JP2022534751A5 - - Google Patents
Info
- Publication number
- JP2022534751A5 JP2022534751A5 JP2021570931A JP2021570931A JP2022534751A5 JP 2022534751 A5 JP2022534751 A5 JP 2022534751A5 JP 2021570931 A JP2021570931 A JP 2021570931A JP 2021570931 A JP2021570931 A JP 2021570931A JP 2022534751 A5 JP2022534751 A5 JP 2022534751A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- quinazoline
- amine
- methoxy
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19177604 | 2019-05-31 | ||
| EP19177604.6 | 2019-05-31 | ||
| EP19201168 | 2019-10-02 | ||
| EP19201168.2 | 2019-10-02 | ||
| PCT/EP2020/064914 WO2020239952A1 (en) | 2019-05-31 | 2020-05-28 | Amino quinazoline derivatives as p2x3 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022534751A JP2022534751A (ja) | 2022-08-03 |
| JP2022534751A5 true JP2022534751A5 (enExample) | 2023-06-05 |
| JP7641917B2 JP7641917B2 (ja) | 2025-03-07 |
Family
ID=70861506
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021570931A Active JP7641917B2 (ja) | 2019-05-31 | 2020-05-28 | Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体 |
| JP2021570930A Active JP7644029B2 (ja) | 2019-05-31 | 2020-05-28 | Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体 |
| JP2025029719A Pending JP2025098014A (ja) | 2019-05-31 | 2025-02-27 | Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021570930A Active JP7644029B2 (ja) | 2019-05-31 | 2020-05-28 | Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体 |
| JP2025029719A Pending JP2025098014A (ja) | 2019-05-31 | 2025-02-27 | Ｐ２ｘ３阻害剤としてのアミノキナゾリン誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20230092892A1 (enExample) |
| EP (2) | EP3976179A1 (enExample) |
| JP (3) | JP7641917B2 (enExample) |
| KR (2) | KR102921972B1 (enExample) |
| CN (3) | CN114269432B (enExample) |
| AU (2) | AU2020281923B2 (enExample) |
| BR (2) | BR112021021738A2 (enExample) |
| CA (2) | CA3139018A1 (enExample) |
| CL (1) | CL2021003165A1 (enExample) |
| CO (1) | CO2021017031A2 (enExample) |
| GE (2) | GEP20257823B (enExample) |
| IL (1) | IL288405A (enExample) |
| MA (2) | MA56021A (enExample) |
| MX (2) | MX2021014113A (enExample) |
| PE (1) | PE20220934A1 (enExample) |
| PH (1) | PH12021552881A1 (enExample) |
| SA (1) | SA521430920B1 (enExample) |
| SG (1) | SG11202112187YA (enExample) |
| WO (2) | WO2020239952A1 (enExample) |
| ZA (1) | ZA202108273B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3142351A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| JP7797204B2 (ja) * | 2019-05-31 | 2026-01-13 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｐ２ｘ３阻害剤としてのピリドピリミジン誘導体 |
| CA3139018A1 (en) * | 2019-05-31 | 2020-12-03 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| UA130430C2 (uk) | 2019-05-31 | 2026-02-18 | Янссен Фармацевтика Нв | НИЗЬКОМОЛЕКУЛЯРНІ ІНГІБІТОРИ КІНАЗИ, ЩО ІНДУКУЄ NF-kB |
| CA3141826A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| WO2022063205A1 (zh) * | 2020-09-24 | 2022-03-31 | 中国医药研究开发中心有限公司 | 芳基甲酰胺类化合物及其制备方法和医药用途 |
| WO2022083657A1 (zh) * | 2020-10-20 | 2022-04-28 | 苏州泽璟生物制药股份有限公司 | 取代苯并或吡啶并嘧啶胺类抑制剂及其制备方法和应用 |
| JP2023550830A (ja) * | 2020-11-27 | 2023-12-05 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｐ２ｘ３阻害剤としての（アザ）キノリン４－アミン誘導体 |
| WO2022112490A1 (en) * | 2020-11-27 | 2022-06-02 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| CN112661803A (zh) * | 2020-12-17 | 2021-04-16 | 上海药明康德新药开发有限公司 | DNA编码化合物库构建中On-DNA 4-胺基喹唑啉化合物的合成方法 |
| US20240239764A1 (en) | 2020-12-22 | 2024-07-18 | Mekanistic Therapeutics | Substituted aminobenzyl heteroaryl compounds as egfr and/or pi3k inhibitors |
| WO2022171118A1 (zh) * | 2021-02-10 | 2022-08-18 | 石药集团中奇制药技术（石家庄）有限公司 | 一种具有抗肿瘤活性的化合物及其用途 |
| CN115677601B (zh) * | 2021-07-29 | 2025-06-03 | 石药集团中奇制药技术（石家庄）有限公司 | 一种具有抗肿瘤活性的化合物及其用途 |
| WO2024235225A1 (zh) * | 2023-05-15 | 2024-11-21 | 苏州泽璟生物制药股份有限公司 | 取代嘧啶并环类抑制剂及其制备方法和应用 |
| AU2024275670A1 (en) | 2023-05-22 | 2026-01-15 | Chiesi Farmaceutici S.P.A. | Salts of amino quinazoline derivatives |
| AR132737A1 (es) | 2023-05-22 | 2025-07-23 | Chiesi Farm Spa | Proceso e intermedios para la preparación de un inhibidor p2x3 |
| WO2025101598A1 (en) * | 2023-11-07 | 2025-05-15 | Zeno Management, Inc. | Bi-cyclic pyrimidine compounds, methods and uses thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH31122A (en) * | 1993-03-31 | 1998-02-23 | Eisai Co Ltd | Nitrogen-containing fused-heterocycle compounds. |
| JPH0710843A (ja) * | 1993-03-31 | 1995-01-13 | Eisai Co Ltd | 含窒素縮合複素環化合物 |
| JP4342007B2 (ja) | 1998-08-10 | 2009-10-14 | 大日本住友製薬株式会社 | キナゾリン誘導体 |
| GB0126433D0 (en) * | 2001-11-03 | 2002-01-02 | Astrazeneca Ab | Compounds |
| CA2557372C (en) * | 2004-03-05 | 2013-01-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 antagonists |
| MX2008002014A (es) * | 2005-08-15 | 2008-03-27 | Hoffmann La Roche | Derivados de piperidina y piperazina como antagonistas de p2x3. |
| CN101300012B (zh) | 2005-09-01 | 2011-09-14 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物在制备治疗呼吸系统疾病的药物中的应用 |
| EP2038264B1 (en) | 2006-06-29 | 2016-10-26 | F.Hoffmann-La Roche Ag | Tetrazole-substituted arylamides |
| EP2136639B1 (en) | 2007-04-02 | 2016-03-09 | Evotec AG | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
| PT2139334E (pt) | 2007-04-17 | 2013-10-02 | Evotec Ag | Compostos heterocíclicos fusionados de 2-cianofenilo, e composições e utilizações dos mesmos |
| CA2715835C (en) | 2008-02-29 | 2017-03-21 | Renovis, Inc. | Amide compounds, compositions and uses thereof |
| JP5608655B2 (ja) | 2008-09-18 | 2014-10-15 | エヴォテック アーゲー | Ｐ２ｘ３受容体活性のモジュレーター |
| JP2013545749A (ja) | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 複素環化合物及びその使用 |
| KR101685862B1 (ko) * | 2012-12-27 | 2016-12-20 | 에프. 호프만-라 로슈 아게 | Comt 억제제 |
| TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
| WO2016053794A1 (en) * | 2014-09-30 | 2016-04-07 | Bristol-Myers Squibb Company | Quinazoline-based kinase inhibitors |
| JPWO2016084922A1 (ja) | 2014-11-28 | 2017-09-07 | 塩野義製薬株式会社 | １，２，４−トリアジン誘導体およびその医薬組成物 |
| WO2016088838A1 (ja) | 2014-12-04 | 2016-06-09 | 塩野義製薬株式会社 | プリン誘導体およびその医薬組成物 |
| EP3230281B1 (en) | 2014-12-09 | 2021-05-26 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| WO2017011729A1 (en) | 2015-07-16 | 2017-01-19 | Patara Pharma, LLC | Combination therapies for the treatment of lung diseases |
| DK3355889T3 (da) * | 2015-09-29 | 2023-05-15 | Afferent Pharmaceuticals Inc | Diaminopyrimidin-p2x3- og p2x2/3-receptormodulatorer til anvendelse i behandling af hoste |
| JP6882289B2 (ja) * | 2015-11-25 | 2021-06-02 | コンバージーン・リミテッド・ライアビリティ・カンパニーＣｏｎｖｅｒｇｅｎｅ Ｌｌｃ | 二環式ｂｅｔブロモドメイン阻害剤及びその使用 |
| CA3029457A1 (en) * | 2016-06-30 | 2018-01-04 | Gilead Sciences, Inc. | 4,6-diaminoquinazolines as cot modulators and methods of use thereof |
| WO2018035061A1 (en) | 2016-08-15 | 2018-02-22 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| EP3558979B1 (en) * | 2016-12-22 | 2021-02-17 | Boehringer Ingelheim International GmbH | Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors |
| GB201700814D0 (en) | 2017-01-17 | 2017-03-01 | Liverpool School Tropical Medicine | Compounds |
| WO2018172250A1 (en) * | 2017-03-21 | 2018-09-27 | Bayer Pharma Aktiengesellschaft | 2-methyl-quinazolines |
| US11000491B2 (en) * | 2017-05-05 | 2021-05-11 | Hepanova, Inc. | Amino-aryl-benzamide compounds and methods of use thereof |
| CA3139018A1 (en) | 2019-05-31 | 2020-12-03 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| JP7797204B2 (ja) | 2019-05-31 | 2026-01-13 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｐ２ｘ３阻害剤としてのピリドピリミジン誘導体 |
-
2020
- 2020-05-28 CA CA3139018A patent/CA3139018A1/en active Pending
- 2020-05-28 PE PE2021001962A patent/PE20220934A1/es unknown
- 2020-05-28 WO PCT/EP2020/064914 patent/WO2020239952A1/en not_active Ceased
- 2020-05-28 CA CA3139019A patent/CA3139019A1/en active Pending
- 2020-05-28 GE GEAP202015818A patent/GEP20257823B/en unknown
- 2020-05-28 SG SG11202112187YA patent/SG11202112187YA/en unknown
- 2020-05-28 JP JP2021570931A patent/JP7641917B2/ja active Active
- 2020-05-28 US US17/615,056 patent/US20230092892A1/en active Pending
- 2020-05-28 CN CN202080040266.2A patent/CN114269432B/zh active Active
- 2020-05-28 KR KR1020217043072A patent/KR102921972B1/ko active Active
- 2020-05-28 GE GEAP202515818A patent/GEAP202515818A/en unknown
- 2020-05-28 MX MX2021014113A patent/MX2021014113A/es unknown
- 2020-05-28 CN CN202410508911.9A patent/CN118239931A/zh active Pending
- 2020-05-28 MA MA056021A patent/MA56021A/fr unknown
- 2020-05-28 JP JP2021570930A patent/JP7644029B2/ja active Active
- 2020-05-28 WO PCT/EP2020/064913 patent/WO2020239951A1/en not_active Ceased
- 2020-05-28 BR BR112021021738A patent/BR112021021738A2/pt unknown
- 2020-05-28 KR KR1020217043074A patent/KR102921974B1/ko active Active
- 2020-05-28 MX MX2021014115A patent/MX2021014115A/es unknown
- 2020-05-28 AU AU2020281923A patent/AU2020281923B2/en active Active
- 2020-05-28 AU AU2020285336A patent/AU2020285336B2/en active Active
- 2020-05-28 EP EP20728765.7A patent/EP3976179A1/en active Pending
- 2020-05-28 PH PH1/2021/552881A patent/PH12021552881A1/en unknown
- 2020-05-28 US US17/615,017 patent/US12466820B2/en active Active
- 2020-05-28 MA MA056022A patent/MA56022A/fr unknown
- 2020-05-28 CN CN202080039837.0A patent/CN113891745B/zh active Active
- 2020-05-28 BR BR112021022099A patent/BR112021022099A2/pt unknown
- 2020-05-28 EP EP20728766.5A patent/EP3976180A1/en active Pending
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2021
- 2021-10-26 ZA ZA2021/08273A patent/ZA202108273B/en unknown
- 2021-11-22 SA SA521430920A patent/SA521430920B1/ar unknown
- 2021-11-25 IL IL288405A patent/IL288405A/en unknown
- 2021-11-29 CL CL2021003165A patent/CL2021003165A1/es unknown
- 2021-12-14 CO CONC2021/0017031A patent/CO2021017031A2/es unknown
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2025
- 2025-02-27 JP JP2025029719A patent/JP2025098014A/ja active Pending