JP2011219478A5 - - Google Patents
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- Publication number
- JP2011219478A5 JP2011219478A5 JP2011104172A JP2011104172A JP2011219478A5 JP 2011219478 A5 JP2011219478 A5 JP 2011219478A5 JP 2011104172 A JP2011104172 A JP 2011104172A JP 2011104172 A JP2011104172 A JP 2011104172A JP 2011219478 A5 JP2011219478 A5 JP 2011219478A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- cdr1
- cdr3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000005024 Castleman disease Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011104172A JP2011219478A (ja) | 2009-03-19 | 2011-05-09 | 関節リウマチ治療剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009067358 | 2009-03-19 | ||
| JP2009067358 | 2009-03-19 | ||
| JP2011104172A JP2011219478A (ja) | 2009-03-19 | 2011-05-09 | 関節リウマチ治療剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511837A Division JP4809930B2 (ja) | 2009-03-19 | 2010-03-19 | 関節リウマチ治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011219478A JP2011219478A (ja) | 2011-11-04 |
| JP2011219478A5 true JP2011219478A5 (enExample) | 2013-05-02 |
Family
ID=42739764
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511837A Active JP4809930B2 (ja) | 2009-03-19 | 2010-03-19 | 関節リウマチ治療剤 |
| JP2011104172A Pending JP2011219478A (ja) | 2009-03-19 | 2011-05-09 | 関節リウマチ治療剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511837A Active JP4809930B2 (ja) | 2009-03-19 | 2010-03-19 | 関節リウマチ治療剤 |
Country Status (5)
| Country | Link |
|---|---|
| JP (2) | JP4809930B2 (enExample) |
| KR (1) | KR101314880B1 (enExample) |
| RU (1) | RU2524152C2 (enExample) |
| TW (1) | TWI457134B (enExample) |
| WO (1) | WO2010107108A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN10515A (enExample) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| TWI438208B (zh) | 2007-01-23 | 2014-05-21 | Chugai Pharmaceutical Co Ltd | 抑制慢性排斥反應之藥劑 |
| CA2728243C (en) | 2008-06-05 | 2020-03-10 | National Cancer Center | Il-6 inhibitor for suppressing neuroinvasion in pancreatic cancer |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| ES2932398T3 (es) | 2010-05-28 | 2023-01-18 | Chugai Pharmaceutical Co Ltd | Potenciador de la respuesta de las células T antitumorales |
| EP3009518B1 (en) | 2013-06-11 | 2020-08-12 | National Center of Neurology and Psychiatry | Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy |
| CA2972393A1 (en) | 2015-02-27 | 2016-09-01 | Chugai Seiyaku Kabushiki Kaisha | Composition for treating il-6-related diseases |
| US10697883B2 (en) | 2015-05-19 | 2020-06-30 | National Center Of Neurology And Psychiatry | Method for determining application of therapy to multiple sclerosis (MS) patient |
| JP7185884B2 (ja) | 2017-05-02 | 2022-12-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
| KR102771895B1 (ko) | 2017-10-20 | 2025-02-21 | 가꼬우호우징 효고 이카다이가쿠 | 항il-6 수용체 항체를 함유하는 수술 후의 유착을 억제하기 위한 의약 조성물 |
| US20210363238A1 (en) | 2018-01-31 | 2021-11-25 | Motokazu Kato | Therapeutic agent for asthma containing il-6 inhibitor |
| EP3949989A4 (en) | 2019-03-29 | 2022-12-14 | Chugai Seiyaku Kabushiki Kaisha | Anti il-6 receptor antibody-containing inhibitor for inhibiting deterioration of bbb function |
| KR20220019670A (ko) | 2019-04-17 | 2022-02-17 | 고쿠리츠다이가쿠호진 히로시마다이가쿠 | Il-6 저해제 및 ccr2 저해제를 조합하여 투여하는 것을 특징으로 하는 비뇨기암의 치료제 |
| US20240158518A1 (en) | 2021-03-12 | 2024-05-16 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for treatment or prevention of myasthenia gravis |
| WO2025198912A1 (en) | 2024-03-21 | 2025-09-25 | Hoffmann-La Roche Inc. | Methods of treating myasthenia gravis |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL182089B1 (en) * | 1994-10-21 | 2001-11-30 | Chugai Pharmaceutical Co Ltd | Pharmaceutic compositions for treating diseases caused by production of il-6 |
| US8993319B2 (en) * | 2004-12-28 | 2015-03-31 | Innate Pharma S.A. | Monoclonal antibodies against NKG2A |
| AU2007285695B2 (en) | 2006-08-18 | 2012-05-24 | Ablynx N.V. | Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling |
| WO2009010539A2 (en) * | 2007-07-19 | 2009-01-22 | Ablynx. N.V. | Receptor for interleukin-6 (il-6) from macaca fascicularis |
| ES2687808T3 (es) * | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| AU2008304756B8 (en) * | 2007-09-26 | 2015-02-12 | Chugai Seiyaku Kabushiki Kaisha | Anti-IL-6 receptor antibody |
| PT2708559T (pt) * | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| TWI440469B (zh) * | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
-
2010
- 2010-03-19 WO PCT/JP2010/054763 patent/WO2010107108A1/ja not_active Ceased
- 2010-03-19 TW TW099108133A patent/TWI457134B/zh active
- 2010-03-19 KR KR1020117024354A patent/KR101314880B1/ko active Active
- 2010-03-19 RU RU2011142183/10A patent/RU2524152C2/ru active
- 2010-03-19 JP JP2010511837A patent/JP4809930B2/ja active Active
-
2011
- 2011-05-09 JP JP2011104172A patent/JP2011219478A/ja active Pending