TW201625635A - 作為可溶性鳥苷酸環化酶活化劑之三唑并吡基衍生物 - Google Patents
作為可溶性鳥苷酸環化酶活化劑之三唑并吡基衍生物 Download PDFInfo
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- TW201625635A TW201625635A TW104137596A TW104137596A TW201625635A TW 201625635 A TW201625635 A TW 201625635A TW 104137596 A TW104137596 A TW 104137596A TW 104137596 A TW104137596 A TW 104137596A TW 201625635 A TW201625635 A TW 201625635A
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- Prior art keywords
- triazolo
- pyrrolo
- pyrimidin
- pyridyl
- methyl
- Prior art date
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Classifications
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Landscapes
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| US9796733B2 (en) | 2014-06-04 | 2017-10-24 | Merck Sharp & Dohme Corp. | Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators |
| JP2017526685A (ja) * | 2014-08-29 | 2017-09-14 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換縮環ピリミジンおよびその使用 |
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| WO2017107052A1 (en) | 2015-12-22 | 2017-06-29 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase stimulators |
| WO2017197555A1 (en) * | 2016-05-16 | 2017-11-23 | Merck Sharp & Dohme Corp. | Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators |
| EP3458063A4 (en) * | 2016-05-18 | 2020-02-26 | Merck Sharp & Dohme Corp. | METHOD FOR USE OF TRIAZOLO-PYRAZINYL-SOLUBLE GUANYLATE CYCLASE ACTIVATORS IN FIBROTIC DISEASES |
| CN105968055B (zh) * | 2016-07-26 | 2018-08-28 | 中国科学院长春应用化学研究所 | 一种芳基嘧啶及其衍生物的制备方法 |
| SI3507291T1 (sl) | 2016-09-02 | 2021-11-30 | Cyclerion Therapeutics, Inc. | Kondenzirani biciklični SGS stimulatorji |
| CN109890379A (zh) | 2016-10-11 | 2019-06-14 | 拜耳制药股份公司 | 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品 |
| EP3525779B1 (de) | 2016-10-11 | 2024-06-05 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend den sgc stimulator vericuguat und den mineralcorticoid-rezeptor-antagonist finerenone |
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| MX2020006433A (es) | 2017-12-19 | 2020-09-17 | Cyclerion Therapeutics Inc | Estimuladores de guanilato ciclasa soluble (sgc). |
| EP3787610A1 (en) | 2018-04-30 | 2021-03-10 | Bayer Aktiengesellschaft | The use of sgc activators and sgc stimulators for the treatment of cognitive impairment |
| EP3793553A1 (en) | 2018-05-15 | 2021-03-24 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| EP3574905A1 (en) | 2018-05-30 | 2019-12-04 | Adverio Pharma GmbH | Method of identifying a subgroup of patients suffering from dcssc which benefits from a treatment with sgc stimulators and sgc activators in a higher degree than a control group |
| US20220128561A1 (en) | 2019-01-17 | 2022-04-28 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble gyanylyl cyclase (sgc) |
| EP4144741B1 (en) * | 2020-04-30 | 2025-07-23 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Pyrimidine-based tricyclic compound and use thereof |
| CN117957228A (zh) * | 2021-04-20 | 2024-04-30 | 帝善多制药公司 | sGC刺激剂 |
| EP4326268A1 (en) | 2021-04-20 | 2024-02-28 | Tisento Therapeutics Inc. | Treatment of cns diseases with sgc stimulators |
| US20240208979A1 (en) * | 2021-04-20 | 2024-06-27 | Tisento Therapeutics Inc. | sGC STIMULATORS |
| EP4605080A1 (en) | 2022-10-18 | 2025-08-27 | Tisento Therapeutics Inc. | Treatment of mitochondrial diseases with sgc stimulators |
| CN116768868B (zh) * | 2023-08-15 | 2023-12-08 | 云南省药物研究所 | 一种哒嗪酮硫代衍生物及其制备方法和应用 |
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| EA201390060A1 (ru) | 2010-07-09 | 2013-07-30 | Байер Интеллектуэль Проперти Гмбх | Аннелированные пиримидины и триазины и их применение для лечения и/или профилактики сердечно-сосудистых заболеваний |
| EP2632551B1 (en) | 2010-10-28 | 2016-07-06 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| JP6005134B2 (ja) | 2011-04-21 | 2016-10-12 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | フルオロアルキル置換ピラゾロピリジンおよびその使用 |
| CA2834901A1 (en) | 2011-05-06 | 2012-11-15 | Bayer Intellectual Property Gmbh | Substituted imidazopyridines and imidazopyridazines and the use thereof |
| CN103906752B (zh) | 2011-07-06 | 2016-08-24 | 拜耳知识产权有限责任公司 | 杂芳基取代的吡唑并吡啶及其用作可溶性鸟苷酸环化酶刺激剂的用途 |
| CN104039784B (zh) | 2011-09-02 | 2017-08-22 | 拜耳知识产权有限责任公司 | 取代的增环嘧啶及其用途 |
| DE102012200352A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung |
| DE102012200349A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
| WO2015088886A1 (en) | 2013-12-11 | 2015-06-18 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| WO2015088885A1 (en) | 2013-12-11 | 2015-06-18 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| US9796733B2 (en) | 2014-06-04 | 2017-10-24 | Merck Sharp & Dohme Corp. | Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators |
-
2015
- 2015-11-13 TW TW104137596A patent/TW201625635A/zh unknown
- 2015-11-19 KR KR1020177016515A patent/KR20170084299A/ko not_active Withdrawn
- 2015-11-19 CA CA2967965A patent/CA2967965A1/en not_active Abandoned
- 2015-11-19 MX MX2017006649A patent/MX2017006649A/es unknown
- 2015-11-19 US US14/945,576 patent/US9822130B2/en active Active
- 2015-11-19 BR BR112017010551A patent/BR112017010551A2/pt not_active Application Discontinuation
- 2015-11-19 WO PCT/US2015/061442 patent/WO2016081668A1/en not_active Ceased
- 2015-11-19 EP EP15801104.9A patent/EP3221319B1/en active Active
- 2015-11-19 CN CN201580063273.3A patent/CN107001389A/zh active Pending
- 2015-11-19 JP JP2017526957A patent/JP2017535561A/ja not_active Withdrawn
- 2015-11-19 RU RU2017121278A patent/RU2017121278A/ru not_active Application Discontinuation
- 2015-11-19 AU AU2015349888A patent/AU2015349888A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2017006649A (es) | 2017-08-21 |
| US20170073355A2 (en) | 2017-03-16 |
| US9822130B2 (en) | 2017-11-21 |
| CN107001389A (zh) | 2017-08-01 |
| RU2017121278A (ru) | 2018-12-21 |
| JP2017535561A (ja) | 2017-11-30 |
| US20160145272A1 (en) | 2016-05-26 |
| EP3221319B1 (en) | 2019-10-30 |
| RU2017121278A3 (enExample) | 2019-04-04 |
| AU2015349888A1 (en) | 2017-05-18 |
| EP3221319A1 (en) | 2017-09-27 |
| CA2967965A1 (en) | 2016-05-26 |
| BR112017010551A2 (pt) | 2018-02-27 |
| KR20170084299A (ko) | 2017-07-19 |
| WO2016081668A1 (en) | 2016-05-26 |
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