JP2022534751A5 - - Google Patents

Info

Publication number
JP2022534751A5
JP2022534751A5 JP2021570931A JP2021570931A JP2022534751A5 JP 2022534751 A5 JP2022534751 A5 JP 2022534751A5 JP 2021570931 A JP2021570931 A JP 2021570931A JP 2021570931 A JP2021570931 A JP 2021570931A JP 2022534751 A5 JP2022534751 A5 JP 2022534751A5
Authority
JP
Japan
Prior art keywords
methyl
quinazoline
amine
methoxy
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021570931A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022534751A (ja
JP7641917B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2020/064914 external-priority patent/WO2020239952A1/en
Publication of JP2022534751A publication Critical patent/JP2022534751A/ja
Publication of JP2022534751A5 publication Critical patent/JP2022534751A5/ja
Application granted granted Critical
Publication of JP7641917B2 publication Critical patent/JP7641917B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021570931A 2019-05-31 2020-05-28 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体 Active JP7641917B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19177604.6 2019-05-31
EP19177604 2019-05-31
EP19201168 2019-10-02
EP19201168.2 2019-10-02
PCT/EP2020/064914 WO2020239952A1 (en) 2019-05-31 2020-05-28 Amino quinazoline derivatives as p2x3 inhibitors

Publications (3)

Publication Number Publication Date
JP2022534751A JP2022534751A (ja) 2022-08-03
JP2022534751A5 true JP2022534751A5 (enExample) 2023-06-05
JP7641917B2 JP7641917B2 (ja) 2025-03-07

Family

ID=70861506

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021570931A Active JP7641917B2 (ja) 2019-05-31 2020-05-28 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体
JP2021570930A Active JP7644029B2 (ja) 2019-05-31 2020-05-28 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体
JP2025029719A Pending JP2025098014A (ja) 2019-05-31 2025-02-27 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021570930A Active JP7644029B2 (ja) 2019-05-31 2020-05-28 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体
JP2025029719A Pending JP2025098014A (ja) 2019-05-31 2025-02-27 Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体

Country Status (20)

Country Link
US (2) US20230092892A1 (enExample)
EP (2) EP3976179A1 (enExample)
JP (3) JP7641917B2 (enExample)
KR (2) KR102921974B1 (enExample)
CN (3) CN118239931A (enExample)
AU (2) AU2020285336B2 (enExample)
BR (2) BR112021021738A2 (enExample)
CA (2) CA3139019A1 (enExample)
CL (1) CL2021003165A1 (enExample)
CO (1) CO2021017031A2 (enExample)
GE (2) GEP20257823B (enExample)
IL (1) IL288405A (enExample)
MA (2) MA56022A (enExample)
MX (2) MX2021014115A (enExample)
PE (1) PE20220934A1 (enExample)
PH (1) PH12021552881A1 (enExample)
SA (1) SA521430920B1 (enExample)
SG (1) SG11202112187YA (enExample)
WO (2) WO2020239951A1 (enExample)
ZA (1) ZA202108273B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2989387T3 (es) 2019-05-31 2024-11-26 Janssen Pharmaceutica Nv Pequeñas moléculas inhibidoras de la quinasa inductora de nf-kb
WO2020243423A1 (en) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Tead inhibitors and uses thereof
BR112021021738A2 (pt) * 2019-05-31 2021-12-28 Chiesi Farm Spa Derivados de amino quinazolina como inibidores de p2x3
US11274082B2 (en) 2019-05-31 2022-03-15 Ikena Oncology, Inc. Tead inhibitors and uses thereof
MX2021014116A (es) * 2019-05-31 2021-12-10 Chiesi Farm Spa Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3).
CN115884970B (zh) * 2020-09-24 2025-09-23 中国医药研究开发中心有限公司 芳基甲酰胺类化合物及其制备方法和医药用途
WO2022083657A1 (zh) * 2020-10-20 2022-04-28 苏州泽璟生物制药股份有限公司 取代苯并或吡啶并嘧啶胺类抑制剂及其制备方法和应用
MX2023005803A (es) * 2020-11-27 2023-05-29 Chiesi Farm Spa Derivados de amino-quinazolina como inhibidores del purinorreceptor 3 p2x (p2x3).
EP4251617B1 (en) * 2020-11-27 2025-03-12 Chiesi Farmaceutici S.p.A. (aza)quinoline 4-amines derivatives as p2x3 inhibitors
CN112661803A (zh) * 2020-12-17 2021-04-16 上海药明康德新药开发有限公司 DNA编码化合物库构建中On-DNA 4-胺基喹唑啉化合物的合成方法
US20240239764A1 (en) 2020-12-22 2024-07-18 Mekanistic Therapeutics Substituted aminobenzyl heteroaryl compounds as egfr and/or pi3k inhibitors
CN114907284B (zh) * 2021-02-10 2023-11-03 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的化合物及其用途
CN115677601B (zh) * 2021-07-29 2025-06-03 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的化合物及其用途
WO2024235225A1 (zh) * 2023-05-15 2024-11-21 苏州泽璟生物制药股份有限公司 取代嘧啶并环类抑制剂及其制备方法和应用
CN121368584A (zh) 2023-05-22 2026-01-20 奇斯药制品公司 用于制备p2x3抑制剂的方法及中间体
CN121175304A (zh) 2023-05-22 2025-12-19 奇斯药制品公司 胺基喹唑啉衍生物的盐
WO2025101598A1 (en) * 2023-11-07 2025-05-15 Zeno Management, Inc. Bi-cyclic pyrimidine compounds, methods and uses thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0710843A (ja) * 1993-03-31 1995-01-13 Eisai Co Ltd 含窒素縮合複素環化合物
PH31122A (en) * 1993-03-31 1998-02-23 Eisai Co Ltd Nitrogen-containing fused-heterocycle compounds.
JP4342007B2 (ja) 1998-08-10 2009-10-14 大日本住友製薬株式会社 キナゾリン誘導体
GB0126433D0 (en) * 2001-11-03 2002-01-02 Astrazeneca Ab Compounds
ES2391636T3 (es) * 2004-03-05 2012-11-28 F. Hoffmann-La Roche Ag Diaminopirimidinas como antagonistas de P2X3 y P2X2/3
ATE537169T1 (de) * 2005-08-15 2011-12-15 Hoffmann La Roche Piperidin- und piperazinderivate als p2x3- antagonisten
KR101012926B1 (ko) 2005-09-01 2011-02-09 에프. 호프만-라 로슈 아게 Ｐ2ｘ3 및 ｐ2ｘ2/3 조정자로서의 다이아미노피리미딘
ES2604542T3 (es) 2006-06-29 2017-03-07 F. Hoffmann-La Roche Ag Arilamidas con sustitución tetrazol
JP5396379B2 (ja) 2007-04-02 2014-01-22 エボテック・アーゲー ピリド−２−イル縮合複素環式化合物ならびにその組成物および使用
WO2008130481A1 (en) 2007-04-17 2008-10-30 Renovis, Inc. 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof
CN101981003B (zh) 2008-02-29 2014-07-02 伊沃泰克股份公司 酰胺化合物、组合物及其应用
JP5608655B2 (ja) 2008-09-18 2014-10-15 エヴォテック アーゲー Ｐ２ｘ３受容体活性のモジュレーター
JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
CA2886139A1 (en) * 2012-12-27 2014-07-03 F. Hoffmann-La Roche Ag Comt inhibitors
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
EP3200797A1 (en) * 2014-09-30 2017-08-09 Bristol-Myers Squibb Company Quinazoline-based kinase inhibitors
WO2016084922A1 (ja) 2014-11-28 2016-06-02 塩野義製薬株式会社 １，２，４－トリアジン誘導体およびその医薬組成物
JPWO2016088838A1 (ja) 2014-12-04 2017-09-14 塩野義製薬株式会社 プリン誘導体およびその医薬組成物
JP6544665B2 (ja) 2014-12-09 2019-07-17 バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ １，３−チアゾール−２−イル置換ベンズアミド
WO2017011729A1 (en) 2015-07-16 2017-01-19 Patara Pharma, LLC Combination therapies for the treatment of lung diseases
PT3355889T (pt) 2015-09-29 2023-04-26 Afferent Pharmaceuticals Inc Moduladores de recetores de diaminopirimidina p2x3 e p2x2/3 para utilização no tratamento da tosse
WO2017091661A1 (en) * 2015-11-25 2017-06-01 Strovel Jeffrey William Bicyclic bet bromodomain inhibitors and uses thereof
ES2800339T3 (es) * 2016-06-30 2020-12-29 Gilead Sciences Inc 4,6-diaminoquinazolinas como moduladores de cuna y métodos de uso de los mismos
EP3497087B1 (en) 2016-08-15 2021-11-10 Neupharma, Inc. Pyrrolo[1,2-c]pyrimidine, imidazo[1,5-c]pyrimidine, quinazoline, purine and imidazo[1,5-a][1,3,5]triazine derivatives as tyrosine kinase inhibitors for the treatment of cancer
US10898487B2 (en) 2016-12-22 2021-01-26 Boehringer Ingelheim International Gmbh Benzylamino substituted quinazolines and derivatives as SOS1 inhibitors
GB201700814D0 (en) 2017-01-17 2017-03-01 Liverpool School Tropical Medicine Compounds
US20220235013A1 (en) * 2017-03-21 2022-07-28 Bayer Pharma Aktiengesellschaft 2-methyl-quinazolines
WO2018204775A1 (en) * 2017-05-05 2018-11-08 Hepanova, Inc. Amino-aryl-benzamide compounds and methods of use thereof
MX2021014116A (es) 2019-05-31 2021-12-10 Chiesi Farm Spa Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3).
BR112021021738A2 (pt) 2019-05-31 2021-12-28 Chiesi Farm Spa Derivados de amino quinazolina como inibidores de p2x3

Similar Documents

Publication Publication Date Title
JP2014521623A5 (enExample)
JP2022534303A5 (enExample)
US10195213B2 (en) Chemical entities that kill senescent cells for use in treating age-related disease
ES2250200T3 (es) Derivados de naftiridina.
JP2014531449A5 (enExample)
JP2019530695A5 (enExample)
HRP20171913T1 (hr) Aminopirimidinilni spojevi kao inhibitori jak
MX2010012290A (es) Combinaciones de inhibidores del receptor del factor de crecimiento endotelial vascular e inhibidores del factor de crecimiento de hepatocito para el tratamiento de cancer.
EP3541813A1 (en) Heterocyclic amides as kinase inhibitors
JP2017515844A5 (enExample)
JP2020511452A5 (enExample)
JP2017512786A5 (enExample)
RU2013114352A (ru) Азабензотиазолы, композиции и способы применения
JP2015515976A5 (enExample)
JP2015517566A5 (enExample)
JP2013530179A (ja) 呼吸器合胞体ウイルス（ｒｓｖ）感染の処置に使用するためのウレイド−ピラゾール誘導体
RU2018138047A (ru) Гетероциклические вещества - агонисты gpr119
RU2019111882A (ru) Антагонисты trpv4
JP2019505595A5 (enExample)
JP2017504652A5 (enExample)
JP2009532438A5 (enExample)
RU2015128025A (ru) Ингибиторы сомт
JP2020502230A5 (enExample)
JP2016514711A5 (enExample)
JP2013544811A5 (enExample)