TW201625635A - 作為可溶性鳥苷酸環化酶活化劑之三唑并吡基衍生物 - Google Patents
作為可溶性鳥苷酸環化酶活化劑之三唑并吡基衍生物 Download PDFInfo
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- TW201625635A TW201625635A TW104137596A TW104137596A TW201625635A TW 201625635 A TW201625635 A TW 201625635A TW 104137596 A TW104137596 A TW 104137596A TW 104137596 A TW104137596 A TW 104137596A TW 201625635 A TW201625635 A TW 201625635A
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- Prior art keywords
- triazolo
- pyrrolo
- pyrimidin
- pyridyl
- methyl
- Prior art date
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Classifications
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Landscapes
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| EP3079700B1 (en) | 2013-12-11 | 2020-11-25 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| EP3079701B1 (en) | 2013-12-11 | 2021-08-11 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| WO2015187470A1 (en) | 2014-06-04 | 2015-12-10 | Merck Sharp & Dohme Corp. | Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators |
| JP2017526685A (ja) * | 2014-08-29 | 2017-09-14 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換縮環ピリミジンおよびその使用 |
| US10245264B2 (en) | 2015-05-27 | 2019-04-02 | Merck Sharp & Dohme Corp. | Substituted imidazo[1,2-a]pyrazines as soluble guanylate cyclase activators |
| EP3310782B1 (en) | 2015-05-28 | 2021-12-01 | Merck Sharp & Dohme Corp. | Imidazo-pyrazinyl derivatives useful as soluble guanylate cyclase activators |
| WO2017107052A1 (en) | 2015-12-22 | 2017-06-29 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase stimulators |
| WO2017197555A1 (en) * | 2016-05-16 | 2017-11-23 | Merck Sharp & Dohme Corp. | Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators |
| EP3458063A4 (en) * | 2016-05-18 | 2020-02-26 | Merck Sharp & Dohme Corp. | METHOD FOR USE OF TRIAZOLO-PYRAZINYL-SOLUBLE GUANYLATE CYCLASE ACTIVATORS IN FIBROTIC DISEASES |
| CN105968055B (zh) * | 2016-07-26 | 2018-08-28 | 中国科学院长春应用化学研究所 | 一种芳基嘧啶及其衍生物的制备方法 |
| PE20190607A1 (es) * | 2016-09-02 | 2019-04-23 | Ironwood Pharmaceuticals Inc | Estimuladores de sgc |
| WO2018069148A1 (de) | 2016-10-11 | 2018-04-19 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend sgc aktivatoren und mineralocorticoid-rezeptor-antagonisten |
| JP7101688B2 (ja) | 2016-10-11 | 2022-07-15 | バイエル・ファルマ・アクティエンゲゼルシャフト | ｓＧＣ刺激薬とミネラルコルチコイド受容体拮抗薬とを含む組み合わせ |
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| SG11202005718PA (en) * | 2017-12-19 | 2020-07-29 | Cyclerion Therapeutics Inc | Sgc stimulators |
| CN112055584A (zh) | 2018-04-30 | 2020-12-08 | 拜耳公司 | sGC活化剂和sGC刺激剂用于治疗认知障碍的用途 |
| CN112384213A (zh) | 2018-05-15 | 2021-02-19 | 拜耳公司 | 用于治疗与神经纤维敏化有关的疾病的1,3-噻唑-2-基取代的苯甲酰胺 |
| US11508483B2 (en) | 2018-05-30 | 2022-11-22 | Adverio Pharma Gmbh | Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group |
| WO2020148379A1 (en) | 2019-01-17 | 2020-07-23 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc) |
| CN115515963B (zh) * | 2020-04-30 | 2025-08-01 | 正大天晴药业集团股份有限公司 | 嘧啶三并环类化合物及其应用 |
| MX2023012398A (es) | 2021-04-20 | 2024-03-13 | Tisento Therapeutics Inc | Estimuladores de guanilil ciclasa soluble (sgc). |
| JP2024516623A (ja) | 2021-04-20 | 2024-04-16 | ティセント セラピューティクス インコーポレーテッド | ｓＧＣ刺激剤でのＣＮＳ疾患の処置 |
| WO2024086182A1 (en) | 2022-10-18 | 2024-04-25 | Tisento Therapeutics Inc. | Treatment of mitochondrial diseases with sgc stimulators |
| CN116768868B (zh) * | 2023-08-15 | 2023-12-08 | 云南省药物研究所 | 一种哒嗪酮硫代衍生物及其制备方法和应用 |
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| WO2012058132A1 (en) | 2010-10-28 | 2012-05-03 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| US9090610B2 (en) | 2011-04-21 | 2015-07-28 | Bayer Intellectual Property Gmbh | Fluoroalkyl-substituted pyrazolopyridines and use thereof |
| ES2592267T3 (es) | 2011-05-06 | 2016-11-29 | Bayer Intellectual Property Gmbh | Imidazopiridinas e imidazopiridazinas sustituidas y su uso |
| EP2729476B1 (de) | 2011-07-06 | 2017-08-23 | Bayer Intellectual Property GmbH | Heteroaryl-substituierte pyrazolopyridine und ihre verwendung als stimulatoren der löslichen guanylatcyclase |
| KR20140068112A (ko) | 2011-09-02 | 2014-06-05 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 치환된 융합 피리미딘 및 그의 용도 |
| DE102012200352A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung |
| DE102012200349A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
| EP3079700B1 (en) | 2013-12-11 | 2020-11-25 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| EP3079701B1 (en) | 2013-12-11 | 2021-08-11 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| WO2015187470A1 (en) | 2014-06-04 | 2015-12-10 | Merck Sharp & Dohme Corp. | Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators |
-
2015
- 2015-11-13 TW TW104137596A patent/TW201625635A/zh unknown
- 2015-11-19 WO PCT/US2015/061442 patent/WO2016081668A1/en not_active Ceased
- 2015-11-19 RU RU2017121278A patent/RU2017121278A/ru not_active Application Discontinuation
- 2015-11-19 CA CA2967965A patent/CA2967965A1/en not_active Abandoned
- 2015-11-19 BR BR112017010551A patent/BR112017010551A2/pt not_active Application Discontinuation
- 2015-11-19 JP JP2017526957A patent/JP2017535561A/ja not_active Withdrawn
- 2015-11-19 KR KR1020177016515A patent/KR20170084299A/ko not_active Withdrawn
- 2015-11-19 AU AU2015349888A patent/AU2015349888A1/en not_active Abandoned
- 2015-11-19 CN CN201580063273.3A patent/CN107001389A/zh active Pending
- 2015-11-19 US US14/945,576 patent/US9822130B2/en active Active
- 2015-11-19 EP EP15801104.9A patent/EP3221319B1/en active Active
- 2015-11-19 MX MX2017006649A patent/MX2017006649A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2967965A1 (en) | 2016-05-26 |
| AU2015349888A1 (en) | 2017-05-18 |
| CN107001389A (zh) | 2017-08-01 |
| BR112017010551A2 (pt) | 2018-02-27 |
| RU2017121278A (ru) | 2018-12-21 |
| WO2016081668A1 (en) | 2016-05-26 |
| RU2017121278A3 (enExample) | 2019-04-04 |
| JP2017535561A (ja) | 2017-11-30 |
| US20170073355A2 (en) | 2017-03-16 |
| US20160145272A1 (en) | 2016-05-26 |
| EP3221319B1 (en) | 2019-10-30 |
| KR20170084299A (ko) | 2017-07-19 |
| EP3221319A1 (en) | 2017-09-27 |
| US9822130B2 (en) | 2017-11-21 |
| MX2017006649A (es) | 2017-08-21 |
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