JP2018510132A5 - - Google Patents
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- Publication number
- JP2018510132A5 JP2018510132A5 JP2017540830A JP2017540830A JP2018510132A5 JP 2018510132 A5 JP2018510132 A5 JP 2018510132A5 JP 2017540830 A JP2017540830 A JP 2017540830A JP 2017540830 A JP2017540830 A JP 2017540830A JP 2018510132 A5 JP2018510132 A5 JP 2018510132A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- chain consists
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 6
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 3
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 108010029697 CD40 Ligand Proteins 0.000 claims 1
- 102100032937 CD40 ligand Human genes 0.000 claims 1
- 229960003697 abatacept Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 229950001109 galiximab Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562111261P | 2015-02-03 | 2015-02-03 | |
| US62/111,261 | 2015-02-03 | ||
| PCT/US2016/016165 WO2016126702A1 (en) | 2015-02-03 | 2016-02-02 | Anti-cd40l antibodies and methods for treating cd40l-related diseases or disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020191310A Division JP2021054826A (ja) | 2015-02-03 | 2020-11-18 | Ｃｄ４０ｌ関連疾患または障害を治療するための抗ｃｄ４０ｌ抗体及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510132A JP2018510132A (ja) | 2018-04-12 |
| JP2018510132A5 true JP2018510132A5 (enExample) | 2019-03-14 |
| JP6797810B2 JP6797810B2 (ja) | 2020-12-09 |
Family
ID=56564599
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540830A Active JP6797810B2 (ja) | 2015-02-03 | 2016-02-02 | Ｃｄ４０ｌ関連疾患または障害を治療するための抗ｃｄ４０ｌ抗体及び方法 |
| JP2020191310A Withdrawn JP2021054826A (ja) | 2015-02-03 | 2020-11-18 | Ｃｄ４０ｌ関連疾患または障害を治療するための抗ｃｄ４０ｌ抗体及び方法 |
| JP2022199466A Pending JP2023036717A (ja) | 2015-02-03 | 2022-12-14 | Ｃｄ４０ｌ関連疾患または障害を治療するための抗ｃｄ４０ｌ抗体及び方法 |
| JP2025006366A Pending JP2025081304A (ja) | 2015-02-03 | 2025-01-16 | Ｃｄ４０ｌ関連疾患または障害を治療するための抗ｃｄ４０ｌ抗体及び方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020191310A Withdrawn JP2021054826A (ja) | 2015-02-03 | 2020-11-18 | Ｃｄ４０ｌ関連疾患または障害を治療するための抗ｃｄ４０ｌ抗体及び方法 |
| JP2022199466A Pending JP2023036717A (ja) | 2015-02-03 | 2022-12-14 | Ｃｄ４０ｌ関連疾患または障害を治療するための抗ｃｄ４０ｌ抗体及び方法 |
| JP2025006366A Pending JP2025081304A (ja) | 2015-02-03 | 2025-01-16 | Ｃｄ４０ｌ関連疾患または障害を治療するための抗ｃｄ４０ｌ抗体及び方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US10106618B2 (enExample) |
| EP (2) | EP4071175A1 (enExample) |
| JP (4) | JP6797810B2 (enExample) |
| KR (2) | KR20250007045A (enExample) |
| CN (2) | CN108064168B (enExample) |
| AU (3) | AU2016215505B8 (enExample) |
| CA (1) | CA2974135A1 (enExample) |
| DK (1) | DK3253412T3 (enExample) |
| GB (1) | GB2552429A (enExample) |
| IL (3) | IL322241A (enExample) |
| MA (1) | MA41459A (enExample) |
| MX (2) | MX392480B (enExample) |
| RU (1) | RU2727646C2 (enExample) |
| SG (2) | SG11201706258WA (enExample) |
| WO (1) | WO2016126702A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2683406T3 (da) | 2011-03-11 | 2019-07-08 | Beth Israel Deaconess Medical Ct Inc | Anti-cd40-antistoffer og anvendelser deraf |
| MA41459A (fr) | 2015-02-03 | 2017-12-12 | Als Therapy Development Inst | Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l |
| CN109069621B (zh) | 2015-09-04 | 2022-09-06 | 普里玛托普医疗股份有限公司 | 人源化抗-cd40抗体及其用途 |
| MA50435A (fr) * | 2017-05-24 | 2020-09-02 | Als Therapy Development Inst | Anticorps anti-ligand anti-cd40 thérapeutiques |
| SMT202400527T1 (it) * | 2019-07-01 | 2025-01-14 | Tonix Pharma Ltd | Anticorpi anti-cd154 e loro usi |
| CN114341197A (zh) * | 2019-07-08 | 2022-04-12 | 普罗根有限公司 | 新的融合蛋白及其用途 |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| US20240059781A1 (en) * | 2021-01-06 | 2024-02-22 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
| US20240101673A1 (en) | 2021-02-03 | 2024-03-28 | Mozart Therapeutics, Inc. | Binding agents and methods of using the same |
| WO2023076876A1 (en) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation of immune responses to viral vectors |
| US12234294B2 (en) | 2021-11-05 | 2025-02-25 | Kiniksa Pharmaceuticals, Gmbh | Pharmaceutical composition of a humanized anti-CD40 antibody |
| CN114149508B (zh) * | 2021-11-25 | 2023-04-28 | 苏州普乐康医药科技有限公司 | 一种结合cd40l的融合蛋白及其应用 |
| KR20230108156A (ko) * | 2022-01-10 | 2023-07-18 | 주식회사 금호에이치티 | Cd40l에 특이적으로 결합하는 항체 및 그의 용도 |
| WO2024211211A1 (en) | 2023-04-03 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Methods of improving transplant survival using il-2 receptor gamma chain antibodies |
| WO2025117849A1 (en) | 2023-11-28 | 2025-06-05 | Eledon Pharmaceuticals, Inc. | Methods and compositions for prevention of transplant rejection |
| WO2025235683A1 (en) | 2024-05-07 | 2025-11-13 | Eledon Pharmaceuticals, Inc. | Methods and compositions for prevention of transplant rejection |
| WO2025235670A1 (en) | 2024-05-07 | 2025-11-13 | Eledon Pharmaceuticals, Inc. | Use of anti-cd40 ligand antibodies for immunosuppression in islet cell transplantation |
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| US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| US5851795A (en) | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
| US5961974A (en) | 1991-10-25 | 1999-10-05 | Immunex Corporation | Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same |
| US5962406A (en) | 1991-10-25 | 1999-10-05 | Immunex Corporation | Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same |
| US5474771A (en) | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| US7070777B1 (en) | 1991-11-15 | 2006-07-04 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting inflammation with an antibody that binds the 5C8 protein |
| IL104684A0 (en) | 1992-02-14 | 1993-06-10 | Bristol Myers Squibb Co | The cd40cr receptor and ligands therefor |
| ES2120067T3 (es) | 1993-09-02 | 1998-10-16 | Dartmouth College | Metodos para inducir tolerancia de celulas t antigeno especifica. |
| US5833987A (en) | 1995-06-07 | 1998-11-10 | Trustees Of Dartmouth College | Treatment of T cell mediated autoimmune disorders |
| US6001358A (en) | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
| US6340459B1 (en) | 1995-12-01 | 2002-01-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients |
| TR200001250T2 (tr) | 1997-01-10 | 2001-03-21 | Biogen, Inc | Ati-CD40L bileşikleri ile lupus nefritis tedavisi |
| EE9900528A (et) | 1997-05-17 | 2000-06-15 | Biogen, Incorporated | CD40:CD154 seostumise katkestaja kasutamine adaptiivsete immuunvastuste, eriti transplantaadi hülgamise takistamiseks |
| JP2002510643A (ja) | 1998-04-03 | 2002-04-09 | トラスティーズ・オブ・ダートマス・カレッジ | 狼瘡およびその関連腎臓疾患の治療および／または後退のための抗−ｇｐ３９抗体の使用 |
| US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
| CA2390412A1 (en) | 1999-11-08 | 2001-05-17 | Idec Pharmaceuticals Corporation | Treatment of b cell malignancies using anti-cd40l antibodies in combination with anti-cd20 antibodies and/or chemotherapeutics and radiotherapy |
| AU2001236621B2 (en) | 2000-02-01 | 2006-06-15 | Mycenax Biotech Inc. | Cd40-binding apc-activating molecules |
| GB0006398D0 (en) | 2000-03-16 | 2000-05-03 | Novartis Ag | Organic compounds |
| AU2001259215A1 (en) | 2000-04-28 | 2001-11-12 | La Jolla Institute For Allergy And Immunology | Human anti-cd40 antibodies and methods of making and using same |
| JP2003533488A (ja) * | 2000-05-12 | 2003-11-11 | ベス・イスラエル・ディーコニス・メディカル・センター・インコーポレーテッド | 免疫抑制を達成するための組成物および方法 |
| EP1305045A1 (en) | 2000-07-12 | 2003-05-02 | Idec Pharmaceuticals Corporation | Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications |
| AU8867501A (en) | 2000-09-01 | 2002-03-13 | Biogen Inc | Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design |
| AU8704101A (en) | 2000-09-01 | 2002-03-13 | Biogen Inc | Novel cd40:cd154 binding interruptor compounds and use thereof to treat immunological complications |
| AU2003217912A1 (en) * | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| US20040146949A1 (en) | 2002-10-25 | 2004-07-29 | Jun Tan | Methods and compounds for disruption of CD40R/CD40L signaling in the treatment of alzheimer's disease |
| KR20120090094A (ko) | 2003-06-13 | 2012-08-16 | 바이오겐 아이덱 엠에이 인코포레이티드 | 아글리코실 항-ｃｄ154(ｃｄ40 리간드) 항체 및 이의 용도 |
| JP2007527703A (ja) | 2003-07-08 | 2007-10-04 | ジェネスト アー／エス | 肺炎球菌表面付着因子Ａタンパク質（ＰｓａＡ）に関する結合メンバー |
| JP4944608B2 (ja) | 2003-07-26 | 2012-06-06 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 改良された抗原結合親和性を有する、変更された抗体 |
| NZ545776A (en) * | 2003-08-22 | 2009-05-31 | Biogen Idec Inc | Improved antibodies having altered effector function and methods for making the same |
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| TWI380996B (zh) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ｏｘ４０ｌ抗體 |
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| ME03071B (me) * | 2011-04-21 | 2019-01-20 | Bristol Myers Squibb Co | Polipeptidi antitela koji antagonizuju cd40 |
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| TW201817744A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
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| JP6215838B2 (ja) | 2011-12-08 | 2017-10-18 | プレシフレックス エスアー | 低容量精密ベローズ |
| SG11201405968SA (en) | 2012-05-11 | 2014-11-27 | Medimmune Llc | Ctla-4 variants |
| CN105121621B (zh) | 2012-10-18 | 2019-08-02 | 张永新 | 用于细胞动静态交替培养的生物反应器系统及其方法 |
| CA2908350C (en) * | 2013-04-02 | 2023-08-08 | Futa Mimoto | Fc region variant |
| EP3041863A4 (en) * | 2013-09-05 | 2017-08-16 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
| CN106132429A (zh) | 2014-03-19 | 2016-11-16 | 百时美施贵宝公司 | 使用针对cd40l的域抗体治疗移植物排斥的方法 |
| BR112016023450A2 (pt) | 2014-04-25 | 2017-10-17 | Bristol Myers Squibb Co | uso de compostos ctla4 para alcançar remissão livre de fármacos em indivíduos com artrite reumatoide precoce |
| US20170233485A1 (en) | 2014-08-18 | 2017-08-17 | Biogen Ma Inc. | Anti-cd40 antibodies and uses thereof |
| MA41459A (fr) * | 2015-02-03 | 2017-12-12 | Als Therapy Development Inst | Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l |
| MA50435A (fr) | 2017-05-24 | 2020-09-02 | Als Therapy Development Inst | Anticorps anti-ligand anti-cd40 thérapeutiques |
-
2016
- 2016-02-01 MA MA041459A patent/MA41459A/fr unknown
- 2016-02-02 EP EP22163613.7A patent/EP4071175A1/en active Pending
- 2016-02-02 JP JP2017540830A patent/JP6797810B2/ja active Active
- 2016-02-02 KR KR1020247042620A patent/KR20250007045A/ko active Pending
- 2016-02-02 IL IL322241A patent/IL322241A/en unknown
- 2016-02-02 GB GB1713871.0A patent/GB2552429A/en not_active Withdrawn
- 2016-02-02 RU RU2017126997A patent/RU2727646C2/ru active
- 2016-02-02 CN CN201680008506.4A patent/CN108064168B/zh active Active
- 2016-02-02 WO PCT/US2016/016165 patent/WO2016126702A1/en not_active Ceased
- 2016-02-02 KR KR1020177021029A patent/KR102747565B1/ko active Active
- 2016-02-02 AU AU2016215505A patent/AU2016215505B8/en active Active
- 2016-02-02 CA CA2974135A patent/CA2974135A1/en active Pending
- 2016-02-02 SG SG11201706258WA patent/SG11201706258WA/en unknown
- 2016-02-02 MX MX2017009694A patent/MX392480B/es unknown
- 2016-02-02 DK DK16747111.9T patent/DK3253412T3/da active
- 2016-02-02 CN CN202111202841.7A patent/CN114195895B/zh active Active
- 2016-02-02 SG SG10201912752QA patent/SG10201912752QA/en unknown
- 2016-02-02 EP EP16747111.9A patent/EP3253412B1/en active Active
-
2017
- 2017-07-19 IL IL253571A patent/IL253571B/en unknown
- 2017-07-26 MX MX2022005655A patent/MX2022005655A/es unknown
- 2017-08-02 US US15/667,477 patent/US10106618B2/en active Active
-
2018
- 2018-09-07 US US16/125,317 patent/US10683356B2/en active Active
-
2020
- 2020-05-13 US US15/931,315 patent/US11014990B2/en active Active
- 2020-11-18 JP JP2020191310A patent/JP2021054826A/ja not_active Withdrawn
-
2021
- 2021-05-17 US US17/322,486 patent/US11692040B2/en active Active
- 2021-11-03 IL IL287823A patent/IL287823A/en unknown
-
2022
- 2022-01-19 AU AU2022200323A patent/AU2022200323B2/en active Active
- 2022-12-14 JP JP2022199466A patent/JP2023036717A/ja active Pending
-
2023
- 2023-06-26 US US18/341,202 patent/US12275793B2/en active Active
-
2024
- 2024-07-02 AU AU2024204572A patent/AU2024204572A1/en active Pending
-
2025
- 2025-01-16 JP JP2025006366A patent/JP2025081304A/ja active Pending
- 2025-01-17 US US19/030,443 patent/US20250263493A1/en active Pending
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