JP2011219478A5 - - Google Patents
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- Publication number
- JP2011219478A5 JP2011219478A5 JP2011104172A JP2011104172A JP2011219478A5 JP 2011219478 A5 JP2011219478 A5 JP 2011219478A5 JP 2011104172 A JP2011104172 A JP 2011104172A JP 2011104172 A JP2011104172 A JP 2011104172A JP 2011219478 A5 JP2011219478 A5 JP 2011219478A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- cdr1
- cdr3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Claims (1)
- 以下の抗体を有効成分として含有する関節リウマチ、小児慢性関節炎またはキャッスルマン病の治療剤；
配列番号：１（VH3-M73のCDR1）に記載のアミノ酸配列を有するCDR1、配列番号：２（VH3-M73のCDR2）に記載のアミノ酸配列を有するCDR2、配列番号：３（VH3-M73のCDR3）に記載のアミノ酸配列を有するCDR3を含む重鎖、および配列番号：４（VL3のCDR1）に記載のアミノ酸配列を有するCDR1、配列番号：５（VL3のCDR2）に記載のアミノ酸配列を有するCDR2、配列番号：６（VL3のCDR3）に記載のアミノ酸配列を有するCDR3を含む軽鎖を含む抗体。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011104172A JP2011219478A (ja) | 2009-03-19 | 2011-05-09 | 関節リウマチ治療剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009067358 | 2009-03-19 | ||
| JP2009067358 | 2009-03-19 | ||
| JP2011104172A JP2011219478A (ja) | 2009-03-19 | 2011-05-09 | 関節リウマチ治療剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511837A Division JP4809930B2 (ja) | 2009-03-19 | 2010-03-19 | 関節リウマチ治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011219478A JP2011219478A (ja) | 2011-11-04 |
| JP2011219478A5 true JP2011219478A5 (ja) | 2013-05-02 |
Family
ID=42739764
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511837A Active JP4809930B2 (ja) | 2009-03-19 | 2010-03-19 | 関節リウマチ治療剤 |
| JP2011104172A Pending JP2011219478A (ja) | 2009-03-19 | 2011-05-09 | 関節リウマチ治療剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010511837A Active JP4809930B2 (ja) | 2009-03-19 | 2010-03-19 | 関節リウマチ治療剤 |
Country Status (5)
| Country | Link |
|---|---|
| JP (2) | JP4809930B2 (ja) |
| KR (1) | KR101314880B1 (ja) |
| RU (1) | RU2524152C2 (ja) |
| TW (1) | TWI457134B (ja) |
| WO (1) | WO2010107108A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2564392T3 (es) | 2007-01-23 | 2016-03-22 | Shinshu University | Inhibidores de IL-6 para el tratamiento de rechazo crónico |
| CN102256623A (zh) | 2008-06-05 | 2011-11-23 | 独立行政法人国立癌症研究中心 | 神经浸润抑制剂 |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| RS63800B1 (sr) | 2010-05-28 | 2022-12-30 | Chugai Pharmaceutical Co Ltd | Poboljšanje antitumorskog odgovora t ćelije |
| EP3009518B1 (en) | 2013-06-11 | 2020-08-12 | National Center of Neurology and Psychiatry | Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy |
| KR101892883B1 (ko) | 2015-02-27 | 2018-10-05 | 추가이 세이야쿠 가부시키가이샤 | Il-6 관련 질환 치료용 조성물 |
| PL3299810T3 (pl) | 2015-05-19 | 2021-12-13 | National Center Of Neurology And Psychiatry | Sposób określania zastosowania nowej terapii u pacjentów ze stwardnieniem rozsianym (sm) |
| JP7185884B2 (ja) | 2017-05-02 | 2022-12-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| TWI822728B (zh) | 2018-01-31 | 2023-11-21 | 加藤元一 | 含有il-6抑制劑的哮喘治療劑 |
| CN113660951A (zh) | 2019-03-29 | 2021-11-16 | 中外制药株式会社 | 含有抗il-6受体抗体的抑制bbb功能低下的抑制剂 |
| MX2021012163A (es) | 2019-04-17 | 2022-01-31 | Univ Hiroshima | Agente terapeutico para cancer urologico que se caracteriza por ser administrado con un inhibidor de il-6 y un inhibidor de ccr2 en combinacion. |
| KR20230156368A (ko) | 2021-03-12 | 2023-11-14 | 추가이 세이야쿠 가부시키가이샤 | 중증 근무력증의 치료 또는 예방용의 의약 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL182089B1 (en) * | 1994-10-21 | 2001-11-30 | Chugai Pharmaceutical Co Ltd | Pharmaceutic compositions for treating diseases caused by production of il-6 |
| KR101564713B1 (ko) * | 2004-12-28 | 2015-11-06 | 이나뜨 파르마 | Ｎｋｇ2ａ에 대한 단클론 항체 |
| WO2008020079A1 (en) * | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
| WO2009010539A2 (en) * | 2007-07-19 | 2009-01-22 | Ablynx. N.V. | Receptor for interleukin-6 (il-6) from macaca fascicularis |
| AU2008304756B8 (en) * | 2007-09-26 | 2015-02-12 | Chugai Seiyaku Kabushiki Kaisha | Anti-IL-6 receptor antibody |
| AR068563A1 (es) * | 2007-09-26 | 2009-11-18 | Chugai Pharmaceutical Co Ltd | Region constante de anticuerpo mutante |
| MY195714A (en) * | 2008-04-11 | 2023-02-07 | Chugai Pharmaceutical Co Ltd | Antigen-Binding Molecule Capable of Binding to Two or More Antigen Molecules Repeatedly |
| TWI440469B (zh) * | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
-
2010
- 2010-03-19 WO PCT/JP2010/054763 patent/WO2010107108A1/ja active Application Filing
- 2010-03-19 KR KR1020117024354A patent/KR101314880B1/ko active IP Right Grant
- 2010-03-19 JP JP2010511837A patent/JP4809930B2/ja active Active
- 2010-03-19 TW TW099108133A patent/TWI457134B/zh active
- 2010-03-19 RU RU2011142183/10A patent/RU2524152C2/ru active
-
2011
- 2011-05-09 JP JP2011104172A patent/JP2011219478A/ja active Pending
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