KR102707968B1 - 비아릴 키나제 억제제 - Google Patents
비아릴 키나제 억제제 Download PDFInfo
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- KR102707968B1 KR102707968B1 KR1020187011873A KR20187011873A KR102707968B1 KR 102707968 B1 KR102707968 B1 KR 102707968B1 KR 1020187011873 A KR1020187011873 A KR 1020187011873A KR 20187011873 A KR20187011873 A KR 20187011873A KR 102707968 B1 KR102707968 B1 KR 102707968B1
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- pyridin
- oxy
- amine
- amino
- dimethylpentyl
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/63—One oxygen atom
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| IN3169/DEL/2015 | 2015-10-01 | ||
| IN3169DE2015 | 2015-10-01 | ||
| PCT/US2016/054464 WO2017059080A1 (en) | 2015-10-01 | 2016-09-29 | Biaryl kinase inhibitors |
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| KR20180056764A KR20180056764A (ko) | 2018-05-29 |
| KR102707968B1 true KR102707968B1 (ko) | 2024-09-20 |
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| WO (1) | WO2017059080A1 (enExample) |
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| KR102379518B1 (ko) | 2014-04-02 | 2022-03-25 | 브리스톨-마이어스 스큅 컴퍼니 | 비아릴 키나제 억제제 |
| US10544120B2 (en) | 2015-10-01 | 2020-01-28 | Bristol-Myers Squibb Company | Biaryl kinase inhibitors |
| ES2767776T3 (es) | 2015-10-01 | 2020-06-18 | Bristol Myers Squibb Co | Inhibidores de biaril cinasa |
| JP7385658B2 (ja) | 2018-10-30 | 2023-11-22 | クロノス バイオ インコーポレイテッド | Cdk9活性を調節するための化合物、組成物、および方法 |
| JP7747523B2 (ja) * | 2019-05-15 | 2025-10-01 | バイオジェン・エムエイ・インコーポレイテッド | ブルトン型チロシンキナーゼの阻害剤 |
| CN117715899A (zh) * | 2021-07-15 | 2024-03-15 | 西藏海思科制药有限公司 | Aak1抑制剂及其用途 |
| WO2023051749A1 (zh) * | 2021-09-30 | 2023-04-06 | 武汉人福创新药物研发中心有限公司 | Aak1抑制剂及其用途 |
| CA3247370A1 (en) * | 2022-04-15 | 2023-10-19 | Lexicon Pharmaceuticals Inc | COMPOUNDS AND METHODS OF TREATMENT FOR SPASTICITY |
| CN115894353B (zh) * | 2022-10-18 | 2025-08-29 | 山西永津集团有限公司 | 一种2,3-二氨基-4-溴吡啶的合成方法 |
| CN120202001A (zh) * | 2022-11-10 | 2025-06-24 | 西藏海思科制药有限公司 | 一种含aak1抑制剂的药物组合物 |
| CN120344529A (zh) * | 2022-12-13 | 2025-07-18 | 上海海雁医药科技有限公司 | 杂环取代的五并六元杂芳基衍生物、其药物组合物及应用与制备方法 |
| CN120641406A (zh) * | 2023-01-16 | 2025-09-12 | 上海海雁医药科技有限公司 | 杂环取代的含氮杂环衍生物、其药物组合物及应用与制备方法 |
| WO2024207945A1 (zh) * | 2023-04-07 | 2024-10-10 | 艾立康药业股份有限公司 | 作为aak1抑制剂的氮杂环类化合物 |
| CN118772152A (zh) * | 2023-04-07 | 2024-10-15 | 艾立康药业股份有限公司 | 作为aak1抑制剂的氮杂环类化合物 |
| CN116396241A (zh) * | 2023-04-12 | 2023-07-07 | 南京优氟医药科技有限公司 | 一种叔丁基(r)-4-乙基-2,2-二氧化物-1,2,3-氧杂噻唑烷-3-羧酸的制备方法 |
| WO2025092928A1 (zh) * | 2023-11-02 | 2025-05-08 | 西藏海思科制药有限公司 | 一种可抑制连接蛋白相关激酶1的化合物、制备及其用途 |
| WO2025225608A1 (en) * | 2024-04-23 | 2025-10-30 | Otsuka Pharmaceutical Co., Ltd. | Tetrahydropyrazolopyridine derivative |
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| WO2013134036A1 (en) | 2012-03-09 | 2013-09-12 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| WO2014022167A1 (en) | 2012-07-31 | 2014-02-06 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
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| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| AU2003286895A1 (en) | 2002-11-05 | 2004-06-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of jak and other protein kinases |
| AU2007238897A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | Anilino-pyrimidine phenyl and benzothiophene analogs |
| US8268827B2 (en) | 2007-11-15 | 2012-09-18 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa. | Pyridazinone derivatives as PARP inhibitors |
| AR093195A1 (es) * | 2012-02-29 | 2015-05-27 | Meiji Seika Pharma Co Ltd | Composicion para el control de plagas que incluye un derivado de iminopiridina |
| HUE036040T2 (hu) | 2012-03-09 | 2018-06-28 | Lexicon Pharmaceuticals Inc | Adaptor-asszociált kináz 1 gátlása fájdalom kezelésére |
| JP2016509066A (ja) | 2013-02-22 | 2016-03-24 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | アダプター関連キナーゼ1(aak1)の阻害剤としての5h−クロメノ[3,4−c]ピリジン |
| WO2015006100A1 (en) | 2013-07-08 | 2015-01-15 | Bristol-Myers Squibb Company | Aryl amide kinase inhibitors |
| WO2015038112A1 (en) | 2013-09-11 | 2015-03-19 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| EP3046919B1 (en) * | 2013-09-19 | 2019-08-07 | Basf Se | N-acylimino heterocyclic compounds |
| EP3099300B1 (en) | 2014-01-29 | 2018-09-05 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| ES2701903T3 (es) | 2014-01-31 | 2019-02-26 | Bristol Myers Squibb Co | Inhibidores de cinasa a base de quinolina |
| KR102379518B1 (ko) * | 2014-04-02 | 2022-03-25 | 브리스톨-마이어스 스큅 컴퍼니 | 비아릴 키나제 억제제 |
| EP3200797A1 (en) | 2014-09-30 | 2017-08-09 | Bristol-Myers Squibb Company | Quinazoline-based kinase inhibitors |
| EP3292124B1 (en) | 2015-04-10 | 2019-05-22 | Bristol-Myers Squibb Company | 6h-isochromeno[3,4-c]pyridines and benzo[c][1,7]naphthyridin-6-(5h)-ones as adaptor associated kinase 1 (aak1) inhibitors |
| US10544120B2 (en) | 2015-10-01 | 2020-01-28 | Bristol-Myers Squibb Company | Biaryl kinase inhibitors |
| ES2767776T3 (es) | 2015-10-01 | 2020-06-18 | Bristol Myers Squibb Co | Inhibidores de biaril cinasa |
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2016
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- 2016-09-29 CN CN201680070096.6A patent/CN108290843B/zh active Active
- 2016-09-29 WO PCT/US2016/054464 patent/WO2017059080A1/en not_active Ceased
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013134036A1 (en) | 2012-03-09 | 2013-09-12 | Bristol-Myers Squibb Company | Aryl ether-base kinase inhibitors |
| WO2014022167A1 (en) | 2012-07-31 | 2014-02-06 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108290843B (zh) | 2021-08-24 |
| KR20180056764A (ko) | 2018-05-29 |
| EP3356330A1 (en) | 2018-08-08 |
| CN108290843A (zh) | 2018-07-17 |
| JP2018529731A (ja) | 2018-10-11 |
| ES2767776T3 (es) | 2020-06-18 |
| WO2017059080A1 (en) | 2017-04-06 |
| US20190040080A1 (en) | 2019-02-07 |
| EP3356330B1 (en) | 2019-11-20 |
| JP6864674B2 (ja) | 2021-04-28 |
| US10246469B2 (en) | 2019-04-02 |
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