JP2010202664A5 - - Google Patents
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- Publication number
- JP2010202664A5 JP2010202664A5 JP2010130425A JP2010130425A JP2010202664A5 JP 2010202664 A5 JP2010202664 A5 JP 2010202664A5 JP 2010130425 A JP2010130425 A JP 2010130425A JP 2010130425 A JP2010130425 A JP 2010130425A JP 2010202664 A5 JP2010202664 A5 JP 2010202664A5
- Authority
- JP
- Japan
- Prior art keywords
- factor viii
- seq
- amino acid
- patient
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37635102P | 2002-04-29 | 2002-04-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004501452A Division JP2005535588A (ja) | 2002-04-29 | 2003-04-28 | 第ｖｉｉｉ因子と低密度リポタンパク質レセプター関連タンパク質との相互作用のアンタゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010202664A JP2010202664A (ja) | 2010-09-16 |
| JP2010202664A5 true JP2010202664A5 (enExample) | 2011-07-21 |
Family
ID=29401334
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004501452A Pending JP2005535588A (ja) | 2002-04-29 | 2003-04-28 | 第ｖｉｉｉ因子と低密度リポタンパク質レセプター関連タンパク質との相互作用のアンタゴニスト |
| JP2010130425A Pending JP2010202664A (ja) | 2002-04-29 | 2010-06-07 | 第ｖｉｉｉ因子と低密度リポタンパク質レセプター関連タンパク質との相互作用のアンタゴニスト |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004501452A Pending JP2005535588A (ja) | 2002-04-29 | 2003-04-28 | 第ｖｉｉｉ因子と低密度リポタンパク質レセプター関連タンパク質との相互作用のアンタゴニスト |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8586538B2 (enExample) |
| EP (1) | EP1497330B1 (enExample) |
| JP (2) | JP2005535588A (enExample) |
| AT (1) | ATE463514T1 (enExample) |
| AU (1) | AU2003227687B2 (enExample) |
| CA (1) | CA2484155C (enExample) |
| DE (1) | DE60332011D1 (enExample) |
| DK (1) | DK1497330T3 (enExample) |
| ES (1) | ES2343681T3 (enExample) |
| WO (1) | WO2003093313A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003256299A1 (en) | 2002-07-01 | 2004-01-19 | Human Genome Sciences, Inc. | Antibodies that specifically bind to reg iv |
| EP1454632A1 (en) * | 2003-02-07 | 2004-09-08 | Aventis Behring GmbH, Intellectual Property/Legal | Pharmaceutical preparation for the treatment of blood-clotting disorders containing factor VIII derived peptides |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| WO2006003183A1 (de) * | 2004-07-02 | 2006-01-12 | Alois Jungbauer | Peptide zur blockierung von fviii-inhibitoren |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| JP2009274958A (ja) | 2006-08-31 | 2009-11-26 | Nara Prefecture | 血液凝固第ｖｉｉｉ因子の活性化を促進する抗体 |
| CA2673459C (en) | 2006-12-22 | 2016-09-13 | Stefan Schulte | Modified coagulation factors with prolonged in vivo half-life |
| AU2009256093A1 (en) * | 2008-06-04 | 2009-12-10 | Bayer Healthcare Llc | FVIII muteins for treatment of von Willebrand disease |
| DK2865760T3 (en) | 2008-06-24 | 2018-01-15 | Csl Behring Gmbh | Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life |
| JP5394864B2 (ja) * | 2009-09-10 | 2014-01-22 | アスモ株式会社 | モータ |
| WO2011095604A1 (en) * | 2010-02-04 | 2011-08-11 | Octapharma Biopharmaceuticals Gmbh | Half-life prolongation of proteins |
| JP6042335B2 (ja) | 2010-09-15 | 2016-12-14 | ノヴォ ノルディスク アー／エス | 細胞取込みが低下した第ｖｉｉｉ因子変異体 |
| WO2013120939A1 (en) | 2012-02-15 | 2013-08-22 | Csl Behring Gmbh | Von willebrand factor variants having improved factor viii binding affinity |
| ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
| BR112016030950A2 (pt) | 2014-07-02 | 2018-03-27 | Csl Ltd | polipeptídeo modificado que se liga ao fator viii, complexo, composição farmacêutica, métodos para tratar uma coagulopatia, para produzir um polipeptídeo que compreende um vwf modificado e para aumentar a afinidade de ligação ao fator viii do vwf e a meia-vida do fator viii, uso de um polipeptídeo modificado ou de um complexo, polinucleotídeo, plasmídeo ou vetor, e, célula hospedeira. |
| CA2978374A1 (en) | 2015-03-06 | 2016-09-15 | Csl Behring Recombinant Facility Ag | Modified von willebrand factor having improved half-life |
| US10772936B2 (en) | 2015-05-22 | 2020-09-15 | CSL Behring Lengnau AG | Methods for preparing modified von Willebrand factor |
| SG10201910896UA (en) | 2015-05-22 | 2020-01-30 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
| AU2017205776B2 (en) | 2016-01-07 | 2020-09-10 | CSL Behring Lengnau AG | Mutated von Willebrand factor |
| MX2018008337A (es) | 2016-01-07 | 2018-09-17 | CSL Behring Lengnau AG | Factor de von willebrand truncado mutado. |
| KR20190085021A (ko) | 2016-11-11 | 2019-07-17 | 체에스엘 베링 렝나우 아게 | 혈우병을 치료하기 위한 절단된 폰 빌레브란트 인자 폴리펩타이드 |
| TW201828974A (zh) | 2016-11-11 | 2018-08-16 | 瑞士商Ｃｓｌ貝林重組技能公司 | 用於血管外施予以治療或預防凝血疾病之截短型類血友病因子（ｖｏｎ Ｗｉｌｌｅｂｒａｎｄ ｆａｃｔｏｒ）多肽類 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0833848T3 (da) * | 1995-06-12 | 2001-11-05 | Sanquin Bloedvoorziening | Faktor IX-bindende peptider afledt af faktor VIII og anvendelse heraf som inhibitorer af blodkoagulation |
| PT1095143E (pt) * | 1998-05-08 | 2008-11-28 | Sanquin Bloedvoorziening | Inibidor para o diagnóstico e tratamento de doentes com hemofilia a |
| DK1129186T4 (da) * | 1998-11-10 | 2017-02-06 | Stichting Sanquin Bloedvoorziening | Et faktor VIII-polypeptid med faktor VIII:C-aktivitet |
| AT409335B (de) * | 1998-11-10 | 2002-07-25 | Immuno Ag | Pharmazeutisches präparat enthaltend einen rezeptor-antagonisten zur behandlung von blutgerinnungsstörungen |
-
2003
- 2003-04-28 WO PCT/EP2003/004425 patent/WO2003093313A2/en not_active Ceased
- 2003-04-28 AT AT03725109T patent/ATE463514T1/de active
- 2003-04-28 AU AU2003227687A patent/AU2003227687B2/en not_active Ceased
- 2003-04-28 CA CA2484155A patent/CA2484155C/en not_active Expired - Lifetime
- 2003-04-28 JP JP2004501452A patent/JP2005535588A/ja active Pending
- 2003-04-28 ES ES03725109T patent/ES2343681T3/es not_active Expired - Lifetime
- 2003-04-28 EP EP03725109A patent/EP1497330B1/en not_active Expired - Lifetime
- 2003-04-28 DK DK03725109.7T patent/DK1497330T3/da active
- 2003-04-28 US US10/512,907 patent/US8586538B2/en not_active Expired - Fee Related
- 2003-04-28 DE DE60332011T patent/DE60332011D1/de not_active Expired - Lifetime
-
2010
- 2010-06-07 JP JP2010130425A patent/JP2010202664A/ja active Pending