MX2009007830A - Inhibidor de rechazo cronico. - Google Patents

Inhibidor de rechazo cronico.

Info

Publication number
MX2009007830A
MX2009007830A MX2009007830A MX2009007830A MX2009007830A MX 2009007830 A MX2009007830 A MX 2009007830A MX 2009007830 A MX2009007830 A MX 2009007830A MX 2009007830 A MX2009007830 A MX 2009007830A MX 2009007830 A MX2009007830 A MX 2009007830A
Authority
MX
Mexico
Prior art keywords
chronic rejection
chronic
rejection
receptor antibody
transplantation
Prior art date
Application number
MX2009007830A
Other languages
English (en)
Inventor
Masafumi Takahashi
Atsushi Izawa
Original Assignee
Univ Shinshu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Shinshu filed Critical Univ Shinshu
Publication of MX2009007830A publication Critical patent/MX2009007830A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se realizó un estudio sobre el efecto inhibidor de un anticuerpo anti-receptor de IL-6 sobre el rechazo crónico. Específicamente, se realizó un estudio sobre el efecto inhibidor de la administración de un anticuerpo anti-receptor de IL-6 de ratón (MR16-1) en sobre el rechazo crónico usando un modelo de rechazo crónico post-trasplante de corazón en ratón. Se analizó histopatológicamente un corazón trasplantado extraído 60 días después del trasplante, y se encontró que la fibrosis en el músculo cardiaco y la lesión de restenosis vascular que son síntomas característicos de rechazo crónico, fueron inhibidas significativamente en un grupo tratado con MR16-1 en comparación con un grupo de control. Por consiguiente, se confirma que la administración de MR16-1 puede inhibir el rechazo crónico de manera efectiva. Es decir, se encuentra por primera vez que el rechazo en la ase crónica después de trasplante de órgano se puede inhibir mediante la administración de un anticuerpo anti-receptor de IL-6.
MX2009007830A 2007-01-23 2008-01-23 Inhibidor de rechazo cronico. MX2009007830A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007012572 2007-01-23
PCT/JP2008/050842 WO2008090901A1 (ja) 2007-01-23 2008-01-23 慢性拒絶反応抑制剤

Publications (1)

Publication Number Publication Date
MX2009007830A true MX2009007830A (es) 2009-10-07

Family

ID=39644475

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009007830A MX2009007830A (es) 2007-01-23 2008-01-23 Inhibidor de rechazo cronico.

Country Status (17)

Country Link
US (1) US9725514B2 (es)
EP (1) EP2123302B1 (es)
JP (1) JP5254807B2 (es)
KR (1) KR101508019B1 (es)
CN (1) CN101646459B (es)
AR (1) AR065004A1 (es)
AU (1) AU2008208321B2 (es)
BR (1) BRPI0806812B8 (es)
CA (1) CA2675625C (es)
CL (1) CL2008000188A1 (es)
ES (1) ES2564392T3 (es)
HK (1) HK1140134A1 (es)
MX (1) MX2009007830A (es)
PE (1) PE20081635A1 (es)
RU (1) RU2450829C2 (es)
TW (1) TWI438208B (es)
WO (1) WO2008090901A1 (es)

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