|
US5078996A
(en)
|
1985-08-16 |
1992-01-07 |
Immunex Corporation |
Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
|
|
US5098702A
(en)
|
1986-04-09 |
1992-03-24 |
Cetus Corporation |
Combination therapy using interleukin-2 and tumor necrosis factor
|
|
CA1341281C
(en)
|
1986-07-09 |
2001-08-07 |
Hubert J.P. Schoemaker |
Immunotherapy of tumor with monoclonal antibody against the 17-1a antigen
|
|
US5785973A
(en)
|
1988-02-01 |
1998-07-28 |
Praxis Biologics, Inc. |
Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines
|
|
JP3082204B2
(ja)
|
1988-09-01 |
2000-08-28 |
ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ |
両栄養性および環境栄養性宿主域を持つ組換え体レトロウイルス
|
|
US5665577A
(en)
|
1989-02-06 |
1997-09-09 |
Dana-Farber Cancer Institute |
Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
|
|
DE69020143T2
(de)
|
1989-02-17 |
1996-01-25 |
Chiron Mimotopes Pty Ltd |
Verfahren zur verwendung und herstellung von peptiden.
|
|
JP3051411B2
(ja)
|
1989-03-14 |
2000-06-12 |
持田製薬株式会社 |
新規ｄｎａならびにそれを含有する発現プラスミド
|
|
US5266491A
(en)
|
1989-03-14 |
1993-11-30 |
Mochida Pharmaceutical Co., Ltd. |
DNA fragment and expression plasmid containing the DNA fragment
|
|
US5436146A
(en)
|
1989-09-07 |
1995-07-25 |
The Trustees Of Princeton University |
Helper-free stocks of recombinant adeno-associated virus vectors
|
|
US5976877A
(en)
|
1990-01-08 |
1999-11-02 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses
|
|
FR2656800B1
(fr)
|
1990-01-08 |
1992-05-15 |
Roussy Inst Gustave |
Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques.
|
|
US7294712B2
(en)
|
1990-06-04 |
2007-11-13 |
Aventis Pharma S.A. |
Nucleotide sequences coding for variable regions of β chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
|
|
US5981276A
(en)
|
1990-06-20 |
1999-11-09 |
Dana-Farber Cancer Institute |
Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
|
|
DK0551401T3
(da)
|
1990-09-14 |
1996-01-22 |
Univ Texas |
Fremgangsmåde og præparater til genterapi og potensering af antitumor-immunitet
|
|
JP3459268B2
(ja)
|
1990-09-17 |
2003-10-20 |
中外製薬株式会社 |
抗癌剤
|
|
EP0529033B1
(fr)
|
1991-02-08 |
2006-08-30 |
Aventis Pharma S.A. |
Sequences nucleotidiques codant pour des regions variables de chaines alpha des recepteurs des lymphocytes humains ainsi que leurs applications
|
|
US6596536B1
(en)
|
1991-02-08 |
2003-07-22 |
Aventis Pharma S.A. |
Nucleotide sequences coding for variable regions of the alpha chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
|
|
KR100227303B1
(ko)
|
1991-02-12 |
1999-12-01 |
장-끌로드 비에이으포스 |
인체 t 임파구 수용체의 베타 사슬의 가변성 영역을 코딩하는 뉴클레오티드 서열, 대응하는 펩티드 세그먼트 및 진단 및 치료 용도
|
|
US5637483A
(en)
|
1991-10-04 |
1997-06-10 |
Whitehead Institute For Biomedical Research |
Irradiated tumor cell vaccine engineered to express GM-CSF
|
|
US5904920A
(en)
|
1991-10-04 |
1999-05-18 |
Whitehead Institute For Biomedical Research |
Regulation of systemic immune responses utilizing cytokines and antigens
|
|
US6506604B2
(en)
|
1993-06-11 |
2003-01-14 |
Cell Genesys, Inc. |
Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
|
|
DK0758383T3
(da)
|
1994-05-06 |
2007-05-29 |
Roussy Inst Gustave |
Oplöselige polypeptidfraktioner af LAG-3-proteinet; fremgangsmåde til fremstilling; terapeutisk sammensætning; antiidiotypisk antistof
|
|
US5872005A
(en)
|
1994-11-03 |
1999-02-16 |
Cell Genesys Inc. |
Packaging cell lines for adeno-associated viral vectors
|
|
JPH11507535A
(ja)
|
1995-06-07 |
1999-07-06 |
イムクローン システムズ インコーポレイテッド |
腫瘍の成長を抑制する抗体および抗体フラグメント類
|
|
US6040183A
(en)
|
1995-06-07 |
2000-03-21 |
University Of North Carloina At Chapel Hill |
Helper virus-free AAV production
|
|
US6093570A
(en)
|
1995-06-07 |
2000-07-25 |
The University Of North Carolina At Chapel Hill |
Helper virus-free AAV production
|
|
US6033674A
(en)
|
1995-12-28 |
2000-03-07 |
Johns Hopkins University School Of Medicine |
Method of treating cancer with a tumor cell line having modified cytokine expression
|
|
US5840839A
(en)
|
1996-02-09 |
1998-11-24 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
|
|
US6277368B1
(en)
|
1996-07-25 |
2001-08-21 |
The Regents Of The University Of California |
Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine
|
|
US6482925B1
(en)
|
1996-11-28 |
2002-11-19 |
Applied Research Systems Ars Holding N.V. |
Mutants of the LAG-3 proteins and nucleotides encoding LAG-3 mutants
|
|
EP0941329B1
(en)
|
1996-11-29 |
2004-07-21 |
Applied Research Systems ARS Holding N.V. |
Methods for preventing graft rejection in transplantation and for producing a universal gene therapy host cell using lymphocyte activation (lag-3)
|
|
AU728220B2
(en)
|
1997-04-14 |
2001-01-04 |
Cell Genesys, Inc. |
Methods for increasing the efficiency of recombinant AAV product
|
|
EP0893507A1
(en)
|
1997-07-25 |
1999-01-27 |
Institut Gustave Roussy |
Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment
|
|
US6037177A
(en)
|
1997-08-08 |
2000-03-14 |
Cell Genesys, Inc. |
Method for increasing the efficiency of recombinant AAV production
|
|
US5994136A
(en)
|
1997-12-12 |
1999-11-30 |
Cell Genesys, Inc. |
Method and means for producing high titer, safe, recombinant lentivirus vectors
|
|
CA2318372C
(en)
|
1998-02-02 |
2008-08-19 |
Johns Hopkins University School Of Medicine |
A universal immunomodulatory cytokine-expressing bystander cell line and related compositions and methods of manufacture and use
|
|
FR2777890B1
(fr)
|
1998-04-22 |
2000-12-29 |
Roussy Inst Gustave |
Composes peptidiques d'hsp70 utiles dans l'immunotherapie du cancer
|
|
AU5458500A
(en)
|
1999-06-02 |
2000-12-18 |
Cell Genesys, Inc. |
Regulation of systemic immune responses utilizing cytokines and antigens
|
|
FR2795415B1
(fr)
|
1999-06-28 |
2003-09-05 |
Roussy Inst Gustave |
Compose peptidique derive d'une orf decalee du gene ice
|
|
AT409086B
(de)
|
1999-11-16 |
2002-05-27 |
Igeneon Krebs Immuntherapie |
Neue verwendung von antikörpern als impfstoffe
|
|
EP1276468A1
(fr)
|
2000-04-26 |
2003-01-22 |
Biovector Therapeutics S.A. |
Utilisation de vecteurs particulaires dans l' immunomodulation
|
|
US7919467B2
(en)
|
2000-12-04 |
2011-04-05 |
Immunotope, Inc. |
Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer
|
|
EP1295895B1
(en)
|
2001-09-19 |
2011-08-10 |
Institut Gustave Roussy |
Peptides and proteins binding to glu-pro motifs, therapeutical compositions containing the same and applications thereof
|
|
EP2272513A1
(en)
|
2002-05-17 |
2011-01-12 |
Celgene Corporation |
Pharmaceutical compositions for treating cancer
|
|
PT1537878E
(pt)
|
2002-07-03 |
2010-11-18 |
Ono Pharmaceutical Co |
Composições de imunopotenciação
|
|
US7439042B2
(en)
|
2002-12-16 |
2008-10-21 |
Globeimmune, Inc. |
Yeast-based therapeutic for chronic hepatitis C infection
|
|
US20040197312A1
(en)
|
2003-04-02 |
2004-10-07 |
Marina Moskalenko |
Cytokine-expressing cellular vaccine combinations
|
|
SG146662A1
(en)
|
2003-10-10 |
2008-10-30 |
Powderject Vaccines Inc |
Method
|
|
FR2868781B1
(fr)
|
2004-04-13 |
2008-02-22 |
Immutep |
Composition de vaccin comprenant un ligand cmh de classe ii couple a un antigene, procede de preparation et utilisations
|
|
JP2006124383A
(ja)
|
2004-09-30 |
2006-05-18 |
Kobayashi Pharmaceut Co Ltd |
樹状細胞活性化剤
|
|
JP2006141346A
(ja)
|
2004-11-24 |
2006-06-08 |
Kobayashi Pharmaceut Co Ltd |
樹状細胞活性化剤
|
|
US7964571B2
(en)
*
|
2004-12-09 |
2011-06-21 |
Egen, Inc. |
Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
|
|
US7919079B2
(en)
|
2006-03-31 |
2011-04-05 |
Biosante Pharmaceuticals, Inc. |
Cancer immunotherapy compositions and methods of use
|
|
US20070231298A1
(en)
|
2006-03-31 |
2007-10-04 |
Cell Genesys, Inc. |
Cytokine-expressing cancer immunotherapy combinations
|
|
KR101586617B1
(ko)
|
2007-06-18 |
2016-01-20 |
머크 샤프 앤 도메 비.브이. |
사람 프로그램된 사멸 수용체 ｐｄ-1에 대한 항체
|
|
US8425897B2
(en)
|
2007-08-30 |
2013-04-23 |
Immutep S.A. |
Compositions containing LAG-3 and cells that secrete GM-CSF and methods of use
|
|
EP2044949A1
(en)
|
2007-10-05 |
2009-04-08 |
Immutep |
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
|
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
|
CA2820384A1
(en)
*
|
2010-12-06 |
2012-06-14 |
Cure Cancer Worldwide Corporation |
Methods of metabolic targeting cancer cells using chemo- and immunotherapy for treating cancer
|
|
MX341076B
(es)
|
2011-03-31 |
2016-08-04 |
Merck Sharp & Dohme |
Formulaciones estables de anticuerpos para el receptor humano pd-1 de meurte programada y tratamientos relacionados.
|
|
SG2014008304A
(en)
|
2012-02-01 |
2014-06-27 |
Compugen Ltd |
C10rf32 antibodies, and uses thereof for treatment of cancer
|
|
AU2013263076B2
(en)
|
2012-05-15 |
2017-08-31 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
|
US9890215B2
(en)
|
2012-06-22 |
2018-02-13 |
King's College London |
Vista modulators for diagnosis and treatment of cancer
|
|
WO2014194293A1
(en)
|
2013-05-30 |
2014-12-04 |
Amplimmune, Inc. |
Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof
|
|
AU2014323523B2
(en)
|
2013-09-20 |
2020-02-20 |
Bristol-Myers Squibb Company |
Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors
|
|
GB201322626D0
(en)
|
2013-12-19 |
2014-02-05 |
Immutep S A |
Combined preparations for the treatment of cancer
|
|
CA2935423C
(en)
|
2014-01-24 |
2023-11-07 |
Dana-Farber Cancer Institute, Inc. |
Antibody molecules to pd-1 and uses thereof
|
|
WO2015131176A1
(en)
|
2014-02-28 |
2015-09-03 |
Podack Eckhard R |
Compositions, methods, and kits for treatment of cancer
|
|
TWI693232B
(zh)
|
2014-06-26 |
2020-05-11 |
美商宏觀基因股份有限公司 |
與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
|
|
GB201500374D0
(en)
|
2015-01-09 |
2015-02-25 |
Immutep S A |
Combined preparations for the treatment of cancer
|