2 (en) | 2015-04-10 | 2019-01-08 | Bristol-Myers Squibb Company | Fused pyridines as kinase inhibitors |
| ES2765730T3 (es) | 2015-10-01 | 2020-06-10 | Bristol Myers Squibb Co | Inhibidores de biaril cinasa |
| CN108290843B (zh) | 2015-10-01 | 2021-08-24 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
-
2016
- 2016-09-29 CN CN201680070096.6A patent/CN108290843B/zh active Active
- 2016-09-29 WO PCT/US2016/054464 patent/WO2017059080A1/en not_active Ceased
- 2016-09-29 US US15/763,281 patent/US10246469B2/en active Active
- 2016-09-29 JP JP2018516728A patent/JP6864674B2/ja active Active
- 2016-09-29 EP EP16781938.2A patent/EP3356330B1/en active Active
- 2016-09-29 KR KR1020187011873A patent/KR102707968B1/ko active Active
- 2016-09-29 ES ES16781938T patent/ES2767776T3/es active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018529731A5 (enExample) | ||
| JP2022184886A5 (enExample) | ||
| JP2016537384A5 (enExample) | ||
| RU2473549C2 (ru) | Пиримидиновые соединения, композиции и способы применения | |
| RU2412943C2 (ru) | ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2 | |
| KR101110530B1 (ko) | 증식성 질환의 치료에 유용한 키나제 억제제 | |
| KR102021159B1 (ko) | 트리시클릭 헤테로시클릭 화합물 및 jak 저해제 | |
| RU2424242C2 (ru) | Азолопиримидины в качестве ингибиторов активности каннабиноидного рецептора 1 | |
| JP2020504136A5 (enExample) | ||
| WO2022093856A1 (en) | Heterocyclic spiro compounds and methods of use | |
| US20240059703A1 (en) | Heterocyclic spiro compounds and methods of use | |
| JP2001097889A (ja) | Ｃｒｆアンタゴニストおよび関連組成物の使用 | |
| US20180282282A1 (en) | Isoquinolines as inhibitors of hpk1 | |
| JP2007522200A5 (enExample) | ||
| JP2016500671A5 (enExample) | ||
| JP2019535664A5 (enExample) | ||
| RU2016140338A (ru) | Азаспиро производные в качестве антагонистов trpm8 | |
| JP2013522354A5 (enExample) | ||
| JP2019536768A5 (enExample) | ||
| HRP20120105T1 (hr) | Aminoheterociklički spojevi | |
| JP2016520116A5 (enExample) | ||
| JP2017535561A5 (enExample) | ||
| JP2015508075A5 (enExample) | ||
| RU2017121278A (ru) | Триазоло-пиразинильные производные, применимые в качестве растворимых активаторов гуанилатциклазы | |
| JP2005500315A5 (enExample) |