JP2014205674A5 - - Google Patents
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- JP2014205674A5 JP2014205674A5 JP2014102751A JP2014102751A JP2014205674A5 JP 2014205674 A5 JP2014205674 A5 JP 2014205674A5 JP 2014102751 A JP2014102751 A JP 2014102751A JP 2014102751 A JP2014102751 A JP 2014102751A JP 2014205674 A5 JP2014205674 A5 JP 2014205674A5
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- JP
- Japan
- Prior art keywords
- antibody
- seq
- amino acid
- acid residues
- variable domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004965 antibodies Human genes 0.000 claims 17
- 108090001123 antibodies Proteins 0.000 claims 17
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 claims 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 3
- 102000005614 monoclonal antibodies Human genes 0.000 claims 3
- 108010045030 monoclonal antibodies Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 230000035693 Fab Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (11)
- （ｉ）配列番号：４のアミノ酸残基３０〜３５と同一のＣＤＲ１領域と、配列番号：４のアミノ酸残基５０〜６６と同一のＣＤＲ２領域と、配列番号：４のアミノ酸残基９８〜１０９と同一のＣＤＲ３領域とを含む重鎖可変ドメインと、
（ｉｉ）配列番号：４３のアミノ酸残基２３〜３５と同一のＣＤＲ１領域と、配列番号：４３のアミノ酸残基５１〜５７と同一のＣＤＲ２領域と、配列番号：４３のアミノ酸残基９０〜１０１と同一のＣＤＲ３領域とを含む軽鎖可変ドメインと
を含む可変ドメインを含み、
当該抗体がヒトＶＥＧＦを特異的に結合し、インビボでのＶＥＧＦ−Ａ活性を中和する、モノクローナル抗体。 - 前記抗体が一価抗体である、請求項１に記載の抗体。
- 前記抗体が二価抗体である、請求項１に記載の抗体。
- 前記抗体が単鎖抗体である、請求項１に記載の抗体。
- 前記抗体がヒト化されている、請求項１に記載の抗体。
- 請求項１に記載のモノクローナル抗体のヒト化型である、モノクローナル抗体。
- 請求項１に記載の抗体と薬学的に許容可能な担体を含有してなる、薬学的組成物。
- 前記抗体が、１０−７Ｍ以下のＫＤでＶＥＧＦを結合する、請求項１に記載の抗体。
- 前記抗体が、Ｆａｂ、Ｆｖ、ｓｃＦｖ又はＦｄ断片である、請求項１に記載の抗体。
- 請求項１に記載の抗体をコードする核酸。
- 請求項１０に記載の核酸を含む細胞。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3971908P | 2008-03-26 | 2008-03-26 | |
| US61/039,719 | 2008-03-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501758A Division JP5823858B2 (ja) | 2008-03-26 | 2008-10-08 | 抗ｖｅｇｆ抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014205674A JP2014205674A (ja) | 2014-10-30 |
| JP2014205674A5 true JP2014205674A5 (ja) | 2015-03-12 |
Family
ID=41114205
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501758A Active JP5823858B2 (ja) | 2008-03-26 | 2008-10-08 | 抗ｖｅｇｆ抗体 |
| JP2014102751A Pending JP2014205674A (ja) | 2008-03-26 | 2014-05-16 | 抗ｖｅｇｆ抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501758A Active JP5823858B2 (ja) | 2008-03-26 | 2008-10-08 | 抗ｖｅｇｆ抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7803371B2 (ja) |
| EP (1) | EP2259795B1 (ja) |
| JP (2) | JP5823858B2 (ja) |
| KR (1) | KR101581244B1 (ja) |
| CN (2) | CN102065888B (ja) |
| AU (1) | AU2008353479B2 (ja) |
| BR (1) | BRPI0822556B1 (ja) |
| CA (3) | CA2719400C (ja) |
| HK (1) | HK1201280A1 (ja) |
| WO (1) | WO2009120178A1 (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102013220B1 (ko) * | 2008-06-25 | 2019-08-23 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | Ｖｅｇｆ를 억제하는 안정하고 가용성인 항체 |
| CN102002104A (zh) * | 2009-08-28 | 2011-04-06 | 江苏先声药物研究有限公司 | 一种抗vegf的单克隆抗体及含有该抗体的药物组合物 |
| CN102686609A (zh) * | 2009-10-23 | 2012-09-19 | 加文医学研究所 | 修饰的可变域分子及其生产和使用方法 |
| WO2012118813A2 (en) | 2011-03-03 | 2012-09-07 | Apexigen, Inc. | Anti-il-6 receptor antibodies and methods of use |
| CN104650229A (zh) * | 2011-11-02 | 2015-05-27 | 埃派斯进有限公司 | 抗-kdr抗体和使用方法 |
| CN103417965B (zh) * | 2012-05-17 | 2018-04-13 | 江苏先声药业有限公司 | 一种含有抗vegf抗体的药物组合物 |
| CN103417964A (zh) * | 2012-05-17 | 2013-12-04 | 江苏先声药物研究有限公司 | 一种抗vegf抗体的用途 |
| JP6408492B2 (ja) | 2013-02-18 | 2018-10-17 | ヴェジェニクス プロプライエタリー リミテッドＶｅｇｅｎｉｃｓ Ｐｔｙ Ｌｉｍｉｔｅｄ | リガンド結合分子およびその使用 |
| US20160130336A1 (en) * | 2013-12-31 | 2016-05-12 | Development Center For Biotechnology | Anti-vegf antibodies and use thereof |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| SG11201705748SA (en) * | 2015-01-16 | 2017-08-30 | Alder Biopharmaceuticals Inc | Anti-glycoprotein antibodies and uses thereof |
| EA036821B1 (ru) * | 2015-07-06 | 2020-12-23 | Юсб Биофарма Срл | Тау-связывающие антитела |
| GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
| GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
| GB201521389D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Method |
| GB201521382D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| WO2017117464A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| AU2020346632A1 (en) * | 2019-09-13 | 2022-05-05 | Provincial Health Services Authority | Anti-oncolytic virus antigen antibodies and methods of using same |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887468B1 (en) * | 1999-04-28 | 2005-05-03 | Board Of Regents, The University Of Texas System | Antibody kits for selectively inhibiting VEGF |
| CN1299833A (zh) * | 1999-12-30 | 2001-06-20 | 华西医科大学口腔医学研究所 | 抗人血管内皮生长因子单链抗体及其制备方法 |
| US20040185040A1 (en) * | 2001-11-21 | 2004-09-23 | Celltech R & D Limited | Modulating immune responses |
| WO2004016740A2 (en) * | 2002-08-15 | 2004-02-26 | Epitomics, Inc. | Humanized rabbit antibodies |
| CN100415765C (zh) * | 2003-08-07 | 2008-09-03 | 宜康公司 | 兔单克隆抗体的人源化方法 |
| US7462697B2 (en) | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
| US7431927B2 (en) * | 2005-03-24 | 2008-10-07 | Epitomics, Inc. | TNFα-neutralizing antibodies |
| KR102007492B1 (ko) * | 2008-06-25 | 2019-08-05 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | 보편적 항체 프레임워크를 사용한 래빗 항체의 인간화 |
| CN102002104A (zh) * | 2009-08-28 | 2011-04-06 | 江苏先声药物研究有限公司 | 一种抗vegf的单克隆抗体及含有该抗体的药物组合物 |
-
2008
- 2008-10-08 CN CN200880128968.5A patent/CN102065888B/zh active Active
- 2008-10-08 BR BRPI0822556-7A patent/BRPI0822556B1/pt active IP Right Grant
- 2008-10-08 US US12/247,933 patent/US7803371B2/en active Active
- 2008-10-08 CA CA2719400A patent/CA2719400C/en active Active
- 2008-10-08 KR KR1020107023342A patent/KR101581244B1/ko active IP Right Grant
- 2008-10-08 CA CA2981887A patent/CA2981887C/en active Active
- 2008-10-08 CN CN201410106341.7A patent/CN103992405B/zh active Active
- 2008-10-08 CA CA3053675A patent/CA3053675A1/en not_active Abandoned
- 2008-10-08 AU AU2008353479A patent/AU2008353479B2/en active Active
- 2008-10-08 JP JP2011501758A patent/JP5823858B2/ja active Active
- 2008-10-08 EP EP08873637.6A patent/EP2259795B1/en active Active
- 2008-10-08 WO PCT/US2008/011620 patent/WO2009120178A1/en active Application Filing
-
2010
- 2010-07-30 US US12/847,757 patent/US8088375B2/en active Active
-
2014
- 2014-05-16 JP JP2014102751A patent/JP2014205674A/ja active Pending
-
2015
- 2015-02-17 HK HK15101772.5A patent/HK1201280A1/xx unknown
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