PE20110875A1 - Derivados de isoindol como inhibidores de bace - Google Patents

Derivados de isoindol como inhibidores de bace

Info

Publication number
PE20110875A1
PE20110875A1 PE2011001034A PE2011001034A PE20110875A1 PE 20110875 A1 PE20110875 A1 PE 20110875A1 PE 2011001034 A PE2011001034 A PE 2011001034A PE 2011001034 A PE2011001034 A PE 2011001034A PE 20110875 A1 PE20110875 A1 PE 20110875A1
Authority
PE
Peru
Prior art keywords
fluoro
isoindol
halogen
amine
derivatives
Prior art date
Application number
PE2011001034A
Other languages
English (en)
Spanish (es)
Inventor
Jorg Holenz
Sofia Karlstrom
Karin Kolmodin
Johan Lindstrom
Laszlo Rakos
Didier Rotticci
Peter Soderman
Britt-Marie Swahn
Berg Stefan Von
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42170158&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110875(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20110875A1 publication Critical patent/PE20110875A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PE2011001034A 2008-11-14 2009-11-13 Derivados de isoindol como inhibidores de bace PE20110875A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11463408P 2008-11-14 2008-11-14
US13976708P 2008-12-22 2008-12-22
US22165309P 2009-06-30 2009-06-30

Publications (1)

Publication Number Publication Date
PE20110875A1 true PE20110875A1 (es) 2012-01-11

Family

ID=42170158

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001034A PE20110875A1 (es) 2008-11-14 2009-11-13 Derivados de isoindol como inhibidores de bace

Country Status (24)

Country Link
US (2) US8030500B2 (enExample)
EP (1) EP2367814A4 (enExample)
JP (1) JP2012508734A (enExample)
KR (1) KR20110091540A (enExample)
CN (1) CN102282140A (enExample)
AR (1) AR074341A1 (enExample)
AU (1) AU2009314664A1 (enExample)
BR (1) BRPI0921879A2 (enExample)
CA (1) CA2743938A1 (enExample)
CL (1) CL2011001098A1 (enExample)
CO (1) CO6362004A2 (enExample)
CR (1) CR20110255A (enExample)
CU (1) CU20110106A7 (enExample)
DO (1) DOP2011000138A (enExample)
EA (1) EA201190020A1 (enExample)
EC (1) ECSP11011051A (enExample)
IL (1) IL212590A0 (enExample)
MX (1) MX2011004918A (enExample)
NI (1) NI201100099A (enExample)
PE (1) PE20110875A1 (enExample)
TW (1) TW201020244A (enExample)
UY (1) UY32241A (enExample)
WO (1) WO2010056196A1 (enExample)
ZA (1) ZA201104396B (enExample)

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EP2634188A4 (en) 2010-10-29 2014-05-07 Shionogi & Co FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE
CN103261199A (zh) 2010-10-29 2013-08-21 盐野义制药株式会社 萘啶衍生物
US20120165346A1 (en) * 2010-12-22 2012-06-28 Astrazeneca Ab Compounds and their use as BACE inhibitors
WO2012147763A1 (ja) 2011-04-26 2012-11-01 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
EP2912035A4 (en) 2012-10-24 2016-06-15 Shionogi & Co DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY
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CN105272884B (zh) * 2015-11-02 2017-05-24 浙江大学 一种邻氰基二苯甲酮衍生物的制备方法
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Also Published As

Publication number Publication date
ZA201104396B (en) 2012-03-28
CA2743938A1 (en) 2010-05-20
AU2009314664A1 (en) 2011-06-23
US20110319426A1 (en) 2011-12-29
UY32241A (es) 2010-06-30
US8030500B2 (en) 2011-10-04
CN102282140A (zh) 2011-12-14
JP2012508734A (ja) 2012-04-12
CL2011001098A1 (es) 2012-02-24
ECSP11011051A (es) 2011-06-30
US20100125082A1 (en) 2010-05-20
AR074341A1 (es) 2011-01-12
TW201020244A (en) 2010-06-01
KR20110091540A (ko) 2011-08-11
CR20110255A (es) 2011-07-04
MX2011004918A (es) 2011-05-30
DOP2011000138A (es) 2011-06-30
IL212590A0 (en) 2011-07-31
EP2367814A1 (en) 2011-09-28
CO6362004A2 (es) 2012-01-20
WO2010056196A1 (en) 2010-05-20
EP2367814A4 (en) 2012-07-04
CU20110106A7 (es) 2012-01-31
BRPI0921879A2 (pt) 2018-10-16
EA201190020A1 (ru) 2012-02-28
NI201100099A (es) 2012-03-19

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