MX9706049A - Adresinas vasculares mucosas y sus usos. - Google Patents
Adresinas vasculares mucosas y sus usos.Info
- Publication number
- MX9706049A MX9706049A MX9706049A MX9706049A MX9706049A MX 9706049 A MX9706049 A MX 9706049A MX 9706049 A MX9706049 A MX 9706049A MX 9706049 A MX9706049 A MX 9706049A MX 9706049 A MX9706049 A MX 9706049A
- Authority
- MX
- Mexico
- Prior art keywords
- madcam
- primate
- recombinant
- proteins
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- External Artificial Organs (AREA)
Abstract
La presente invencion se refiere a ácidos nucleicos recombinantes y/o alejados, que codifican MadCAMs primates, y a proteínas de polipéptidos que aquí se refieren como MadCAMs primates recombinantes y/o aisladas. Además, la invencion se refiere a constructores ácidos nucleicos recombinantes, que comprenden un ácido nucleico que codifica una MadCAM primate de la presente invencion, una parte de la misma o una variante, a células huésped que comprenden dichos constructores, utiles para la produccion de proteínas recombinantes; el uso de ácidos nucleicos y/o proteínas de ensayos para identificar los inhibidores (por ejemplo, antagonistas) de la funcion de MAdCAM primate; y a anticuerpos reactivos con la MadCAM primate, los cuales son utiles en métodos in vitro y aplicaciones terapéuticas o diagnosticas. De igual modo, la invencion se refiere al tratamiento de individuos, particularmente humanos, que sufren de una enfermedad (por ejemplo, la enfermedad inflamatoria del intestino) asociada con el aumento de leucocitos en el aparato gastrointestinal u otros tejidos, por ejemplo, como resultado de la union de leucocitos a las células que expresan la molécula MAdCAM (endotelio asociado con el intestino), que comprenden administrar el individuo una cantidad efectiva de un agente, tal como un anticuerpo, que inhiba la union de los leucocitos a la MAdCAM.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/386,857 US6551593B1 (en) | 1995-02-10 | 1995-02-10 | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
| US08/523,004 US7750137B2 (en) | 1995-09-01 | 1995-09-01 | Mucosal vascular addressins |
| PCT/US1996/002153 WO1996024673A1 (en) | 1995-02-10 | 1996-02-12 | Mucosal vascular addressins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9706049A true MX9706049A (es) | 1998-02-28 |
Family
ID=27011628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9706049A MX9706049A (es) | 1995-02-10 | 1996-02-12 | Adresinas vasculares mucosas y sus usos. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0808367B1 (es) |
| JP (1) | JP4205162B2 (es) |
| AT (1) | ATE366809T1 (es) |
| AU (1) | AU4986296A (es) |
| CA (1) | CA2212702C (es) |
| DE (1) | DE69637155T2 (es) |
| DK (1) | DK0808367T3 (es) |
| ES (1) | ES2290955T3 (es) |
| MX (1) | MX9706049A (es) |
| NZ (1) | NZ303523A (es) |
| PT (1) | PT808367E (es) |
| WO (1) | WO1996024673A1 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998020110A1 (en) * | 1996-11-01 | 1998-05-14 | Human Genome Sciences, Inc. | HUMAN MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 (MAdCAM-1) AND SPLICE VARIANTS THEREOF |
| AU7348798A (en) * | 1997-05-09 | 1998-12-08 | John P. Robarts Research Institute, The | Method for dislodging infiltrated leukocytes from a tissue |
| US7090845B2 (en) | 1998-05-13 | 2006-08-15 | Genentech, Inc. | Diagnosis and treatment of hepatic disorders |
| WO1999058573A1 (en) * | 1998-05-13 | 1999-11-18 | Genentech, Inc. | Diagnosis and treatment of hepatic disorders |
| AU2007201698B2 (en) * | 1998-05-13 | 2011-10-13 | Genentech, Inc. | Diagnosis and treatment of hepatic disorders |
| AUPR524101A0 (en) | 2001-05-25 | 2001-06-21 | Council Of The Queensland Institute Of Medical Research, The | Antigen targeting |
| WO2003047526A2 (en) * | 2001-11-30 | 2003-06-12 | Incyte Genomics, Inc. | Cell adhesion and extracellular matrix proteins |
| WO2004081049A1 (en) * | 2003-03-10 | 2004-09-23 | Auckland Uniservices Limited | Monoclonal antibodies that recognise mucosal addressin cell adhesion molecule-1 (madcam-1), soluble madcam-1 and uses thereof |
| ES2355260T3 (es) | 2003-05-01 | 2011-03-24 | The Scripps Research Institute | Antagonistas de cadherina r selectivos y procedimientos. |
| MX350383B (es) * | 2004-01-09 | 2017-09-04 | Pfizer | Anticuerpos contra madcam. |
| RU2453558C2 (ru) * | 2004-09-03 | 2012-06-20 | Дженентек, Инк. | Гуманизированные антагонистические антитела против бета7 и их применение |
| JP2009500390A (ja) * | 2005-07-08 | 2009-01-08 | ファイザー・リミテッド | 新規ＭＡｄＣＡＭ抗体 |
| WO2007007152A2 (en) * | 2005-07-11 | 2007-01-18 | Pfizer Limited | Anti-madcam antibodies to treat metastatic cancers and chloroma |
| CN102124344B (zh) * | 2008-05-16 | 2015-04-01 | 霍夫曼-拉罗奇有限公司 | 生物标记用于评估β7整联蛋白拮抗剂治疗胃肠道炎性病症的用途 |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| TWI723339B (zh) | 2011-05-02 | 2021-04-01 | 美商千禧製藥公司 | 抗-α4β7抗體之調配物 |
| US20170327584A1 (en) | 2014-11-26 | 2017-11-16 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the Treatment of Fistulizing Crohn's Disease |
| WO2016105572A1 (en) | 2014-12-24 | 2016-06-30 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-α4β7 INTEGRIN ANTIBODY |
| MA41636A (fr) | 2015-03-06 | 2018-01-09 | Millennium Pharm Inc | Méthode de traitement de la cholangite sclérosante primitive |
| US20190077868A1 (en) | 2016-03-14 | 2019-03-14 | Millennium Pharmaceuticals, Inc. | Methods of treating or preventing graft versus host disease |
| WO2017160699A2 (en) | 2016-03-14 | 2017-09-21 | Millennium Pharmaceuticals, Inc. | Method of preventing graft versus host disease |
| WO2017165742A1 (en) | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments |
| US11760803B2 (en) | 2016-03-24 | 2023-09-19 | Takeda Pharmaceutical Company Limited | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
| US10918716B2 (en) | 2016-05-04 | 2021-02-16 | Millennium Pharmaceuticals, Inc. | Triple combination therapy for treating Crohn's disease |
| MA45245A (fr) | 2016-06-12 | 2019-04-17 | Millennium Pharm Inc | Méthode de traitement de maladie intestinale inflammatoire |
| WO2018104893A1 (en) | 2016-12-06 | 2018-06-14 | Glaxosmithkline Intellectual Property Development Limited | Alpha4-beta7 antibodies with incrased fcrn binding and/or half-life |
| AU2018256840A1 (en) | 2017-04-28 | 2019-11-07 | Millennium Pharmaceuticals, Inc. | Method of treating pediatric disorders with antibodies specific for alpha 4 beta 7 integrin (vedolizumab) |
| WO2019014572A1 (en) | 2017-07-14 | 2019-01-17 | Pfizer, Inc. | ANTIBODIES DIRECTED AGAINST MADCAM |
| EP3972992A4 (en) * | 2019-05-20 | 2023-07-19 | Pandion Operations, Inc. | ANTI-MADCAM IMMUNE TOLERANCE |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994013312A1 (en) * | 1992-12-15 | 1994-06-23 | The Board Of Trustees Of The Leland Stanford Junior University | Mucosal vascular addressin, dna and expression |
-
1996
- 1996-02-12 DE DE69637155T patent/DE69637155T2/de not_active Expired - Lifetime
- 1996-02-12 DK DK96906504T patent/DK0808367T3/da active
- 1996-02-12 AT AT96906504T patent/ATE366809T1/de active
- 1996-02-12 ES ES96906504T patent/ES2290955T3/es not_active Expired - Lifetime
- 1996-02-12 AU AU49862/96A patent/AU4986296A/en not_active Abandoned
- 1996-02-12 NZ NZ303523A patent/NZ303523A/en not_active IP Right Cessation
- 1996-02-12 MX MX9706049A patent/MX9706049A/es active IP Right Grant
- 1996-02-12 EP EP96906504A patent/EP0808367B1/en not_active Revoked
- 1996-02-12 WO PCT/US1996/002153 patent/WO1996024673A1/en active IP Right Grant
- 1996-02-12 CA CA2212702A patent/CA2212702C/en not_active Expired - Lifetime
- 1996-02-12 JP JP52449196A patent/JP4205162B2/ja not_active Expired - Fee Related
- 1996-02-12 PT PT96906504T patent/PT808367E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2212702C (en) | 2010-04-20 |
| DE69637155D1 (de) | 2007-08-23 |
| EP0808367A1 (en) | 1997-11-26 |
| PT808367E (pt) | 2007-10-22 |
| JPH10513365A (ja) | 1998-12-22 |
| ES2290955T3 (es) | 2008-02-16 |
| ATE366809T1 (de) | 2007-08-15 |
| CA2212702A1 (en) | 1996-08-15 |
| DE69637155T2 (de) | 2008-02-07 |
| NZ303523A (en) | 2002-02-01 |
| AU4986296A (en) | 1996-08-27 |
| JP4205162B2 (ja) | 2009-01-07 |
| DK0808367T3 (da) | 2007-11-05 |
| WO1996024673A1 (en) | 1996-08-15 |
| EP0808367B1 (en) | 2007-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights | ||
| FG | Grant or registration |