JP2017537105A5 - - Google Patents
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- Publication number
- JP2017537105A5 JP2017537105A5 JP2017528845A JP2017528845A JP2017537105A5 JP 2017537105 A5 JP2017537105 A5 JP 2017537105A5 JP 2017528845 A JP2017528845 A JP 2017528845A JP 2017528845 A JP2017528845 A JP 2017528845A JP 2017537105 A5 JP2017537105 A5 JP 2017537105A5
- Authority
- JP
- Japan
- Prior art keywords
- humanized antibody
- therapeutic agent
- seq
- intravenous infusion
- subsequent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 claims 17
- 229940124597 therapeutic agent Drugs 0.000 claims 14
- 238000001802 infusion Methods 0.000 claims 11
- 238000001990 intravenous administration Methods 0.000 claims 11
- 206010016717 Fistula Diseases 0.000 claims 9
- 230000003890 fistula Effects 0.000 claims 9
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 230000035876 healing Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 230000002519 immonomodulatory effect Effects 0.000 claims 2
- 102000006495 integrins Human genes 0.000 claims 2
- 108010044426 integrins Proteins 0.000 claims 2
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102100024484 Codanin-1 Human genes 0.000 claims 1
- 101000980888 Homo sapiens Codanin-1 Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 206010002156 anal fistula Diseases 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
- 229960002170 azathioprine Drugs 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960001428 mercaptopurine Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 229960004914 vedolizumab Drugs 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021153317A JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2024127719A JP2024161423A (ja) | 2014-11-26 | 2024-08-02 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462084815P | 2014-11-26 | 2014-11-26 | |
| US62/084,815 | 2014-11-26 | ||
| PCT/US2015/062705 WO2016086147A1 (en) | 2014-11-26 | 2015-11-25 | Vedolizumab for the treatment of fistulizing crohn's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021153317A Division JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017537105A JP2017537105A (ja) | 2017-12-14 |
| JP2017537105A5 true JP2017537105A5 (enExample) | 2019-01-10 |
Family
ID=54834962
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528845A Withdrawn JP2017537105A (ja) | 2014-11-26 | 2015-11-25 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2021153317A Active JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2024127719A Pending JP2024161423A (ja) | 2014-11-26 | 2024-08-02 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021153317A Active JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2024127719A Pending JP2024161423A (ja) | 2014-11-26 | 2024-08-02 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20170327584A1 (enExample) |
| EP (2) | EP3224280A1 (enExample) |
| JP (3) | JP2017537105A (enExample) |
| WO (1) | WO2016086147A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| EP3224280A1 (en) * | 2014-11-26 | 2017-10-04 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| US20170360926A1 (en) | 2014-12-24 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-alpha4beta7 INTEGRIN ANTIBODY |
| US11760803B2 (en) | 2016-03-24 | 2023-09-19 | Takeda Pharmaceutical Company Limited | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
| US10918716B2 (en) | 2016-05-04 | 2021-02-16 | Millennium Pharmaceuticals, Inc. | Triple combination therapy for treating Crohn's disease |
| JP7202893B2 (ja) * | 2016-06-12 | 2023-01-12 | 武田薬品工業株式会社 | 炎症性腸疾患を治療する方法 |
| JP7129912B2 (ja) | 2016-12-07 | 2022-09-02 | 株式会社ステリック再生医科学研究所 | 慢性疾患の治療及び予防用医薬組成物 |
| US20210031012A1 (en) | 2018-01-26 | 2021-02-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| US12171764B2 (en) | 2018-06-20 | 2024-12-24 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a JAK or other kinase inhibitor |
| US20230312700A1 (en) | 2018-06-20 | 2023-10-05 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
| WO2019246271A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| EP4045039B1 (en) * | 2019-10-16 | 2025-04-23 | Morphic Therapeutic, Inc. | Inhibiting human integrin alpha4beta7 |
| JP2023518394A (ja) | 2020-03-18 | 2023-05-01 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | 瘻孔を治療するための装置及び方法 |
| AU2024282654A1 (en) | 2023-05-30 | 2025-12-04 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | エル． モリソン，シェリー | ドメイン‐変性不変部を有する抗体 |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
| US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| US7803904B2 (en) | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
| ES2290955T3 (es) | 1995-02-10 | 2008-02-16 | Millennium Pharmaceuticals, Inc. | Adresinas vasculares de mucosas y sus usos. |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US20010046496A1 (en) | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| EP2402310A1 (en) | 2002-05-24 | 2012-01-04 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
| CA2500492C (en) | 2002-11-18 | 2010-03-16 | Solomon Ungashe | Aryl sulfonamides |
| AR047372A1 (es) | 2004-01-09 | 2006-01-18 | Pfizer | Anticuerpos contra madcam |
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| DK1784426T3 (da) | 2004-09-03 | 2012-03-12 | Genentech Inc | Humaniserede anti-beta7-antagonister og anvendelser deraf |
| CA2629147A1 (en) | 2005-11-17 | 2007-05-31 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with .alpha.4.beta.7 integrin |
| WO2008150490A2 (en) * | 2007-06-01 | 2008-12-11 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of psoriasis and crohn's disease |
| MX357213B (es) | 2009-03-20 | 2018-06-29 | Amgen Inc | Anticuerpo de antagonista especifico de heterodimero alfa-4-beta-7. |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| KR102136208B1 (ko) | 2011-05-02 | 2020-07-21 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
| US9616121B2 (en) * | 2012-06-04 | 2017-04-11 | Center for Digestive Diseases | Therapeutic combinations for treating Johne's disease |
| EP3224280A1 (en) * | 2014-11-26 | 2017-10-04 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| US20170360926A1 (en) | 2014-12-24 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-alpha4beta7 INTEGRIN ANTIBODY |
| US10918716B2 (en) | 2016-05-04 | 2021-02-16 | Millennium Pharmaceuticals, Inc. | Triple combination therapy for treating Crohn's disease |
| JP7202893B2 (ja) | 2016-06-12 | 2023-01-12 | 武田薬品工業株式会社 | 炎症性腸疾患を治療する方法 |
| JP2020517671A (ja) | 2017-04-28 | 2020-06-18 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 小児の障害を処置する方法 |
| CA3065000A1 (en) | 2017-05-26 | 2018-11-29 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of chronic pouchitis |
-
2015
- 2015-11-25 EP EP15805720.8A patent/EP3224280A1/en not_active Withdrawn
- 2015-11-25 JP JP2017528845A patent/JP2017537105A/ja not_active Withdrawn
- 2015-11-25 WO PCT/US2015/062705 patent/WO2016086147A1/en not_active Ceased
- 2015-11-25 US US15/529,308 patent/US20170327584A1/en not_active Abandoned
- 2015-11-25 EP EP19174177.6A patent/EP3581585A1/en active Pending
-
2019
- 2019-03-11 US US16/297,990 patent/US11884731B2/en active Active
-
2021
- 2021-09-21 JP JP2021153317A patent/JP7579227B2/ja active Active
-
2023
- 2023-12-11 US US18/535,781 patent/US20240376210A1/en active Pending
-
2024
- 2024-08-02 JP JP2024127719A patent/JP2024161423A/ja active Pending
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