JP2010527365A5 - - Google Patents
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- Publication number
- JP2010527365A5 JP2010527365A5 JP2010508500A JP2010508500A JP2010527365A5 JP 2010527365 A5 JP2010527365 A5 JP 2010527365A5 JP 2010508500 A JP2010508500 A JP 2010508500A JP 2010508500 A JP2010508500 A JP 2010508500A JP 2010527365 A5 JP2010527365 A5 JP 2010527365A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- alkyl
- ethyl
- methyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 methoxy, hydroxy, amino, chloro, amino Chemical group 0.000 claims 36
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000001153 fluoro group Chemical group F* 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 5
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims 1
- 241001024304 Mino Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- 125000004267 aziridin-2-yl group Chemical group [H]N1C([H])([H])C1([H])* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93834707P | 2007-05-16 | 2007-05-16 | |
| US60/938,347 | 2007-05-16 | ||
| PCT/US2008/062808 WO2008144223A2 (en) | 2007-05-16 | 2008-05-07 | Triazolyl aminopyrimidine compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527365A JP2010527365A (ja) | 2010-08-12 |
| JP2010527365A5 true JP2010527365A5 (enExample) | 2011-06-16 |
| JP5248600B2 JP5248600B2 (ja) | 2013-07-31 |
Family
ID=39951591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508500A Expired - Fee Related JP5248600B2 (ja) | 2007-05-16 | 2008-05-07 | トリアゾリルアミノピリミジン化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8063035B2 (enExample) |
| EP (1) | EP2155734A2 (enExample) |
| JP (1) | JP5248600B2 (enExample) |
| KR (1) | KR101131261B1 (enExample) |
| CN (1) | CN101679395B (enExample) |
| AR (1) | AR066473A1 (enExample) |
| AU (1) | AU2008254319B2 (enExample) |
| BR (1) | BRPI0811433A2 (enExample) |
| CA (1) | CA2691997A1 (enExample) |
| CL (1) | CL2008001323A1 (enExample) |
| EA (1) | EA016781B1 (enExample) |
| MX (1) | MX2009012228A (enExample) |
| PE (1) | PE20090216A1 (enExample) |
| TW (1) | TW200908981A (enExample) |
| WO (1) | WO2008144223A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7964729B2 (en) | 2006-08-28 | 2011-06-21 | Massachusetts Institute Of Technology | Sox-based kinase sensor |
| US8101628B2 (en) | 2006-12-21 | 2012-01-24 | Eli Lilly And Company | Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer |
| SI2125794T1 (sl) | 2006-12-21 | 2011-02-28 | Lilly Co Eli | Spojine imidazolidinonil aminopirimidina za zdravljenje raka |
| US8440835B2 (en) | 2007-02-26 | 2013-05-14 | Massachusetts Institute Of Technology | Environmentally sensitive fluorophores |
| EA016781B1 (ru) | 2007-05-16 | 2012-07-30 | Эли Лилли Энд Компани | Триазолиламинопиримидиновые соединения |
| WO2008144222A2 (en) * | 2007-05-16 | 2008-11-27 | Eli Lilly And Company | Triazolyl aminopyrimidine compounds |
| KR101123178B1 (ko) * | 2009-04-09 | 2012-06-13 | (주)에스메디 | 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물 |
| EP2470652A1 (en) * | 2009-08-25 | 2012-07-04 | OncoTherapy Science, Inc. | Ercc6l as target genes for cancer therapy and diagnosis |
| WO2011025546A1 (en) * | 2009-08-31 | 2011-03-03 | Massachusetts Institute Of Technology | 1, 2, 3-triazole containing protein kinase sensors |
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| US9611201B2 (en) * | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| JP7090037B2 (ja) * | 2016-06-23 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | 新規な［１，２，３］トリアゾロ［４，５－ｄ］ピリミジン誘導体 |
| US11084829B2 (en) | 2018-09-24 | 2021-08-10 | Rapt Therapeutics, Inc. | Ubiquitin-specific-processing protease 7 (USP7) modulators and uses thereof |
| KR20220059951A (ko) * | 2019-09-05 | 2022-05-10 | 더 유니버시티 오브 멜버른 | 질화 억제제 |
| CN112341428A (zh) * | 2020-11-04 | 2021-02-09 | 菏泽鸿特药业有限公司 | 一种噻吩-2-乙胺的生产方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4929726A (en) * | 1988-02-09 | 1990-05-29 | Georgia State University Foundation, Inc. | Novel diazines and their method of preparation |
| WO2004063192A1 (en) | 2003-01-10 | 2004-07-29 | Pharmacopeia Drug Discovery, Inc. | Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| JP2007533602A (ja) * | 2003-07-31 | 2007-11-22 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 置換ベンゾチオフェン化合物及びそれらの使用 |
| AU2005316312B2 (en) * | 2004-12-17 | 2009-10-22 | Amgen, Inc. | Aminopyrimidine compounds and methods of use |
| TW200800201A (en) | 2005-11-18 | 2008-01-01 | Lilly Co Eli | Pyrimidinyl benzothiophene compounds |
| US8008481B2 (en) | 2006-03-31 | 2011-08-30 | Ericsson Anna M | Indazole compounds |
| US8101628B2 (en) | 2006-12-21 | 2012-01-24 | Eli Lilly And Company | Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer |
| SI2125794T1 (sl) * | 2006-12-21 | 2011-02-28 | Lilly Co Eli | Spojine imidazolidinonil aminopirimidina za zdravljenje raka |
| EA016781B1 (ru) | 2007-05-16 | 2012-07-30 | Эли Лилли Энд Компани | Триазолиламинопиримидиновые соединения |
| WO2008144222A2 (en) | 2007-05-16 | 2008-11-27 | Eli Lilly And Company | Triazolyl aminopyrimidine compounds |
-
2008
- 2008-05-07 EA EA200971068A patent/EA016781B1/ru not_active IP Right Cessation
- 2008-05-07 BR BRPI0811433A patent/BRPI0811433A2/pt not_active IP Right Cessation
- 2008-05-07 WO PCT/US2008/062808 patent/WO2008144223A2/en not_active Ceased
- 2008-05-07 MX MX2009012228A patent/MX2009012228A/es active IP Right Grant
- 2008-05-07 CN CN2008800157689A patent/CN101679395B/zh not_active Expired - Fee Related
- 2008-05-07 PE PE2008000798A patent/PE20090216A1/es not_active Application Discontinuation
- 2008-05-07 AR ARP080101932A patent/AR066473A1/es unknown
- 2008-05-07 EP EP08747731A patent/EP2155734A2/en not_active Withdrawn
- 2008-05-07 JP JP2010508500A patent/JP5248600B2/ja not_active Expired - Fee Related
- 2008-05-07 CA CA002691997A patent/CA2691997A1/en not_active Abandoned
- 2008-05-07 KR KR1020097023340A patent/KR101131261B1/ko not_active Expired - Fee Related
- 2008-05-07 CL CL2008001323A patent/CL2008001323A1/es unknown
- 2008-05-07 US US12/598,926 patent/US8063035B2/en not_active Expired - Fee Related
- 2008-05-07 AU AU2008254319A patent/AU2008254319B2/en not_active Ceased
- 2008-05-07 TW TW097116886A patent/TW200908981A/zh unknown
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