JP2017537105A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017537105A5 JP2017537105A5 JP2017528845A JP2017528845A JP2017537105A5 JP 2017537105 A5 JP2017537105 A5 JP 2017537105A5 JP 2017528845 A JP2017528845 A JP 2017528845A JP 2017528845 A JP2017528845 A JP 2017528845A JP 2017537105 A5 JP2017537105 A5 JP 2017537105A5
- Authority
- JP
- Japan
- Prior art keywords
- humanized antibody
- therapeutic agent
- seq
- intravenous infusion
- subsequent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 claims 17
- 229940124597 therapeutic agent Drugs 0.000 claims 14
- 238000001802 infusion Methods 0.000 claims 11
- 238000001990 intravenous administration Methods 0.000 claims 11
- 206010016717 Fistula Diseases 0.000 claims 9
- 230000003890 fistula Effects 0.000 claims 9
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 230000035876 healing Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 230000002519 immonomodulatory effect Effects 0.000 claims 2
- 102000006495 integrins Human genes 0.000 claims 2
- 108010044426 integrins Proteins 0.000 claims 2
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102100024484 Codanin-1 Human genes 0.000 claims 1
- 101000980888 Homo sapiens Codanin-1 Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 206010002156 anal fistula Diseases 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
- 229960002170 azathioprine Drugs 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960001428 mercaptopurine Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 229960004914 vedolizumab Drugs 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021153317A JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2024127719A JP2024161423A (ja) | 2014-11-26 | 2024-08-02 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462084815P | 2014-11-26 | 2014-11-26 | |
| US62/084,815 | 2014-11-26 | ||
| PCT/US2015/062705 WO2016086147A1 (en) | 2014-11-26 | 2015-11-25 | Vedolizumab for the treatment of fistulizing crohn's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021153317A Division JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017537105A JP2017537105A (ja) | 2017-12-14 |
| JP2017537105A5 true JP2017537105A5 (enExample) | 2019-01-10 |
Family
ID=54834962
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528845A Withdrawn JP2017537105A (ja) | 2014-11-26 | 2015-11-25 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2021153317A Active JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2024127719A Pending JP2024161423A (ja) | 2014-11-26 | 2024-08-02 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021153317A Active JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2024127719A Pending JP2024161423A (ja) | 2014-11-26 | 2024-08-02 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20170327584A1 (enExample) |
| EP (2) | EP3224280A1 (enExample) |
| JP (3) | JP2017537105A (enExample) |
| WO (1) | WO2016086147A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| EP3224280A1 (en) * | 2014-11-26 | 2017-10-04 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| US20170360926A1 (en) | 2014-12-24 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-alpha4beta7 INTEGRIN ANTIBODY |
| EP3433275A1 (en) | 2016-03-24 | 2019-01-30 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
| MA44864A (fr) | 2016-05-04 | 2019-03-13 | Icahn School Med Mount Sinai | Trithérapie pour le traitement d'une maladie intestinale inflammatoire |
| CA3027286A1 (en) | 2016-06-12 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | Method of treating inflammatory bowel disease |
| EP3552632B1 (en) | 2016-12-07 | 2023-07-12 | Stelic Institute & Co., Inc. | Medicinal composition for treating and preventing inflammatory bowel disease |
| WO2019147824A1 (en) | 2018-01-26 | 2019-08-01 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| WO2019246313A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
| US20210363233A1 (en) | 2018-06-20 | 2021-11-25 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| WO2019246273A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a jak or other kinase inhibitor |
| WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| MX2022004406A (es) * | 2019-10-16 | 2022-08-25 | Morphic Therapeutic Inc | INHIBICIÓN DE INTEGRINA A4ß7 HUMANA. |
| EP4120922A4 (en) | 2020-03-18 | 2024-05-01 | Millennium Pharmaceuticals, Inc. | DEVICES AND METHODS FOR TREATING FISTULA |
| TW202504919A (zh) | 2023-05-30 | 2025-02-01 | 美商派拉岡醫療公司 | α4β7整合素抗體組合物及使用方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | エル． モリソン，シェリー | ドメイン‐変性不変部を有する抗体 |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| AU675916B2 (en) | 1991-06-14 | 1997-02-27 | Genentech Inc. | Method for making humanized antibodies |
| ATE297465T1 (de) | 1991-11-25 | 2005-06-15 | Enzon Inc | Verfahren zur herstellung von multivalenten antigenbindenden proteinen |
| EP0714409A1 (en) | 1993-06-16 | 1996-06-05 | Celltech Therapeutics Limited | Antibodies |
| US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| US7803904B2 (en) | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
| DE69637155T2 (de) | 1995-02-10 | 2008-02-07 | Millennium Pharmaceuticals, Inc., Cambridge | Addressine der schleimhaut und der blutgefässe und ihre verwendung |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US20010046496A1 (en) | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| NZ566263A (en) | 2002-05-24 | 2009-09-25 | Millennium Pharm Inc | CCR9 inhibitors and methods of use thereof |
| PT1562940E (pt) | 2002-11-18 | 2007-07-23 | Chemocentryx Inc | Sulfonamidas de arilo. |
| JP4315982B2 (ja) | 2004-01-09 | 2009-08-19 | ファイザー インコーポレイティッド | ＭＡｄＣＡＭに対する抗体 |
| US20060045872A1 (en) * | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| SI2990422T1 (sl) | 2004-09-03 | 2018-10-30 | Genentech, Inc. | Humanizirani antagonisti proti beta7 in njihove uporabe |
| CA2629147A1 (en) | 2005-11-17 | 2007-05-31 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with .alpha.4.beta.7 integrin |
| WO2008150490A2 (en) * | 2007-06-01 | 2008-12-11 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of psoriasis and crohn's disease |
| SG10201801337WA (en) | 2009-03-20 | 2018-03-28 | Amgen Inc | Alpha-4-Beta-7 Heterodimer Specific Antagonist Antibody |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| CA3051418C (en) | 2011-05-02 | 2021-05-18 | Millennium Pharmaceuticals, Inc. | Methods of treating inflammatory bowel disease |
| EP2854852A4 (en) * | 2012-06-04 | 2016-04-13 | Centre For Digestive Diseases Pty Ltd | COMPOSITIONS AND METHODS OF TREATING MORBUS CROHN AND RELATED DISEASES AND INFECTIONS |
| EP3224280A1 (en) * | 2014-11-26 | 2017-10-04 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| US20170360926A1 (en) | 2014-12-24 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-alpha4beta7 INTEGRIN ANTIBODY |
| MA44864A (fr) | 2016-05-04 | 2019-03-13 | Icahn School Med Mount Sinai | Trithérapie pour le traitement d'une maladie intestinale inflammatoire |
| CA3027286A1 (en) | 2016-06-12 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | Method of treating inflammatory bowel disease |
| CA3061320A1 (en) | 2017-04-28 | 2018-11-01 | Millennium Pharmaceuticals, Inc. | Method of treating pediatric disorders |
| EP3630184A4 (en) | 2017-05-26 | 2021-03-17 | Millennium Pharmaceuticals, Inc. | METHODS FOR THE TREATMENT OF CHRONIC POCHITIS |
-
2015
- 2015-11-25 EP EP15805720.8A patent/EP3224280A1/en not_active Withdrawn
- 2015-11-25 WO PCT/US2015/062705 patent/WO2016086147A1/en not_active Ceased
- 2015-11-25 JP JP2017528845A patent/JP2017537105A/ja not_active Withdrawn
- 2015-11-25 EP EP19174177.6A patent/EP3581585A1/en active Pending
- 2015-11-25 US US15/529,308 patent/US20170327584A1/en not_active Abandoned
-
2019
- 2019-03-11 US US16/297,990 patent/US11884731B2/en active Active
-
2021
- 2021-09-21 JP JP2021153317A patent/JP7579227B2/ja active Active
-
2023
- 2023-12-11 US US18/535,781 patent/US20240376210A1/en active Pending
-
2024
- 2024-08-02 JP JP2024127719A patent/JP2024161423A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017537105A5 (enExample) | ||
| Picard et al. | Current knowledge and management of hypersensitivity reactions to monoclonal antibodies | |
| JP2020002171A5 (enExample) | ||
| JP2015534579A5 (enExample) | ||
| JP2014514346A5 (enExample) | ||
| JP2018184417A5 (enExample) | ||
| JP2013533858A5 (enExample) | ||
| JP2014533279A5 (enExample) | ||
| JP2015525798A5 (enExample) | ||
| JP2016530280A5 (enExample) | ||
| JP2014515763A5 (enExample) | ||
| JP2015529225A5 (enExample) | ||
| JP2016528247A5 (enExample) | ||
| JP2018502120A5 (enExample) | ||
| JP2019514974A5 (enExample) | ||
| JP2017507139A5 (enExample) | ||
| JP2003531129A5 (enExample) | ||
| RU2017108173A (ru) | Комбинированная терапия на основе антител, активирующих человеческий cd40, и антител к человеческому pd-l1 | |
| JP2020517696A5 (enExample) | ||
| JP2019530713A5 (enExample) | ||
| JP2017503014A5 (enExample) | ||
| JP2015096065A5 (enExample) | ||
| JP7307044B2 (ja) | 逐次的抗癌治療 | |
| JP2018512402A5 (enExample) | ||
| JP2018529661A5 (enExample) |